Gene Symbol: Mapk12
Description: mitogen-activated protein kinase 12
Alias: Sapk3, mitogen-activated protein kinase 12, ERK-6, MAP kinase 12, MAP kinase p38 gamma, MAPK 12, SAP kinase-3, extracellular signal-regulated kinase 6, mitogen-activated protein kinase p38 gamma, stress-activated protein kinase 3
Species: rat
Products:     Mapk12

Top Publications

  1. Tortorella L, Lin C, Pilch P. ERK6 is expressed in a developmentally regulated manner in rodent skeletal muscle. Biochem Biophys Res Commun. 2003;306:163-8 pubmed
    Rat ERK6, also known as SAPK3 and p38gamma, exhibits a distinct pattern of expression during muscle development in vitro and in vivo...
  2. Court N, Kuo I, Quigley O, Bogoyevitch M. Phosphorylation of the mitochondrial protein Sab by stress-activated protein kinase 3. Biochem Biophys Res Commun. 2004;319:130-7 pubmed
    ..Here, we show that stress-activated protein kinase-3 (SAPK3), a p38 MAPK subfamily member, localizes to the mitochondria...
  3. Eyers C, McNeill H, Knebel A, Morrice N, Arthur S, Cuenda A, et al. The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. Biochem J. 2005;389:127-35 pubmed
    ..shock, which was unaffected by SB 203580 and/or PD 184352, or in splenocytes from mice that do not express either SAPK3/p38gamma or SAPK4/p38delta...
  4. Yin J, Liu Y, Xu Y, Zhang Y, Chen J, Shu B, et al. Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain. J Pineal Res. 2006;41:124-9 pubmed
    ..We conclude that MEL can efficiently arrest peroxynitrite-induced tau hyperphosphorylation, and the underlying mechanism may involve scavenging the reactive species and suppressing the activated GSK-3beta and p38 MAPK family. ..
  5. Hasegawa M, Cuenda A, Spillantini M, Thomas G, Buee Scherrer V, Cohen P, et al. Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition. J Biol Chem. 1999;274:12626-31 pubmed
    ..Here we show that stress-activated protein kinase-3 (SAPK3, also called ERK6 and p38gamma), a member of the mitogen-activated protein kinase family that is abundantly ..
  6. Conrad P, Rust R, Han J, Millhorn D, Beitner Johnson D. Selective activation of p38alpha and p38gamma by hypoxia. Role in regulation of cyclin D1 by hypoxia in PC12 cells. J Biol Chem. 1999;274:23570-6 pubmed
    ..These studies demonstrate that an extremely typical physiological stress (hypoxia) causes selective activation of specific p38 signaling elements; and they also identify a downstream target of these pathways. ..
  7. Sabio G, Arthur J, Kuma Y, Peggie M, Carr J, Murray Tait V, et al. p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. EMBO J. 2005;24:1134-45 pubmed
    ..homologue of the Drosophila tumour suppressor Dlg, as a physiological substrate for the p38gamma MAP kinase (SAPK3/p38gamma) isoform...
  8. Lechner C, Zahalka M, Giot J, Møller N, Ullrich A. ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation. Proc Natl Acad Sci U S A. 1996;93:4355-9 pubmed
  9. Bellon S, Fitzgibbon M, Fox T, Hsiao H, Wilson K. The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation. Structure. 1999;7:1057-65 pubmed
    ..The conformation of the phosphorylation loop is likely to be similar in all activated MAP kinases, but not all activated MAP kinases form dimers. ..

More Information


  1. Sabio G, Reuver S, Feijoo C, Hasegawa M, Thomas G, Centeno F, et al. Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2. Biochem J. 2004;380:19-30 pubmed
    b>SAPK3 (stress-activated protein kinase-3, also known as p38gamma) is a member of the mitogen-activated protein kinase family; it phosphorylates substrates in response to cellular stress, and has been shown to bind through its C-terminal ..
  2. Mertens S, Craxton M, Goedert M. SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases. FEBS Lett. 1996;383:273-6 pubmed
    ..Transcripts encoding stress-activated protein kinase-3 are widely expressed, with high levels in skeletal muscle. ..
  3. Court N, Ingley E, Klinken S, Bogoyevitch M. Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-activated protein kinase-3. Biochim Biophys Acta. 2005;1744:68-75 pubmed
    Stress-activated protein kinase-3 (SAPK3) is unique amongst the mitogen-activated protein kinase (MAPK) family with its C-terminal 5 amino acids directing interaction with the PDZ domain-containing substrates alpha1-Syntrophin and SAP90/..
  4. Zheng A, Cao L, Qin S, Chen Y, Li Y, Zhang D. Exenatide Regulates Substrate Preferences Through the p38? MAPK Pathway After Ischaemia/Reperfusion Injury in a Rat Heart. Heart Lung Circ. 2017;26:404-412 pubmed publisher
    ..This protective effect was mediated, at least in part, through modulation of the cardiac p38? MAPK. ..
  5. Goedert M, Hasegawa M, Jakes R, Lawler S, Cuenda A, Cohen P. Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases. FEBS Lett. 1997;409:57-62 pubmed
    ..SAPK1gamma (also called JNK1), SAPK2a (also called p38, RK, CSBPs, Mpk2 and Mxi2), SAPK2b (also called p38beta), SAPK3 (also called ERK6 and p38gamma) and SAPK4 phosphorylate tau at many serine/threonine-prolines, as assessed by the ..
  6. Court N, dos Remedios C, Cordell J, Bogoyevitch M. Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3). J Mol Cell Cardiol. 2002;34:413-26 pubmed
    ..A third isoform of p38 MAPK, known variously as stress-activated protein kinase-3 (SAPK3), p38- gamma or ERK6, has been previously shown to differ from p38- alpha/ beta both in its molecular weight and ..
  7. Cuenda A, Rousseau S. p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta. 2007;1773:1358-75 pubmed
    ..Here we focus on these emergent roles of p38MAPKs and their implication in different pathologies. ..