Gene Symbol: Mapk10
Description: mitogen activated protein kinase 10
Alias: Jnk3, SAPKC, SAPb, Serk2, mitogen-activated protein kinase 10, MAP kinase 10, MAPK 10, SAPK-beta, Stress activated protein kinase beta, c-Jun N-terminal kinase 3, p54-beta, stress-activated protein kinase JNK3
Species: rat
Products:     Mapk10

Top Publications

  1. Yang D, Kuan C, Whitmarsh A, Rincon M, Zheng T, Davis R, et al. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature. 1997;389:865-70 pubmed
    ..One member of the JNK family, Jnk3, may be required for stress-induced neuronal apoptosis, as it is selectively expressed in the nervous system...
  2. Meeker R, Fernandes A. Osmotic and glutamate receptor regulation of c-Jun NH(2)-terminal protein kinase in neuroendocrine cells. Am J Physiol Endocrinol Metab. 2000;279:E475-86 pubmed
    ..Thus different JNK pathways may mediate individual cellular responses to osmotic stress, with JNK-2 linked to osmotic and glutamate receptor stimulation in magnocellular neuroendocrine cells...
  3. Yoshitane H, Honma S, Imamura K, Nakajima H, Nishide S, Ono D, et al. JNK regulates the photic response of the mammalian circadian clock. EMBO Rep. 2012;13:455-61 pubmed publisher
    ..Mice deficient for neuron-specific isoform JNK3 have altered behavioural rhythms, with longer free-running period and compromised phase shifts to light...
  4. Tönges L, Planchamp V, Koch J, Herdegen T, Bahr M, Lingor P. JNK isoforms differentially regulate neurite growth and regeneration in dopaminergic neurons in vitro. J Mol Neurosci. 2011;45:284-93 pubmed publisher
    ..Knockdown of JNK3 resulted in the most prominent neurite outgrowth impairment...
  5. Zhao J, Pei D, Zhang Q, Zhang G. Down-regulation Cdc42 attenuates neuronal apoptosis through inhibiting MLK3/JNK3 cascade during ischemic reperfusion in rat hippocampus. Cell Signal. 2007;19:831-43 pubmed
    ..Most importantly, knock-down endogenous Cdc42 selectively suppressed the MLK3/MKK7/JNK3 cascade, and subsequently blocked the phosphorylation of c-Jun and FasL expression...
  6. Zhang S, Garcia Gras E, Wycuff D, Marriot S, Kadeer N, Yu W, et al. Identification of direct serum-response factor gene targets during Me2SO-induced P19 cardiac cell differentiation. J Biol Chem. 2005;280:19115-26 pubmed
    ..The 12 regulated SRF target genes, Mapk10 (JNK3), Txnl2, Azi2, Tera, Sema3a, Lrp4, Actc1, Myl3, Hspg2, Pgm2, Hif3a, and Asb5, have been implicated in ..
  7. McDonald P, Chow C, Miller W, Laporte S, Field M, Lin F, et al. Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science. 2000;290:1574-7 pubmed
    ..We identified c-Jun amino-terminal kinase 3 (JNK3) as a binding partner of beta-arrestin 2 using a yeast two-hybrid screen and by coimmunoprecipitation from mouse ..
  8. Johnson G, Nakamura K. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Biochim Biophys Acta. 2007;1773:1341-8 pubmed
    ..In this review, we present our current understanding of JNK regulation and their involvement in homeostasis and dysregulation in human disease. ..
  9. Choi W, Kim H, Xia Z. JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death. Toxicology. 2015;328:75-81 pubmed publisher
    ..Here we report that the neural specific JNK3 isoform of the JNKs, but not JNK1 or JNK2, is responsible for this neuron death in primary cultured dopamine ..

More Information


  1. Zhu X, Raina A, Rottkamp C, Aliev G, Perry G, Boux H, et al. Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J Neurochem. 2001;76:435-41 pubmed
    ..We found that JNK2/SAPK-alpha and JNK3/SAPK-beta were related to neurofibrillary pathology and JNK1/SAP-Kgamma related to Hirano bodies in cases of AD but ..
  2. Yang G, Zhou X, Zhu J, Liu R, Zhang S, Coquinco A, et al. JNK3 couples the neuronal stress response to inhibition of secretory trafficking. Sci Signal. 2013;6:ra57 pubmed publisher
    ..We found that c-Jun amino-terminal kinase 3 (JNK3) inhibited secretory trafficking by promoting the depletion of phosphatidylinositol 4-phosphate (PI4P) in the Golgi ..
  3. Sury M, Agarinis C, Widmer H, Leib S, Christen S. JNK is activated but does not mediate hippocampal neuronal apoptosis in experimental neonatal pneumococcal meningitis. Neurobiol Dis. 2008;32:142-50 pubmed publisher
    ..Here we show in a neonatal rat model of pneumococcal meningitis that JNK3 but not JNK1 or JNK2 is activated in the hippocampus during the acute phase of infection...
  4. Bouman L, Schlierf A, Lutz A, Shan J, Deinlein A, Kast J, et al. Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ. 2011;18:769-82 pubmed publisher
  5. Butterfield L, Zentrich E, Beekman A, Heasley L. Stress- and cell type-dependent regulation of transfected c-Jun N-terminal kinase and mitogen-activated protein kinase kinase isoforms. Biochem J. 1999;338 ( Pt 3):681-6 pubmed
    ..Reverse transcription and PCR revealed that JNK3 is endogenously expressed in SCLC cells, but not in either chromaffin or neuronally differentiated PC12 cells...
  6. Kyriakis J, Banerjee P, Nikolakaki E, Dai T, Rubie E, Ahmad M, et al. The stress-activated protein kinase subfamily of c-Jun kinases. Nature. 1994;369:156-60 pubmed
    ..9). SAPKs therefore define a new TNF-alpha and stress-activated signalling pathway, possibly initiated by sphingomyelin-based second messengers, which regulates the activity of c-Jun. ..
  7. Chen B, Ma X, Geng Z, Huang S, Zhai L, Guo Y, et al. Up-regulation of c-Jun NH2-terminal kinase-interacting protein 3 (JIP3) contributes to BDNF-enhanced neurotransmitter release. J Neurochem. 2015;135:453-65 pubmed publisher
  8. Kieran M, Katz S, Vail B, Zon L, Mayer B. Concentration-dependent positive and negative regulation of a MAP kinase by a MAP kinase kinase. Oncogene. 1999;18:6647-57 pubmed
    ..We show that SEK1/MKK4, a MAP kinase kinase proposed to activate SAPK/JNK, is a very potent inhibitor of p54 SAPK beta/JNK3 both in vitro and in vivo if present at equimolar or higher ratios...
  9. Kim Y, Zhou P, Qian L, Chuang J, Lee J, Li C, et al. MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. J Exp Med. 2007;204:2063-74 pubmed
    ..from other MyD88s in that MyD88-5 is preferentially expressed in neurons, colocalizes in part with mitochondria and JNK3, and regulates neuronal death...
  10. Abdelli S, Bonny C. JNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling. PLoS ONE. 2012;7:e35997 pubmed publisher
    We have recently shown that silencing of the brain/islet specific c-Jun N-terminal Kinase3 (JNK3) isoform enhances both basal and cytokine-induced beta-cell apoptosis, whereas silencing of JNK1 or JNK2 has opposite effects...
  11. Apara A, Galvão J, Wang Y, Blackmore M, Trillo A, Iwao K, et al. KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS. J Neurosci. 2017;37:9632-9644 pubmed publisher
    ..We identified a novel binding partner, MAPK10/JNK3 kinase, and found that JNK3 (c-Jun N-terminal kinase 3) is critical for KLF9's axon-growth-suppressive ..
  12. Mielke K. Growth-arrest-dependent expression and phosphorylation of p27kip at serine10 is mediated by the JNK pathway in C6 glioma cells. Mol Cell Neurosci. 2008;38:301-11 pubmed publisher
    ..The observation that the expression of the JNK3 gene is lost in many human gliomas makes the JNK pathway an interesting target for investigation...
  13. Song X, Raman D, Gurevich E, Vishnivetskiy S, Gurevich V. Visual and both non-visual arrestins in their "inactive" conformation bind JNK3 and Mdm2 and relocalize them from the nucleus to the cytoplasm. J Biol Chem. 2006;281:21491-9 pubmed their interactions with two proteins involved in "life-and-death" decisions in the cell, the kinase JNK3 and the ubiquitin ligase Mdm2...
  14. Pan J, Zhang Q, Zhang G. The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region. Neuroscience. 2005;131:147-59 pubmed
    ..pattern of JNK signaling including mixed lineage kinase (MLK)3, mitogen-activated protein kinase kinase (MKK)7 and JNK3 in hippocampal CA1 and CA3/DG regions at various time points after 15 min of ischemia...
  15. Qi D, Liu H, Niu J, Fan X, Wen X, Du Y, et al. Heat shock protein 72 inhibits c-Jun N-terminal kinase 3 signaling pathway via Akt1 during cerebral ischemia. J Neurol Sci. 2012;317:123-9 pubmed publisher
    ..mild heat shock could increase the phosphorylation of protein kinase B (Akt), inhibit the assembly of MLK3-MKK7-JNK3 signaling module, diminish the phosphorylation of JNK3 and c-Jun, and decrease the activation of caspase-3...
  16. Han D, Zhang Q, Yong Liu -, Li C, Zong Y, Yu C, et al. Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion. FEBS Lett. 2008;582:1298-306 pubmed publisher
    ..assembly of the GluR6-PSD-95-MLK3 module induced by cerebral ischemia and the activation of the MLK3-MKK4/7-JNK3 cascade...
  17. Gupta R, Ghosh S. Phosphorylation of voltage-dependent anion channel by c-Jun N-terminal Kinase-3 leads to closure of the channel. Biochem Biophys Res Commun. 2015;459:100-6 pubmed publisher
    Stress activated c-Jun N-terminal Kinase-3 (JNK3) has been reported to act on mitochondrion to promote neuronal cell death...
  18. Atkinson P, Cho C, Hansen M, Green S. Activity of all JNK isoforms contributes to neurite growth in spiral ganglion neurons. Hear Res. 2011;278:77-85 pubmed publisher
    ..By transfecting epitope-tagged JNK1, JNK2, or JNK3 isoforms into SGNs, we found that all are present in the nucleus and cytoplasm and that there is no preferential ..
  19. Mori Y, Higuchi M, Hirabayashi Y, Fukuda M, Gotoh Y. JNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked release. EMBO J. 2008;27:76-87 pubmed
    ..Furthermore, mutation of Ser135 abrogated enhancement of Ca2+-evoked release by Syt 4. These results provide a molecular basis for the effect of growth factors on Ca2+-mediated secretion. ..
  20. Qi D, Tao J, Zhang L, Li M, Wang M, Qu R, et al. Neuroprotection of Cilostazol against ischemia/reperfusion-induced cognitive deficits through inhibiting JNK3/caspase-3 by enhancing Akt1. Brain Res. 2016;1653:67-74 pubmed publisher
    ..05). Additionally, Akt1 phosphorylation levels were evidently up-regulated (P<0.05), while the activation of JNK3, which is an important contributor to I/R-induced neuron apoptosis, was reduced by CTL after I/R (P<0...