Map3k11

Summary

Gene Symbol: Map3k11
Description: mitogen-activated protein kinase kinase kinase 11
Alias: Mlk-3, Mlk3, RHOE, mixed lineage kinase 3
Species: rat

Top Publications

  1. ncbi Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation
    Bei Miao
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, 84 West Huai hai Road, Xuzhou, Jiangsu 221002, China
    J Biol Chem 280:21693-9. 2005
  2. pmc The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis
    Z Xu
    Department of Pathology and Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mol Cell Biol 21:4713-24. 2001
  3. ncbi Evidence for a role of mixed lineage kinases in neuronal apoptosis
    M Mota
    Eisai London Research Laboratories, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 21:4949-57. 2001
  4. ncbi Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family
    H Teramoto
    Laboratory of Cellular Development and Oncology, NIDR, National Institutes of Health, Bethesda, Maryland 20892 4330, USA
    J Biol Chem 271:27225-8. 1996
  5. doi Mechanisms and functions of p38 MAPK signalling
    Ana Cuadrado
    CNIO, Spanish National Cancer Center, Madrid, Spain
    Biochem J 429:403-17. 2010
  6. pmc Cbl negatively regulates JNK activation and cell death
    Andrew A Sproul
    Department of Biological Sciences, Columbia University, New York, New York, USA
    Cell Res 19:950-61. 2009
  7. pmc S-nitrosylation of mixed lineage kinase 3 contributes to its activation after cerebral ischemia
    Shu Qun Hu
    Jiangsu Key Laboratory of Brain Disease Bioinformation and Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou, Jiangsu 221002, China
    J Biol Chem 287:2364-77. 2012
  8. ncbi The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region
    J Pan
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, 84 West Huai hai Road, Xuzhou 221002, Jiangsu, PR China
    Neuroscience 131:147-59. 2005
  9. doi K252a suppresses neuronal cells apoptosis through inhibiting the translocation of Bax to mitochondria induced by the MLK3/JNK signaling after transient global brain ischemia in rat hippocampal CA1 subregion
    Qing Wang
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, P R China
    J Recept Signal Transduct Res 31:307-13. 2011
  10. ncbi Delayed activation and regulation of MKK7 in hippocampal CA1 region following global cerebral ischemia in rats
    Quanguang Zhang
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, 84 West Huai hai Road, Xuzhou, Jiangsu, 221002, PR China
    Life Sci 74:37-45. 2003

Scientific Experts

  • Gary Johnson
  • Guang Yi Zhang
  • Quan Guang Zhang
  • Dong Sheng Pei
  • Dong Han
  • Qing Xiu Zhang
  • Shu Qun Hu
  • Qing Wang
  • Yan Yan Zong
  • Ana Cuadrado
  • Andrew A Sproul
  • Xiao Hui Yin
  • Rajakishore Mishra
  • Jie Zhao
  • Zhiheng Xu
  • Ya Feng Sun
  • Qiu Hua Guan
  • Ran Wang
  • J Pan
  • Bei Miao
  • Anindita Ganguly
  • Ki Yong Kim
  • Quanguang Zhang
  • Chang Cheng Sun
  • Z Xu
  • Yong Ping Wu
  • Jun Song Ye
  • M Mota
  • Tao Song
  • Dong hai Liu
  • Yong Liu
  • Angel R Nebreda
  • Yan Dong
  • Darrell W Brann
  • Michael Wilhelm
  • Ruimin Wang
  • Lloyd A Greene
  • Stephen Gire
  • Chang Zhou Yu
  • Chong Li
  • - Yong-Liu
  • Jing Zhi Yan
  • Wei Wang
  • Xiao Mei Liu
  • Ajay Rana
  • Basabi Rana
  • Manoj K Barthwal
  • Lucas Wong
  • Gautam Sondarva
  • James R Woodgett
  • Malay Chatterjee
  • Jing Xu
  • Qian Lu
  • G Y Zhang
  • Tian le Xu
  • Q G Zhang
  • Takashi Momoi
  • Seong Jin Kim
  • Nikolai Kholodilov
  • Tinmarla Frances Oo
  • Robert Pratt
  • Margarita Rzhetskaya
  • Byung Chul Kim
  • Olga Yarygina
  • Robert E Burke
  • Guangyi Zhang
  • Xinzhen Fu
  • Hui Tian
  • H Teramoto
  • J Chernoff
  • A C Maroney
  • N V Kukekov
  • C E Bazenet
  • P Dobrzanski
  • L A Greene
  • M Reeder
  • H Miyata
  • O A Coso
  • T Igishi
  • J S Gutkind
  • T Miki

Detail Information

Publications20

  1. ncbi Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation
    Bei Miao
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, 84 West Huai hai Road, Xuzhou, Jiangsu 221002, China
    J Biol Chem 280:21693-9. 2005
    ..In our present results, ischemic preconditioning could not only inhibit activations of mixed lineage kinase 3, JNK1/2, and c-Jun but also enhanced activation of Akt1...
  2. pmc The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis
    Z Xu
    Department of Pathology and Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mol Cell Biol 21:4713-24. 2001
    ..We show here that members of the mixed-lineage kinase (MLK) family (including MLK1, MLK2, MLK3, and dual leucine zipper kinase [DLK]) are expressed in neuronal cells and are likely to act between Rac1/Cdc42 and ..
  3. ncbi Evidence for a role of mixed lineage kinases in neuronal apoptosis
    M Mota
    Eisai London Research Laboratories, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 21:4949-57. 2001
    ..The mixed lineage kinase 3 (MLK3) belongs to a family of mitogen-activated protein (MAP) kinase kinase kinases...
  4. ncbi Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family
    H Teramoto
    Laboratory of Cellular Development and Oncology, NIDR, National Institutes of Health, Bethesda, Maryland 20892 4330, USA
    J Biol Chem 271:27225-8. 1996
    ..of homology to that in Pak1 that is involved in binding to Rac1 and Cdc42 led to the identification of mixed lineage kinase 3 (MLK3), also known as protein-tyrosine kinase 1, as a potential candidate for this function...
  5. doi Mechanisms and functions of p38 MAPK signalling
    Ana Cuadrado
    CNIO, Spanish National Cancer Center, Madrid, Spain
    Biochem J 429:403-17. 2010
    ..Finally, we discuss how genetic mouse models are facilitating the identification of physiological functions for p38 MAPKs, which may impinge on their eventual use as therapeutic targets...
  6. pmc Cbl negatively regulates JNK activation and cell death
    Andrew A Sproul
    Department of Biological Sciences, Columbia University, New York, New York, USA
    Cell Res 19:950-61. 2009
    ..Apoptotic stimuli lead to loss of Cbl protein/activity, thereby removing a critical brake on JNK activation and on cell death...
  7. pmc S-nitrosylation of mixed lineage kinase 3 contributes to its activation after cerebral ischemia
    Shu Qun Hu
    Jiangsu Key Laboratory of Brain Disease Bioinformation and Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou, Jiangsu 221002, China
    J Biol Chem 287:2364-77. 2012
    Previous studies in our laboratory have shown that mixed lineage kinase 3 (MLK3) can be activated following global ischemia...
  8. ncbi The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region
    J Pan
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, 84 West Huai hai Road, Xuzhou 221002, Jiangsu, PR China
    Neuroscience 131:147-59. 2005
    ..These results indicated that cerebral ischemia induced the continuous activation of MLK3/MKK7/JNK3 cascade, which all had two active waves only in the CA1 region...
  9. doi K252a suppresses neuronal cells apoptosis through inhibiting the translocation of Bax to mitochondria induced by the MLK3/JNK signaling after transient global brain ischemia in rat hippocampal CA1 subregion
    Qing Wang
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, P R China
    J Recept Signal Transduct Res 31:307-13. 2011
    ..These findings imply that K252a induced neuroprotection against ischemia/reperfusion in rat hippocampal CA1 subregion via inhibiting the mitochondrial apoptosis pathway induced by JNK activation...
  10. ncbi Delayed activation and regulation of MKK7 in hippocampal CA1 region following global cerebral ischemia in rats
    Quanguang Zhang
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, 84 West Huai hai Road, Xuzhou, Jiangsu, 221002, PR China
    Life Sci 74:37-45. 2003
    ..Consistent with the active phase, the interaction of MLK3, ASK1 and phospho-JNK with MKK7 was increased compared with sham control, as shown by coimmunoprecipitation ..
  11. ncbi CEP11004, a novel inhibitor of the mixed lineage kinases, suppresses apoptotic death in dopamine neurons of the substantia nigra induced by 6-hydroxydopamine
    Anindita Ganguly
    Department of Neurology, The College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Neurochem 88:469-80. 2004
    ..We conclude that c-jun phosphorylation is a general feature of apoptosis in living dopamine neurons and that the mixed lineage kinases play a functional role as up-stream mediators of cell death in these neurons...
  12. pmc Role of Rac1 GTPase in JNK signaling and delayed neuronal cell death following global cerebral ischemia
    Quan Guang Zhang
    Developmental Neurobiology Program, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Brain Res 1265:138-47. 2009
    ..Rac1 has been shown to interact with POSH (plenty of SH3s), a scaffold protein that binds to and regulates MLK3 and JNK activation...
  13. doi Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion
    Dong Han
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou, Jiangsu 221002, People s Republic of China
    FEBS Lett 582:1298-306. 2008
    ..The agonists inhibited the increased assembly of the GluR6-PSD-95-MLK3 module induced by cerebral ischemia and the activation of the MLK3-MKK4/7-JNK3 cascade...
  14. ncbi Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3
    Rajakishore Mishra
    Department of Internal Medicine, Cardiovascular and Cancer Research Institute, The Texas A and M University System HSC, College of Medicine, Texas 76504, USA
    J Biol Chem 282:30393-405. 2007
    b>Mixed lineage kinase 3 (MLK3) is a mitogen-activated protein kinase kinase kinase member that activates the c-Jun N-terminal kinase (JNK) pathway. Aberrant activation of MLK3 has been implicated in neurodegenerative diseases...
  15. ncbi Crosstalk between PSD-95 and JIP1-mediated signaling modules: the mechanism of MLK3 activation in cerebral ischemia
    Qing Xiu Zhang
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou 221002, China
    Biochemistry 46:4006-16. 2007
    Our previous study indicates that global ischemia facilitates the assembly of the GluR6.PSD-95.MLK3 signaling module, which in turn activated MLK3, leading to exacerbated ischemic neuron death...
  16. pmc The c-jun kinase/stress-activated pathway: regulation, function and role in human disease
    Gary L Johnson
    University of North Carolina at Chapel Hill, Department of Pharmacology, and Lineberger Comprehensive Cancer Center, 31 331 LCC Chapel Hill, NC 27599, USA
    Biochim Biophys Acta 1773:1341-8. 2007
    ..In this review, we present our current understanding of JNK regulation and their involvement in homeostasis and dysregulation in human disease...
  17. ncbi Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells
    Ki Yong Kim
    Laboratory of Cell Regulation and Carcinogenesis, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:29478-84. 2004
    ..We show here that the members of the mixed lineage kinase (MLK) family (including MLK1, MLK2, MLK3, and dual leucine zipper-bearing kinase (DLK)) are expressed in FaO rat hepatoma cells and are likely to act ..
  18. ncbi Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats
    Ran Wang
    Research Center for Biochemistry and Molecular Biology, Jiangsu Key Laboratory for Brain Disease Bioinformation, Xuzhou Medical College, Xuzhou, China
    J Neurochem 99:1543-54. 2006
    ..with beta-estradiol 3-benzoate (E2) enhanced Akt1 activation and reduced the activation of mixed-lineage kinase 3 (MLK3), mitogen-activated protein kinase kinase 4/7 (MKK4/7), and c-Jun N-terminal kinase 1/2 (JNK1/2) in the hippocampal ..
  19. ncbi N-Acetylcysteine inhibit the translocation of mixed lineage kinase-3 from cytosol to plasma membrane during transient brain ischemia in rat hippocampus
    Dong Sheng Pei
    Department of Neurobiology and Biophysics, School of Life Science, University of Science and Technology of China, Hefei 230027, PR China
    Neurosci Lett 391:38-42. 2005
    Mixed lineage kinase-3 (MLK3) is a recently described member of the MLK subfamily of Ser/Thr protein kinases that interacts with mitogen-activated protein kinase (MAPK) pathways...
  20. ncbi Down-regulation Cdc42 attenuates neuronal apoptosis through inhibiting MLK3/JNK3 cascade during ischemic reperfusion in rat hippocampus
    Jie Zhao
    Research Center for Biochemistry and Molecular Biology, Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College, Xuzhou, China
    Cell Signal 19:831-43. 2007
    ..Here we reported that ischemia/reperfusion significantly elevated Cdc42 activity, enhanced assembly of the Cdc42-MLK3 complex and activation of JNK pathway...

Research Grants34

  1. REGULATION OF SEQUENTIAL PROTEIN KINASE PATHWAYS
    Gary Johnson; Fiscal Year: 2007
    ....
  2. Function of MEKK3 and its osmosensing scaffold protein
    Gary Johnson; Fiscal Year: 2007
    ..These studies will define the mechanism for OSM/MEKK3 regulation of MAPK activation in osmoregulation, a critical regulatory response for homeostasis. ..
  3. RECEPTOR INTERACTION WITH GTP-REGULATORY PROTEINS
    Gary L Johnson; Fiscal Year: 2010
    ..Defining the global control not just of MAPK activity but protein degradation and gene expression by MEKK1 will identify novel therapeutic strategies for treating disease. ..
  4. REGULATION OF SEQUENTIAL PROTEIN KINASE PATHWAYS
    Gary L Johnson; Fiscal Year: 2010
    ..abstract_text> ..
  5. RECEPTOR INTERACTION WITH GTP-REGULATORY PROTEINS
    Gary Johnson; Fiscal Year: 2009
    ..Defining the global control not just of MAPK activity but protein degradation and gene expression by MEKK1 will identify novel therapeutic strategies for treating disease. ..
  6. Function of MEKK3 and its osmosensing scaffold protein
    Gary Johnson; Fiscal Year: 2009
    ....
  7. Function of MEKK3 and its osmosensing scaffold protein
    Gary L Johnson; Fiscal Year: 2010
    ....
  8. Inhibitor Screens for Five MAPK Kinase Kinases Important in Human Disease
    Gary Johnson; Fiscal Year: 2006
    ....
  9. RECEPTOR INTERACTION WITH GTP REGULATORY PROTEINS
    Gary Johnson; Fiscal Year: 2007
    ..Cumulatively, the studies will define new strategies for the development of pharmacological ligandsto regulate subsets of receptor functions that will have much more selective effects on target cells and tissues. ..
  10. NIH--EGF/NEU RECEPTOR SIGNAL TRANSDUCTION
    Gary Johnson; Fiscal Year: 2001
    ..4) Define the role of Cbl in ErbB1 signaling and the mediation of survival. ..
  11. REGULATION OF SEQUENTIAL PROTEIN KINASE PATHWAYS
    Gary Johnson; Fiscal Year: 2001
    ....
  12. REGULATION OF SEQUENTIAL PROTEIN KINASE PATHWAYS
    Gary Johnson; Fiscal Year: 2005
    ..abstract_text> ..
  13. UNC Center for Nanosensing the Stressome (RMI)
    Gary Johnson; Fiscal Year: 2004
    ..abstract_text> ..
  14. Function of MEKK3 and its osmosensing scaffold protein
    Gary Johnson; Fiscal Year: 2006
    ..These studies will define the mechanism for OSM/MEKK3 regulation of MAPK activation in osmoregulation, a critical regulatory response for homeostasis. ..
  15. REGULATION OF SEQUENTIAL PROTEIN KINASE PATHWAYS
    Gary L Johnson; Fiscal Year: 2010
    ..abstract_text> ..