Gene Symbol: Map1b
Description: microtubule-associated protein 1B
Alias: Mtap1b, microtubule-associated protein 1B, MAP-1B, neuraxin
Species: rat
Products:     Map1b

Top Publications

  1. Zauner W, Kratz J, Staunton J, Feick P, Wiche G. Identification of two distinct microtubule binding domains on recombinant rat MAP 1B. Eur J Cell Biol. 1992;57:66-74 pubmed
    ..The protein encoded was immunoreactive with monoclonal antibodies raised against calf MAP 1B, rat MAP 1X, and rat MAP 5, as shown by immunoblotting...
  2. Edelmann W, Zervas M, Costello P, Roback L, Fischer I, Hammarback J, et al. Neuronal abnormalities in microtubule-associated protein 1B mutant mice. Proc Natl Acad Sci U S A. 1996;93:1270-5 pubmed
    ..The roles of each of the different MAPs are not well understood. One of these proteins, MAP1B, is expressed in different portions of the brain and has been postulated to have a role in neuronal plasticity and ..
  3. DiTella M, Feiguin F, Carri N, Kosik K, Caceres A. MAP-1B/TAU functional redundancy during laminin-enhanced axonal growth. J Cell Sci. 1996;109 ( Pt 2):467-77 pubmed
  4. Schoenfeld T, McKerracher L, Obar R, Vallee R. MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS. J Neurosci. 1989;9:1712-30 pubmed
    ..We report here that MAP 1A and MAP 1B are, in fact, related at the level of subunit composition...
  5. Brugg B, Reddy D, Matus A. Attenuation of microtubule-associated protein 1B expression by antisense oligodeoxynucleotides inhibits initiation of neurite outgrowth. Neuroscience. 1993;52:489-96 pubmed
    ..These results indicate that microtubule-associated protein 1B is an essential component of the molecular mechanism underlying the formation of neuronal processes. ..
  6. Rienitz A, Grenningloh G, Hermans Borgmeyer I, Kirsch J, Littauer U, Prior P, et al. Neuraxin, a novel putative structural protein of the rat central nervous system that is immunologically related to microtubule-associated protein 5. EMBO J. 1989;8:2879-88 pubmed
    ..wt 94 kd. Sequence analysis identified a novel type of neuron-specific protein (named neuraxin) which is characterized by an unusual amino acid composition, 12 central heptadecarepeats and putative protein ..
  7. Scales T, Lin S, Kraus M, Goold R, Gordon Weeks P. Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons. J Cell Sci. 2009;122:2424-35 pubmed publisher
    b>MAP1B is a developmentally regulated microtubule-associated phosphoprotein that regulates microtubule dynamics in growing axons and growth cones...
  8. Schmoll H, Badan I, Fischer B, Wagner A. Dynamics of gene expression for immediate early- and late genes after seizure activity in aged rats. Arch Gerontol Geriatr. 2001;32:199-218 pubmed
    ..toward earlier times in the maximum expression of growth-related molecules, the microtubule-associated protein 1B (MAP1B) mRNA, which was very evident in 18 month old rats...
  9. Noiges R, Eichinger R, Kutschera W, Fischer I, Nemeth Z, Wiche G, et al. Microtubule-associated protein 1A (MAP1A) and MAP1B: light chains determine distinct functional properties. J Neurosci. 2002;22:2106-14 pubmed
    The microtubule-associated proteins 1A (MAP1A) and 1B (MAP1B) are distantly related protein complexes consisting of heavy and light chains and are thought to play a role in regulating the neuronal cytoskeleton, MAP1B during ..

More Information


  1. Yamauchi E, Titani K, Taniguchi H. Specific binding of acidic phospholipids to microtubule-associated protein MAP1B regulates its interaction with tubulin. J Biol Chem. 1997;272:22948-53 pubmed
    Microtubule-associated protein MAP1B, a major neuronal cytoskeletal protein, is expressed highly during the early stage of brain development and is thought to play an important role in brain development...
  2. Bergstrom R, Sinjoanu R, Ferreira A. Agrin induced morphological and structural changes in growth cones of cultured hippocampal neurons. Neuroscience. 2007;149:527-36 pubmed
    ..Together, these data provide further insights into the potential molecular mechanisms underlying the effects of agrin on neurite outgrowth in rat central neurons. ..
  3. Gandini M, Sandoval A, Zamponi G, Felix R. The MAP1B-LC1/UBE2L3 complex catalyzes degradation of cell surface CaV2.2 channels. Channels (Austin). 2014;8:452-7 pubmed publisher
    ..involves the interaction between the channel and the light chain (LC1) of the microtubule associated protein B (MAP1B)...
  4. Uchida Y. Overexpression of full-length but not N-terminal truncated isoform of microtubule-associated protein (MAP) 1B accelerates apoptosis of cultured cortical neurons. J Biol Chem. 2003;278:366-71 pubmed
    ..Here we report that nonaggregated or aggregated Abeta induced microtubule-associated protein 1B (MAP1B) mRNA, especially the alternative transcript containing exon 3U, before disruption of the cell membrane by Abeta...
  5. Ma D, Nothias F, Boyne L, Fischer I. Differential regulation of microtubule-associated protein 1B (MAP1B) in rat CNS and PNS during development. J Neurosci Res. 1997;49:319-32 pubmed
    b>MAP1B is a major cytoskeletal protein in growing axons and is strongly regulated during brain development...
  6. Trivedi N, Marsh P, Goold R, Wood Kaczmar A, Gordon Weeks P. Glycogen synthase kinase-3beta phosphorylation of MAP1B at Ser1260 and Thr1265 is spatially restricted to growing axons. J Cell Sci. 2005;118:993-1005 pubmed
    ..GSK-3beta phosphorylation of MAP1B appears to act as a molecular switch regulating the control that MAP1B exerts on microtubule dynamics in growing ..
  7. Emery D, Raghupathi R, Saatman K, Fischer I, Grady M, McIntosh T. Bilateral growth-related protein expression suggests a transient increase in regenerative potential following brain trauma. J Comp Neurol. 2000;424:521-31 pubmed
    ..The regional expression of proteins associated with axonal elongation, such as microtubule-associated protein 1B (MAP1B), its phosphorylated isoform (MAP1B-P), growth-associated protein 43 (GAP-43), and polysialylated neural cell-..
  8. Soares S, von Boxberg Y, Lombard M, Ravaille Veron M, Fischer I, Eyer J, et al. Phosphorylated MAP1B is induced in central sprouting of primary afferents in response to peripheral injury but not in response to rhizotomy. Eur J Neurosci. 2002;16:593-606 pubmed
    ..A potential neuron-intrinsic factor that may permit axonal sprouting is microtubule-associated protein 1B (MAP1B) in a specific phosphorylated form (MAP1B-P), restricted to growing or regenerating axons...
  9. Gressens P, Muaku S, Besse L, Nsegbe E, Gallego J, Delpech B, et al. Maternal protein restriction early in rat pregnancy alters brain development in the progeny. Brain Res Dev Brain Res. 1997;103:21-35 pubmed
    ..However, the almost complete normalization in adults of brain architecture and differentiation as well as our physiological data strongly suggest a remarkable plasticity of the developing brain following an early aggression. ..
  10. Silva A, Queiroz D, Castro Neto E, Naffah Mazzacoratti M, Godinho R, Porto C, et al. Segment-specific decrease of both catecholamine concentration and acetylcholinesterase activity are accompanied by nerve refinement in the rat cauda epididymis during sexual maturation. J Androl. 2002;23:374-83 pubmed
    ..Immunohistochemical studies against microtubule-associated protein 1B (MAP 1B), a neuronal cytoskeletal marker, further substantiated the quantitative changes observed in catecholaminergic and ..
  11. Gomi F, Uchida Y. MAP1B 1-126 interacts with tubulin isoforms and induces neurite outgrowth and neuronal death of cultured cortical neurons. Brain Res. 2012;1433:1-8 pubmed publisher
    Previously we reported that overexpression of MAP1B containing N-terminal 126 amino acids promoted neuronal death. Here, we identified ?-, ?-, and ?III-tubulins as proteins interacting with MAP1B 1-126 by two-hybrid and pull-down assays...
  12. Pang Z, Umberger G, Geddes J. Neuronal loss and cytoskeletal disruption following intrahippocampal administration of the metabolic inhibitor malonate: lack of protection by MK-801. J Neurochem. 1996;66:474-84 pubmed
    ..Cytoskeletal alterations included the loss of microtubule-associated protein 2 (MAP2) and dendritic MAP1B immunoreactivity, whereas axonal MAP1B and tau proteins were relatively spared...
  13. Kuo T, Hong C, Hsueh Y. Bcl11A/CTIP1 regulates expression of DCC and MAP1b in control of axon branching and dendrite outgrowth. Mol Cell Neurosci. 2009;42:195-207 pubmed publisher
    ..Finally, the expression of DCC and MAP1b, two molecules involved in direction and branching of axon outgrowth, is controlled by Bcl11A-L...
  14. Badan I, Dinca I, Buchhold B, Suofu Y, Walker L, Gratz M, et al. Accelerated accumulation of N- and C-terminal beta APP fragments and delayed recovery of microtubule-associated protein 1B expression following stroke in aged rats. Eur J Neurosci. 2004;19:2270-80 pubmed
    ..of an altered temporal relationship between factors promoting brain plasticity [microtubule-associated protein 1B (MAP1B)] and neurotoxic factors such as C-terminal betaAPP...
  15. Henríquez D, Bodaleo F, Montenegro Venegas C, Gonzalez Billault C. The light chain 1 subunit of the microtubule-associated protein 1B (MAP1B) is responsible for Tiam1 binding and Rac1 activation in neuronal cells. PLoS ONE. 2012;7:e53123 pubmed publisher
    Microtubule-associated protein 1B (MAP1B) is a neuronal protein involved in the stabilization of microtubules both in the axon and somatodendritic compartments...
  16. Matsumoto H, Jiang J, Mitani D, Sato E. Distribution and gene expression of cytoskeletal proteins in two-cell rat embryos and developmental arrest. J Exp Zool. 2002;293:641-8 pubmed
    ..Although distributions of alpha-actinin, MAP1A, MAP1B/MAP5, and MAP2 were disturbed in arrested embryos, these abnormal distributions occurred following the initiations ..
  17. Maurin J, Couble M, Staquet M, Carrouel F, About I, Avila J, et al. Microtubule-associated protein 1b, a neuronal marker involved in odontoblast differentiation. J Endod. 2009;35:992-6 pubmed publisher
    ..The aim of this work was to identify the MAP-1B expression in in vitro and in vivo human odontoblasts during development and carious processes. The expression of MAP2 and tau was also studied...
  18. Shah R, Anderson K, Rapoport M, Ferreira A. Estrogen-induced changes in the microtubular system correlate with a decreased susceptibility of aging neurons to beta amyloid neurotoxicity. Mol Cell Neurosci. 2003;24:503-16 pubmed the pool of unstable microtubules and the expression of juvenile microtubule-associated proteins MAP2c and MAP1b. These results provide further evidence that experimental conditions capable of increasing the pool of unstable ..
  19. Benjamin S, Cambray Deakin M, Burgoyne R. Effect of hypothyroidism on the expression of three microtubule-associated proteins (1A, 1B and 2) in developing rat cerebellum. Neuroscience. 1988;27:931-9 pubmed
    ..The results show that the restricted subcellular localization of these microtubule-associated proteins is maintained in the cerebellum of hypothyroid rats but the developmental changes in their expression are delayed. ..
  20. Tymanskyj S, Scales T, Gordon Weeks P. MAP1B enhances microtubule assembly rates and axon extension rates in developing neurons. Mol Cell Neurosci. 2012;49:110-9 pubmed publisher
    The microtubule-associated protein MAP1B is known to have important roles in neuronal development, particularly during neuronal migration and axonogenesis, but its precise molecular actions are unknown...
  21. Fischer B, Wagner A. Synaptic plasticity is preserved in the temporal cortex of 20-month-old rats. Arch Gerontol Geriatr. 1997;25:27-39 pubmed
    ..analysis we found that 72 h after the onset of seizure, the mRNA for microtubule-associated protein 1B (MAP1B), a marker of synaptic plasticity, was increased in the cortex of 3-month-old rats...
  22. Ma D, Connors T, Nothias F, Fischer I. Regulation of the expression and phosphorylation of microtubule-associated protein 1B during regeneration of adult dorsal root ganglion neurons. Neuroscience. 2000;99:157-70 pubmed
    ..These observations underscore the difference between axonal development and regeneration and the importance of injury-related effects that occur locally. ..
  23. Akita J, Takahashi M, Hojo M, Nishida A, Haruta M, Honda Y. Neuronal differentiation of adult rat hippocampus-derived neural stem cells transplanted into embryonic rat explanted retinas with retinoic acid pretreatment. Brain Res. 2002;954:286-93 pubmed
    ..We conclude that the microenvironment supplied by embryonic retinas is conductive to neuronal differentiation in general. RA stimulation before transplantation was also effective in stimulating differentiation. ..
  24. Tortosa E, Adolfs Y, Fukata M, Pasterkamp R, Kapitein L, Hoogenraad C. Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Neuron. 2017;94:809-825.e7 pubmed publisher
    ..We propose a model in which MAP6's palmitoylation mediates microtubule stabilization, allows efficient organelle trafficking, and controls axon maturation in vitro and in situ. ..
  25. Gong B, Miki T, Seino S, Renaud J. A K(ATP) channel deficiency affects resting tension, not contractile force, during fatigue in skeletal muscle. Am J Physiol Cell Physiol. 2000;279:C1351-8 pubmed
    ..It is also suggested that the K(ATP) channel plays an important role in protecting muscle function in older mice...
  26. Gong C, Wegiel J, Lidsky T, Zuck L, Avila J, Wisniewski H, et al. Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain. Brain Res. 2000;853:299-309 pubmed
    The function of the neuronal high molecular weight microtubule-associated proteins (MAPs) MAP1b and MAP2 is regulated by the degree of their phosphorylation, which in turn is controlled by the activities of protein kinases and protein ..
  27. Stroth U, Meffert S, Gallinat S, Unger T. Angiotensin II and NGF differentially influence microtubule proteins in PC12W cells: role of the AT2 receptor. Brain Res Mol Brain Res. 1998;53:187-95 pubmed
    ..neurite formation, we examined the effect of AT2 receptor stimulation on the microtubule components, beta-tubulin, MAP1B and MAP2, by Western blot analysis and immunofluorescence in quiescent and nerve growth factor (NGF)-..
  28. Soares S, Barnat M, Salim C, von Boxberg Y, Ravaille Veron M, Nothias F. Extensive structural remodeling of the injured spinal cord revealed by phosphorylated MAP1B in sprouting axons and degenerating neurons. Eur J Neurosci. 2007;26:1446-61 pubmed
    ..We have previously shown that a phosphorylated form of microtubule-associated protein-1B, MAP1B-P, is expressed by growing axons, but is detected in intact adult SC in fibers exhibiting a somatotopic ..
  29. Palenzuela R, Gutiérrez Y, Draffin J, Lario A, Benoist M, Esteban J. MAP1B Light Chain Modulates Synaptic Transmission via AMPA Receptor Intracellular Trapping. J Neurosci. 2017;37:9945-9963 pubmed publisher
    ..In this work, we uncovered a new role for the microtubule-associated protein MAP1B in modulating access of AMPARs to the postsynaptic membrane...
  30. Wang Z, Nie B, Chen H, Lu Y. Panaxynol induces neurite outgrowth in PC12D cells via cAMP- and MAP kinase-dependent mechanisms. Chem Biol Interact. 2006;159:58-64 pubmed
    ..neurite outgrowth in PC12D cells, concentration-dependently reduce cell division and up-regulate molecular marker (MAP1B) expression in PC12D cells. Panaxynol induces the elevation of intracellular cAMP in PC12D cells...
  31. Lönn P, Zaia K, Israelsson C, Althini S, Usoskin D, Kylberg A, et al. BMP enhances transcriptional responses to NGF during PC12 cell differentiation. Neurochem Res. 2005;30:753-65 pubmed
    ..BMP4 alone induced Smad6, Mtap1b and Hes1. Egr3 was the gene most strongly upregulated by NGF and BMP4...
  32. Zhao L, Ku L, Chen Y, Xia M, LoPresti P, Feng Y. QKI binds MAP1B mRNA and enhances MAP1B expression during oligodendrocyte development. Mol Biol Cell. 2006;17:4179-86 pubmed
    Microtubule-associated protein 1B (MAP1B) is essential for neural development. Besides the abundant expression in neurons, MAP1B recently was found in myelinating oligodendroglia...
  33. Kawakami S, Muramoto K, Ichikawa M, Kuroda Y. Localization of microtubule-associated protein (MAP) 1B in the postsynaptic densities of the rat cerebral cortex. Cell Mol Neurobiol. 2003;23:887-94 pubmed
    ..have been suggested to be important for synapse formation among cortical neurons, the localization of MAP1B in synapses has not yet been confirmed. In this report, we examine the localization of MAP1B in synaptic regions...
  34. Schmoll H, Badan I, Grecksch G, Walker L, Kessler C, Popa Wagner A. Kindling status in sprague-dawley rats induced by pentylenetetrazole: involvement of a critical development period. Am J Pathol. 2003;162:1027-34 pubmed
    ..of the plasticity-associated proteins, growth-associated protein-43 (GAP-43), microtubule-associated protein 1B (MAP1B), and tissue plasminogen activator (tPA) mRNAs in the hippocampus...
  35. Jiménez Mateos E, Gonzalez Billault C, Dawson H, Vitek M, Avila J. Role of MAP1B in axonal retrograde transport of mitochondria. Biochem J. 2006;397:53-9 pubmed
    The MAPs (microtubule-associated proteins) MAP1B and tau are well known for binding to microtubules and stabilizing these structures...
  36. Stroissnigg H, Trancikova A, Descovich L, Fuhrmann J, Kutschera W, Kostan J, et al. S-nitrosylation of microtubule-associated protein 1B mediates nitric-oxide-induced axon retraction. Nat Cell Biol. 2007;9:1035-45 pubmed
    ..S-nitrosylation occurs at Cys 2457 in the COOH terminus. Nitrosylation of MAP1B leads to enhanced interaction with microtubules and correlates with the inhibition of neuroblastoma cell ..
  37. Fowler J, McCracken E, Dewar D, McCulloch J. Intracerebral injection of AMPA causes axonal damage in vivo. Brain Res. 2003;991:104-12 pubmed
    ..AMPA receptor antagonism may have therapeutic potential to salvage both axons and neuronal perikarya in a number of neurological disorders. ..
  38. Fawcett J, Mathews G, Housden E, Goedert M, Matus A. Regenerating sciatic nerve axons contain the adult rather than the embryonic pattern of microtubule associated proteins. Neuroscience. 1994;61:789-804 pubmed
  39. Gumy L, Katrukha E, Grigoriev I, Jaarsma D, Kapitein L, Akhmanova A, et al. MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons. Neuron. 2017;94:347-362.e7 pubmed publisher
    ..We propose that selective axonal cargo trafficking requires the MAP2-defined pre-axonal filtering zone and the ability of cargos to switch between distinct kinesin motor activities. ..
  40. Franzen R, Tanner S, Dashiell S, Rottkamp C, Hammer J, Quarles R. Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein. J Cell Biol. 2001;155:893-8 pubmed
    ..demonstrated that MAG binds to a phosphorylated neuronal isoform of microtubule-associated protein 1B (MAP1B) expressed in dorsal root ganglion neurons (DRGNs) and axolemma-enriched fractions from myelinated axons of brain, ..
  41. Lebeau G, Miller L, Tartas M, McAdam R, Laplante I, Badeaux F, et al. Staufen 2 regulates mGluR long-term depression and Map1b mRNA distribution in hippocampal neurons. Learn Mem. 2011;18:314-26 pubmed publisher
    ..In addition, Stau2, but not Stau1, knockdown reduces the dendritic localization of Map1b mRNA, a specific transcript involved in mGluR-LTD...
  42. Nozumi M, Togano T, Takahashi Niki K, Lu J, Honda A, Taoka M, et al. Identification of functional marker proteins in the mammalian growth cone. Proc Natl Acad Sci U S A. 2009;106:17211-6 pubmed publisher
    ..Most of the proteins we identified have not previously been implicated in axon growth and thus their identification presents a significant step forward, providing marker proteins and candidate neuronal growth-associated proteins. ..
  43. Gonzalez Billault C, Engelke M, Jimenez Mateos E, Wandosell F, Caceres A, Avila J. Participation of structural microtubule-associated proteins (MAPs) in the development of neuronal polarity. J Neurosci Res. 2002;67:713-9 pubmed
    ..In this report we have characterized the effect of the combined suppression of MAP1B and tau, and MAP1B and MAP2 on neuronal polarization in cultured hippocampal cells grown on a laminin-containing ..
  44. Wang Q, Ding Y, Kohtz D, Kohtz S, Mizushima N, Cristea I, et al. Induction of autophagy in axonal dystrophy and degeneration. J Neurosci. 2006;26:8057-68 pubmed
    ..In brain, LC3 interacts with high affinity with the microtubule-associated protein 1B (MAP1B). We show that MAP1B binds to LC3 of both cytosolic form (LC3I) and lipidated form (LC3II)...
  45. Mann S, Hammarback J. Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B. J Biol Chem. 1994;269:11492-7 pubmed
    Light chain 3 (LC3) is a subunit of the neuronal microtubule-associated proteins (MAPs), MAP1A and MAP1B. Recent findings show that the cDNAs for MAP1A and MAP1B encode polyproteins that contain the MAP1A or MAP1B heavy chain and a LC2 ..
  46. Borland G, Gupta M, Magiera M, Rundell C, Fuld S, Yarwood S. Microtubule-associated protein 1B-light chain 1 enhances activation of Rap1 by exchange protein activated by cyclic AMP but not intracellular targeting. Mol Pharmacol. 2006;69:374-84 pubmed
    ..In the present study, we investigated whether the structurally related LC1 of MAP1B also interacts with EPAC1...
  47. Sun H, Hu X, Emerit M, Schoenebeck J, Kimmel C, Peoples R, et al. Modulation of 5-HT3 receptor desensitization by the light chain of microtubule-associated protein 1B expressed in HEK 293 cells. J Physiol. 2008;586:751-62 pubmed
    ..Here, we report that the light chain (LC1) of microtubule-associated protein 1B (MAP1B) specifically interacted with the 5-HT(3A) receptor, a predominant serotonin-gated ion channel in the brain...
  48. Goold R, Gordon Weeks P. The MAP kinase pathway is upstream of the activation of GSK3beta that enables it to phosphorylate MAP1B and contributes to the stimulation of axon growth. Mol Cell Neurosci. 2005;28:524-34 pubmed
    ..glycogen synthase kinase 3beta (GSK3beta), enabling it to phosphorylate the microtubule-associated protein 1B (MAP1B)...
  49. Teng J, Takei Y, Harada A, Nakata T, Chen J, Hirokawa N. Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization. J Cell Biol. 2001;155:65-76 pubmed
    b>MAP1B and MAP2 are major members of neuronal microtubule-associated proteins (MAPs). To gain insights into the function of MAP2 in vivo, we generated MAP2-deficient (map2(-/-)) mice...
  50. Grossman G, Beight C, Ebke L, Pauer G, Hagstrom S. Interaction of tubby-like protein-1 (Tulp1) and microtubule-associated protein (MAP) 1A and MAP1B in the mouse retina. Adv Exp Med Biol. 2014;801:511-8 pubmed publisher
    ..Our previous work has shown an association between Tulp1 and the microtubule-associated protein, MAP1B. An allele of Mtap1a, which encodes the MAP1A protein, significantly delays photoreceptor degeneration in Tulp1 ..
  51. Müller H, Neder A, Sommer C, Schäbitz W. Different postischemic protein expression of the GABA(A) receptor alpha2 subunit and the plasticity-associated protein MAP1B after treatment with BDNF versus G-CSF in the rat brain. Restor Neurol Neurosci. 2009;27:27-39 pubmed publisher
    ..Structural plasticity was further analyzed immunohistochemically using antibodies against MAP1B, MAP2 and synaptophysin...
  52. Sachana M, Flaskos J, Sidiropoulou E, Yavari C, Hargreaves A. Inhibition of extension outgrowth in differentiating rat C6 glioma cells by chlorpyrifos and chlorpyrifos oxon: effects on microtubule proteins. Toxicol In Vitro. 2008;22:1387-91 pubmed publisher
    ..C6 cell lysates revealed that 4 h exposure to CPF was associated with decreased levels of the cytoskeletal protein MAP1B compared to controls, whereas the levels of the cytoskeletal proteins tubulin and MAP2c were not significantly ..
  53. Kitamura C, Shirai K, Inoue M, Tashiro T. Changes in the subcellular distribution of microtubule-associated protein 1B during synaptogenesis of cultured rat cortical neurons. Cell Mol Neurobiol. 2007;27:57-73 pubmed
    Microtubule-associated protein 1B (MAP1B) is expressed mainly in the brain during early development and plays important roles in the regulation of microtubule dynamics which is essential to neurite outgrowth and elongation...
  54. Mantych K, Ferreira A. Agrin differentially regulates the rates of axonal and dendritic elongation in cultured hippocampal neurons. J Neurosci. 2001;21:6802-9 pubmed
    ..In the presence of agrin, there was an upregulation of the expression of microtubule-associated proteins MAP1B, MAP2, and tau. In contrast, a downregulation of the expression of these MAPs was detected in agrin-depleted cells...
  55. Liu D, Fischer I. Isolation and sequencing of the 5' end of the rat microtubule-associated protein (MAP1B)-encoding cDNA. Gene. 1996;171:307-8 pubmed
    We have isolated and sequenced the 5' end of the cDNA encoding the rat microtubule-associated protein 1B (MAP1B). We found that this region is highly homologous to the corresponding regions of the human [Lien et al...