Mael

Summary

Gene Symbol: Mael
Description: maelstrom spermatogenic transposon silencer
Alias: RGD1309333, protein maelstrom homolog, maelstrom homolog
Species: rat
Products:     Mael

Top Publications

  1. Soper S, van der Heijden G, Hardiman T, Goodheart M, Martin S, de Boer P, et al. Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis. Dev Cell. 2008;15:285-97 pubmed publisher
    ..In the adult Mael(-/-) testes, LINE-1 (L1) derepression occurred at the onset of meiosis...
  2. Aravin A, van der Heijden G, CastaƱeda J, Vagin V, Hannon G, Bortvin A. Cytoplasmic compartmentalization of the fetal piRNA pathway in mice. PLoS Genet. 2009;5:e1000764 pubmed publisher
    ..cell biological approaches to examine the performance of the piRNA pathway in germ cells of mice lacking Maelstrom (MAEL), an evolutionarily conserved protein implicated in transposon silencing in fruit flies and mice...
  3. Costa Y, Speed R, Gautier P, Semple C, Maratou K, Turner J, et al. Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?. Hum Mol Genet. 2006;15:2324-34 pubmed
    ..Here we show that MAEL, the ortholog of Drosophila's high mobility group box protein Maelstrom, is associated not only with the silenced ..
  4. Takebe M, Onohara Y, Yokota S. Expression of MAEL in nuage and non-nuage compartments of rat spermatogenic cells and colocalization with DDX4, DDX25 and MIWI. Histochem Cell Biol. 2013;140:169-81 pubmed publisher
    The functions of MAELSTROM protein (MAEL) in spermatogenesis are gradually being identified but the precise distribution of MAEL in spermatogenic cells during spermatogenesis has not yet been mapped...