Gene Symbol: Ltbp1
Description: latent transforming growth factor beta binding protein 1
Alias: latent-transforming growth factor beta-binding protein 1, LTBP-1, LanC (bacterial lantibiotic synthetase component C)-like 1, TGF-beta-1-BP-1, transforming growth factor beta-1-binding protein 1, transforming growth factor beta-1-masking protein large subunit, transforming growth factor-beta (TGF-beta) masking protein large subunit
Species: rat
Products:     Ltbp1

Top Publications

  1. Dallas S, Miyazono K, Skerry T, Mundy G, Bonewald L. Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein. J Cell Biol. 1995;131:539-49 pubmed
  2. Tsuji T, Okada F, Yamaguchi K, Nakamura T. Molecular cloning of the large subunit of transforming growth factor type beta masking protein and expression of the mRNA in various rat tissues. Proc Natl Acad Sci U S A. 1990;87:8835-9 pubmed
    ..The large subunit mRNA is synthesized in parallel with the expression of TGF-beta 1 mRNA in various rat tissues. ..
  3. Kanzaki T, Otabe M. Latent transforming growth factor-beta binding protein-1, a component of latent transforming growth factor-beta complex, accelerates the migration of aortic smooth muscle cells in diabetic rats through integrin-beta3. Diabetes. 2003;52:824-8 pubmed
    ..Taken together, these observations suggest that LTBP-1 plays a critical role in intimal thickening of diabetic artery through the acceleration of SMC migration via integrin-beta(3). ..
  4. Koli K, Ryynänen M, Keski Oja J. Latent TGF-beta binding proteins (LTBPs)-1 and -3 coordinate proliferation and osteogenic differentiation of human mesenchymal stem cells. Bone. 2008;43:679-88 pubmed publisher
    ..Our results provide evidence that LTBP isoforms can differentially regulate TGF-beta activation and ECM accumulation during osteogenic differentiation. ..
  5. Porst M, Daniel C, Plank C, Schocklmann H, Reinhardt D, Hartner A. Induction and coexpression of latent transforming growth factor beta-binding protein-1 and fibrillin-1 in experimental glomerulonephritis. Nephron Exp Nephrol. 2006;102:e99-104 pubmed
    ..An interaction of these molecules could stabilize latent TGF-beta complexes and thus attenuate the activation of TGF-beta during this self-limited glomerular disease. ..
  6. Kwok S, Qin L, Partridge N, Selvamurugan N. Parathyroid hormone stimulation and PKA signaling of latent transforming growth factor-beta binding protein-1 (LTBP-1) mRNA expression in osteoblastic cells. J Cell Biochem. 2005;95:1002-11 pubmed
    ..Overall, we demonstrate here that PTH stimulates LTBP-1 mRNA expression in osteoblastic cells and this is PKA-dependent. This event may be important for PTH action via TGF-beta in bone remodeling. ..
  7. Maeda S, Dean D, Gomez R, Schwartz Z, Boyan B. The first stage of transforming growth factor beta1 activation is release of the large latent complex from the extracellular matrix of growth plate chondrocytes by matrix vesicle stromelysin-1 (MMP-3). Calcif Tissue Int. 2002;70:54-65 pubmed
    ..Mr 25 kDa), the latency-associated peptide (LAP; Mr 75 kDa), and the latent TGF-beta1 binding protein-1 (LTBP1; Mr 190 kDa)...
  8. Zhu Y, Culmsee C, Roth Eichhorn S, Krieglstein J. Beta(2)-adrenoceptor stimulation enhances latent transforming growth factor-beta-binding protein-1 and transforming growth factor-beta1 expression in rat hippocampus after transient forebrain ischemia. Neuroscience. 2001;107:593-602 pubmed
    ..Our data demonstrate a concomitant increase in LTBP-1 and TGF-beta1 expression in the ischemic hippocampus after stimulation of beta(2)-adrenoceptors. ..
  9. Oklu R, Hesketh R. The latent transforming growth factor beta binding protein (LTBP) family. Biochem J. 2000;352 Pt 3:601-10 pubmed
    ..Over the past few years, three members of the LTBP family have been identified, in addition to the protoype LTBP1 first sequenced in 1990...

More Information


  1. Saharinen J, Hyytiäinen M, Taipale J, Keski Oja J. Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action. Cytokine Growth Factor Rev. 1999;10:99-117 pubmed
    ..The significance of this structural diversity is mostly unclear at present. ..
  2. Roth Eichhorn S, Kuhl K, Gressner A. Subcellular localization of (latent) transforming growth factor beta and the latent TGF-beta binding protein in rat hepatocytes and hepatic stellate cells. Hepatology. 1998;28:1588-96 pubmed
    ..Baseline information is provided from which new hypotheses regarding intracellular functions of TGF-beta, LAP, and LTBP in liver parenchymal and stellate cells can be concluded. ..
  3. Pedrozo H, Schwartz Z, Gomez R, Ornoy A, Xin Sheng W, Dallas S, et al. Growth plate chondrocytes store latent transforming growth factor (TGF)-beta 1 in their matrix through latent TGF-beta 1 binding protein-1. J Cell Physiol. 1998;177:343-54 pubmed
    ..transforming growth factor beta (TGF-beta) as well as a 290 kDa form containing latent TGF-beta binding protein-1 (LTBP1), which targets the latent complex to the matrix for storage...
  4. Pedrozo H, Schwartz Z, Mokeyev T, Ornoy A, Xin Sheng W, Bonewald L, et al. Vitamin D3 metabolites regulate LTBP1 and latent TGF-beta1 expression and latent TGF-beta1 incorporation in the extracellular matrix of chondrocytes. J Cell Biochem. 1999;72:151-65 pubmed
    ..TGF-beta1 in latent form (LTGF-beta1) and store it in the extracellular matrix via LTGF-beta1 binding protein (LTBP1)...
  5. Westhoff J, Sawitza I, Keski Oja J, Gressner A, Breitkopf K. PDGF-BB induces expression of LTBP-1 but not TGF-beta1 in a rat cirrhotic fat storing cell line. Growth Factors. 2003;21:121-30 pubmed
    ..This divergent regulation may represent an important mechanism for modulation of TGF-beta bioavailability. ..
  6. Dallas S, Sivakumar P, Jones C, Chen Q, Peters D, Mosher D, et al. Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1. J Biol Chem. 2005;280:18871-80 pubmed
    ..Here we show that fibronectin is critical for the incorporation of LTBP1 and transforming growth factor-beta (TGF beta) into the ECM of osteoblasts and fibroblasts...
  7. Koli K, Hyytiäinen M, Ryynänen M, Keski Oja J. Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts. Exp Cell Res. 2005;310:370-82 pubmed
    ..Our results suggest that ECM is an important site of deposition also for LTBP-3 and -4 and that the temporal and spatial targeting of the TGF-beta complexes are associated with ECM maturation. ..
  8. Lamers M, Gimenes F, Nogueira F, Nicolau J, Gama P, Santos M. Chronic hyperglycaemia increases TGFbeta2 signaling and the expression of extracellular matrix proteins in the rat parotid gland. Matrix Biol. 2007;26:572-82 pubmed
    ..TGFbeta receptor II (TbetaRII), phosphorylated Smads 2 and 3 (pSmads 2-3) and Latent TGFbeta Binding Protein 1 (LTBP1)...
  9. Soo C, Hu F, Zhang X, Wang Y, Beanes S, Lorenz H, et al. Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair. Am J Pathol. 2000;157:423-33 pubmed
    ..This inverse relationship between fibromodulin expression and scarring in both fetal and adult rat wound repair suggests that fibromodulin may be a biologically relevant modulator of TGF-beta activity during scar formation. ..
  10. Saharinen J, Keski Oja J. Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta. Mol Biol Cell. 2000;11:2691-704 pubmed
  11. Isogai Z, Ono R, Ushiro S, Keene D, Chen Y, Mazzieri R, et al. Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein. J Biol Chem. 2003;278:2750-7 pubmed
    ..In tissues where LTBP-1 is not expressed, LTBP-4 may substitute for LTBP-1, because the C-terminal end of LTBP-4 binds equally well to fibrillin. A model depicting the relationship between LTBP-1 and fibrillin microfibrils is proposed. ..
  12. Hori Y, Katoh T, Hirakata M, Joki N, Kaname S, Fukagawa M, et al. Anti-latent TGF-beta binding protein-1 antibody or synthetic oligopeptides inhibit extracellular matrix expression induced by stretch in cultured rat mesangial cells. Kidney Int. 1998;53:1616-25 pubmed
  13. Nakajima Y, Miyazono K, Kato M, Takase M, Yamagishi T, Nakamura H. Extracellular fibrillar structure of latent TGF beta binding protein-1: role in TGF beta-dependent endothelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart. J Cell Biol. 1997;136:193-204 pubmed
    ..These results suggest that LTBP-1 exists as an extracellular fibrillar structure and plays a role in the storage of TGF beta as a large latent TGF beta complex. ..