Gene Symbol: Ltb4r
Description: leukotriene B4 receptor
Alias: Ltb4r1, leukotriene B4 receptor 1, BLT-1, BLT1, LTB4-R 1, LTB4-R1
Species: rat
Products:     Ltb4r

Top Publications

  1. Han C, Huang H, Hu M, Luo W, Gao Y, Wang Q, et al. [Involvement of leukotrine B4 receptors in the inflammatory responses and immunological regulation in vitro]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2009;25:273-6 pubmed
    b>BLT1 and BLT2 were both recently cloned and identified as two subtypes of leukotrine B4 (LTB4) receptors...
  2. Han C, Huang H, Hu M, Wang Q, Gao Y, Liu Y. Time-dependent expression of leukotriene B4 receptors in rat collagen-induced arthritis. Prostaglandins Other Lipid Mediat. 2007;83:225-30 pubmed
    ..Since BLT(1) and BLT(2) play distinct roles during CIA, this study may provide basis for new therapies targeting BLT(1) and BLT(2), respectively, for the treatment of arthritic inflammation at different stages. ..
  3. Zhang S, Deng Y, Zhu Y, Dong X, Jiang J, Xie Q. Intracerebroventricular injection of leukotriene B4 attenuates antigen-induced asthmatic response via BLT1 receptor stimulating HPA-axis in sensitized rats. Respir Res. 2010;11:39 pubmed publisher
    ..Here, we investigated how the increased LTB4 level in brain interacts with HPA axis in regulating antigen-induced asthmatic response in sensitized rats...
  4. Toda A, Yokomizo T, Masuda K, Nakao A, Izumi T, Shimizu T. Cloning and characterization of rat leukotriene B(4) receptor. Biochem Biophys Res Commun. 1999;262:806-12 pubmed
    ..The present results suggest important roles of LTB(4) in macrophage recruitment and activation. ..
  5. Iizuka Y, Yokomizo T, Terawaki K, Komine M, Tamaki K, Shimizu T. Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes. J Biol Chem. 2005;280:24816-23 pubmed
    ..Two G-protein-coupled receptors for LTB4, BLT1 and BLT2, have been cloned from human and shown to be high and low affinity LTB4 receptors, respectively...
  6. Heller E, Liu E, Tager A, Sinha S, Roberts J, Koehn S, et al. Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment. Circulation. 2005;112:578-86 pubmed
    ..LTB(4) signals primarily through its high-affinity G protein-coupled receptor BLT1, which is expressed on specific leukocyte subsets...
  7. Bäck M, Bu D, Bränström R, Sheikine Y, Yan Z, Hansson G. Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia. Proc Natl Acad Sci U S A. 2005;102:17501-6 pubmed
    ..Inhibition of LTB(4)/BLT(1) signaling during the response to vascular injury reduced intimal hyperplasia, suggesting this pathway as a possible target for therapy. ..
  8. Jala V, Shao W, Haribabu B. Phosphorylation-independent beta-arrestin translocation and internalization of leukotriene B4 receptors. J Biol Chem. 2005;280:4880-7 pubmed
    Leukotriene B4 (LTB4) activates the G-protein-coupled receptor leukotriene B4 receptor 1 (BLT1) to mediate a diverse array of cellular responses in leukocytes including chemotaxis, calcium mobilization, degranulation, and gene expression...
  9. Serezani C, Aronoff D, Sitrin R, Peters Golden M. FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. Blood. 2009;114:3316-24 pubmed publisher
    ..In this study, we report that the LTB(4) receptor leukotriene B(4) receptor 1 (BLT1) redistributes from nonlipid raft (LR) to LR membrane microdomains upon immunoglobulin G-red blood cell, but not ..

More Information


  1. Ye Z, Zhuang Z, Wu L, Liu J, Chen Q, Zhang X, et al. Expression and cell distribution of leukotriene B4 receptor 1 in the rat brain cortex after experimental subarachnoid hemorrhage. Brain Res. 2016;1652:127-134 pubmed publisher
    ..of neutrophils, and its biological effects are mediated primarily through the high-affinity LTB4 receptor 1 (BLT1)...