Lrp5

Summary

Gene Symbol: Lrp5
Description: LDL receptor related protein 5
Alias: low-density lipoprotein receptor-related protein 5
Species: rat
Products:     Lrp5

Top Publications

  1. Holmen S, Salic A, Zylstra C, Kirschner M, Williams B. A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J Biol Chem. 2002;277:34727-35 pubmed
    ..by binding to seven-transmembrane spanning receptors of the Frizzled (Fz) family together with the coreceptors LRP5 and -6, members of the low density lipoprotein receptor-related protein family (LRP)...
  2. Yadav V, Ryu J, Suda N, Tanaka K, Gingrich J, Schutz G, et al. Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell. 2008;135:825-37 pubmed publisher
    Loss- and gain-of-function mutations in the broadly expressed gene Lrp5 affect bone formation, causing osteoporosis and high bone mass, respectively...
  3. Kelly O, Pinson K, Skarnes W. The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development. 2004;131:2803-15 pubmed
    Recent work has identified LDL receptor-related family members, Lrp5 and Lrp6, as co-receptors for the transduction of Wnt signals...
  4. Lindvall C, Evans N, Zylstra C, Li Y, Alexander C, Williams B. The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis. J Biol Chem. 2006;281:35081-7 pubmed
    ..Here we have shown that mice deficient for the Wnt co-receptor Lrp5 are resistant to Wnt1-induced mammary tumors, which have been shown to be derived from the mammary stem/progenitor ..
  5. Dong Y, Lathrop W, Weaver D, Qiu Q, Cini J, Bertolini D, et al. Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity. Biochem Biophys Res Commun. 1998;251:784-90 pubmed
    ..We predict that LR3 is a multi-functional protein with potential mitogenic activity. ..
  6. Gong Y, Slee R, Fukai N, Rawadi G, Roman Roman S, Reginato A, et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell. 2001;107:513-23 pubmed
    In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass accrual during growth...
  7. Xia C, Liu H, Cheung D, Wang M, Cheng C, Du X, et al. A model for familial exudative vitreoretinopathy caused by LPR5 mutations. Hum Mol Genet. 2008;17:1605-12 pubmed publisher
    ..reveals a single nucleotide insertion in the gene encoding the low-density lipoprotein receptor-related protein 5 (LRP5), causing a frame shift and resulting in the replacement of the C-terminal 39 amino acid residues by 20 new amino ..
  8. Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, et al. LDL-receptor-related proteins in Wnt signal transduction. Nature. 2000;407:530-5 pubmed
    ..is homologous to two members of the mammalian low-density lipoprotein receptor (LDLR)-related protein (LRP) family, LRP5 and LRP6 (refs 12-15). Here we report that LRP6 functions as a co-receptor for Wnt signal transduction...
  9. Fujino T, Asaba H, Kang M, Ikeda Y, Sone H, Takada S, et al. Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci U S A. 2003;100:229-34 pubmed
    A Wnt coreceptor low-density lipoprotein receptor-related protein 5 (LRP5) plays an essential role in bone accrual and eye development. Here, we show that LRP5 is also required for normal cholesterol and glucose metabolism...

More Information

Publications60

  1. Saarinen A, Saukkonen T, Kivela T, Lahtinen U, Laine C, Somer M, et al. Low density lipoprotein receptor-related protein 5 (LRP5) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemia. Clin Endocrinol (Oxf). 2010;72:481-8 pubmed publisher
    Mutations in the low-density lipoprotein receptor-related protein 5 gene (LRP5) underlie osteoporosis-pseudoglioma syndrome. Animal models implicate a role for LRP5 in lipid and glucose homeostasis...
  2. Sawakami K, Robling A, Ai M, Pitner N, Liu D, Warden S, et al. The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. J Biol Chem. 2006;281:23698-711 pubmed
    The cell surface receptor, low-density lipoprotein receptor-related protein 5 (LRP5) is a key regulator of bone mass...
  3. Babij P, Zhao W, Small C, Kharode Y, Yaworsky P, Bouxsein M, et al. High bone mass in mice expressing a mutant LRP5 gene. J Bone Miner Res. 2003;18:960-74 pubmed
    A unique mutation in LRP5 is associated with high bone mass in man. Transgenic mice expressing this LRP5 mutation have a similar phenotype with high bone mass and enhanced strength...
  4. Lindvall C, Zylstra C, Evans N, West R, Dykema K, Furge K, et al. The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development. PLoS ONE. 2009;4:e5813 pubmed publisher
    Canonical Wnt signals are transduced through a Frizzled receptor and either the LRP5 or LRP6 co-receptor; such signals play central roles during development and in disease...
  5. Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer. 2008;8:387-98 pubmed publisher
    ..Since then, further components of the Wnt pathway have been identified and their epistatic relationships have been defined. This article is a Timeline of crucial discoveries about the components and functions of this essential pathway. ..
  6. Kato M, Patel M, Levasseur R, Lobov I, Chang B, Glass D, et al. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol. 2002;157:303-14 pubmed
    ..Here we show that mice with a targeted disruption of Lrp5 develop a low bone mass phenotype...
  7. Mao J, Wang J, Liu B, Pan W, Farr G, Flynn C, et al. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell. 2001;7:801-9 pubmed
    ..In addition, the LRP-5 sequences involved in interactions with Axin are required for LEF-1 activation. Thus, we conclude that the binding of Axin to LRP-5 is an important part of the Wnt signal transduction pathway. ..
  8. Robling A, Niziolek P, Baldridge L, Condon K, Allen M, Alam I, et al. Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem. 2008;283:5866-75 pubmed
    ..The recent discovery of the antagonistic effects of sclerostin on Lrp5 receptor signaling, a crucial mediator of skeletal mechanotransduction, provides a potential mechanism for the ..
  9. Holmen S, Giambernardi T, Zylstra C, Buckner Berghuis B, Resau J, Hess J, et al. Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J Bone Miner Res. 2004;19:2033-40 pubmed
    Humans and mice lacking Lrp5 have low BMD. To evaluate whether Lrp5 and Lrp6 interact genetically to control bone or skeletal development, we created mice carrying mutations in both Lrp5 and the related gene Lrp6...
  10. Lui P, Lee Y, Wong Y, Zhang X, Dai K, Rolf C. Expression of Wnt pathway mediators in metaplasic tissue in animal model and clinical samples of tendinopathy. Rheumatology (Oxford). 2013;52:1609-18 pubmed publisher
    ..At various times the tendons were harvested for immunohistochemical staining of Wnt3a, ?-catenin, Lrp5 and Tcf1...
  11. Xu Q, Wang Y, Dabdoub A, Smallwood P, Williams J, Woods C, et al. Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell. 2004;116:883-95 pubmed
    ..These data define a Norrin-Fz4 signaling system that plays a central role in vascular development in the eye and ear, and they indicate that ligands unrelated to Wnts can act through Fz receptors. ..
  12. Fretz J, Zella L, Kim S, Shevde N, Pike J. 1,25-Dihydroxyvitamin D3 induces expression of the Wnt signaling co-regulator LRP5 via regulatory elements located significantly downstream of the gene's transcriptional start site. J Steroid Biochem Mol Biol. 2007;103:440-5 pubmed
    ..the Wnt family of proteins with a membrane receptor Frizzled on osteoblasts, an interaction that is facilitated by LRP5/LRP6 co-receptors...
  13. Piao S, Lee S, Kim H, Yum S, Stamos J, Xu Y, et al. Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. PLoS ONE. 2008;3:e4046 pubmed publisher
    ..These observations demonstrate that phosphorylated LRP6/5 both recruits and directly inhibits GSK3beta using two distinct portions of its cytoplasmic sequence, and suggest a novel mechanism of activation in this signaling pathway. ..
  14. Ding Y, Xi Y, Chen T, Wang J, Tao D, Wu Z, et al. Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. J Cell Biol. 2008;182:865-72 pubmed publisher
    The low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) are coreceptors for Frizzled and transmit signals from the plasma membrane to the cytosol. However, the mechanism for LRP5/6 signal transmission remains undefined...
  15. Li Z, Yang J, Vazquez E, Rose D, Vakar Lopez F, Mathew P, et al. Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone. Oncogene. 2008;27:596-603 pubmed
    ..MDA PCa 2b cells did not induce bone formation in calvaria from mice lacking the Wnt co-receptor Lrp5. In human specimens, WNT7b was not expressed in normal prostate but was expressed in areas of high-grade prostate ..
  16. Jiang X, Chen Y, Xu L, Li X, Cao F, Li L, et al. Association of LPR5 polymorphism with bone mass density and cholesterol level in population of Chinese Han. Exp Clin Endocrinol Diabetes. 2010;118:388-91 pubmed publisher
    ..near the osteoprotegerin (OPG) gene and rs3736228 in the low-density lipoprotein receptor-related protein 5 (LRP5) gene, were found to be associated with osteoporosis and osteoporotic fractures in Caucasians in a genome wide ..
  17. Caira F, Stock S, Gleason T, McGee E, Huang J, Bonow R, et al. Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation. J Am Coll Cardiol. 2006;47:1707-12 pubmed
    ..due to an osteoblastic differentiation process mediated by the low-density lipoprotein receptor-related protein 5 (Lrp5) signaling pathway to cause valve thickening...
  18. González Sancho J, Brennan K, Castelo Soccio L, Brown A. Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol Cell Biol. 2004;24:4757-68 pubmed
    ..Moreover, neither Dickkopf1, which inhibits Wnt/beta-catenin signaling by binding the Wnt coreceptors LRP5 and -6, nor dominant-negative LRP5/6 constructs could block Wnt-mediated Dvl phosphorylation...
  19. Sunters A, Armstrong V, Zaman G, Kypta R, Kawano Y, Lanyon L, et al. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 r. J Biol Chem. 2010;285:8743-58 pubmed publisher
    ..Initiation of this pathway does not involve the Wnt/LRP5/Frizzled receptor and does not culminate in increased IGF transcription...
  20. Lappalainen S, Saarinen A, Utriainen P, Voutilainen R, Jääskeläinen J, Makitie O. LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children. Clin Endocrinol (Oxf). 2009;70:725-31 pubmed publisher
    ..We hypothesized that genetic variation in low density lipoprotein (LDL) receptor-related protein 5 (LRP5), which is involved in Wnt signalling in the adrenal cortex and in cholesterol metabolism, plays a role in the ..
  21. Kulkarni N, Halladay D, Miles R, Gilbert L, Frolik C, Galvin R, et al. Effects of parathyroid hormone on Wnt signaling pathway in bone. J Cell Biochem. 2005;95:1178-90 pubmed
    ..Several Wnt pathway components, including low-density lipoprotein-receptor-related protein 5 (LRP5), LRP6, FZD-1, Dickkopf-1 (Dkk-1), and Kremen-1 (KRM-1), were expressed in bone in vivo and in osteoblasts in vitro...
  22. Zhou J, He H, Yang L, Chen S, Guo H, Xia L, et al. Effects of pulsed electromagnetic fields on bone mass and Wnt/?-catenin signaling pathway in ovariectomized rats. Arch Med Res. 2012;43:274-82 pubmed publisher
    ..showed that PEMFs increased the mRNA expressions of Wnt3a, low-density lipoprotein receptor-related protein 5(LRP5), ?-catenin, c-myc and runt-related gene 2 (Runx2), and reduced dickkopf1 (DKK1) in ovariectomized rats...
  23. Jiang Y, Zhang Y, Zhang H, Zhu B, Li P, Lu C, et al. Pravastatin prevents steroid-induced osteonecrosis in rats by suppressing PPAR? expression and activating Wnt signaling pathway. Exp Biol Med (Maywood). 2014;239:347-55 pubmed publisher
    ..proliferator-activated receptor gamma (PPAR?), Wnt3a, low density lipoprotein receptor-related protein 5 (LRP5), ?-catenin and runt-related transcription factor 2 (RUNX2) at both mRNA and protein levels were further detected ..
  24. Stathopoulou M, Dedoussis G, Trovas G, Katsalira A, Hammond N, Deloukas P, et al. Low-density lipoprotein receptor-related protein 5 polymorphisms are associated with bone mineral density in Greek postmenopausal women: an interaction with calcium intake. J Am Diet Assoc. 2010;110:1078-83 pubmed publisher
    The low-density lipoprotein receptor-related protein 5 (LRP5) has been shown to play a significant role in bone biology...
  25. Xiong D, Shen H, Zhao L, Xiao P, Yang T, Guo Y, et al. Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. J Bone Miner Res. 2006;21:1678-95 pubmed
    ..We detected four genes (DBP, LRP5, CYP17, and RANK) that showed highly suggestive associations (10,000-permutation derived empirical global p < or ..
  26. Zhang B, Luo S, Wang Q, Suzuki T, Xiong W, Mei L. LRP4 serves as a coreceptor of agrin. Neuron. 2008;60:285-97 pubmed publisher
    ..These observations indicate that LRP4 is a coreceptor of agrin that is necessary for MuSK signaling and AChR clustering and identify a potential target protein whose mutation and/or autoimmunization may cause muscular dystrophies. ..
  27. Jiao X, Ventruto V, Trese M, Shastry B, Hejtmancik J. Autosomal recessive familial exudative vitreoretinopathy is associated with mutations in LRP5. Am J Hum Genet. 2004;75:878-84 pubmed
    ..This region contains LRP5 but not FZD4; mutations in both of these genes cause autosomal dominant FEVR...
  28. Sun L, Pan J, Peng Y, Wu Y, Li J, Liu X, et al. Anabolic steroids reduce spinal cord injury-related bone loss in rats associated with increased Wnt signaling. J Spinal Cord Med. 2013;36:616-22 pubmed publisher
    ..SCI reduced mRNA levels of Wnt signaling-related genes Wnt3a, low-density lipoprotein receptor-related protein 5 (LRP5), Fzd5, Tcf7, and ectodermal-neural cortex 1 (ENC1) in osteoblasts, whereas nandrolone increased expression of each ..
  29. Ryan P, Young J. Evidence against a human cell-specific role for LRP6 in anthrax toxin entry. PLoS ONE. 2008;3:e1817 pubmed publisher
    ..but other studies performed with cells from gene-knockout mice demonstrated no role for either LRP6 or the related LRP5 protein in anthrax toxin entry...
  30. Niziolek P, Bullock W, Warman M, Robling A. Missense Mutations in LRP5 Associated with High Bone Mass Protect the Mouse Skeleton from Disuse- and Ovariectomy-Induced Osteopenia. PLoS ONE. 2015;10:e0140775 pubmed publisher
    The low density lipoprotein receptor-related protein-5 (LRP5), a co-receptor in the Wnt signaling pathway, modulates bone mass in humans and in mice...
  31. Akhter M, Wells D, Short S, Cullen D, Johnson M, Haynatzki G, et al. Bone biomechanical properties in LRP5 mutant mice. Bone. 2004;35:162-9 pubmed
    ..substitution at amino acid residue 171 in the gene coding for low-density lipoprotein receptor-related protein 5 (LRP5) [Bone Miner. Res. 16(4) (2001) 758]...
  32. Dubrow S, Hruby P, Akhter M. Gender specific LRP5 influences on trabecular bone structure and strength. J Musculoskelet Neuronal Interact. 2007;7:166-73 pubmed
    A mutation in LRP5 (low-density lipoprotein receptor-related protein 5) has been shown to increase bone mass and density in humans and animals...
  33. Toomes C, Bottomley H, Jackson R, Towns K, Scott S, Mackey D, et al. Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q. Am J Hum Genet. 2004;74:721-30 pubmed
    ..Here, we describe mutations in a second gene at the EVR1 locus, low-density-lipoprotein receptor-related protein 5 (LRP5), a Wnt coreceptor...
  34. Alapati D, Rong M, Chen S, Lin C, Li Y, Wu S. Inhibition of LRP5/6-mediated Wnt/?-catenin signaling by Mesd attenuates hyperoxia-induced pulmonary hypertension in neonatal rats. Pediatr Res. 2013;73:719-25 pubmed publisher
    ..Low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) are Wnt coreceptors that bind to Wnt ligands and mediate canonical Wnt/?-catenin signaling...
  35. Ergun S, Akay G, Ergun M, Percin E. LRP5-linked osteoporosis-pseudoglioma syndrome mimicking isolated microphthalmia. Eur J Med Genet. 2017;60:200-204 pubmed publisher
    ..When the results of the exome and microarray data were considered together as a splice-site mutation in LRP5 gene [c...
  36. Björklund P, Akerstrom G, Westin G. An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling. PLoS Med. 2007;4:e328 pubmed
    ..Mechanisms that may account for this activation have not been identified, except for a few cases of beta-catenin (CTNNB1) stabilizing mutation in pHPT tumors...
  37. Cheung W, Jin L, Smith D, Cheung P, Kwan E, Low L, et al. A family with osteoporosis pseudoglioma syndrome due to compound heterozygosity of two novel mutations in the LRP5 gene. Bone. 2006;39:470-6 pubmed
    ..is an autosomal recessive disorder due to mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene...
  38. Wang Z, Shu W, Lu M, Morrisey E. Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Mol Cell Biol. 2005;25:5022-30 pubmed
    ..involves the binding of Wnt ligands to cell surface receptors of the frizzled family and coreceptors of the LRP5/6 family...
  39. Lobov I, Rao S, Carroll T, Vallance J, Ito M, Ondr J, et al. WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature. 2005;437:417-21 pubmed
    ..These findings indicate that macrophages can use WNT ligands to influence cell-fate decisions--including cell death--in adjacent cells, and raise the possibility that they do so in many different cellular contexts. ..
  40. Caruso A, Motolese M, Iacovelli L, Caraci F, Copani A, Nicoletti F, et al. Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells. J Neurochem. 2006;98:364-71 pubmed
    ..In contrast, the enforced expression of LRP5 unmasked an inhibition by ApoE2 and ApoE3, which, however, were less effective than ApoE4 in inhibiting Wnt ..
  41. Badders N, Goel S, Clark R, Klos K, Kim S, Bafico A, et al. The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. PLoS ONE. 2009;4:e6594 pubmed publisher
    ..The Wnt signaling receptors, Lrp5/6, are uniquely required for canonical Wnt activity...
  42. Ye X, Wang Y, Cahill H, Yu M, Badea T, Smallwood P, et al. Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell. 2009;139:285-98 pubmed publisher
    ..Mutations in the Frizzled-4 (Fz4) receptor, Lrp5 coreceptor, or Norrin ligand cause retinal hypovascularization, but the mechanisms by which Norrin/Fz4/Lrp ..
  43. Liu M, Li Y, Pan J, Liu H, Wang S, Teng J, et al. Effects of zuogui pill (see text) on Wnt singal transduction in rats with glucocorticoid-induced osteoporosis. J Tradit Chin Med. 2011;31:98-102 pubmed
    ..Zuogui Pill can prevent and treat glucocorticoid-induced osteoporosis in rats by up-regulating the expression of the key signal molecules Wnt1, LRP-5 and beta-catenin in Wnt signal transduction pathway. ..
  44. Urano T, Shiraki M, Narusawa K, Usui T, Sasaki N, Hosoi T, et al. Q89R polymorphism in the LDL receptor-related protein 5 gene is associated with spinal osteoarthritis in postmenopausal Japanese women. Spine (Phila Pa 1976). 2007;32:25-9 pubmed
    ..polymorphism (SNP) causing an amino-acid change (Q89R) in the low-density lipoprotein receptor-related protein 5 (LRP5) coding region with spinal osteoarthritis...
  45. Qin M, Kondo H, Tahira T, Hayashi K. Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy. Hum Genet. 2008;122:615-23 pubmed
    Mutations in Norrin signaling genes (NDP, FZD4 and LRP5) have been found in patients with familial exudative vitreoretinopathy (FEVR) and the altered signaling is suspected to play a critical role in its pathogenesis...
  46. Qiu W, Andersen T, Bollerslev J, Mandrup S, Abdallah B, Kassem M. Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells. J Bone Miner Res. 2007;22:1720-31 pubmed
    Genetic mutations in the LRP5 gene affect Wnt signaling and lead to changes in bone mass in humans. Our in vivo and in vitro results show that activated mutation T253I of LRP5 enhances osteogenesis and inhibits adipogenesis...
  47. Jacobsen C, Barber L, Ayturk U, Roberts H, Deal L, Schwartz M, et al. Targeting the LRP5 pathway improves bone properties in a mouse model of osteogenesis imperfecta. J Bone Miner Res. 2014;29:2297-306 pubmed publisher
    The cell surface receptor low-density lipoprotein receptor-related protein 5 (LRP5) is a key regulator of bone mass and bone strength...
  48. Iwaniec U, Wronski T, Liu J, Rivera M, Arzaga R, Hansen G, et al. PTH stimulates bone formation in mice deficient in Lrp5. J Bone Miner Res. 2007;22:394-402 pubmed
    b>Lrp5 deficiency decreases bone formation and results in low bone mass. This study evaluated the bone anabolic response to intermittent PTH treatment in Lrp5-deficient mice...
  49. Spoelgen R, Adams K, Koker M, Thomas A, Andersen O, Hallett P, et al. Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11. Neuroscience. 2009;158:1460-8 pubmed publisher
  50. Korvala J, Juppner H, Makitie O, Sochett E, Schnabel D, Mora S, et al. Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity. BMC Med Genet. 2012;13:26 pubmed publisher
    ..can be caused by heterozygous missense mutations in the Low-density lipoprotein receptor-related protein 5 (LRP5) gene, and the role of LRP5 is further investigated here...
  51. Caricasole A, Ferraro T, Iacovelli L, Barletta E, Caruso A, Melchiorri D, et al. Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. J Biol Chem. 2003;278:37024-31 pubmed
    ..Our functional analysis indicates that WNT7A can specifically act via a Frizzled-5.LRP6 receptor complex in PC12 cells and that this activity can be antagonized by Dickkopf-1 and Dickkopf-3. ..