Gene Symbol: Lpin1
Description: lipin 1
Alias: phosphatidate phosphatase LPIN1
Species: rat
Products:     Lpin1

Top Publications

  1. Finck B, Gropler M, Chen Z, Leone T, Croce M, Harris T, et al. Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab. 2006;4:199-210 pubmed
    ..These results identify lipin 1 as a selective physiological amplifier of the PGC-1alpha/PPARalpha-mediated control of hepatic lipid metabolism. ..
  2. Higashida K, Higuchi M, Terada S. Potential role of lipin-1 in exercise-induced mitochondrial biogenesis. Biochem Biophys Res Commun. 2008;374:587-91 pubmed publisher
    ..These results may suggest that enhanced expression of lipin-1 is involved in exercise-induced mitochondrial enzyme adaptations, possibly through AMPK- and beta2-AR-related mechanisms. ..
  3. Peterfy M, Phan J, Xu P, Reue K. Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat Genet. 2001;27:121-4 pubmed
    ..The gene (Lpin1) encodes a novel nuclear protein which we have named lipin...
  4. Huffman T, Mothe Satney I, Lawrence J. Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin. Proc Natl Acad Sci U S A. 2002;99:1047-52 pubmed
    ..Thus, lipin represents a target of the mTOR pathway, and potentially links this nutrient-sensing pathway to adipocyte development. ..
  5. Donkor J, Sariahmetoglu M, Dewald J, Brindley D, Reue K. Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. J Biol Chem. 2007;282:3450-7 pubmed
    We previously identified mutations in the Lpin1 gene, encoding lipin-1, as the underlying cause of lipodystrophy in the fatty liver dystrophy (fld) mutant mouse...
  6. Grimsey N, Han G, O Hara L, Rochford J, Carman G, Siniossoglou S. Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2. J Biol Chem. 2008;283:29166-74 pubmed publisher
    ..We propose that distinct and non-redundant functions of lipin 1 and 2 regulate lipid production during the cell cycle and adipocyte differentiation. ..
  7. Liu G, Gerace L. Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells. PLoS ONE. 2009;4:e7031 pubmed publisher
  8. Romić S, Tepavčević S, Žakula Z, Milosavljević T, Kostić M, Petković M, et al. Gender differences in the expression and cellular localization of lipin 1 in the hearts of fructose-fed rats. Lipids. 2014;49:655-63 pubmed publisher
    ..Increased inhibitory phosphorylation of IRS-1 is possible link between cardiac lipid metabolism and insulin resistance in FFR. ..
  9. Kok B, Dyck J, Harris T, Brindley D. Differential regulation of the expressions of the PGC-1? splice variants, lipins, and PPAR? in heart compared to liver. J Lipid Res. 2013;54:1662-77 pubmed publisher
    ..Our results identify novel differences in the regulation of lipins, PPAR?, and PGC-1? splice variants during fasting in heart versus liver, even though the ultimate outcome in both tissues is to increase FA turnover and oxidation. ..

More Information


  1. Han S, Bahmanyar S, Zhang P, Grishin N, Oegema K, Crooke R, et al. Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. J Biol Chem. 2012;287:3123-37 pubmed publisher
    ..The nuclear fraction of lipin-1b is increased when CTDNEP1 and NEP1-R1 are co-expressed. Therefore, NEP1-R1 is functionally conserved from yeast to humans and functions in the lipin activation pathway. ..
  2. Kim D, Kim J, Koh M, Kim Y, Lee J, Chanda D, et al. Estrogen-related receptor ? (ERR?) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling. J Biol Chem. 2011;286:38035-42 pubmed publisher
  3. Huang H, Gao Q, Peng X, Choi S, Sarma K, Ren H, et al. piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling. Dev Cell. 2011;20:376-87 pubmed publisher
    ..We propose that mitochondrial-surface PA generated by MitoPLD/Zuc recruits or activates nuage components critical for piRNA production. ..
  4. Langner C, Birkenmeier E, Ben Zeev O, Schotz M, Sweet H, Davisson M, et al. The fatty liver dystrophy (fld) mutation. A new mutant mouse with a developmental abnormality in triglyceride metabolism and associated tissue-specific defects in lipoprotein lipase and hepatic lipase activities. J Biol Chem. 1989;264:7994-8003 pubmed
    ..This mutation could serve as a useful model for (i) analyzing the homeostatic mechanisms controlling lipid metabolism in newborn mice and (ii) understanding and treating certain inborn errors in human triglyceride metabolism. ..
  5. Manmontri B, Sariahmetoglu M, Donkor J, Bou Khalil M, Sundaram M, Yao Z, et al. Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically. J Lipid Res. 2008;49:1056-67 pubmed publisher
    ..Selective lipin-1 expression explains the GC and cAMP effects on increased hepatic PAP1 activity, which occurs in hepatic steatosis during starvation, diabetes, stress, and ethanol consumption. ..
  6. Verheijen M, Chrast R, Burrola P, Lemke G. Local regulation of fat metabolism in peripheral nerves. Genes Dev. 2003;17:2450-64 pubmed
    ..However, several such genes, including SREBP-1, SREBP-2, and Lpin1, are also expressed in the endoneurium...
  7. Kim H, Kumar A, Wang L, Liu G, Keller S, Lawrence J, et al. Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Mol Cell Biol. 2010;30:3126-39 pubmed publisher
    ..These observations place lipin 1 as a potentially important link between triacylglycerol synthesis and adipose tissue inflammation. ..
  8. Mitra M, Schilling J, Wang X, Jay P, Huss J, Su X, et al. Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor ? coactivator 1?/estrogen related receptor axis. J Mol Cell Cardiol. 2011;51:120-8 pubmed publisher
    ..We also demonstrate that the expression of the gene encoding lipin 1 (Lpin1) is under the control of the estrogen-related receptors (ERRs) and their coactivator the peroxisome proliferator-..
  9. Mul J, Nadra K, Jagalur N, Nijman I, Toonen P, Medard J, et al. A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the rat. J Biol Chem. 2011;286:26781-93 pubmed publisher
    The Lpin1 gene encodes the phosphatidate phosphatase (PAP1) enzyme Lipin 1, which plays a critical role in lipid metabolism...
  10. Croce M, Eagon J, LaRiviere L, Korenblat K, Klein S, Finck B. Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss. Diabetes. 2007;56:2395-9 pubmed
    ..These studies suggest that hepatic lipin 1beta and PGC-1alpha expression are downregulated by obesity and obesity-related metabolic perturbations in human subjects, likely due to alterations in insulin concentration or sensitivity. ..
  11. Chen S, Zhuang X, Liu Y, Sun A, Chen C. Expression and significance of lipin1 and AMPK? in hepatic insulin resistance in diet-induced insulin resistance rats. Exp Clin Endocrinol Diabetes. 2012;120:84-8 pubmed publisher
    ..These findings indicated that the decrease in lipin1 expression and AMPK? activation may contribute to hepatic insulin resistance in diet-induced obese rats. ..
  12. Lecker S, Jagoe R, Gilbert A, Gomes M, Baracos V, Bailey J, et al. Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. FASEB J. 2004;18:39-51 pubmed
    ..Thus, different types of muscle atrophy share a common transcriptional program that is activated in many systemic diseases. ..
  13. Romić S, Krskova K, Olszanecki R, Balazova L, Lory V, Koricanac G, et al. Obesity- and age-related alterations in FAT/CD36 translocation and lipin-1 subcellular localization in skeletal muscle of the Zucker rats. Gen Physiol Biophys. 2017;36:399-406 pubmed publisher