Gene Symbol: Lpar3
Description: lysophosphatidic acid receptor 3
Alias: Edg7, lysophosphatidic acid receptor 3, LPA receptor 3, LPA-3, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7, lysophosphatidic acid receptor Edg-7, snGPCR32
Species: rat
Products:     Lpar3

Top Publications

  1. Panupinthu N, Zhao L, Possmayer F, Ke H, Sims S, Dixon S. P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid. J Biol Chem. 2007;282:3403-12 pubmed
    ..This pathway may contribute to P2X7-stimulated osteogenesis during skeletal development and mechanotransduction. ..
  2. Yang J, Nie Y, Wang F, Hou J, Cong X, Hu S, et al. Reciprocal regulation of miR-23a and lysophosphatidic acid receptor signaling in cardiomyocyte hypertrophy. Biochim Biophys Acta. 2013;1831:1386-94 pubmed publisher
  3. Inoue S, Tanabe E, Shibata A, Hirane M, Araki M, Dong Y, et al. Ethionine regulates cell motile activity through LPA receptor-3 in liver epithelial WB-F344 cells. Mol Cell Biochem. 2013;383:173-7 pubmed publisher
    ..The expression of the Lpar3 gene in ethionine-treated cells was significantly higher than that in untreated cells...
  4. Alcántara Hernández R, Hernández Méndez A, Campos Martínez G, Meizoso Huesca A, García Sáinz J. Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA1, LPA2, and LPA3. PLoS ONE. 2015;10:e0140583 pubmed publisher
  5. Yamada T, Ohoka Y, Kogo M, Inagaki S. Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs). J Biol Chem. 2005;280:19358-63 pubmed
    ..Taken together, these results indicate that formation of the LPA receptor/PDZ domain-containing RhoGEF complex plays a pivotal role in LPA-induced RhoA activation. ..
  6. Kim M, Lee H, Park K, Shin E, Jo S, Yun J, et al. Lysophosphatidic acid stimulates cell proliferation in rat chondrocytes. Biochem Pharmacol. 2005;70:1764-71 pubmed
    ..This study demonstrates the physiological role of LPA on the modulation of rat primary chondrocyte proliferation, and the crucial role played by ERK in the process. ..
  7. Hayashi M, Okabe K, Yamawaki Y, Teranishi M, Honoki K, Mori T, et al. Loss of lysophosphatidic acid receptor-3 enhances cell migration in rat lung tumor cells. Biochem Biophys Res Commun. 2011;405:450-4 pubmed publisher
    ..In this study, to assess an involvement of the other LPA receptor, Lpar3, in the pathogenesis of rat lung tumor cells, we measured the expression levels of the Lpar3 gene and its DNA ..
  8. Furuta D, Yamane M, Tsujiuchi T, Moriyama R, Fukushima N. Lysophosphatidic acid induces neurite branch formation through LPA3. Mol Cell Neurosci. 2012;50:21-34 pubmed publisher
    ..These findings suggest that the novel signaling pathway involving LPA(3), G(q), and Rnd2 may play an important role in neuronal network formation. ..
  9. Moller T, Contos J, Musante D, Chun J, Ransom B. Expression and function of lysophosphatidic acid receptors in cultured rodent microglial cells. J Biol Chem. 2001;276:25946-52 pubmed
    ..We examined whether any of the known LPA receptor genes (lp(A1)/Edg2, lp(A2)/Edg4, and lp(A3)/Edg7) are expressed by cultured mouse or rat microglia...

More Information


  1. Siess W, Tigyi G. Thrombogenic and atherogenic activities of lysophosphatidic acid. J Cell Biochem. 2004;92:1086-94 pubmed
    ..Antagonists of LPA receptors might be useful in preventing LPA-elicited thrombus formation and neointima formation in patients with cardiovascular diseases. ..
  2. Kim J, Keys J, Eckhart A. Vascular smooth muscle migration and proliferation in response to lysophosphatidic acid (LPA) is mediated by LPA receptors coupling to Gq. Cell Signal. 2006;18:1695-701 pubmed
  3. Okabe K, Hayashi M, Kato K, Okumura M, Fukui R, Honoki K, et al. Lysophosphatidic acid receptor-3 increases tumorigenicity and aggressiveness of rat hepatoma RH7777 cells. Mol Carcinog. 2013;52:247-54 pubmed publisher
    ..to assess the biological role of LPA receptor-3 (LPA3 ) in the pathogenesis of tumor cells, we generated the Lpar3-expressing cells (RHa3B12 and RHa3G8) from rat hepatoma RH7777 cells, and examined their abilities of cell ..
  4. Hama K, Bandoh K, Kakehi Y, Aoki J, Arai H. Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors. FEBS Lett. 2002;523:187-92 pubmed
    ..acid (LPA) exerts multiple biological functions through G protein-coupled receptors (EDG2/LPA(1), EDG4/LPA(2), and EDG7/LPA(3)) and is present in serum where it is associated with albumin...
  5. Zhou Z, Niu J, Zhang Z. The role of lysophosphatidic acid receptors in phenotypic modulation of vascular smooth muscle cells. Mol Biol Rep. 2010;37:2675-86 pubmed publisher
    ..These data suggest that LPA-induced phenotypic modulation is mediated through the PTX-insensitive G-protein(s), possibly Gq-coupled LPA3 receptor. ..
  6. Fayyaz S, Japtok L, Schumacher F, Wigger D, Schulz T, Haubold K, et al. Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity. Cell Physiol Biochem. 2017;43:445-456 pubmed publisher
    ..5-25). LPA is able to interrupt insulin signaling in primary rat hepatocytes via the LPA3 receptor subtype. Moreover, the bioactive lipid LPA (16: 0) is increased in obesity. ..
  7. Beltrame J, Sordelli M, Cella M, Perez Martinez S, Franchi A, Ribeiro M. Lysophosphatidic acid increases the production of pivotal mediators of decidualization and vascularization in the rat uterus. Placenta. 2013;34:751-6 pubmed publisher
    ..These results suggest the participation of LPA/LPA3 in the production of crucial molecules involved in vascularization and decidualization, two main processes that prepare the uterine milieu for embryo invasion during implantation. ..