Gene Symbol: Loxl3
Description: lysyl oxidase-like 3
Alias: lysyl oxidase homolog 3
Mäki J, Kivirikko K. Cloning and characterization of a fourth human lysyl oxidase isoenzyme. Biochem J. 2001;355:381-7 pubmed
..Recombinant LOXL3, expressed in HT-1080 cells, was secreted into the culture medium but was not detected by immunofluorescence ..
Peinado H, Del Carmen Iglesias de la Cruz M, Olmeda D, Csiszar K, Fong K, Vega S, et al
. A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. EMBO J. 2005;24:3446-58 pubmed
..Here we show that lysyl-oxidase-like 2 and 3 (LOXL2 and LOXL3), two members of the lysyl-oxidase gene family, interact and cooperate with Snail to downregulate E-cadherin ..
Zhang J, Liu Z, Zhang T, Lin Z, Li Z, Zhang A, et al
. Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice. Sci Rep. 2016;6:33856 pubmed publisher
Lysyl oxidase-like 3 (LOXL3), a human disease gene candidate, is a member of the lysyl oxidase (LOX) family and is indispensable for mouse palatogenesis and vertebral column development...
Ma L, Huang C, Wang X, Xin D, Wang L, Zou Q, et al
. Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation. Mol Cell. 2017;65:296-309 pubmed publisher
..LOX-like 3 (Loxl3) associates with Stat3 in the nucleus to deacetylate and deacetyliminate Stat3 on multiple acetyl-lysine sites...
Zhang J, Yang R, Liu Z, Hou C, Zong W, Zhang A, et al
. Loss of lysyl oxidase-like 3 causes cleft palate and spinal deformity in mice. Hum Mol Genet. 2015;24:6174-85 pubmed publisher
..In this study, we investigated the essential role of lysyl oxidase-like 3 (LOXL3), a member of the LOX family, in embryonic development...
Kraft Sheleg O, Zaffryar Eilot S, Genin O, Yaseen W, Soueid Baumgarten S, Kessler O, et al
. Localized LoxL3-Dependent Fibronectin Oxidation Regulates Myofiber Stretch and Integrin-Mediated Adhesion. Dev Cell. 2016;36:550-61 pubmed publisher
..We show that lysyl oxidase-like 3 (LoxL3) is a key regulator of integrin signaling that ensures localized control of the cascade...