Gene Symbol: Loxl2
Description: lysyl oxidase-like 2
Alias: lysyl oxidase homolog 2, lysyl oxidase-like protein 2
Species: rat
Products:     Loxl2

Top Publications

  1. Xu L, Go E, Finney J, Moon H, Lantz M, Rebecchi K, et al. Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells. J Biol Chem. 2013;288:5357-63 pubmed publisher
    ..The catalytic domain of hLOX was not secreted from S2 cells using the same expression system. These results suggest that the N-glycan at Asn-644 of hLOXL2 enhances the solubility and stability of the LOX catalytic domain. ..
  2. Millanes Romero A, Herranz N, Perrera V, Iturbide A, Loubat Casanovas J, Gil J, et al. Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition. Mol Cell. 2013;52:746-57 pubmed publisher
    ..the Snail1 transcription factor represses mouse pericentromeric transcription, acting through the H3K4 deaminase LOXL2. Since Snail1 plays a key role in the epithelial-to-mesenchymal transition (EMT), we analyzed the regulation of ..
  3. Cuevas E, Moreno Bueno G, Canesin G, Santos V, Portillo F, Cano A. LOXL2 catalytically inactive mutants mediate epithelial-to-mesenchymal transition. Biol Open. 2014;3:129-37 pubmed publisher
    Lysyl-oxidase-like 2 (LOXL2) is a member of the lysyl oxidase family that catalyzes the cross-linking of collagens or elastins in the extracellular matrix, thus regulating the tensile strength of tissues...
  4. Herranz N, Dave N, Millanes Romero A, Pascual Reguant L, Morey L, Diaz V, et al. Lysyl oxidase-like 2 (LOXL2) oxidizes trimethylated lysine 4 in histone H3. FEBS J. 2016;283:4263-4273 pubmed publisher
    ..Here we describe that its deamination can be catalyzed by lysyl oxidase-like 2 protein (LOXL2), presenting an unconventional chemical mechanism for H3K4 modification...
  5. Peinado H, Del Carmen Iglesias de la Cruz M, Olmeda D, Csiszar K, Fong K, Vega S, et al. A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. EMBO J. 2005;24:3446-58 pubmed
    ..Here we show that lysyl-oxidase-like 2 and 3 (LOXL2 and LOXL3), two members of the lysyl-oxidase gene family, interact and cooperate with Snail to downregulate E-..
  6. Iftikhar M, Hurtado P, Bais M, Wigner N, Stephens D, Gerstenfeld L, et al. Lysyl oxidase-like-2 (LOXL2) is a major isoform in chondrocytes and is critically required for differentiation. J Biol Chem. 2011;286:909-18 pubmed publisher
    ..A remarkable coincidence of LOXL2 expression with the chondrogenic phase of fracture healing was found, prompting more detailed analyses of LOXL2 ..
  7. Bignon M, Pichol Thievend C, Hardouin J, Malbouyres M, Bréchot N, Nasciutti L, et al. Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane. Blood. 2011;118:3979-89 pubmed publisher
    ..Here, we report the characterization of lysyl oxidase-like protein-2 (LOXL2) as a hypoxia-target expressed in neovessels and accumulated in the endothelial ECM...
  8. Li T, Xu L, Wu Z, Liao L, SHEN J, Xu X, et al. Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase-like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma. Hum Pathol. 2012;43:1068-76 pubmed publisher
    ..These results suggest that lysyl oxidase L2 exerts a critical effect on esophageal squamous cell carcinoma progression and can be a predictive marker of lymph node metastasis and outcome. ..
  9. Cuevas E, Eraso P, Mazón M, Santos V, Moreno Bueno G, Cano A, et al. LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway. Sci Rep. 2017;7:44988 pubmed publisher
    ..Among them, overexpression of LOXL2 (lysyl oxidase-like 2) induces EMT independent of its catalytic activity...

More Information


  1. Iturbide A, Pascual Reguant L, Fargas L, Cebrià J, Alsina B, García de Herreros A, et al. LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes during Neural Progenitor Differentiation. Mol Cell. 2015;58:755-66 pubmed publisher
    ..uncontrolled and nonenzymatic, many enzymatic oxidations occur on enzyme-selected lysine residues; for instance, LOXL2 oxidizes lysines by converting the ε-amino groups into aldehyde groups...