Gene Symbol: Loxl1
Description: lysyl oxidase-like 1
Alias: lysyl oxidase homolog 1
Species: rat
Products:     Loxl1

Top Publications

  1. Micheal S, Khan M, Akhtar F, Ali M, Ahmed A, den Hollander A, et al. Role of Lysyl oxidase-like 1 gene polymorphisms in Pakistani patients with pseudoexfoliative glaucoma. Mol Vis. 2012;18:1040-4 pubmed
    Single nucleotide polymorphisms (SNPs) rs1048661 (p.R141L) and rs3825942 (p.G153D) in the lysyl oxidase-like 1 (LOXL1) gene have been previously reported to be associated with pseudoexfoliation glaucoma (PEXG) in various Asian and ..
  2. Rautenbach R, Bardien S, Harvey J, Ziskind A. An investigation into LOXL1 variants in black South African individuals with exfoliation syndrome. Arch Ophthalmol. 2011;129:206-10 pubmed publisher
    To investigate the association between 2 lysyl oxidase-like 1 (LOXL1) polymorphisms, rs1048661 (R141L) and rs3825942 (G153D), and exfoliation syndrome (XFS) in black South African individuals.
  3. Chakrabarti S, Rao K, Kaur I, Parikh R, Mandal A, Chandrasekhar G, et al. The LOXL1 gene variations are not associated with primary open-angle and primary angle-closure glaucomas. Invest Ophthalmol Vis Sci. 2008;49:2343-7 pubmed publisher
    ..Recently, single nucleotide polymorphisms (SNPs) in the LOXL1 gene have been implicated in exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) but not in the primary ..
  4. Gong W, Chiang S, Chen L, Tam P, Jia L, Leung D, et al. Evaluation of LOXL1 polymorphisms in primary open-angle glaucoma in southern and northern Chinese. Mol Vis. 2008;14:2381-9 pubmed
    The lysyl oxidase-like protein 1 (LOXL1) gene is strongly associated with exfoliation glaucoma, which is very rare in the Chinese population...
  5. Wolf C, Gramer E, Muller Myhsok B, Pasutto F, Gramer G, Wissinger B, et al. Lysyl oxidase-like 1 gene polymorphisms in German patients with normal tension glaucoma, pigmentary glaucoma and exfoliation glaucoma. J Glaucoma. 2010;19:136-41 pubmed publisher
    To evaluate the association between lysyl-oxidase-like 1 (LOXL1) gene polymorphisms and exfoliation glaucoma, pigmentary glaucoma and normal tension glaucoma in a case-control cohort of German patients.
  6. Lee K, Ho S, Thalamuthu A, Venkatraman A, Venkataraman D, Pek D, et al. Association of LOXL1 polymorphisms with pseudoexfoliation in the Chinese. Mol Vis. 2009;15:1120-6 pubmed
    Single nucleotide polymorphisms (SNPs) within the lysyl oxidase like-1 gene (LOXL1; rs1048661 and rs3825942) were found to confer risk to pseudoexfoliation glaucoma (XFG) through the pseudoexfoliation syndrome (XFS) in Nordic, Caucasian, ..
  7. Nilsson M, Adamo H, Bergh A, Halin Bergström S. Inhibition of Lysyl Oxidase and Lysyl Oxidase-Like Enzymes Has Tumour-Promoting and Tumour-Suppressing Roles in Experimental Prostate Cancer. Sci Rep. 2016;6:19608 pubmed publisher
    ..Further investigations are needed to understand the circumstances under which LOX inhibition may be used as a therapeutic target for cancer patients. ..
  8. Kim Y, Peyrol S, So C, Boyd C, Csiszar K. Coexpression of the lysyl oxidase-like gene (LOXL) and the gene encoding type III procollagen in induced liver fibrosis. J Cell Biochem. 1999;72:181-8 pubmed
    ..Moreover, the substrate specificity of the LOXL protein may be different to that of lysyl oxidase and this difference may be collagen-type specific. ..
  9. Fuse N, Mengkegale M, Miyazawa A, Abe T, Nakazawa T, Wakusawa R, et al. Polymorphisms in ARMS2 (LOC387715) and LOXL1 genes in the Japanese with age-related macular degeneration. Am J Ophthalmol. 2011;151:550-6.e1 pubmed publisher
    To determine whether polymorphisms in the ARMS2 (LOC387715) gene and the lysyl oxidase-like 1 (LOXL1) gene are associated with age-related macular degeneration (AMD) in Japanese patients. Clinically relevant laboratory investigation...

More Information


  1. Fan B, Pasquale L, Rhee D, Li T, Haines J, Wiggs J. LOXL1 promoter haplotypes are associated with exfoliation syndrome in a U.S. Caucasian population. Invest Ophthalmol Vis Sci. 2011;52:2372-8 pubmed publisher
    b>LOXL1 is a major genetic risk factor for exfoliation syndrome (ES) and exfoliation glaucoma (EG)...
  2. Cao L, Wang J, Tseu I, Luo D, Post M. Maternal exposure to endotoxin delays alveolarization during postnatal rat lung development. Am J Physiol Lung Cell Mol Physiol. 2009;296:L726-37 pubmed publisher
    ..This morphological delay in alveolar development disappeared after PN14. Tropoelastin, LOXL1, VEGF, VEGFR2, and PDGFRalpha mRNA expression of LPS-exposed animals was significantly greater than those of ..
  3. Behmoaras J, Slove S, Seve S, Vranckx R, Sommer P, Jacob M. Differential expression of lysyl oxidases LOXL1 and LOX during growth and aging suggests specific roles in elastin and collagen fiber remodeling in rat aorta. Rejuvenation Res. 2008;11:883-9 pubmed publisher
    ..Gene knockout studies in mice suggested a role for lysyl oxidase-like (LOXL1) in adult elastin synthesis and a role for its isoform, lysyl oxidase (LOX), in the synthesis of both collagens ..
  4. Yu H, Liu X, Kiss S, Connolly E, Gragoudas E, Michaud N, et al. Increased choroidal neovascularization following laser induction in mice lacking lysyl oxidase-like 1. Invest Ophthalmol Vis Sci. 2008;49:2599-605 pubmed publisher
    ..This study investigated the influence of defective elastic fiber maintenance in the development of laser-induced CNV...
  5. Hayashi K, Cao T, Passmore H, Jourdan Le Saux C, Fogelgren B, Khan S, et al. Progressive hair loss and myocardial degeneration in rough coat mice: reduced lysyl oxidase-like (LOXL) in the skin and heart. J Invest Dermatol. 2004;123:864-71 pubmed
    ..Based on these results, loxl appears non-allelic to rc. Heart- and skin-specific downregulation of LOXL in rc mice, however, may contribute to the extracellular matrix alterations and the rc phenotype. ..
  6. Trantow C, Mao M, Petersen G, Alward E, Alward W, Fingert J, et al. Lyst mutation in mice recapitulates iris defects of human exfoliation syndrome. Invest Ophthalmol Vis Sci. 2009;50:1205-14 pubmed publisher
    ..The purpose of this study was to determine the anatomic basis for Lyst-mediated transillumination defects, test whether Lyst mutant mice develop other features of XFS, and describe the molecular basis of the beige mutation...
  7. Creasey R, Sharma S, Gibson C, Craig J, Ebner A, Becker T, et al. Atomic force microscopy-based antibody recognition imaging of proteins in the pathological deposits in pseudoexfoliation syndrome. Ultramicroscopy. 2011;111:1055-61 pubmed publisher
    ..Lysyl oxidase-Like 1 (LOXL1), a protein identified as a component of PEX aggregates, is detected by an antibody-modified AFM probe...
  8. Campion S, Catlin N, Houseman E, Hensley J, Sui Y, Gaido K, et al. Molecular alterations underlying the enhanced disruption of spermatogenesis by 2,5-hexanedione and carbendazim co-exposure. Reprod Toxicol. 2012;33:382-9 pubmed publisher
    ..Further analysis of candidate genes by qRT-PCR at both 3 and 24 h after co-exposure, revealed that Loxl1 and Clca2/Clca4l were both decreased in expression...
  9. Ozbek E, Polat E, Ozcan L, Otunctemur A, Emrence Z, Ustek D. TT polymorphism in rs2165241 and rs1048661 region in lysyl oxidase like-1 gene may have a role in stress urinary incontinence physiopathology. J Obstet Gynaecol Res. 2013;39:237-42 pubmed publisher
    ..In patients, the TT polymorphism in the rs1048661 and rs2165241 region were found to be significant. The homozygote TT polymorphism in the rs1048661 and rs2165241 region of LOX-L1 gene may be responsible from SUI physiopathology. ..
  10. Liu Y, Whigham B, Wheeler J, Williams S, Rautenbach R, Ziskind A, et al. The role of lysyl oxidase-like 1 DNA copy number variants in exfoliation glaucoma. Mol Vis. 2012;18:2976-81 pubmed
    To investigate whether DNA copy number variants (CNVs) in the lysyl oxidase-like 1 (LOXL1) gene are associated with exfoliation glaucoma (XFG) in black South Africans.
  11. Miyazaki H, Oka N, Koga A, Ohmura H, Ueda T, Imaizumi T. Comparison of gene expression profiling in pressure and volume overload-induced myocardial hypertrophies in rats. Hypertens Res. 2006;29:1029-45 pubmed
    ..In conclusion, we found that many genes were regulated in VO, PO, or both. In addition, a novel role of MT in the hypertrophied myocardium was suggested. ..
  12. Thomassin L, Werneck C, Broekelmann T, Gleyzal C, Hornstra I, Mecham R, et al. The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers. J Biol Chem. 2005;280:42848-55 pubmed
    ..These results have raised the interesting possibility that sequence differences between the pro-domain of LOX and LOXL account for some of the functional differences observed for the two enzymes. ..
  13. Kasım B, Irkec M, Alikasifoglu M, Orhan M, Mocan M, Aktas D. Association of LOXL1 gene polymorphisms with exfoliation syndrome/glaucoma and primary open angle glaucoma in a Turkish population. Mol Vis. 2013;19:114-20 pubmed
    To investigate the association of lysyl oxidase like 1 (LOXL1) variants with exfoliation syndrome (XFS), exfoliation glaucoma (XFG), and primary open angle glaucoma (POAG) in a Turkish population.