Gene Symbol: Lin28a
Description: lin-28 homolog A
Alias: Lin28, RGD1566408, protein lin-28 homolog A
Species: rat
Products:     Lin28a

Top Publications

  1. Balzer E, Heine C, Jiang Q, Lee V, Moss E. LIN28 alters cell fate succession and acts independently of the let-7 microRNA during neurogliogenesis in vitro. Development. 2010;137:891-900 pubmed publisher
    b>LIN28 is an RNA-binding protein that is expressed in many developing tissues. It can block let-7 (Mirlet7) microRNA processing and help promote pluripotency...
  2. Zhu H, Shyh Chang N, Segrè A, Shinoda G, Shah S, Einhorn W, et al. The Lin28/let-7 axis regulates glucose metabolism. Cell. 2011;147:81-94 pubmed publisher
    The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis...
  3. Moss E, Tang L. Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites. Dev Biol. 2003;258:432-42 pubmed
    ..elegans lin-4 and let-7 microRNAs, suggesting that microRNA regulation is a conserved feature of the Lin-28 gene in diverse animals. ..
  4. Polesskaya A, Cuvellier S, Naguibneva I, Duquet A, Moss E, Harel Bellan A. Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency. Genes Dev. 2007;21:1125-38 pubmed
    ..Our results unravel novel mechanisms of translational regulation in skeletal muscle and suggest that Lin-28 performs the role of "translational enhancer" in embryonic and adult cells and tissues. ..
  5. Balzer E, Moss E. Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules. RNA Biol. 2007;4:16-25 pubmed
    b>Lin28 is a conserved cytoplasmic protein with an unusual pairing of RNA-binding motifs: a cold shock domain and a pair of retroviral-type CCHC zinc fingers. In the nematode C. elegans, it is a regulator of developmental timing...
  6. Rybak A, Fuchs H, Smirnova L, Brandt C, Pohl E, Nitsch R, et al. A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell Biol. 2008;10:987-93 pubmed publisher
  7. Heo I, Joo C, Cho J, Ha M, Han J, Kim V. Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol Cell. 2008;32:276-84 pubmed publisher
    ..Here, we report the RNA-binding proteins, Lin28a and Lin28b, as posttranscriptional repressors of let-7 miRNA biogenesis...
  8. West J, Viswanathan S, Yabuuchi A, Cunniff K, Takeuchi A, Park I, et al. A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature. 2009;460:909-13 pubmed publisher
    ..RNAs to screen candidate genes for effects on the development of Stella(+) cells in vitro, we discovered that Lin28, a negative regulator of let-7 microRNA processing, is essential for proper PGC development...
  9. Heo I, Joo C, Kim Y, Ha M, Yoon M, Cho J, et al. TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell. 2009;138:696-708 pubmed publisher
    As key regulators in cellular functions, microRNAs (miRNAs) themselves need to be tightly controlled. Lin28, a pluripotency factor, was reported to downregulate let-7 miRNA by inducing uridylation of let-7 precursor (pre-let-7)...

More Information


  1. Viswanathan S, Daley G, Gregory R. Selective blockade of microRNA processing by Lin28. Science. 2008;320:97-100 pubmed publisher
    ..Here we show that Lin28, a developmentally regulated RNA binding protein, selectively blocks the processing of pri-let-7 miRNAs in ..
  2. Urbach A, Yermalovich A, Zhang J, Spina C, Zhu H, Perez Atayde A, et al. Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev. 2014;28:971-82 pubmed publisher
    ..Here we show that overexpression of the heterochronic regulator Lin28 during kidney development in mice markedly expands nephrogenic progenitors by blocking their final wave of ..
  3. Jin J, Jing W, Lei X, Feng C, Peng S, Boris Lawrie K, et al. Evidence that Lin28 stimulates translation by recruiting RNA helicase A to polysomes. Nucleic Acids Res. 2011;39:3724-34 pubmed publisher
    The stem cell protein Lin28 functions to inhibit the biogenesis of a group of miRNAs but also stimulates the expression of a subset of mRNAs at the post-transcriptional level, the underlying mechanism of which is not yet understood...
  4. Cho J, Chang H, Kwon S, Kim B, Kim Y, Choe J, et al. LIN28A is a suppressor of ER-associated translation in embryonic stem cells. Cell. 2012;151:765-777 pubmed publisher
    ..In this study, we obtain a genome-wide view of the molecular function of LIN28A in mouse embryonic stem cells by carrying out RNA crosslinking-immunoprecipitation-sequencing (CLIP-seq) and ..
  5. Yue Y, Zhang D, Jiang S, Li A, Guo A, Wu X, et al. LIN28 expression in rat spinal cord after injury. Neurochem Res. 2014;39:862-74 pubmed publisher
    b>LIN28, an RNA-binding protein, is known to be involved in the regulation of many cellular processes, such as embryonic stem cell proliferation, cell fate succession, developmental timing, and oncogenesis...
  6. Hu J, Wang F, Zhu X, Yuan Y, Ding M, Gao S. Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing components and its dominant-negative mutant caused two-cell-stage embryonic arrest. Dev Dyn. 2010;239:407-24 pubmed publisher
    ..EIF2C2(AGO2), DDX6 and LSM14A, and germline-specific chromatoid body components including PIWIL1, PIWIL2, and LIN28. ZAR1L colocalized with ZAR1 and interacted with human LIN28...
  7. O Day E, Le M, Imai S, Tan S, Kirchner R, Arthanari H, et al. An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates. J Biol Chem. 2015;290:17909-22 pubmed publisher
    ..In particular it increases mature let-7 levels, decreases OCT4, HMGA1, CCNB1, CDK4, and Lin28A protein, decreases sphere formation, and inhibits colony formation...