Gene Symbol: Lims1
Description: LIM zinc finger domain containing 1
Alias: Pinch1, RGD1560732, LIM and senescent cell antigen-like-containing domain protein 1, LIM and senescent cell antigen-like domains 1, LIM-type zinc finger domains 1
Species: rat
Products:     Lims1

Top Publications

  1. Yang Y, Wang X, Hawkins C, Chen K, Vaynberg J, Mao X, et al. Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase. J Biol Chem. 2009;284:5836-44 pubmed publisher
    ..These data provide atomic insight into a novel modular recognition and demonstrate how PINCH is specifically recruited by ILK to mediate the FA assembly and cell-extracellular matrix communication. ..
  2. Li S, Bordoy R, Stanchi F, Moser M, Braun A, Kudlacek O, et al. PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage. J Cell Sci. 2005;118:2913-21 pubmed
    b>PINCH1 is composed of 5 LIM domains, binds integrin-linked kinase (ILK) and locates to integrin-mediated adhesion sites...
  3. Legate K, Montanez E, Kudlacek O, Fassler R. ILK, PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol. 2006;7:20-31 pubmed
    ..All these proteins have synergistic functions at focal adhesions, but recent work has indicated that these proteins might also have separate roles within a cell. They function as regulators of gene transcription or cell-cell adhesion. ..
  4. Jung K, Chen K, Kretzler M, Wu C. TGF-beta1 regulates the PINCH-1-integrin-linked kinase-alpha-parvin complex in glomerular cells. J Am Soc Nephrol. 2007;18:66-73 pubmed
  5. Chiswell B, Zhang R, Murphy J, Boggon T, Calderwood D. The structural basis of integrin-linked kinase-PINCH interactions. Proc Natl Acad Sci U S A. 2008;105:20677-82 pubmed publisher
    ..We report a 1.6-A crystal structure of the ILK ankyrin repeat domain bound to the PINCH1 LIM1 domain, revealing the molecular basis of ILK-PINCH interactions and providing a structural description of ..
  6. Liang X, Sun Y, Ye M, Scimia M, Cheng H, Martin J, et al. Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation. 2009;120:568-76 pubmed publisher
    ..Two PINCH proteins, PINCH1 and PINCH2, have been described in mammals and share high homology...
  7. Donthamsetty S, Bhave V, Mars W, Bowen W, Orr A, Haynes M, et al. Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis. PLoS ONE. 2013;8:e74625 pubmed publisher
    ..PINCH2 elimination was systemic whereas PINCH1 elimination was targeted to hepatocytes. The genetically modified mice were born normal...
  8. Porcheri C, Suter U, Jessberger S. Dissecting integrin-dependent regulation of neural stem cell proliferation in the adult brain. J Neurosci. 2014;34:5222-32 pubmed publisher
    ..Here we show that genetic deletion of integrin-linked kinase (ILK) increases NSPC proliferation through PINCH1/2-dependent enhancement of c-Jun N-terminal protein kinase activity in both neurogenic regions of the adult mouse ..
  9. Liang X, Zhou Q, Li X, Sun Y, Lu M, Dalton N, et al. PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes. Mol Cell Biol. 2005;25:3056-62 pubmed
    b>PINCH1, an adaptor protein composed of five LIM domains, mediates protein-protein interactions and functions as a component of the integrin-integrin-linked kinase (ILK) complex...

More Information


  1. Kim S, Kim N, Lee S, Kim D, Lee Y, Ahn S, et al. TGF-beta1-induced PINCH-1-ILK-alpha-parvin complex formation regulates mesangial cell proliferation and hypertrophy. Exp Mol Med. 2007;39:514-23 pubmed
    ..TGF-beta1-induced alteration of the PIP complex formation may be importantly implicated in the development and progression of glomerular failure shown in several kidney diseases. ..
  2. Jia L, Li X, Gu Y, Cui W. Early Activation of PINCH/ Glycogen-Synthase Kinase 3?/ERK Pathway in Obstructive Nephropathy Rat Model. Am J Nephrol. 2016;44:396-403 pubmed
    ..However, ERK1/2 proteins showed no statistically significant difference between UUO and sham groups. PINCH/GSK3?/ERK pathway was early molecular responses to obstructed kidney induced by UUO in rat. ..
  3. Braun A, Bordoy R, Stanchi F, Moser M, Kostka G G, Ehler E, et al. PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions. Exp Cell Res. 2003;284:239-50 pubmed
    ..Here we describe a new isoform of PINCH, which we call PINCH2. Therefore, we rename PINCH to PINCH1. PINCH2 has an overall similarity of 92% to PINCH1 and contains five LIM domains like PINCH1...
  4. Qiu P, Wheater M, Qiu Y, Sosne G. Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK. FASEB J. 2011;25:1815-26 pubmed publisher
    ..In addition, the results of this study serve as a foundation for developing T?(4) as a new anti-inflammatory therapy. ..
  5. Wang D, Li Y, Wu C, Liu Y. PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression. PLoS ONE. 2011;6:e17048 pubmed publisher
    b>PINCH1, an adaptor protein containing five LIM domains, plays an important role in regulating the integrin-mediated cell adhesion, migration and epithelial-mesenchymal transition...
  6. Zhang Y, Chen K, Tu Y, Velyvis A, Yang Y, Qin J, et al. Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. J Cell Sci. 2002;115:4777-86 pubmed
    ..These results provide new insights into the molecular mechanism underlying the assembly and regulation of cell-matrix adhesion structures. ..
  7. Ito S, Takahara Y, Hyodo T, Hasegawa H, Asano E, Hamaguchi M, et al. The roles of two distinct regions of PINCH-1 in the regulation of cell attachment and spreading. Mol Biol Cell. 2010;21:4120-9 pubmed publisher
    ..Thus, these data reveal how specific domains of PINCH-1 direct two independent pathways: one utilizing ILK to allow cell attachment, and the other recruiting Rsu-1 to activate Rac1 in order to promote cell spreading. ..