Lhb

Summary

Gene Symbol: Lhb
Description: luteinizing hormone beta polypeptide
Alias: lutropin subunit beta, LH-B, LSH-B, LSH-beta, Luteinizing hormone (lutropin) subunit beta, luteinizing hormone beta subunit, luteinizing hormone subunit beta, lutropin beta chain
Species: rat

Top Publications

  1. pmc A carboxyl-terminal sequence in the lutropin beta subunit contributes to the sorting of lutropin to the regulated pathway
    Albina Jablonka-Shariff
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 283:11485-92. 2008
  2. doi In vivo oestrogenic modulation of Egr1 and Pitx1 gene expression in female rat pituitary gland
    Alina Gajewska
    Department of NeuroendocrinologyThe Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka Street 3, 05 110 Jablonna n Warsaw, PolandNeuroendocrinology DepartmentMedical Centre for Postgraduate Education, Marymoncka 99 103 Street, 01 813 Warsaw, PolandDepartment of Molecular BiologyInstitute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, 05 552 Magdalenka, Poland
    J Mol Endocrinol 53:355-66. 2014
  3. pmc A novel carboxyl-terminal heptapeptide initiates the regulated secretion of LH from unique sub-domains of the ER
    Albina Jablonka-Shariff
    Departments of Developmental Biology and Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 8:e65002. 2013
  4. pmc AMP-activated protein kinase is a key intermediary in GnRH-stimulated LHβ gene transcription
    Josefa Andrade
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22903, USA
    Mol Endocrinol 27:828-39. 2013
  5. doi Induction of dual-specificity phosphatase 1 (DUSP1) by pulsatile gonadotropin-releasing hormone stimulation: role for gonadotropin subunit expression in mouse pituitary LbetaT2 cells
    Indri N Purwana
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Biol Reprod 84:996-1004. 2011
  6. ncbi Regulation of luteinizing hormone receptor in hippocampal neurons following different long-lasting treatments of castrated adult rats
    H Abtahi
    Department of Basic Sciences, Faculty of Allied Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
    Indian J Exp Biol 51:218-27. 2013
  7. pmc The mechanism responsible for the supraphysiologic gonadotropin surge in females treated with gonadotropin-releasing hormone (GnRH) agonist and primed with GnRH antagonist
    Joelle E Taylor
    Reproductive Biology and Medicine Branch, National Institutes of Health, Bethesda, Maryland 20814, USA
    Fertil Steril 93:1668-75. 2010
  8. ncbi The gene encoding the beta-subunit of rat luteinizing hormone. Analysis of gene structure and evolution of nucleotide sequence
    L Jameson
    J Biol Chem 259:15474-80. 1984
  9. pmc Nucleotide sequence of the cDNA encoding the precursor of the beta subunit of rat lutropin
    W W Chin
    Proc Natl Acad Sci U S A 80:4649-53. 1983
  10. ncbi The regulation and organization of thyroid stimulating hormone genes
    I A Kourides
    Recent Prog Horm Res 40:79-120. 1984

Scientific Experts

  • A Gajewska
  • Laura L Burger
  • Daniel J Haisenleder
  • Alan C Dalkin
  • U B Kaiser
  • Jinyan Cao
  • Albina Jablonka-Shariff
  • Naomi Litichever
  • H Abtahi
  • Josefa Andrade
  • Margaret A Shupnik
  • Indri N Purwana
  • Irving Boime
  • Fernanda A Mafra
  • Weiming Zheng
  • Joelle E Taylor
  • Heidi E Walsh
  • Yitzhak Koch
  • Eran Gershon
  • Nava Dekel
  • K Pals
  • Tamar D Schirman-Hildesheim
  • Cheryl D Horton
  • Lisa M Halvorson
  • Haruhiko Kanasaki
  • Kohji Miyazaki
  • Qiaorong Jiang
  • Hernan Valdes-Socin
  • Toshie Yonehara
  • E Szabo
  • M R Sadeghi
  • Jessica Quinn
  • Richad Z Becker
  • H Edalatkhah
  • N Lakpour
  • S Talebi
  • A R Mahmoudi
  • M A Akhondi
  • S B Jameie
  • M Amiri
  • H Heidari-Vala
  • A H Zarnani
  • M Shabani
  • Aki Oride
  • Tselmeg Mijiddorj
  • Karen D Gray
  • Bradley T Miller
  • Jonathan Kim
  • Bianca Bianco
  • Angela M B Souza
  • James H Segars
  • Denise M Christofolini
  • William H Catherino
  • Caio P Barbosa
  • Richard T Scott
  • Karina Zulli
  • Christopher A Pearl
  • Dalia Galiani
  • M Roudbaraki
  • C Denef
  • Nurit Ben-Aroya
  • Anna Comstock
  • Kyeong Hoon Jeong
  • Francois P Pralong
  • Rolf C Gaillard
  • Adrian F Daly
  • Roberto Salvi
  • Pascale Quatresooz
  • Albert Beckers
  • Pierre Marie Tebeu
  • Yoko Yamada
  • Kohji Fukunaga
  • Hideyuki Yamamoto
  • Eishichi Miyamoto
  • A Arimura
  • K Koves
  • N Suzuki
  • A Nemeskeri
  • A Heinzlmann
  • F P Zhang
  • I Huhtaniemi
  • A Rannikko
  • W W Chin
  • I A Kourides
  • J F Habener
  • A S Chang
  • L Jameson
  • A N Hollenberg
  • J E Godine
  • L K Tan

Detail Information

Publications27

  1. pmc A carboxyl-terminal sequence in the lutropin beta subunit contributes to the sorting of lutropin to the regulated pathway
    Albina Jablonka-Shariff
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 283:11485-92. 2008
    ..These data are the first to identify a novel structural determinant responsible for the sorting of a member of the glycoprotein hormone family into the regulated secretory pathway...
  2. doi In vivo oestrogenic modulation of Egr1 and Pitx1 gene expression in female rat pituitary gland
    Alina Gajewska
    Department of NeuroendocrinologyThe Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka Street 3, 05 110 Jablonna n Warsaw, PolandNeuroendocrinology DepartmentMedical Centre for Postgraduate Education, Marymoncka 99 103 Street, 01 813 Warsaw, PolandDepartment of Molecular BiologyInstitute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, 05 552 Magdalenka, Poland
    J Mol Endocrinol 53:355-66. 2014
    EGR1 and PITX1 are transcription factors required for gonadotroph cell Lhb promoter activation. To determine changes in Egr1 and Pitx1 mRNA levels in central and peripheral pituitary stimulations, an in vivo model based on i.c.v...
  3. pmc A novel carboxyl-terminal heptapeptide initiates the regulated secretion of LH from unique sub-domains of the ER
    Albina Jablonka-Shariff
    Departments of Developmental Biology and Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 8:e65002. 2013
    ..These data suggest that, at least for LH, the molecular decision to enter the regulated secretory pathway is a pre-Golgi event controlled by the novel C-terminal heptapeptide...
  4. pmc AMP-activated protein kinase is a key intermediary in GnRH-stimulated LHβ gene transcription
    Josefa Andrade
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22903, USA
    Mol Endocrinol 27:828-39. 2013
    ..These studies indicate a novel role for AMPK in GnRH-stimulated transcription in pituitary gonadotropes and a potential common mechanism for GnRH and metabolic modulation of fertility...
  5. doi Induction of dual-specificity phosphatase 1 (DUSP1) by pulsatile gonadotropin-releasing hormone stimulation: role for gonadotropin subunit expression in mouse pituitary LbetaT2 cells
    Indri N Purwana
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Biol Reprod 84:996-1004. 2011
    ..Overexpression of MAP3K1, a kinase upstream of MAPK3/1, increased both the Lhb and the Fshb subunit promoter activities, which could be completely inhibited by cotransfection with DUSP1-..
  6. ncbi Regulation of luteinizing hormone receptor in hippocampal neurons following different long-lasting treatments of castrated adult rats
    H Abtahi
    Department of Basic Sciences, Faculty of Allied Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
    Indian J Exp Biol 51:218-27. 2013
    ..This implies that LH decreases the efficiency of translation through either producing non-functional LHR molecules or preventing their translation...
  7. pmc The mechanism responsible for the supraphysiologic gonadotropin surge in females treated with gonadotropin-releasing hormone (GnRH) agonist and primed with GnRH antagonist
    Joelle E Taylor
    Reproductive Biology and Medicine Branch, National Institutes of Health, Bethesda, Maryland 20814, USA
    Fertil Steril 93:1668-75. 2010
    ..To elucidate the physiologic mechanism responsible for the supraphysiologic gonadotropin release from the pituitary induced by gonadotropin-releasing hormone (GnRH) agonist in female rats primed with GnRH antagonist...
  8. ncbi The gene encoding the beta-subunit of rat luteinizing hormone. Analysis of gene structure and evolution of nucleotide sequence
    L Jameson
    J Biol Chem 259:15474-80. 1984
    ..Isolation and characterization of the rat LH beta gene further defines the evolution of glycoprotein hormone genes and will facilitate the study of cellular and molecular mechanisms which regulate LH beta gene expression...
  9. pmc Nucleotide sequence of the cDNA encoding the precursor of the beta subunit of rat lutropin
    W W Chin
    Proc Natl Acad Sci U S A 80:4649-53. 1983
    ..The availability of cDNAs for both the alpha and beta subunits of lutropin will facilitate studies of the regulation of lutropin expression...
  10. ncbi The regulation and organization of thyroid stimulating hormone genes
    I A Kourides
    Recent Prog Horm Res 40:79-120. 1984
  11. ncbi Isolation and characterization of testis-specific cDNAs for luteinizing hormone beta-subunit in the rat
    F P Zhang
    Department of Physiology, University of Turku, Finland
    Biochem Biophys Res Commun 210:858-65. 1995
    ..The present findings provide further evidence in the rat for expression of testis-specific mRNA variants of the LH beta gene. Their translation products may form a novel class of testicular para/autocrine factors...
  12. pmc Aryl hydrocarbon receptor activation in lactotropes and gonadotropes interferes with estradiol-dependent and -independent preprolactin, glycoprotein alpha and luteinizing hormone beta gene expression
    Jinyan Cao
    Molecular and Cellular Biology Graduate Program, 435 Morrill I North, University of Massachusetts Amherst, 637 North Pleasant Street, Amherst, MA 01003 9298, United States
    Mol Cell Endocrinol 333:151-9. 2011
    ..Prl) expression in vivo and in vitro; conversely, E(2) blocked TCDD upregulation of luteinizing hormone beta (Lhb) and glycoprotein hormone alpha polypeptide (Cga) expression...
  13. doi The orphan nuclear receptors COUP-TFI and COUP-TFII regulate expression of the gonadotropin LHβ gene
    Weiming Zheng
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9032, USA
    Mol Cell Endocrinol 330:59-71. 2010
    ..To our knowledge, these data are the first to demonstrate COUP-TF expression and function in pituitary gonadotropes...
  14. doi Luteinizing hormone beta-subunit gene (LHbeta) polymorphism in infertility and endometriosis-associated infertility
    Fernanda A Mafra
    Division of Gynecological Pathology and Human Reproduction, Department of Gynecology and Obstetrics, ABC School of Medicine, Avenida Principe de Gales 821, CEP 09060 650 Santo André, Brazil
    Eur J Obstet Gynecol Reprod Biol 151:66-9. 2010
    ..To establish the frequency of LHbeta G1502A polymorphism in infertile women with endometriosis, infertile women without endometriosis and a control group...
  15. pmc Regulation of Lhb and Egr1 gene expression by GNRH pulses in rat pituitaries is both c-Jun N-terminal kinase (JNK)- and extracellular signal-regulated kinase (ERK)-dependent
    Laura L Burger
    Division of Endocrinology and Metabolism, Department of Medicine, and the Center for Research in Reproduction, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Biol Reprod 81:1206-15. 2009
    Pulsatile GNRH regulates the gonadotropin subunit genes in a differential manner, with faster frequencies favoring Lhb gene expression and slower frequencies favoring Fshb...
  16. doi Hormonal regulation of GnRH and LHbeta mRNA expression in cultured rat granulosa cells
    Naomi Litichever
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, Israel
    J Mol Neurosci 39:78-85. 2009
    ..These results suggest that the expression of LHbeta in the ovary is regulated by locally produced GnRH and by FSH from either the ovary or the pituitary...
  17. ncbi Regulation of gonadotropin subunit gene transcription by gonadotropin-releasing hormone: measurement of primary transcript ribonucleic acids by quantitative reverse transcription-polymerase chain reaction assays
    A C Dalkin
    Division of Endocrinology, Department of Internal Medicine and the Center for Research in Reproduction, University of Virginia, Charlottesville, Virginia 22908, USA
    Endocrinology 142:139-46. 2001
    ..Additionally, concentrations are elevated in long term castrates, and following an exogenous GnRH pulse the transcriptional burst is rapid and brief...
  18. pmc Proteasome regulation of dynamic transcription factor occupancy on the GnRH-stimulated luteinizing hormone beta-subunit promoter
    Heidi E Walsh
    University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Endocrinol 23:237-50. 2009
    ..Together, these results demonstrate that degradation via the proteasome is vital to GnRH-stimulated LHbeta expression, and this occurs in part by allowing proper transcription factor associations with the LHbeta promoter...
  19. doi Growth hormone-releasing hormone and glucocorticoids determine the balance between luteinising hormone (LH) beta- and LH beta/follicle-stimulating hormone beta-positive gonadotrophs and somatotrophs in the 14-day-old rat pituitary tissue in aggregate cell
    K Pals
    Laboratory of Cell Pharmacology, University of Leuven, Medical School, Campus Gasthuisberg O and N, Leuven, Belgium
    J Neuroendocrinol 20:535-48. 2008
    ..GHRH may not expand the somatotroph population unless glucocorticoid hormone is present to maintain terminal differentiation...
  20. ncbi Sp1 binds to the rat luteinizing hormone beta (LHbeta) gene promoter and mediates gonadotropin-releasing hormone-stimulated expression of the LHbeta subunit gene
    U B Kaiser
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:12943-51. 1998
    ..These data define GnRH-responsive elements in the LHbeta 5'-flanking sequence and suggest that Sp1 plays an important role in conferring GnRH responsiveness to the LHbeta subunit gene...
  21. doi Local production of the gonadotropic hormones in the rat ovary
    Tamar D Schirman-Hildesheim
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell Endocrinol 282:32-8. 2008
    ..Thus, these findings may imply the existence of a local GnRH-gonadotropin axis in the mammalian ovary that may be involved in the management of processes that lead to ovulation...
  22. pmc Pulsatile gonadotropin-releasing hormone stimulation of gonadotropin subunit transcription in rat pituitaries: evidence for the involvement of Jun N-terminal kinase but not p38
    D J Haisenleder
    Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Endocrinology 149:139-45. 2008
    ..For LHbeta, JNK is essential in mediating responses to pulsatile GnRH. JNK also regulates FSHbeta transcription (i.e. maintaining basal expression) but does not play a role in responses to GnRH...
  23. ncbi Pituitary homeobox 1 (Pitx1) stimulates rat LHbeta gene expression via two functional DNA-regulatory regions
    Qiaorong Jiang
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9032, USA
    J Mol Endocrinol 35:145-58. 2005
    ..These results further our understanding of the molecular mechanisms that regulate expression of this critical reproductive gene promoter...
  24. ncbi Hypogonadism in a patient with a mutation in the luteinizing hormone beta-subunit gene
    Hernan Valdes-Socin
    Department of Endocrinology, Centre Hospitalier Universitaire de Liege, Domaine du Sart Tilman, Liege, Belgium
    N Engl J Med 351:2619-25. 2004
    ..This case illustrates the important physiological role that luteinizing hormone plays in male sexual maturation and fertility...
  25. ncbi Regulation of luteinizing hormone-beta and follicle-stimulating hormone (FSH)-beta gene transcription by androgens: testosterone directly stimulates FSH-beta transcription independent from its role on follistatin gene expression
    Laura L Burger
    Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Endocrinology 145:71-8. 2004
    ..The increase in FSH-beta PT in response to T was androgen specific and occurs in the presence of excess FS, suggesting that T stimulates FSH-beta transcription independently of modulation of FS...
  26. ncbi Characterization of alphaT3-1 cells stably transfected with luteininzing hormone beta-subunit complementary deoxyribonucleic acid
    Toshie Yonehara
    Department of Pharmacology, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Endocr J 50:341-54. 2003
    ..These results suggest that GnRH directly regulates LH secretion as well as LHbeta-subunit synthesis, and that LH2 cells are a useful model for the study of LH secretion induced by several secretagogues...
  27. ncbi Cell immunoblot assay study demonstrating the release of PACAP from individual anterior pituitary cells of rats and the effect of PACAP on LH release
    E Szabo
    Department of Human Morphology and Developmental Biology, Faculty of Medicine, Semmelweis University, Tuzolto u 58, H 1094, Budapest, Hungary
    Regul Pept 109:75-81. 2002
    ..The effect of PACAP on LH release was different in female and male pituitary cultures...