Gene Symbol: Lepr
Description: leptin receptor
Alias: leptin receptor, LEP-R, Leptin receptor (fatty), OB receptor, OB-R
Species: rat
Products:     Lepr

Top Publications

  1. Tamasi J, Arey B, Bertolini D, Feyen J. Characterization of bone structure in leptin receptor-deficient Zucker (fa/fa) rats. J Bone Miner Res. 2003;18:1605-11 pubmed
    To investigate the role of leptin in bone formation, the skeleton of the obese female leptin receptor-deficient Zucker rat was examined using pQCT, microCT, and histomorphometry...
  2. Iida M, Murakami T, Ishida K, Mizuno A, Kuwajima M, Shima K. Substitution at codon 269 (glutamine --> proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun. 1996;224:597-604 pubmed
    We recently cloned one of spliced variant forms of rat leptin receptor (OB-R), which contains a short intracellular domain, and found obese-phenotype-linked nucleotide alteration in the extracellular domain of the cDNA from the Zucker (..
  3. Phillips M, Liu Q, Hammond H, Dugan V, Hey P, Caskey C, et al. Leptin receptor missense mutation in the fatty Zucker rat. Nat Genet. 1996;13:18-9 pubmed
  4. Ducy P, Amling M, Takeda S, Priemel M, Schilling A, Beil F, et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell. 2000;100:197-207 pubmed
    ..To test this hypothesis, we studied leptin-deficient and leptin receptor-deficient mice that are obese and hypogonadic...
  5. Farooqi I, Wangensteen T, Collins S, Kimber W, Matarese G, Keogh J, et al. Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. N Engl J Med. 2007;356:237-47 pubmed
    A single family has been described in which obesity results from a mutation in the leptin-receptor gene (LEPR), but the prevalence of such mutations in severe, early-onset obesity has not been systematically examined...
  6. Takaya K, Ogawa Y, Isse N, Okazaki T, Satoh N, Masuzaki H, et al. Molecular cloning of rat leptin receptor isoform complementary DNAs--identification of a missense mutation in Zucker fatty (fa/fa) rats. Biochem Biophys Res Commun. 1996;225:75-83 pubmed
    We cloned the full-length rat leptin receptor (Ob-R) isoform complementary DNAs (cDNAs) and examined the gene expression in rats. We also identified a mutation in Ob-R in Zucker fatty (fa/fa) rats...
  7. Lord G, Matarese G, Howard J, Baker R, Bloom S, Lechler R. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature. 1998;394:897-901 pubmed
    ..Our findings suggest a new role for leptin in linking nutritional status to cognate cellular immune function, and provide a molecular mechanism to account for the immune dysfunction observed in starvation. ..
  8. Matsui H, Motooka M, Koike H, Inoue M, Iwasaki T, Suzuki T, et al. Ischemia/reperfusion in rat heart induces leptin and leptin receptor gene expression. Life Sci. 2007;80:672-80 pubmed
    ..We examined the expression of leptin (ob) and leptin receptor (ob-R) genes in the rat heart following ischemia/reperfusion, which was induced by coronary artery ligation, ..
  9. Colli S, Silveira Cavalcante F, Peixoto Martins M, Sampaio F, da Fonte Ramos C. Leptin role in the rat prostate ventral lobe. Fertil Steril. 2011;95:1490-3.e1 pubmed publisher

More Information


  1. Williams D, Baskin D, Schwartz M. Hindbrain leptin receptor stimulation enhances the anorexic response to cholecystokinin. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1238-46 pubmed publisher
    ..neurons positive for phospho-STAT3 staining in the area surrounding the site of injection, confirming local leptin receptor activation...
  2. Purdham D, Zou M, Rajapurohitam V, Karmazyn M. Rat heart is a site of leptin production and action. Am J Physiol Heart Circ Physiol. 2004;287:H2877-84 pubmed
    ..In view of emerging evidence for cardiac effects of leptin, it is proposed that the heart is a target for leptin action and that the peptide modulates function through a paracrine- or autocrine-dependent manner. ..
  3. Song S, Woo H, Bae C, Kim Y, Kim Y. Expression of leptin receptor in nasal polyps: leptin as a mucosecretagogue. Laryngoscope. 2010;120:1046-50 pubmed publisher
    ..b>Leptin receptor expression was analyzed using reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot ..
  4. Mancuso P, Peters Golden M, Goel D, Goldberg J, Brock T, Greenwald Yarnell M, et al. Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia. J Immunol. 2011;186:1081-90 pubmed publisher
    ..These data provide novel insights into the intracellular signaling events by which leptin contributes to host defense against bacterial pneumonia. ..
  5. Koros C, Boukouvalas G, Gerozissis K, Kitraki E. Fat diet affects leptin receptor levels in the rat cerebellum. Nutrition. 2009;25:85-7 pubmed publisher
    ..Our data show for the first time that Ob-R levels in the rat cerebellum are subject to diet-induced alterations and that these changes are sexually dimorphic. ..
  6. Carlo A, Meyerhof W, Williams L. Early developmental expression of leptin receptor gene and [125I]leptin binding in the rat forebrain. J Chem Neuroanat. 2007;33:155-63 pubmed
    ..and function of leptin receptors is well described in the adult brain, little is known about the ontogeny of leptin receptor system around the time of birth...
  7. Ferla R, Bonomi M, Otvos L, Surmacz E. Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects. BMC Cancer. 2011;11:303 pubmed publisher
  8. Flak J, Patterson C, Garfield A, D Agostino G, Goforth P, Sutton A, et al. Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance. Nat Neurosci. 2014;17:1744-1750 pubmed publisher
    ..Hypoglycemia activates neurons of the parabrachial nucleus (PBN) that coexpress leptin receptor (LepRb) and cholecystokinin (CCK) (PBN LepRb(CCK) neurons), which project to the ventromedial hypothalamic ..
  9. Howard J, Flier J. Attenuation of leptin and insulin signaling by SOCS proteins. Trends Endocrinol Metab. 2006;17:365-71 pubmed
  10. Lopez M, Seoane L, Tovar S, Garcia M, Nogueiras R, Dieguez C, et al. A possible role of neuropeptide Y, agouti-related protein and leptin receptor isoforms in hypothalamic programming by perinatal feeding in the rat. Diabetologia. 2005;48:140-8 pubmed
    ..Leptin levels were analysed using RIA. Leptin receptor mRNA levels were analysed using RT-PCR. Neuropeptide mRNA levels were analysed using in situ hybridisation...
  11. McPherson K, Taylor L, Johnson A, Didion S, Geurts A, Garrett M, et al. Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats. Am J Physiol Renal Physiol. 2016;311:F793-F804 pubmed publisher
    ..development of renal injury within the genetic background of the Dahl salt-sensitive rat with a dysfunctional leptin receptor derived from zinc-finger nucleases (SSLepRmutant strain)...
  12. Chen Y, Lu W, Gao N, Long Y, Shao Y, Liu M, et al. Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene. Sci China Life Sci. 2017;60:152-157 pubmed publisher
    ..methodology by applying transcription activator-like effector nucleases (TALENs) technology to generate Leptin receptor (Lepr) knockout rats on the Sprague Dawley (SD) genetic background...
  13. Liu Z, Bian J, Liu J, Endoh A. Obesity reduced the gene expressions of leptin receptors in hypothalamus and liver. Horm Metab Res. 2007;39:489-94 pubmed
    The expression of leptin receptor (OB-R) is downregulated by leptin in some cell lines. This study investigated the expressions of leptin receptors at central nerve system and peripheral site in a dietary model of obesity...
  14. Smith J, Waddell B. Leptin receptor expression in the rat placenta: changes in ob-ra, ob-rb, and ob-re with gestational age and suppression by glucocorticoids. Biol Reprod. 2002;67:1204-10 pubmed
    ..Because glucocorticoids inhibit feto-placental growth, placental leptin receptor (Ob-R) expression was also measured after manipulation of feto-placental glucocorticoid exposure...
  15. Iversen P, Drevon C, Reseland J. Prevention of leptin binding to its receptor suppresses rat leukemic cell growth by inhibiting angiogenesis. Blood. 2002;100:4123-8 pubmed
    ..We studied rats with transplanted AML to test if a neutralizing anti-leptin receptor monoclonal antibody (mAb) (anti-OB-R) could inhibit leukemogenesis...
  16. Barrenetxe J, Villaro A, Guembe L, Pascual I, Munoz Navas M, Barber A, et al. Distribution of the long leptin receptor isoform in brush border, basolateral membrane, and cytoplasm of enterocytes. Gut. 2002;50:797-802 pubmed
    ..Recent studies have demonstrated leptin and leptin receptor expression in gastric epithelial cells...
  17. Hastings J, Wiesner G, Lambert G, Morris M, Head G, Esler M. Influence of leptin on neurotransmitter overflow from the rat brain in vitro. Regul Pept. 2002;103:67-74 pubmed
    ..b>Leptin receptor mRNA and immunoreactivity has been reported in various brain regions, while recent studies suggest that ..
  18. Koga S, Kojima A, Kuwabara S, Yoshiyama Y. Immunohistochemical analysis of tau phosphorylation and astroglial activation with enhanced leptin receptor expression in diet-induced obesity mouse hippocampus. Neurosci Lett. 2014;571:11-6 pubmed publisher
    ..Interestingly, these changes were associated with enhanced astrocytic leptin receptor (LepR) expression and mild microgliosis, but not A? accumulation...
  19. Cassano S, Pucino V, La Rocca C, Procaccini C, De Rosa V, Marone G, et al. Leptin modulates autophagy in human CD4+CD25- conventional T cells. Metabolism. 2014;63:1272-9 pubmed publisher
  20. Rolland V, Clement K, Dugail I, Guy Grand B, Basdevant A, Froguel P, et al. Leptin receptor gene in a large cohort of massively obese subjects: no indication of the fa/fa rat mutation. Detection of an intronic variant with no association with obesity. Obes Res. 1998;6:122-7 pubmed
    ..by the disruption of the leptin-receptor signal through genetic defects at the level of either leptin (OB) or leptin receptor (OB-R) has raised the question of the relevance of these genes to morbid obesity in humans...
  21. Lin Y, Huang J, Hileman S, Martin K, Hull R, Davis M, et al. Leptin decreases heart rate associated with increased ventricular repolarization via its receptor. Am J Physiol Heart Circ Physiol. 2015;309:H1731-9 pubmed publisher
    ..During inhibition of β-adrenergic receptor activity, high concentration of leptin in myocardium can cause deep bradycardia, prolonged QT interval, and ventricular arrhythmias. ..
  22. Kimura S, Sasase T, Ohta T, Sato E, Matsushita M. Characteristics of bone turnover, bone mass and bone strength in Spontaneously Diabetic Torii-Lepr fa rats. J Bone Miner Metab. 2012;30:312-20 pubmed publisher
    The Spontaneously Diabetic Torii-Lepr (fa) (SDT-fa/fa) rat is a new model of obese type 2 diabetes...
  23. Gruen M, Plummer M, Zhang W, Posey K, Linton M, Fazio S, et al. Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I. J Lipid Res. 2005;46:2007-14 pubmed
    Obese mice without leptin (ob/ob) or the leptin receptor (db/db) have increased plasma HDL levels and accumulate a unique lipoprotein referred to as LDL/HDL1...
  24. Jang M, Shin M, Kim K, Cho S, Bahn G, Kim E, et al. Nicotine administration decreases neuropeptide Y expression and increases leptin receptor expression in the hypothalamus of food-deprived rats. Brain Res. 2003;964:311-5 pubmed
    The effects of nicotine on the expressions of neuropeptide Y (NPY) and leptin receptor in the rat hypothalamus were investigated via immunohistochemistry...
  25. Martínez Abundis E, Rajapurohitam V, Gertler A, Karmazyn M. Identification of functional leptin receptors expressed in ventricular mitochondria. Mol Cell Biochem. 2015;408:155-62 pubmed publisher
    ..specific receptors, although its principle actions are dependent on the activation of the long form of the leptin receptor, termed OBRb...
  26. Seeber R, Smith J, Waddell B. Plasma leptin-binding activity and hypothalamic leptin receptor expression during pregnancy and lactation in the rat. Biol Reprod. 2002;66:1762-7 pubmed
    ..was due to either increased plasma leptin-binding activity and/or reduced expression of hypothalamic leptin receptor. Plasma leptin increased from 2.2 +/- 0.4 ng/ml before pregnancy to a maximum at midgestation (4.2 +/- 0...
  27. Meli R, Pacilio M, Raso G, Esposito E, Coppola A, Nasti A, et al. Estrogen and raloxifene modulate leptin and its receptor in hypothalamus and adipose tissue from ovariectomized rats. Endocrinology. 2004;145:3115-21 pubmed
    ..or treatment with a selective estrogen receptor modulator, raloxifene (RAL), alters leptinemia and modulates leptin receptor (Ob-R) abundance in hypothalamus and white adipose tissue, similar to the modification of adipose status ..
  28. Barnes M, Rogers R, Van Meter M, Hermann G. Co-localization of TRHR1 and LepRb receptors on neurons in the hindbrain of the rat. Brain Res. 2010;1355:70-85 pubmed publisher
    ..to determine if neurons or afferent fibers in the hindbrain possess both TRH type 1 receptor and long-form leptin receptor [TRHR1; LepRb, respectively]...
  29. Stofkova A, Skurlova M, Tybitanclova K, Veselsky L, Zelezna B, Jurcovicova J. Relationship among nitric oxide, leptin, ACTH, corticosterone, and IL-1beta, in the early and late phases of adjuvant arthritis in male Long Evans rats. Life Sci. 2006;79:2486-91 pubmed
    ..The suppression of leptin may be a consequence of permanent activation of NO, IL-1beta, and of lower weight gain. Circulating leptin does not seem to play a key role in the progression of chronic arthritis. ..
  30. Wang M, Zhou Y, Newgard C, Unger R. A novel leptin receptor isoform in rat. FEBS Lett. 1996;392:87-90 pubmed
  31. Szalay F, Folhoffer A, Horvath A, Csak T, Speer G, Nagy Z, et al. Serum leptin, soluble leptin receptor, free leptin index and bone mineral density in patients with primary biliary cirrhosis. Eur J Gastroenterol Hepatol. 2005;17:923-8 pubmed
    ..We investigated the relationship between serum leptin levels, soluble leptin receptor (sOB-R), free leptin index (FLI) and BMD in patients with primary biliary cirrhosis (PBC)...
  32. Brown R, Adams J, Pelekanos R, Wan Y, McKinstry W, Palethorpe K, et al. Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat Struct Mol Biol. 2005;12:814-21 pubmed
    ..We propose an activation mechanism involving a relative rotation of subunits within a dimeric receptor as a result of asymmetric placement of the receptor-binding sites on the ligand. ..
  33. Delgado M, Gracia Sancho J, Marrone G, Rodriguez Vilarrupla A, Deulofeu R, Abraldes J, et al. Leptin receptor blockade reduces intrahepatic vascular resistance and portal pressure in an experimental model of rat liver cirrhosis. Am J Physiol Gastrointest Liver Physiol. 2013;305:G496-502 pubmed publisher
    ..CCl4-cirrhotic rats received the leptin receptor-blocker ObR antibody, or its vehicle, every other day for 1 wk...
  34. Dayi A, Agilkaya S, Ozbal S, Cetin F, Aksu I, Gencoglu C, et al. Maternal aerobic exercise during pregnancy can increase spatial learning by affecting leptin expression on offspring's early and late period in life depending on gender. ScientificWorldJournal. 2012;2012:429803 pubmed publisher
    ..b>Leptin receptor expression significantly increased in the prepubertal male, adult male, and adult female pups...
  35. Li J, Yan J, Chen K, Wang Q, Zhao X, Zhang Y. [High fat diet induces obesity and alters the expression of MCHR1 and OB-Rb in the adipose tissue]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011;36:823-9 pubmed publisher
    ..HF) diet on the body weight and the mRNA expression of melanin concentrating hormone receptor 1 (MCHR1) and leptin receptor (OB-Rb) in the adipose tissue in rats, the two important and opposite factors in regulating the body weight...
  36. Moralejo D, Hansen C, Treuting P, Hessner M, Fuller J, Van Yserloo B, et al. Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats. Physiol Genomics. 2010;41:9-20 pubmed publisher
    Rodents homozygous for autosomal leptin receptor gene mutations not only become obese, insulin resistant, and hyperleptinemic but also develop a dysregulated immune system...
  37. Benoit C, Ould Hamouda H, Crépin D, Gertler A, Amar L, Taouis M. Early leptin blockade predisposes fat-fed rats to overweight and modifies hypothalamic microRNAs. J Endocrinol. 2013;218:35-47 pubmed publisher
  38. de Luis D, Gonzalez Sagrado M, Aller R, Izaola O, Conde R. Influence of Lys656Asn polymorphism of the leptin receptor gene on insulin resistance in nondiabetic obese patients. J Diabetes Complications. 2008;22:199-204 pubmed publisher
    Alterations of the normal leptin receptor (LEPR) gene may be involved in the development of obesity. Leptin has been shown to be able to modulate insulin secretion...
  39. Manzella D, Parillo M, Razzino T, Gnasso P, Buonanno S, Gargiulo A, et al. Soluble leptin receptor and insulin resistance as determinant of sleep apnea. Int J Obes Relat Metab Disord. 2002;26:370-5 pubmed
    ..Twenty subjects with different body mass index (mean BMI 30.9+/-4.2). Insulin action and plasma soluble leptin receptor were measured by euglycemic hyperinsulinemic glucose clamp and by ELISA method, respectively...
  40. Rodrigues A, de Moura E, Passos M, Dutra S, Lisboa P. Postnatal early overnutrition changes the leptin signalling pathway in the hypothalamic-pituitary-thyroid axis of young and adult rats. J Physiol. 2009;587:2647-61 pubmed publisher
    ..These changes may help to explain future development of metabolic and endocrine dysfunctions, such as metabolic syndrome and hypothyroidism. ..
  41. Jelsing J, Larsen P, Vrang N. The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion. Neurosci Lett. 2009;463:125-9 pubmed publisher
  42. Shih C, Au L, Chan J. Differential role of leptin receptors at the hypothalamic paraventricular nucleus in tonic regulation of food intake and cardiovascular functions. J Biomed Sci. 2003;10:367-78 pubmed
    ..Our results indicate that whereas the Ob-Rs in the PVN are involved in the tonic regulation of food intake, they might not be actively involved in the tonic regulation of cardiovascular functions. ..
  43. Li X, Yan J, Jiang L, Dai L. Age-related variations of leptin receptor expression in the growth plate of spine and limb: gender- and region-specific changes. Histochem Cell Biol. 2011;135:487-97 pubmed publisher
    ..underlying these effects, we investigated the spatial and temporal expressions of the active form of the leptin receptor (Ob-Rb) in the tibial and spinal growth plates of the female and male rats during postnatal development...
  44. Nascimento A, Luvizotto R, Leopoldo A, Lima Leopoldo A, Seiva F, Justulin L, et al. Long-term high-fat diet-induced obesity decreases the cardiac leptin receptor without apparent lipotoxicity. Life Sci. 2011;88:1031-8 pubmed publisher
    ..However, this does not result in altered levels of AMPK or ACC phosphorylations in this animal model. ..
  45. Park H, Kwon H, Lim H, Hong B, Lee J, Park B, et al. Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Exp Mol Med. 2001;33:95-102 pubmed
    ..a tyrosine kinase-dependent intracellular pathway and promote angiogenic processes via activation of leptin receptor (Ob-R) in endothelial cells...
  46. Bates S, Stearns W, Dundon T, Schubert M, Tso A, Wang Y, et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature. 2003;421:856-9 pubmed
    Secretion of leptin from adipocytes communicates body energy status to the brain by activating the leptin receptor long form (LRb)...
  47. Rosmond R, Chagnon Y, Holm G, Chagnon M, Perusse L, Lindell K, et al. Hypertension in obesity and the leptin receptor gene locus. J Clin Endocrinol Metab. 2000;85:3126-31 pubmed
    Recent animal studies indicate that leptin is involved in the regulation of blood pressure through the leptin receptor. Therefore, 51-yr-old men (N = 284) were selected; and anthropometric, endocrine, metabolic, and hemodynamic variables ..
  48. Pastar I, Khan A, Stojadinovic O, Lebrun E, Medina M, Brem H, et al. Induction of specific microRNAs inhibits cutaneous wound healing. J Biol Chem. 2012;287:29324-35 pubmed publisher
    ..to target multiple genes important for wound healing, including early growth response factor 3, vinculin, and leptin receptor (LepR)...
  49. Séron K, Couturier C, Belouzard S, Bacart J, Monte D, Corset L, et al. Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway. J Biol Chem. 2011;286:17968-81 pubmed publisher
    Endospanin-1 is a negative regulator of the cell surface expression of leptin receptor (OB-R), and endospanin-2 is a homologue of unknown function...
  50. Di Yorio M, Bilbao M, Faletti A. Neuropeptide Y regulates the leptin receptors in rat hypothalamic and pituitary explant cultures. Regul Pept. 2014;188:13-20 pubmed publisher
    ..These results reinforce the fact that NPY and its NPY Y1 receptor play a critical role in reproduction by modulating leptin sensitivity. ..
  51. Hommel J, Trinko R, Sears R, Georgescu D, Liu Z, Gao X, et al. Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron. 2006;51:801-10 pubmed
    The leptin hormone is critical for normal food intake and metabolism. While leptin receptor (Lepr) function has been well studied in the hypothalamus, the functional relevance of Lepr expression in the ventral tegmental area (VTA) has ..
  52. Sukhotnik I, Coran A, Mogilner J, Shamian B, Karry R, Lieber M, et al. Leptin affects intestinal epithelial cell turnover in correlation with leptin receptor expression along the villus-crypt axis after massive small bowel resection in a rat. Pediatr Res. 2009;66:648-53 pubmed publisher
    ..we examine the responsiveness of intestinal epithelial cell turnover to leptin (LEP) in correlation with leptin receptor (LEPr) expression along the villus-crypt axis in a rat with short bowel syndrome (SBS)...
  53. Ciriello J, Caverson M. Carotid chemoreceptor afferent projections to leptin receptor containing neurons in nucleus of the solitary tract. Peptides. 2014;58:30-5 pubmed publisher
    Neurons expressing the leptin receptor (Ob-R) exist within the caudal nucleus of the solitary tract (NTS). Additionally, afferent neurons expressing the Ob-R have been identified within the nodose ganglion and NTS...