Lep

Summary

Gene Symbol: Lep
Description: leptin
Alias: obese, leptin, obesity factor
Species: rat
Products:     Lep

Top Publications

  1. Matheny M, Shapiro A, Tumer N, Scarpace P. Region-specific diet-induced and leptin-induced cellular leptin resistance includes the ventral tegmental area in rats. Neuropharmacology. 2011;60:480-7 pubmed publisher
    Diet-induced obesity (DIO) results in region-specific cellular leptin resistance in the arcuate nucleus (ARC) of the hypothalamus in one strain of mice and in several medial basal hypothalamic regions in another...
  2. Burgos Ramos E, Chowen J, Arilla Ferreiro E, Canelles S, Argente J, Barrios V. Chronic central leptin infusion modifies the response to acute central insulin injection by reducing the interaction of the insulin receptor with IRS2 and increasing its association with SOCS3. J Neurochem. 2011;117:175-85 pubmed publisher
    b>Leptin and insulin have overlapping intracellular signaling mechanisms and exert anorexigenic actions in the hypothalamus...
  3. Scarpace P, Matheny M, Kirichenko N, Gao Y, Tümer N, Zhang Y. Leptin overexpression in VTA trans-activates the hypothalamus whereas prolonged leptin action in either region cross-desensitizes. Neuropharmacology. 2013;65:90-100 pubmed publisher
    High-fat feeding or CNS leptin overexpression in chow-fed rats results in a region-specific cellular leptin resistance in medial basal hypothalamic regions and the ventral tegmental area (VTA)...
  4. Lee M, Yang R, Gong D, Fried S. Feeding and insulin increase leptin translation. Importance of the leptin mRNA untranslated regions. J Biol Chem. 2007;282:72-80 pubmed
    The post-transcriptional mechanisms by which feeding and insulin increase leptin production are poorly understood...
  5. Dumond H, Presle N, Terlain B, Mainard D, Loeuille D, Netter P, et al. Evidence for a key role of leptin in osteoarthritis. Arthritis Rheum. 2003;48:3118-29 pubmed
    To evaluate the contribution of leptin (an adipose tissue-derived hormone) to the pathophysiology of osteoarthritis (OA), by determining the level of leptin in both synovial fluid (SF) and cartilage specimens obtained from human joints...
  6. Pelleymounter M, Cullen M, Baker M, Hecht R, Winters D, Boone T, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995;269:540-3 pubmed
    C57BL/6J mice with a mutation in the obese (ob) gene are obese, diabetic, and exhibit reduced activity, metabolism, and body temperature...
  7. Li Y, Wu X, Zhou S, Owyang C. Low-affinity CCK-A receptors are coexpressed with leptin receptors in rat nodose ganglia: implications for leptin as a regulator of short-term satiety. Am J Physiol Gastrointest Liver Physiol. 2011;300:G217-27 pubmed publisher
    The paradigm for the control of feeding behavior has changed significantly. Research has shown that leptin, in the presence of CCK, may mediate the control of short-term food intake...
  8. Levin B, Dunn Meynell A, Banks W. Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset. Am J Physiol Regul Integr Comp Physiol. 2004;286:R143-50 pubmed
    ..were compared with those bred to be diet resistant (DR) on a 31% fat high-energy diet with regard to their central leptin signaling and blood-brain barrier (BBB) transport...
  9. Choi Y, Li C, Hartzell D, Little D, Della Fera M, Baile C. ICV leptin effects on spontaneous physical activity and feeding behavior in rats. Behav Brain Res. 2008;188:100-8 pubmed
    Although leptin causes negative energy balance by reducing food intake and increasing energy expenditure, the effect of leptin on spontaneous physical activity (SPA) is not clearly established...
  10. Loffreda S, Yang S, Lin H, Karp C, Brengman M, Wang D, et al. Leptin regulates proinflammatory immune responses. FASEB J. 1998;12:57-65 pubmed
    ..Decreased expression of leptin or of functional leptin receptors results in hyperphagia, decreased energy expenditure, and obesity...

Detail Information

Publications62

  1. Matheny M, Shapiro A, Tumer N, Scarpace P. Region-specific diet-induced and leptin-induced cellular leptin resistance includes the ventral tegmental area in rats. Neuropharmacology. 2011;60:480-7 pubmed publisher
    Diet-induced obesity (DIO) results in region-specific cellular leptin resistance in the arcuate nucleus (ARC) of the hypothalamus in one strain of mice and in several medial basal hypothalamic regions in another...
  2. Burgos Ramos E, Chowen J, Arilla Ferreiro E, Canelles S, Argente J, Barrios V. Chronic central leptin infusion modifies the response to acute central insulin injection by reducing the interaction of the insulin receptor with IRS2 and increasing its association with SOCS3. J Neurochem. 2011;117:175-85 pubmed publisher
    b>Leptin and insulin have overlapping intracellular signaling mechanisms and exert anorexigenic actions in the hypothalamus...
  3. Scarpace P, Matheny M, Kirichenko N, Gao Y, Tümer N, Zhang Y. Leptin overexpression in VTA trans-activates the hypothalamus whereas prolonged leptin action in either region cross-desensitizes. Neuropharmacology. 2013;65:90-100 pubmed publisher
    High-fat feeding or CNS leptin overexpression in chow-fed rats results in a region-specific cellular leptin resistance in medial basal hypothalamic regions and the ventral tegmental area (VTA)...
  4. Lee M, Yang R, Gong D, Fried S. Feeding and insulin increase leptin translation. Importance of the leptin mRNA untranslated regions. J Biol Chem. 2007;282:72-80 pubmed
    The post-transcriptional mechanisms by which feeding and insulin increase leptin production are poorly understood...
  5. Dumond H, Presle N, Terlain B, Mainard D, Loeuille D, Netter P, et al. Evidence for a key role of leptin in osteoarthritis. Arthritis Rheum. 2003;48:3118-29 pubmed
    To evaluate the contribution of leptin (an adipose tissue-derived hormone) to the pathophysiology of osteoarthritis (OA), by determining the level of leptin in both synovial fluid (SF) and cartilage specimens obtained from human joints...
  6. Pelleymounter M, Cullen M, Baker M, Hecht R, Winters D, Boone T, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995;269:540-3 pubmed
    C57BL/6J mice with a mutation in the obese (ob) gene are obese, diabetic, and exhibit reduced activity, metabolism, and body temperature...
  7. Li Y, Wu X, Zhou S, Owyang C. Low-affinity CCK-A receptors are coexpressed with leptin receptors in rat nodose ganglia: implications for leptin as a regulator of short-term satiety. Am J Physiol Gastrointest Liver Physiol. 2011;300:G217-27 pubmed publisher
    The paradigm for the control of feeding behavior has changed significantly. Research has shown that leptin, in the presence of CCK, may mediate the control of short-term food intake...
  8. Levin B, Dunn Meynell A, Banks W. Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset. Am J Physiol Regul Integr Comp Physiol. 2004;286:R143-50 pubmed
    ..were compared with those bred to be diet resistant (DR) on a 31% fat high-energy diet with regard to their central leptin signaling and blood-brain barrier (BBB) transport...
  9. Choi Y, Li C, Hartzell D, Little D, Della Fera M, Baile C. ICV leptin effects on spontaneous physical activity and feeding behavior in rats. Behav Brain Res. 2008;188:100-8 pubmed
    Although leptin causes negative energy balance by reducing food intake and increasing energy expenditure, the effect of leptin on spontaneous physical activity (SPA) is not clearly established...
  10. Loffreda S, Yang S, Lin H, Karp C, Brengman M, Wang D, et al. Leptin regulates proinflammatory immune responses. FASEB J. 1998;12:57-65 pubmed
    ..Decreased expression of leptin or of functional leptin receptors results in hyperphagia, decreased energy expenditure, and obesity...
  11. Mattace Raso G, Esposito E, Iacono A, Pacilio M, Coppola A, Bianco G, et al. Leptin induces nitric oxide synthase type II in C6 glioma cells. Role for nuclear factor-kappaB in hormone effect. Neurosci Lett. 2006;396:121-6 pubmed
    ..Here we investigated the in vitro effect of leptin on inducible nitric oxide synthase (iNOS) expression in a glioma cell line (C6)...
  12. Otero M, Lago R, Lago F, Reino J, Gualillo O. Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. Arthritis Res Ther. 2005;7:R581-91 pubmed
    The objective of the present study was to investigate the effect of leptin, alone or in combination with IL-1, on nitric oxide synthase (NOS) type II activity in vitro in human primary chondrocytes, in the mouse chondrogenic ATDC5 cell ..
  13. Ogawa Y, Masuzaki H, Isse N, Okazaki T, Mori K, Shigemoto M, et al. Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats. J Clin Invest. 1995;96:1647-52 pubmed
    The obese (ob) gene has recently been isolated through a positional cloning approach, the mutation of which causes a marked hereditary obesity and diabetes mellitus in mice...
  14. Muse E, Cheng A, Chen L, Scherer T, Pocai A, Su K, et al. Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nat Med. 2008;14:667-75 pubmed publisher
    b>Leptin (encoded by Lep) controls body weight by regulating food intake and fuel partitioning. Obesity is characterized by leptin resistance and increased endocannabinoid tone...
  15. Cabanelas A, Cordeiro A, Santos Almeida N, Monteiro de Paula G, Coelho V, Ortiga Carvalho T, et al. Effect of triiodothyronine on adiponectin expression and leptin release by white adipose tissue of normal rats. Horm Metab Res. 2010;42:254-60 pubmed publisher
    Previous studies have shown that alterations in thyroid status may lead to changes in serum leptin and adiponectin, both in humans and rodents. The mechanisms, especially for adiponectin, are unclear...
  16. Patterson C, Bouret S, Dunn Meynell A, Levin B. Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling. Am J Physiol Regul Integr Comp Physiol. 2009;296:R537-48 pubmed publisher
    ..To test the hypothesis that this effect is due to increased central leptin sensitivity, 4-wk-old DIO rats were fed the HE diet and left sedentary (Sed), exercised for 3 wk, and then ..
  17. Rodríguez A, Fortuno A, Gomez Ambrosi J, Zalba G, Diez J, Fruhbeck G. The inhibitory effect of leptin on angiotensin II-induced vasoconstriction in vascular smooth muscle cells is mediated via a nitric oxide-dependent mechanism. Endocrinology. 2007;148:324-31 pubmed
    b>Leptin inhibits the contractile response induced by angiotensin (Ang) II in vascular smooth muscle cells (VSMCs) of the aorta...
  18. Hama H, Saito A, Takeda T, Tanuma A, Xie Y, Sato K, et al. Evidence indicating that renal tubular metabolism of leptin is mediated by megalin but not by the leptin receptors. Endocrinology. 2004;145:3935-40 pubmed
    b>Leptin is secreted by adipocytes and is a circulating factor that regulates food intake and energy expenditure...
  19. Fortuno A, Rodríguez A, Gomez Ambrosi J, Muñiz P, Salvador J, Diez J, et al. Leptin inhibits angiotensin II-induced intracellular calcium increase and vasoconstriction in the rat aorta. Endocrinology. 2002;143:3555-60 pubmed
    Besides its role in body weight control leptin may also act as a vasoactive hormone. This study was designed to investigate whether leptin modifies angiotensin II (ANG II)-induced vascular responses...
  20. Miyazaki S, Izawa T, Ogasawara J, Sakurai T, Nomura S, Kizaki T, et al. Effect of exercise training on adipocyte-size-dependent expression of leptin and adiponectin. Life Sci. 2010;86:691-8 pubmed publisher
    Our aim was to evaluate the effect of exercise training (TR) on adipocyte-size-dependent expression of leptin and adiponectin. Male Wistar rats were divided into 2 groups, sedentary control (CR) and TR group, and both monitored for 9weeks...
  21. Matarese G, Leiter E, La Cava A. Leptin in autoimmunity: many questions, some answers. Tissue Antigens. 2007;70:87-95 pubmed
    ..Among those molecules, the adipocyte-derived cytokine leptin has been shown to significantly influence innate and adaptive immune responses both in normal and in pathological ..
  22. Cettour Rose P, Burger A, Meier C, Visser T, Rohner Jeanrenaud F. Central stimulatory effect of leptin on T3 production is mediated by brown adipose tissue type II deiodinase. Am J Physiol Endocrinol Metab. 2002;283:E980-7 pubmed
    To assess whether intracerebroventricular leptin administration affects monodeiodinase type II (D2) activity in the tissues where it is expressed [cerebral cortex, hypothalamus, pituitary, and brown adipose tissue (BAT)], hepatic ..
  23. Wold L, Relling D, Duan J, Norby F, Ren J. Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: role of Jak/STAT pathway. Hypertension. 2002;39:69-74 pubmed
    b>Leptin regulates cardiovascular function. Leptin levels are elevated in obesity and hypertension and may play a role in cardiovascular dysfunctions in these comorbidities...
  24. Ducroc R, Sakar Y, Fanjul C, Barber A, Bado A, Lostao M. Luminal leptin inhibits L-glutamine transport in rat small intestine: involvement of ASCT2 and B0AT1. Am J Physiol Gastrointest Liver Physiol. 2010;299:G179-85 pubmed publisher
    ..We have demonstrated that leptin is secreted into the stomach lumen after a meal and modulates the transport of sugars after binding to its ..
  25. Luvizotto R, Síbio M, Olímpio R, Nascimento A, Lima Leopoldo A, Leopoldo A, et al. Supraphysiological triiodothyronine doses diminish leptin and adiponectin gene expression, but do not alter resistin expression in calorie restricted obese rats. Horm Metab Res. 2011;43:452-7 pubmed publisher
    ..The present study determined the effect of T(3) on serum concentrations and gene expression of the adipokines leptin, resistin, and adiponectin in calorie-restricted obese rats...
  26. Lord G, Matarese G, Howard J, Baker R, Bloom S, Lechler R. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature. 1998;394:897-901 pubmed
    ..The cloning of the obese gene and identification of its protein product leptin has provided fundamental insight into the hypothalamic regulation of body weight...
  27. Pérez C, Fernández Galaz C, Fernández Agulló T, Arribas C, Andrés A, Ros M, et al. Leptin impairs insulin signaling in rat adipocytes. Diabetes. 2004;53:347-53 pubmed
    b>Leptin modulates glucose homeostasis by acting as an insulin-sensitizing factor in most insulin target tissues. Nevertheless, insulin-dependent glucose uptake in white adipose tissue decreases after in vivo treatment with leptin...
  28. Delahaye F, Breton C, Risold P, Enache M, Dutriez Casteloot I, Laborie C, et al. Maternal perinatal undernutrition drastically reduces postnatal leptin surge and affects the development of arcuate nucleus proopiomelanocortin neurons in neonatal male rat pups. Endocrinology. 2008;149:470-5 pubmed
    ..The present study aimed at examining the impact of maternal undernutrition on leptin plasma levels in newborn male rats and on the arcuate nucleus proopiomelanocortin (POMC) and neuropeptide Y (NPY) ..
  29. Guilmeau S, Buyse M, Tsocas A, Laigneau J, Bado A. Duodenal leptin stimulates cholecystokinin secretion: evidence of a positive leptin-cholecystokinin feedback loop. Diabetes. 2003;52:1664-72 pubmed
    Some of the actions of leptin depend on cholecystokinin (CCK). However, it is unknown whether leptin modulates the release of CCK...
  30. Martínez Abundis E, Rajapurohitam V, Gertler A, Karmazyn M. Identification of functional leptin receptors expressed in ventricular mitochondria. Mol Cell Biochem. 2015;408:155-62 pubmed publisher
    b>Leptin is a 16 kDa pro-satiety peptide produced primarily not only by white adipocytes but also by numerous other tissues including the heart...
  31. Nemati M, Zardooz H, Rostamkhani F, Abadi A, Foroughi F. High-fat diet effects on metabolic responses to chronic stress. Arch Physiol Biochem. 2017;123:182-191 pubmed publisher
    ..High-fat diet increased abdominal fat weight and plasma leptin, and insulin levels in response to stress without affecting HOMA-IR index and islets' insulin secretion...
  32. Wang L, Yuan J, Zhang H, Ding H, Tang X, Wei Y. Effect of leptin on bone metabolism in rat model of traumatic brain injury and femoral fracture. Chin J Traumatol. 2011;14:7-13 pubmed
    To observe serum and callus leptin expression within the setting of fracture and traumatic brain injury (TBI)...
  33. Conceição E, Trevenzoli I, Oliveira E, Franco J, Carlos A, Nascimento Saba C, et al. Higher white adipocyte area and lower leptin production in adult rats overfed during lactation. Horm Metab Res. 2011;43:513-6 pubmed publisher
    ..fat mass content, hyperinsulinemia and insulin resistance, hypertension, lower HDL cholesterol, hyperphagia, and leptin resistance. Leptin resistance is often associated with hyperleptinemia...
  34. García Ruiz I, Gómez Izquierdo E, Díaz Sanjuán T, Grau M, Solís Muñoz P, Muñoz Yagüe T, et al. Sp1 and Sp3 transcription factors mediate leptin-induced collagen ?1(I) gene expression in primary culture of male rat hepatic stellate cells. Endocrinology. 2012;153:5845-56 pubmed publisher
    Mechanisms by which leptin stimulates collagen ?(1)(I) [Col1a(I)] gene expression are unclear...
  35. Rodrigues A, de Moura E, Passos M, Dutra S, Lisboa P. Postnatal early overnutrition changes the leptin signalling pathway in the hypothalamic-pituitary-thyroid axis of young and adult rats. J Physiol. 2009;587:2647-61 pubmed publisher
    ..Since leptin regulates the hypothalamic-pituitary-thyroid axis and the metabolism of thyroid hormones, we studied the leptin ..
  36. Elshafie M, Fouad G, Shaaban M, Helmi A, Ewies A. The effect of leptin on maturation of the ovarian compartments of albino rats: an ultrastructural and histological study. Gynecol Endocrinol. 2008;24:67-78 pubmed publisher
    b>Leptin serves as a signal to the central nervous system with information on the critical amount of adipose tissue stores that is necessary for activation of the hypothalamic-pituitary-ovarian axis...
  37. Vuolteenaho K, Koskinen A, Kukkonen M, Nieminen R, Päivärinta U, Moilanen T, et al. Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production. Mediators Inflamm. 2009;2009:345838 pubmed publisher
    ..b>Leptin is an adipokine regulating energy balance, and it has recently been related also to arthritis and inflammation as ..
  38. Trevaskis J, Coffey T, Cole R, Lei C, Wittmer C, Walsh B, et al. Amylin-mediated restoration of leptin responsiveness in diet-induced obesity: magnitude and mechanisms. Endocrinology. 2008;149:5679-87 pubmed publisher
    Previously, we reported that combination treatment with rat amylin (100 microg/kg.d) and murine leptin (500 microg/kg...
  39. Abdennebi Najar L, Desai M, Han G, Casillas E, Jean D, Arieh G, et al. Basal, endogenous leptin is metabolically active in newborn rat pups. J Matern Fetal Neonatal Med. 2011;24:1486-91 pubmed publisher
    The adipocyte-derived hormone leptin regulates food intake and body weight via the activation of JAK-STAT pathway in mammalian adult hypothalamic neurons...
  40. Asrih M, Veyrat Durebex C, Poher A, Lyautey J, Rohner Jeanrenaud F, Jornayvaz F. Leptin as a Potential Regulator of FGF21. Cell Physiol Biochem. 2016;38:1218-25 pubmed publisher
    ..However, the identification of factors involved in FGF21 regulation is far from complete. As leptin is a potent metabolic modulator as well, we aimed at characterizing whether leptin may regulate FGF21...
  41. Madhavadas S, Kutty B, Subramanian S. Amyloid beta lowering and cognition enhancing effects of ghrelin receptor analog [D-Lys (3)] GHRP-6 in rat model of obesity. Indian J Biochem Biophys. 2014;51:257-62 pubmed
    ..analog [D-Lys (3)] GHRP-6 to obese rats resulted in significant restoration of serum cholesterol, glucose, leptin and ghrelin levels to that of control with concomitant reduction in hippocampal Abeta and AChE levels...
  42. de Oliveira C, Scarabelot V, de Souza A, de Oliveira C, Medeiros L, de Macedo I, et al. Obesity and chronic stress are able to desynchronize the temporal pattern of serum levels of leptin and triglycerides. Peptides. 2014;51:46-53 pubmed publisher
    ..metabolic syndrome, increasing delta weight, Lee index, weight fractions of adipose tissue, and triglycerides and leptin levels...
  43. Watson E, Hahm S, Mizuno T, Windsor J, Montgomery C, Scherer P, et al. VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity. Endocrinology. 2005;146:5151-63 pubmed
    ..at 7-8 wk of age, when lean MC4R(-)/MC4R(-) mice already have impaired insulin tolerance but are not yet obese. VGF mutant mice also resisted developing obesity and hyperglycemia in response to a high-fat/high-carbohydrate ..
  44. Ferla R, Bonomi M, Otvos L, Surmacz E. Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects. BMC Cancer. 2011;11:303 pubmed publisher
    b>Leptin is a pleiotropic hormone whose mitogenic and angiogenic activity has been implicated in the development and progression of several malignancies, including brain tumors...
  45. Baltaci A, Mogulkoc R. Leptin, NPY, Melatonin and Zinc Levels in Experimental Hypothyroidism and Hyperthyroidism: The Relation to Zinc. Biochem Genet. 2017;55:223-233 pubmed publisher
    ..And also thyroid hormones have important activity on metabolism and feeding. NPY and leptin are affective on food intake and regulation of appetite...
  46. Irving A, Wallace L, Durakoglugil D, Harvey J. Leptin enhances NR2B-mediated N-methyl-D-aspartate responses via a mitogen-activated protein kinase-dependent process in cerebellar granule cells. Neuroscience. 2006;138:1137-48 pubmed
    It is well documented that the hormone leptin regulates energy balance via its actions in the hypothalamus. However, evidence is accumulating that leptin plays a key role in numerous CNS functions...
  47. Zeinoaldini S, Swarts J, Van de Heijning B. Chronic leptin infusion advances, and immunoneutralization of leptin postpones puberty onset in normally fed and feed restricted female rats. Peptides. 2006;27:1652-8 pubmed
    Does leptin play a vital role in initiating puberty in female rats and can it overrule a nutrionally imposed (i.e...
  48. Ishii S, Kamegai J, Tamura H, Shimizu T, Sugihara H, Oikawa S. Hypothalamic neuropeptide Y/Y1 receptor pathway activated by a reduction in circulating leptin, but not by an increase in circulating ghrelin, contributes to hyperphagia associated with triiodothyronine-induced thyrotoxicosis. Neuroendocrinology. 2003;78:321-30 pubmed
    Food intake is regulated by hypothalamic neuropeptides which respond to peripheral signals. Plasma ghrelin and leptin levels reflect peripheral energy balance and regulate hypothalamic neuropeptides such as neuropeptide Y (NPY), pro-..
  49. Mumtaz S, AlSaif S, Wray S, Noble K. Inhibitory effect of visfatin and leptin on human and rat myometrial contractility. Life Sci. 2015;125:57-62 pubmed publisher
    ..was to investigate the effect of visfatin on in vitro myometrial contractility in human and rat, and compare it to leptin. Myometrial strips from term pregnant women having a caesarean section or rats were dissected, superfused with ..
  50. Aizawa Abe M, Ebihara K, Ebihara C, Mashimo T, Takizawa A, Tomita T, et al. Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver. Physiol Genomics. 2013;45:786-93 pubmed publisher
    b>Leptin is one of the key molecules in maintaining energy homeostasis...
  51. Sartor D, Verberne A. Gastric leptin: a novel role in cardiovascular regulation. Am J Physiol Heart Circ Physiol. 2010;298:H406-14 pubmed publisher
    Gastric-derived leptin affects satiety and gastrointestinal function via vagal mechanisms and has been shown to interact with the gut hormone cholecystokinin (CCK)...
  52. van den Heuvel J, Eggels L, Fliers E, Kalsbeek A, Adan R, la Fleur S. Differential modulation of arcuate nucleus and mesolimbic gene expression levels by central leptin in rats on short-term high-fat high-sugar diet. PLoS ONE. 2014;9:e87729 pubmed publisher
    b>Leptin resistance is a common hallmark of obesity. Rats on a free-choice high-fat high-sugar (fcHFHS) diet are resistant to peripherally administered leptin...
  53. Takatani Nakase T, Takahashi K. Leptin suppresses non-apoptotic cell death in ischemic rat cardiomyocytes by reduction of iPLA(2) activity. Biochem Biophys Res Commun. 2015;463:13-7 pubmed publisher
    Caspase-independent, non-apoptotic cell death is an important therapeutic target in myocardial ischemia. Leptin, an adipose-derived hormone, is known to exhibit cytoprotective effects on the ischemic heart, but the mechanisms are poorly ..
  54. Anderwald C, Müller G, Koca G, Fürnsinn C, Waldhausl W, Roden M. Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2. Mol Endocrinol. 2002;16:1612-28 pubmed
    b>Leptin has both insulin-like and insulin-antagonistic effects on glucose metabolism. To test whether leptin interferes directly with insulin signaling, we perfused isolated rat livers with leptin (0.1, 0...
  55. Naef L, Gjerde E, Long H, Richard D, Walker C. Neonatal onset of leptin signalling in dopamine neurones of the ventral tegmental area in the rat. J Neuroendocrinol. 2014;26:835-43 pubmed publisher
    b>Leptin inhibits feeding by acting on hypothalamic and mesolimbic dopamine (DA) pathways involved in the homeostatic and hedonic control of energy balance...
  56. Benoit C, Ould Hamouda H, Crépin D, Gertler A, Amar L, Taouis M. Early leptin blockade predisposes fat-fed rats to overweight and modifies hypothalamic microRNAs. J Endocrinol. 2013;218:35-47 pubmed publisher
    Perinatal leptin impairment has long-term consequences on energy homeostasis leading to body weight gain. The underlying mechanisms are still not clearly established. We aimed to analyze the long-term effects of early leptin blockade...
  57. Leone A, Spatola G, Cucco D, Tessitore V, Bonaventura G, Uzzo M. Immunohistochemical expression and distribution of orexin, orphanin and leptin in the major salivary glands of some mammals. Folia Histochem Cytobiol. 2012;50:504-12 pubmed publisher
    The aim of the study was to determine by immunochemistry the expression of leptin, orexin A and orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow...
  58. Cammisotto P, Bukowiecki L. Role of calcium in the secretion of leptin from white adipocytes. Am J Physiol Regul Integr Comp Physiol. 2004;287:R1380-6 pubmed
    The mechanism by which calcium regulates leptin secretion was studied in adipocytes isolated from rat white adipose tissue...
  59. Pérez Echarri N, Perez Matute P, Martinez J, Marti A, Moreno Aliaga M. Serum and gene expression levels of leptin and adiponectin in rats susceptible or resistant to diet-induced obesity. J Physiol Biochem. 2005;61:333-42 pubmed
    The aim of the present study was to identify the role of leptin and adiponectin in the development of resistance or susceptibility to diet-induced obesity in rats...
  60. Sun B, Song L, Tamashiro K, Moran T, Yan J. Large litter rearing improves leptin sensitivity and hypothalamic appetite markers in offspring of rat dams fed high-fat diet during pregnancy and lactation. Endocrinology. 2014;155:3421-33 pubmed publisher
    ..Male and female pups with maternal HF diet (HF-NL) had greater body weight and adiposity, higher plasma leptin levels, impaired glucose tolerance, abnormal hypothalamic leptin signaling pathways (lower leptin receptor-b [OB-..
  61. Liang R, Zhang W, Song Y. Levels of leptin and IL-6 in lungs and blood are associated with the severity of chronic obstructive pulmonary disease in patients and rat models. Mol Med Rep. 2013;7:1470-6 pubmed publisher
    The aim of the present study was to compare leptin and interleukin (IL)-6 expression in patients and rat models with chronic obstructive pulmonary disease (COPD)...
  62. Liapakis I, Anagnostoulis S, Karayiannakis A, Karayiannakis A, Korkolis D, Lambropoulou M, et al. Recombinant leptin administration improves early angiogenesis in full-thickness skin flaps: an experimental study. In Vivo. 2008;22:247-52 pubmed
    b>Leptin is a potent direct angiogenic factor that stimulates endothelial cell migration and activation in vitro, and angiogenesis in vivo...