Ldlr

Summary

Gene Symbol: Ldlr
Description: low density lipoprotein receptor
Alias: LDLRA, low-density lipoprotein receptor, LDL receptor
Species: rat
Products:     Ldlr

Top Publications

  1. Bishop R. Structure of the hamster low density lipoprotein receptor gene. J Lipid Res. 1992;33:549-57 pubmed
    ..To extend the usefulness of the hamster as an experimental model, the hamster LDL receptor gene was isolated and characterized. The gene is composed of 18 exons and 17 introns which span 26 kilobases...
  2. Lamsa R, Helisalmi S, Herukka S, Tapiola T, Pirttila T, Vepsalainen S, et al. Genetic study evaluating LDLR polymorphisms and Alzheimer's disease. Neurobiol Aging. 2008;29:848-55 pubmed
    ..The specific risk haplotype GTT was associated with an increased level of tau and ptau in both men and women. Our findings suggest that LDLR gene may be associated with AD risk and its CSF biomarkers, especially in women.
  3. Abifadel M, Varret M, Rabes J, Allard D, Ouguerram K, Devillers M, et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet. 2003;34:154-6 pubmed
    ..by an increase in low-density lipoprotein cholesterol levels that is associated with mutations in the genes LDLR (encoding low-density lipoprotein receptor) or APOB (encoding apolipoprotein B)...
  4. Nassoury N, Blasiole D, Tebon Oler A, Benjannet S, Hamelin J, Poupon V, et al. The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR. Traffic. 2007;8:718-32 pubmed
    ..proprotein convertase subtilisin kexin 9 (PCSK9) to elicit the degradation of the low-density lipoprotein receptor (LDLR) protein...
  5. Rashid S, Curtis D, Garuti R, Anderson N, Bashmakov Y, Ho Y, et al. Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9. Proc Natl Acad Sci U S A. 2005;102:5374-9 pubmed
    ..likely due to a gain-of-function mechanism because overexpression of either WT or mutant PCSK9 reduces hepatic LDL receptor protein (LDLR) in mice...
  6. Lo Surdo P, Bottomley M, Calzetta A, Settembre E, Cirillo A, Pandit S, et al. Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH. EMBO Rep. 2011;12:1300-5 pubmed publisher
    ..PCSK9 (proprotein convertase subtilisin/kexin type 9) is a key regulator of low-density lipoprotein receptor (LDLR) levels and cardiovascular health. We have determined the crystal structure of LDLR bound to PCSK9 at neutral pH...
  7. Kim J, Castellano J, Jiang H, Basak J, Parsadanian M, Pham V, et al. Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron. 2009;64:632-44 pubmed publisher
    ..LDLR, a member of the LDL receptor family, binds to apoE, yet its potential role in AD pathogenesis remains unclear...
  8. Verges M, Havel R, Mostov K. A tubular endosomal fraction from rat liver: biochemical evidence of receptor sorting by default. Proc Natl Acad Sci U S A. 1999;96:10146-51 pubmed
  9. Bartuzi P, Billadeau D, Favier R, Rong S, Dekker D, Fedoseienko A, et al. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nat Commun. 2016;7:10961 pubmed publisher
    The low-density lipoprotein receptor (LDLR) plays a pivotal role in clearing atherogenic circulating low-density lipoprotein (LDL) cholesterol...

More Information

Publications75

  1. Garcimartín A, Santos López J, Bastida S, Benedí J, Sánchez Muniz F. Silicon-Enriched Restructured Pork Affects the Lipoprotein Profile, VLDL Oxidation, and LDL Receptor Gene Expression in Aged Rats Fed an Atherogenic Diet. J Nutr. 2015;145:2039-45 pubmed publisher
    ..Plasma lipid concentrations, lipoprotein profile, the degree of VLDL oxidation, and LDL receptor gene (Ldlr) expression were tested...
  2. Pallottini V, Martini C, Cavallini G, Donati A, Bergamini E, Notarnicola M, et al. Modified HMG-CoA reductase and LDLr regulation is deeply involved in age-related hypercholesterolemia. J Cell Biochem. 2006;98:1044-53 pubmed
    ..The levels of other related proteins, whose transcription is SREBP dependent, that is low density lipoprotein receptor (LDLr) and Caveolin 1, have been also measured...
  3. van Ree J, Hofker M, van den Broek W, van Deursen J, van der Boom H, Frants R, et al. Increased response to cholesterol feeding in apolipoprotein C1-deficient mice. Biochem J. 1995;305 ( Pt 3):905-11 pubmed
    ..006 g/ml are poor competitors for 125I-labelled LDL binding to the LDL receptor on HepG2 cells...
  4. Lee L, Mohler W, Schafer B, Freudenberger J, Byrne Connolly N, Eager K, et al. Nucleotide sequence of the rat low density lipoprotein receptor cDNA. Nucleic Acids Res. 1989;17:1259-60 pubmed
  5. Persson L, Gälman C, Angelin B, Rudling M. Importance of proprotein convertase subtilisin/kexin type 9 in the hormonal and dietary regulation of rat liver low-density lipoprotein receptors. Endocrinology. 2009;150:1140-6 pubmed publisher
    Hormonal or dietary challenge can stimulate hepatic low-density lipoprotein receptor (LDLR) expression through posttranscriptional mechanisms...
  6. Gopalraj R, Zhu H, Kelly J, Mendiondo M, Pulliam J, Bennett D, et al. Genetic association of low density lipoprotein receptor and Alzheimer's disease. Neurobiol Aging. 2005;26:1-7 pubmed
    The low density lipoprotein receptor (LDLR) is an attractive candidate gene for genetic association with Alzheimer's disease (AD) because: (i) the LDLR is an apolipoprotein E (apoE) receptor, alleles of which have been associated with AD, ..
  7. Minahk C, Kim K, Nelson R, Trigatti B, Lehner R, Vance D. Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes. J Biol Chem. 2008;283:6449-58 pubmed publisher
    ..Strikingly, in the absence of the LDL receptor, PC incorporation into hepatocytes was inhibited by only 30%, whereas cholesteryl ether uptake was inhibited by ..
  8. Kim H, Gil S, Andrieux K, Nicolas V, Appel M, Chacun H, et al. Low-density lipoprotein receptor-mediated endocytosis of PEGylated nanoparticles in rat brain endothelial cells. Cell Mol Life Sci. 2007;64:356-64 pubmed
    ..with nanoparticles preincubated with apolipoprotein E and blocking of low-density lipoprotein receptors (LDLR) clearly suggested that the LDLR-mediated pathway was involved in the endocytosis of PEGPHDCA nanoparticles by RBEC. ..
  9. Segatto M, Di Giovanni A, Marino M, Pallottini V. Analysis of the protein network of cholesterol homeostasis in different brain regions: an age and sex dependent perspective. J Cell Physiol. 2013;228:1561-7 pubmed publisher
    ..the behavior of 3-hydroxy 3-methylglutaryl coenzyme A reductase (HMGR) and low-density lipoprotein receptor (LDLr) in adult (3-month-old) and aged (12-month-old) male and female rats...
  10. Zabalawi M, Bharadwaj M, Horton H, Cline M, Willingham M, Thomas M, et al. Inflammation and skin cholesterol in LDLr-/-, apoA-I-/- mice: link between cholesterol homeostasis and self-tolerance?. J Lipid Res. 2007;48:52-65 pubmed
    Diet-fed low density lipoprotein receptor-deficient/apolipoprotein A-I-deficient (LDLr-/-, apoA-I-/-) mice accumulate a 10-fold greater mass of cholesterol in their skin despite a 1...
  11. Badeau R, Metso J, Tikkanen M, Jauhiainen M. High-density lipoprotein-associated 17beta-estradiol fatty acyl ester uptake by Fu5AH hepatoma cells: implications of the roles of scavenger receptor class B, type I and the low-density lipoprotein receptor. Biochim Biophys Acta. 2007;1771:1329-34 pubmed
    ..HDL-E2-FAE was hydrolyzed into free E2 with the maximum at 24 h. Fu5AH cells facilitate HDL-E2 uptake by at least SR-BI and LDL receptor pathways and intracellular hydrolysis of E2-FAE into free E2 ensues.
  12. Segatto M, Trapani L, Marino M, Pallottini V. Age- and sex-related differences in extra-hepatic low-density lipoprotein receptor. J Cell Physiol. 2011;226:2610-6 pubmed publisher
    To determine whether differences in LDLr behavior in extra-hepatic tissues and whether extra-hepatic receptors could differentially contribute to cholesterol homeostasis under physiological conditions, we evaluated the presence and ..
  13. Chen Z, Fitzgerald R, Li G, Davidson N, Schonfeld G. Hepatic secretion of apoB-100 is impaired in hypobetalipoproteinemic mice with an apoB-38.9-specifying allele. J Lipid Res. 2004;45:155-63 pubmed
    ..The greater-than-expected decreases in apoB-100 production rates of FHBL heterozygous humans appear to be attributable to a defect in secretion rather than in the synthesis of apoB-100 from the unaffected apoB allele. ..
  14. Hennig B, Hellier S, Frodsham A, Zhang L, Klenerman P, Knapp S, et al. Association of low-density lipoprotein receptor polymorphisms and outcome of hepatitis C infection. Genes Immun. 2002;3:359-67 pubmed
    The low-density lipoprotein receptor (LDLR) has been proposed to promote hepatitis C virus endocytosis and the cell membrane protein CD81 may also promote HCV host cell entry...
  15. Katsouri L, Georgopoulos S. Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model. PLoS ONE. 2011;6:e21880 pubmed publisher
    ..The low-density lipoprotein receptor (LDLR) regulates ApoE levels in the periphery and in the central nervous system...
  16. Cooper A, Nutik R, Chen J. Characterization of the estrogen-induced lipoprotein receptor of rat liver. J Lipid Res. 1987;28:59-68 pubmed
    ..cross-reacted with an ethinyl estradiol-induced protein of the same molecular weight as the bovine adrenal LDL receptor, was expanded. This antibody, designated P1B3, immunoprecipitated the induced lipoprotein receptor...
  17. Hayashi T, Kamada H, Jin G, Deguchi K, Nagotani S, Sehara Y, et al. Different expression of low density lipoprotein receptor and ApoE between young adult and old rat brains after ischemia. Neurol Res. 2006;28:822-5 pubmed
    ..Impaired lipid recruitment causes disturbance of synaptogenesis and thus brain plasticity reduction. This molecular mechanism may result in poor functional recovery of aged stroke patients. ..
  18. Loyer X, Potteaux S, Vion A, Guerin C, Boulkroun S, Rautou P, et al. Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice. Circ Res. 2014;114:434-43 pubmed publisher
    ..In Ldlr(-/-) mice, miR-92a expression was markedly enhanced by hypercholesterolemia, in particular in atheroprone areas of ..
  19. Ueno M, Wu B, Nakagawa T, Nagai Y, Onodera M, Huang C, et al. The expression of LDL receptor in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model. Histochem Cell Biol. 2010;133:669-76 pubmed publisher
    ..expression of representative efflux and influx transporters of Abeta, such as low-density lipoprotein receptor (LDLR), LDL-related protein 1 (LRP1), and the receptor for advanced glycation end product (RAGE) in the hippocampus of ..
  20. Kirk E, Sutherland P, Wang S, Chait A, LeBoeuf R. Dietary isoflavones reduce plasma cholesterol and atherosclerosis in C57BL/6 mice but not LDL receptor-deficient mice. J Nutr. 1998;128:954-9 pubmed
    ..C57BL/6 and LDL receptor-deficient (LDLr-null) mice were fed soy protein-based, high fat diets with isoflavones present (IF+, 20...
  21. Lopez D, Abisambra Socarrás J, Bedi M, Ness G. Activation of the hepatic LDL receptor promoter by thyroid hormone. Biochim Biophys Acta. 2007;1771:1216-25 pubmed
    ..Treatment of Hx rats with T3 restored LDL receptor mRNA levels in about 1 h and caused a 6-fold increase 2.5 h after T3 administration...
  22. Zinkhan E, Zalla J, Carpenter J, Yu B, Yu X, Chan G, et al. Intrauterine growth restriction combined with a maternal high-fat diet increases hepatic cholesterol and low-density lipoprotein receptor activity in rats. Physiol Rep. 2016;4: pubmed publisher
    ..a maternal HFD increased hepatic cholesterol levels, low-density lipoprotein (LDL) receptor protein levels, and Ldlr activity in female rat offspring at birth and both sexes at postnatal day 14 relative to non-IUGR offspring both ..
  23. Smith P, Cowan A, White B. The low-density lipoprotein receptor is regulated by estrogen and forms a functional complex with the estrogen-regulated protein ezrin in pituitary GH3 somatolactotropes. Endocrinology. 2004;145:3075-83 pubmed
    ..We report here that low-density lipoprotein (LDL) receptor (LDLR) gene expression and LDL uptake are strongly up-regulated by estrogen in pituitary somatolactotropic GH(3) cells...
  24. Jones C, Hammer R, Li W, Cohen J, Hobbs H, Herz J. Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia. J Biol Chem. 2003;278:29024-30 pubmed
    ..As in FH, the rate of clearance of circulating low density lipoprotein (LDL) by the LDL receptor (LDLR) in the liver is markedly reduced in ARH...
  25. Lopez D, Ness G. Characterization of the rat LDL receptor 5'-flanking region. Biochim Biophys Acta. 2006;1761:492-500 pubmed
    A 1.5-kb genomic DNA fragment corresponding to the 5'-flanking region of the rat LDL receptor gene was cloned and putative regulatory regions were identified...
  26. Rodriguez E, Mateo I, Llorca J, Sánchez Quintana C, Infante J, Berciano J, et al. No association between low density lipoprotein receptor genetic variants and Alzheimer's disease risk. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:541-3 pubmed
    ..To evaluate the relationship between low density lipoprotein receptor (LDLR) genetic variant and AD, independently or in concert with the APOE epsilon4 allele, we examined ..
  27. Xu Z, Chen Y, Huang A, Varghese Z, Moorhead J, Yan F, et al. Inflammatory stress exacerbates lipid-mediated renal injury in ApoE/CD36/SRA triple knockout mice. Am J Physiol Renal Physiol. 2011;301:F713-22 pubmed publisher
    ..This study was designed to investigate whether inflammation exacerbates lipid accumulation via LDL receptors (LDLr), thereby causing renal injury in C57BL/6J mice, apolipoprotein E (ApoE) knockout (KO) mice, and ApoE/CD36/..
  28. Wang H, Quan C, Hu C, Xie B, Du Y, Chen L, et al. A lipidomics study reveals hepatic lipid signatures associating with deficiency of the LDL receptor in a rat model. Biol Open. 2016;5:979-86 pubmed publisher
    ..Taken together, the LDLR knockout rat offers a new model of hypercholesterolemia, and the lipidomics analysis reveals hepatic lipid signatures associating with deficiency of the LDL receptor.
  29. Basak J, Verghese P, Yoon H, Kim J, Holtzman D. Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of A? uptake and degradation by astrocytes. J Biol Chem. 2012;287:13959-71 pubmed publisher
    ..In the current study, we demonstrate that modulating levels of the low-density lipoprotein receptor (LDLR), a cell surface receptor that regulates the amount of apolipoprotein E (apoE) in the brain, altered both the ..
  30. Sithu S, Malovichko M, Riggs K, Wickramasinghe N, Winner M, Agarwal A, et al. Atherogenesis and metabolic dysregulation in LDL receptor-knockout rats. JCI Insight. 2017;2: pubmed publisher
    ..in genetically engineered mice with disturbed cholesterol metabolism such as those lacking either the LDL receptor (Ldlr) or apolipoprotein E (apoe). Few other animal models of atherosclerosis are available...
  31. Yamamoto T, Davis C, Brown M, Schneider W, Casey M, Goldstein J, et al. The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell. 1984;39:27-38 pubmed
    The nucleotide sequence of a cloned 5.3 kilobase cDNA for the human low density lipoprotein receptor revealed five domains in the 839 amino acid protein: 322 NH2-terminal amino acids, extremely rich in disulfide-bonded cysteine residues (..
  32. Veniant M, Zlot C, Walzem R, Pierotti V, Driscoll R, Dichek D, et al. Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice. J Clin Invest. 1998;102:1559-68 pubmed
    The role of the low density lipoprotein receptor (LDLR) in the clearance of apo-B48-containing lipoproteins and the role of the LDLR-related protein (LRP) in the removal of apo-B100-containing lipoproteins have not been clearly defined...
  33. Hazra A, Pyszczynski N, Dubois D, Almon R, Jusko W. Modeling of corticosteroid effects on hepatic low-density lipoprotein receptors and plasma lipid dynamics in rats. Pharm Res. 2008;25:769-80 pubmed
    This study examines methylprednisolone (MPL) effects on the dynamics of hepatic low-density lipoprotein receptor (LDLR) mRNA and plasma lipids associated with increased risks for atherosclerosis...
  34. Martínez Oliván J, Arias Moreno X, Hurtado Guerrero R, Carrodeguas J, Miguel Romero L, Marina A, et al. The closed conformation of the LDL receptor is destabilized by the low Ca(++) concentration but favored by the high Mg(++) concentration in the endosome. FEBS Lett. 2015;589:3534-40 pubmed publisher
    The LDL receptor (LDLR) internalizes LDL and VLDL particles. In the endosomes, it adopts a closed conformation important for recycling, by interaction of two modules of the ligand binding domain (LR4-5) and a β-propeller motif...
  35. Bertram L, Hsiao M, McQueen M, Parkinson M, Mullin K, Blacker D, et al. The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data. Neurobiol Aging. 2007;28:18.e1-4 pubmed
    ..The low density lipoprotein receptor (LDLR) is an interesting candidate because it maps within the linked interval, and is intimately ..
  36. Kulinski A, Rustaeus S, Vance J. Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation. J Biol Chem. 2002;277:31516-25 pubmed
  37. Soutar A, Naoumova R. Mechanisms of disease: genetic causes of familial hypercholesterolemia. Nat Clin Pract Cardiovasc Med. 2007;4:214-25 pubmed
    ..mutations in LDLRAP1, which encodes a protein required for clathrin-mediated internalization of the LDL receptor by liver cells, has also been documented...
  38. Kim D, Iijima H, Goto K, Sakai J, Ishii H, Kim H, et al. Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain. J Biol Chem. 1996;271:8373-80 pubmed
    ..b>LDL receptor deficient Chinese hamster ovary cells expressing human apoER2 bound apoE rich beta-migrating VLDL with high ..
  39. Bruder E, Taylor J, Kamer K, Raff H. Development of the ACTH and corticosterone response to acute hypoxia in the neonatal rat. Am J Physiol Regul Integr Comp Physiol. 2008;295:R1195-203 pubmed publisher
    ..Analysis of adrenal mRNA expression revealed a hypoxia-induced increase in Ldlr mRNA at PD2, while both Ldlr and Star mRNA were increased at PD8...
  40. Seidah N, Poirier S, Denis M, Parker R, Miao B, Mapelli C, et al. Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation. PLoS ONE. 2012;7:e41865 pubmed publisher
    ..convertase subtilisin/kexin-9 (PCSK9) enhances the degradation of hepatic low-density lipoprotein receptor (LDLR)...
  41. Meiner V, Landsberger D, Berkman N, Reshef A, Segal P, Seftel H, et al. A common Lithuanian mutation causing familial hypercholesterolemia in Ashkenazi Jews. Am J Hum Genet. 1991;49:443-9 pubmed
    ..PCR amplification of a DNA fragment that includes the mutation in heterozygous individuals results in the formation of a heteroduplex that can be demonstrated by PAGE and used for molecular diagnosis. ..
  42. Molino Y, David M, Varini K, Jabès F, Gaudin N, Fortoul A, et al. Use of LDL receptor-targeting peptide vectors for in vitro and in vivo cargo transport across the blood-brain barrier. FASEB J. 2017;31:1807-1827 pubmed publisher
    ..There is some evidence that the LDL receptor (LDLR) is expressed at the BBB and may participate in the transport of endogenous ligands from blood to brain, ..
  43. Tolleshaug H, Hobgood K, Brown M, Goldstein J. The LDL receptor locus in familial hypercholesterolemia: multiple mutations disrupt transport and processing of a membrane receptor. Cell. 1983;32:941-51 pubmed
    ..Pedigree studies show that each mutation segregates as an allele at the LDL receptor locus...
  44. Ngo Sock E, Chapados N, Lavoie J. LDL receptor and Pcsk9 transcripts are decreased in liver of ovariectomized rats: effects of exercise training. Horm Metab Res. 2014;46:550-5 pubmed publisher
    ..In contrast, gene expression of hepatic low-density lipoprotein receptor (LDL-R), LDL receptor-related protein (Lrp1), proprotein convertase subtilisin/kexin type 9 (Pcsk9), sterol regulatory element ..
  45. Malloy S, Altenburg M, Knouff C, Lanningham Foster L, Parks J, Maeda N. Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3. Arterioscler Thromb Vasc Biol. 2004;24:91-7 pubmed
    Increased expression of the low-density lipoprotein receptor (LDLR) is generally considered beneficial for reducing plasma cholesterol and atherosclerosis, and its downregulation has been thought to explain the association between ..
  46. Martini C, Pallottini V, Cavallini G, Donati A, Bergamini E, Trentalance A. Caloric restrictions affect some factors involved in age-related hypercholesterolemia. J Cell Biochem. 2007;101:235-43 pubmed
    ..SREBP cleavage activating protein (SCAP), sterol regulatory element binding protein (SREBP), and low density lipoprotein receptor (LDLr)...
  47. Ness G, Kohlruss N, Gertz K. Association of the low-density lipoprotein receptor with caveolae in hamster and rat liver. Biochem Biophys Res Commun. 2003;303:177-81 pubmed
    ..In liver homogenates from both hamsters and rats, the fractions with the highest concentrations of LDL receptor coincided with the location of caveolin-1, a marker of the cholesterol-rich caveolae...
  48. Lucarelli M, Borrelli V, Fiori A, Cucina A, Granata F, Potenza R, et al. The expression of native and oxidized LDL receptors in brain microvessels is specifically enhanced by astrocytes-derived soluble factor(s). FEBS Lett. 2002;522:19-23 pubmed
    ..Since both receptors were found to be expressed also in astrocytes, these cells are likely to contribute substantially to the lipoprotein management at the blood-brain barrier and in the brain compartment. ..
  49. Tserentsoodol N, Sztein J, Campos M, Gordiyenko N, Fariss R, Lee J, et al. Uptake of cholesterol by the retina occurs primarily via a low density lipoprotein receptor-mediated process. Mol Vis. 2006;12:1306-18 pubmed
    ..Immunohistochemistry and fluorescent confocal microscopy were used to localize apoB (an LDL marker protein) and LDL receptor (LDLR) protein in rat and monkey retinas. ..
  50. Cheng D, Huang R, Lanham I, Cathcart H, Howard M, Corder E, et al. Functional interaction between APOE4 and LDL receptor isoforms in Alzheimer's disease. J Med Genet. 2005;42:129-31 pubmed
    ..associated with Alzheimer's disease, including the coding polymorphisms in exons 8 and 13 in the low density lipoprotein receptor gene (LDLR), situated on chromosome 19p13.2...
  51. Asahina M, Mashimo T, Takeyama M, Tozawa R, Hashimoto T, Takizawa A, et al. Hypercholesterolemia and atherosclerosis in low density lipoprotein receptor mutant rats. Biochem Biophys Res Commun. 2012;418:553-8 pubmed publisher
    To establish low density lipoprotein receptor (LDLR) mutant rats as a hypercholesterolemia and atherosclerosis model, we screened the rat LDLR gene for mutations using an N-ethyl-N-nitrosourea mutagenesis archive of rat gene data, and ..
  52. Niesen M, Bedi M, Lopez D. Diabetes alters LDL receptor and PCSK9 expression in rat liver. Arch Biochem Biophys. 2008;470:111-5 pubmed
    Since the hepatic LDL receptor is regarded as a major determinant of plasma LDL levels, the effect of diabetes on the expression of this receptor was examined in rat liver...
  53. Chen X, Wang H, Bajaj K, Zhang P, Meng Z, Ma D, et al. SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. elife. 2013;2:e00444 pubmed publisher
    ..However, these animals exhibit markedly reduced plasma cholesterol, with mutations in Apoe and Ldlr epistatic to Sec24a, suggesting a receptor-mediated lipoprotein clearance mechanism...
  54. Ivaturi S, Wooten C, Nguyen M, Ness G, Lopez D. Distribution of the LDL receptor within clathrin-coated pits and caveolae in rat and human liver. Biochem Biophys Res Commun. 2014;445:422-7 pubmed publisher
    ..a combination of discontinuous sucrose gradients and Triton solubilization studies, we demonstrated that the LDL receptor could be located simultaneously in clathrin-coated pits and caveolae in rat and human liver and in human ..
  55. Chong S, Dollah M, Chong P, Maha A. Phaleria macrocarpa (Scheff.) Boerl fruit aqueous extract enhances LDL receptor and PCSK9 expression in vivo and in vitro. J Ethnopharmacol. 2011;137:817-27 pubmed publisher
    ..1) body weight, (2) blood lipid profile (total cholesterol, triglyceride, HDL and LDL) and (3) hepatic LDL receptor (160 kDa and 120 kDa) and PCSK9 proteins...
  56. Nissen P, Damgaard D, Stenderup A, Nielsen G, Larsen M, Faergeman O. Genomic characterization of five deletions in the LDL receptor gene in Danish Familial Hypercholesterolemic subjects. BMC Med Genet. 2006;7:55 pubmed
    ..disease that is most frequently caused by mutations in the gene encoding the receptor for low density lipoproteins (LDLR)...
  57. Lee J, Lin Y, Hsu H, Huang Y, Wu C, Ryu S, et al. Genetic polymorphisms of low density lipoprotein receptor can modify stroke presentation. Neurol Res. 2010;32:535-40 pubmed publisher
    Low density lipoprotein is transcytosed across the blood-brain barrier mediated by low density lipoprotein receptor (LDLR)...
  58. Johnson L, Olsen R, Merkens L, Debarber A, Steiner R, Sullivan P, et al. Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner. Neurobiol Dis. 2014;64:150-62 pubmed publisher
    ..ApoE mediates cholesterol metabolism by binding various receptors. The low-density lipoprotein receptor (LDLR) has a high affinity for apoE, and is the only member of its receptor family to demonstrate an apoE isoform ..
  59. Rivas L, Zabaleta M, Toro F, Bianco N, De Sanctis J. Decreased transcription, expression and function of low-density lipoprotein receptor in leukocytes from patients with systemic lupus erythematosus. Autoimmunity. 2009;42:266-8 pubmed
    The low-density lipoprotein receptor (LDLR) is directly involved in the metabolism of low-density lipoprotein (LDL) and its impairment causes accumulation of plasmatic LDL leading to atherosclerosis, a prevalent disease in patients with ..
  60. Matsuda S, Miura E, Matsuda K, Kakegawa W, Kohda K, Watanabe M, et al. Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4. Neuron. 2008;57:730-45 pubmed publisher
    ..These results indicate that AP-4 may regulate proper somatodendritic-specific distribution of its cargo proteins, including AMPA receptor-TARP complexes and the autophagic pathway in neurons. ..
  61. Wang C, Zhou X, Ye S, Han D, Tan X, Zheng F, et al. Combined effects of apoE-CI-CII cluster and LDL-R gene polymorphisms on chromosome 19 and coronary artery disease risk. Int J Hyg Environ Health. 2006;209:265-73 pubmed
    ..Drinking and smoking enhance the genetic predisposition to CAD. ..
  62. Mochi M, Cevoli S, Cortelli P, Pierangeli G, Scapoli C, Soriani S, et al. Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura. J Neurol Sci. 2003;213:7-10 pubmed
    We performed a genetic association study with the LDL receptor gene (LDLR) on chromosome 19p13...
  63. Michaely P, Li W, Anderson R, Cohen J, Hobbs H. The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits. J Biol Chem. 2004;279:34023-31 pubmed
    ..To further define the role of ARH in LDLR function, we compared the subcellular distribution of the LDLR in lymphocytes from normal and ARH-/- subjects...
  64. Humphries S, Whittall R, Hubbart C, Maplebeck S, Cooper J, Soutar A, et al. Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk. J Med Genet. 2006;43:943-9 pubmed
    To determine the relative frequency of mutations in three different genes (low-density lipoprotein receptor (LDLR), APOB, PCSK9), and to examine their effect in development of coronary heart disease (CHD) in patients with clinically ..
  65. Grosskopf I, Baroukh N, Lee S, Kamari Y, Harats D, Rubin E, et al. Apolipoprotein A-V deficiency results in marked hypertriglyceridemia attributable to decreased lipolysis of triglyceride-rich lipoproteins and removal of their remnants. Arterioscler Thromb Vasc Biol. 2005;25:2573-9 pubmed
    ..b>LDL receptor levels were slightly elevated in apoa5(-/-) mice consistent with lower remnant uptake rates...
  66. Gent J, Braakman I. Low-density lipoprotein receptor structure and folding. Cell Mol Life Sci. 2004;61:2461-70 pubmed
    ..The low-density lipoprotein receptor (LDLR) is the prototype of a large family of structurally homologous cell surface receptors, which fold in the ER and ..