Gene Symbol: Lcp2
Description: lymphocyte cytosolic protein 2
Alias: Slp76, lymphocyte cytosolic protein 2, lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD)
Species: rat
Products:     Lcp2

Top Publications

  1. Hendricks Taylor L, Motto D, Zhang J, Siraganian R, Koretzky G. SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells. J Biol Chem. 1997;272:1363-7 pubmed
  2. Roose J, Diehn M, Tomlinson M, Lin J, Alizadeh A, Botstein D, et al. T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PLoS Biol. 2003;1:E53 pubmed
    ..Our data suggest that physiologic gene expression programs depend upon tonic activity of signaling pathways independent of receptor ligation. ..
  3. Wu J, Jordan M, Silverman M, Peterson E, Koretzky G. Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell function. J Immunol. 2004;172:6768-74 pubmed
    ..Thus, failure to bind ADAP does not underlie the functional defects exhibited by SLP-76 SH2 domain mutant-expressing mast cells. ..
  4. Lasserre R, Charrin S, Cuche C, Danckaert A, Thoulouze M, de Chaumont F, et al. Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse. EMBO J. 2010;29:2301-14 pubmed publisher
    ..Moreover, they underscore the importance of ezrin and Dlg1 in the regulation of NF-AT activation through p38. ..
  5. Devkota S, Joseph R, Min L, Bruce Fulton D, Andreotti A. Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation. J Mol Biol. 2015;427:2734-47 pubmed publisher
    ..These data contribute to the evolving model for the molecular events occurring early in the T cell activation process. ..