Lcn2

Summary

Gene Symbol: Lcn2
Description: lipocalin 2
Alias: Sip24, neutrophil gelatinase-associated lipocalin, NGAL, alpha-2-microglobulin-related protein, alpha-2U globulin-related protein, lipocalin 2 (oncogene 24p3), p25, siderocalin LCN2
Species: rat
Products:     Lcn2

Top Publications

  1. Devireddy L, Gazin C, Zhu X, Green M. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell. 2005;123:1293-305 pubmed
    ..Our results reveal an unanticipated role for intracellular iron regulation in an apoptotic pathway relevant to BCR-ABL-induced myeloproliferative disease and its treatment. ..
  2. Berger T, Togawa A, Duncan G, Elia A, You Ten A, Wakeham A, et al. Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Proc Natl Acad Sci U S A. 2006;103:1834-9 pubmed
    ..To investigate these functions in vivo, we generated gene-targeted lipocalin 2-deficient mice (Lcn2-/- mice)...
  3. Eirin A, Gloviczki M, Tang H, Rule A, Woollard J, Lerman A, et al. Chronic renovascular hypertension is associated with elevated levels of neutrophil gelatinase-associated lipocalin. Nephrol Dial Transplant. 2012;27:4153-61 pubmed publisher
    ..Neutrophil gelatinase-associated lipocalin (NGAL), an acute phase protein induced in inflammatory conditions and ischemia, is a novel biomarker for acute kidney ..
  4. Wasilewska A, Taranta Janusz K, Debek W, Zoch Zwierz W, Kuroczycka Saniutycz E. KIM-1 and NGAL: new markers of obstructive nephropathy. Pediatr Nephrol. 2011;26:579-86 pubmed publisher
    ..to determine whether urinary (u) kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) may be useful non-invasive biomarkers in children with congenital hydronephrosis (HN) caused by ureteropelvic ..
  5. Alter M, Kretschmer A, von Websky K, Tsuprykov O, Reichetzeder C, Simon A, et al. Early urinary and plasma biomarkers for experimental diabetic nephropathy. Clin Lab. 2012;58:659-71 pubmed
    ..fatty acid binding protein (H-FABP), osteopontin (OPN), nephrin, and Neutrophil gelatinase-associated lipocalin (NGAL) in urine, and kidney injury molecule (KIM)-1, clusterin, and tissue inhibitior of metalloproteinases (TIMP) 1 in ..
  6. Borkham Kamphorst E, Drews F, Weiskirchen R. Induction of lipocalin-2 expression in acute and chronic experimental liver injury moderated by pro-inflammatory cytokines interleukin-1? through nuclear factor-?B activation. Liver Int. 2011;31:656-65 pubmed publisher
    Lipocalin-2 (LCN2) belongs to the lipocalin superfamily, sharing a barrel-shaped tertiary structure with a hydrophobic pocket and an ability to bind lipophilic molecules...
  7. Igarashi T, Suzuki T, Mori K, Inoue K, Seki H, Yamada T, et al. The effects of epidural anesthesia on growth of Escherichia coli at pseudosurgical site: the roles of the lipocalin-2 pathway. Anesth Analg. 2015;121:81-9 pubmed publisher
    ..These observations suggest a potential mechanism by which epidural anesthesia could reduce the risk of SSI. ..
  8. Rouse R, Stewart S, Thompson K, Zhang J. Kidney injury biomarkers in hypertensive, diabetic, and nephropathy rat models treated with contrast media. Toxicol Pathol. 2013;41:662-80 pubmed publisher
    ..2m, Lcn-2, and BUN were the best predictors of histopathology defined kidney injury. ..
  9. Sohotnik R, Nativ O, Abbasi A, Awad H, Frajewicki V, Bishara B, et al. Phosphodiesterase-5 inhibition attenuates early renal ischemia-reperfusion-induced acute kidney injury: assessment by quantitative measurement of urinary NGAL and KIM-1. Am J Physiol Renal Physiol. 2013;304:F1099-104 pubmed publisher
    ..Furthermore, urinary excretion of NGAL and KIM-1, two novel biomarkers of kidney injury, substantially increased following I/R insult...

More Information

Publications64

  1. Lai H, Wu Y, Lai S, Lin W. Lipocalin-2 gene expression during liver regeneration after partial hepatectomy in rats. Int J Surg. 2013;11:314-8 pubmed publisher
    Lipocalin-2 (Lcn2) is related to cell proliferation. We studied Lcn2 gene expression during liver regeneration after partial hepatectomy (PH). Male Wistar rats were sacrificed before and 2, 4, 6, 12, 24, 72 h, 7 days after 70% or 40% PH...
  2. Phillips J, Holder D, Ennulat D, Gautier J, Sauer J, Yang Y, et al. Rat Urinary Osteopontin and Neutrophil Gelatinase-Associated Lipocalin Improve Certainty of Detecting Drug-Induced Kidney Injury. Toxicol Sci. 2016;151:214-23 pubmed publisher
    ..demonstrate the diagnostic potential of urinary osteopontin (OPN) and neutrophil gelatinase-associated lipocalin (NGAL) for drug-induced kidney injury (DIKI) in rats using data from a recent regulatory qualification submission of ..
  3. Wang X, Pal R, Chen X, Kumar K, Kim O, Michaelis E. Genome-wide transcriptome profiling of region-specific vulnerability to oxidative stress in the hippocampus. Genomics. 2007;90:201-12 pubmed
  4. Rached E, Hoffmann D, Blumbach K, Weber K, Dekant W, Mally A. Evaluation of putative biomarkers of nephrotoxicity after exposure to ochratoxin a in vivo and in vitro. Toxicol Sci. 2008;103:371-81 pubmed publisher
  5. Chang S, Kim D, Ko S, Jang H, Jo Y, Kim M. The level of nitric oxide regulates lipocalin-2 expression under inflammatory condition in RINm5F beta-cells. Biochem Biophys Res Commun. 2016;476:7-14 pubmed publisher
    ..Collectively, NO level affects LCN-2 expression via regulation of LCN-2 protein stability under inflammatory condition and LCN-2 may reduce beta-cell viability by promoting apoptosis. ..
  6. Sultan S, Pascucci M, Ahmad S, Malik I, Bianchi A, Ramadori P, et al. LIPOCALIN-2 is a major acute-phase protein in a rat and mouse model of sterile abscess. Shock. 2012;37:191-6 pubmed publisher
    ..The liver is the main source of serum LCN-2 in the case of APR. ABBREVIATIONS-LCN-2-lipocalin-2-??M-??-macroglobulin-HO-1-hemoxygenase 1-IL-6-interleukin 6-SAA-serum amyloid A-TO-turpentine oil-APR-acute-phase reaction. ..
  7. Zheng L, Lee S, Yin G, Mori K, Suk K. Down-regulation of lipocalin 2 contributes to chemoresistance in glioblastoma cells. J Neurochem. 2009;111:1238-51 pubmed publisher
    ..More importantly, in conjunction with the morphological changes, the expression of lipocalin-2 (lcn2), a 25-kDa secreted proapoptotic protein, was markedly reduced in the BCNU-resistant C6R cells...
  8. Gouweleeuw L, Hovens I, van Leeuwen B, Schoemaker R. Neutrophil gelatinase-associated lipocalin and microglial activity are associated with distinct postoperative behavioral changes in rats. Behav Brain Res. 2017;319:104-109 pubmed publisher
    Neutrophil gelatinase-associated lipocalin (NGAL) has recently gained interest as a marker for neuroinflammation and associated behavioral dysfunction...
  9. Nejat M, Hill J, Pickering J, Edelstein C, Devarajan P, Endre Z. Albuminuria increases cystatin C excretion: implications for urinary biomarkers. Nephrol Dial Transplant. 2012;27 Suppl 3:iii96-103 pubmed publisher
    ..urinary biomarkers of acute kidney injury (AKI) such as cystatin C and neutrophil gelatinase-associated lipocalin (NGAL), are normally absorbed from the glomerular filtrate by receptor-mediated transport...
  10. Cheng Q, Ng K, Xu A, Li C, Liu X, Guo D, et al. The roles of lipocalin-2 in small-for-size fatty liver graft injury. Ann Surg. 2014;260:1062-72 pubmed publisher
    To investigate the roles and underlying mechanism of an inflammatory mediator-lipocalin-2 (Lcn2) in small-for-size fatty graft liver injury...
  11. Kao T, Peng Y, Tsou H, Salter D, Lee H. Nerve growth factor promotes expression of novel genes in intervertebral disc cells that regulate tissue degradation: Laboratory investigation. J Neurosurg Spine. 2014;21:653-61 pubmed publisher
    ..Microarray analysis demonstrated increased expression of chitinase 3-like 1 (Chi3l1), lipocalin 2 (Lcn2), and matrix metalloproteinase-3 (Mmp3) following NGF stimulation of rat IVD cells in vitro...
  12. Fu W, Li B, Wang S, Chen M, Deng R, Ye C, et al. Changes of the tubular markers in type 2 diabetes mellitus with glomerular hyperfiltration. Diabetes Res Clin Pract. 2012;95:105-9 pubmed publisher
    ..and kidney injury molecule 1 (KIM-1), as well as serum and urinary neutrophil gelatinase-associated lipocalin (NGAL), were measured and compared. The correlation of these markers with eGFR was analyzed in the GHF group...
  13. Entin Meer M, Ben Shoshan J, Maysel Auslender S, Levy R, Goryainov P, Schwartz I, et al. Accelerated renal fibrosis in cardiorenal syndrome is associated with long-term increase in urine neutrophil gelatinase-associated lipocalin levels. Am J Nephrol. 2012;36:190-200 pubmed publisher
    ..levels compared to CKD only, a significant long-term elevation in urine neutrophil gelatinase-associated lipocalin (Ngal) levels was detectable post-MI induction...
  14. Chan Y, Paz V, Wool I. The primary structure of rat alpha 2 mu globulin-related protein. Nucleic Acids Res. 1988;16:11368 pubmed
  15. Devireddy L, Hart D, Goetz D, Green M. A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Cell. 2010;141:1006-17 pubmed publisher
    ..Siderophore-depleted mammalian cells and zebrafish embryos fail to synthesize heme, an iron-dependent mitochondrial process. Our results reveal features of intracellular iron homeostasis that are conserved from bacteria through humans. ..
  16. Sunil V, Patel K, Nilsen Hamilton M, Heck D, Laskin J, Laskin D. Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver. Exp Mol Pathol. 2007;83:177-87 pubmed
    ..These data suggest that the acute phase response to acute endotoxemia involves induction of 24p3 in both the lung and liver. This protein may be important in restoring tissue homeostasis following LPS-induced injury. ..
  17. Sadar S, Kaspate D, Vyawahare N. Protective effect of L-glutamine against diabetes-induced nephropathy in experimental animal: Role of KIM-1, NGAL, TGF-?1, and collagen-1. Ren Fail. 2016;38:1483-1495 pubmed
    ..05) by LG (500 and 1000?mg/kg) treatment. Upregulated renal KIM-1, NGAL, TGF-?1, and collagen-1 mRNA expression after STZ administration was significantly inhibited (p?<?...
  18. Hraba Renevey S, Turler H, Kress M, Salomon C, Weil R. SV40-induced expression of mouse gene 24p3 involves a post-transcriptional mechanism. Oncogene. 1989;4:601-8 pubmed
    ..The biological implications of these results are discussed. ..
  19. Tsuda H, Kotani T, Nakano T, Imai K, Hirako S, Li H, et al. Lipocalin 2 as a new biomarker for fetal lung hypoplasia in congenital diaphragmatic hernia. Clin Chim Acta. 2016;462:71-76 pubmed publisher
    ..A microarray analysis and RT-PCR showed decreased gene expression levels of lipocalin 2 (LCN2) in the nitrofen-induced CDH lungs (p<0.05)...
  20. Kamezaki K, Shimoda K, Numata A, Aoki K, Kato K, Takase K, et al. The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis. Eur J Haematol. 2003;71:412-7 pubmed
    ..These observations show that 24p3 is not involved in the G-CSF withdrawal-induced apoptosis, although it is essential in IL-3 withdrawal-induced apoptosis. ..
  21. Elkhalil A, Nilsen Hamilton M, Yoshizawa F, Sugita S. Expression of SIP24 in the peripartum and postpartum rat uterus. Connect Tissue Res. 2005;46:235-41 pubmed
    b>SIP24 is, a 24 kDa superinducible protein, is an acute phase protein that is expressed in several tissues and organs and is identified in the human, mouse, and rat genome as lipocalin 2 (lcn2)...
  22. Khalyfa A, Chlon T, Qiang H, Agarwal N, Cooper N. Microarray reveals complement components are regulated in the serum-deprived rat retinal ganglion cell line. Mol Vis. 2007;13:293-308 pubmed
    ..The two most highly upregulated genes were Fdft1 and Lgals3 (8 h), C3 and Fcgrt (24 h), C and Lcn2 (48 h), and Mgp and C3 (96 h)...
  23. Peters H, Waanders F, Meijer E, van den Brand J, Steenbergen E, van Goor H, et al. High urinary excretion of kidney injury molecule-1 is an independent predictor of end-stage renal disease in patients with IgA nephropathy. Nephrol Dial Transplant. 2011;26:3581-8 pubmed publisher
    ..Urinary kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) are markers for the detection of early tubular damage caused by various renal conditions...
  24. Aoyama M, Isshiki K, Kume S, Chin Kanasaki M, Araki H, Araki S, et al. Fructose induces tubulointerstitial injury in the kidney of mice. Biochem Biophys Res Commun. 2012;419:244-9 pubmed publisher
    ..fibrosis localized on the outer cortex of the kidney together with the increase of mRNA expression of Kim1 and Ngal in the absence of distinct glomerular lesions and albuminuria - decidedly different from diabetic nephropathy...
  25. Lee S, Park J, Lee W, Kim H, Park H, Mori K, et al. Lipocalin-2 is an autocrine mediator of reactive astrocytosis. J Neurosci. 2009;29:234-49 pubmed publisher
    ..This process is collectively referred to as reactive astrocytosis. Lipocalin 2 (lcn2) is a member of the lipocalin family that binds to small hydrophobic molecules...
  26. Ragab D, Abdallah D, El Abhar H. Cilostazol renoprotective effect: modulation of PPAR-?, NGAL, KIM-1 and IL-18 underlies its novel effect in a model of ischemia-reperfusion. PLoS ONE. 2014;9:e95313 pubmed publisher
    ..also opposed the I/R-induced elevation in tissue contents/activity of neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (?im-1), nuclear factor-?B, interleu?in-18, caspase-1, as well as malondialdehyde, iNOS, ..
  27. Torrens C, Kelsall C, Hopkins L, Anthony F, Curzen N, Hanson M. Atorvastatin restores endothelial function in offspring of protein-restricted rats in a cholesterol-independent manner. Hypertension. 2009;53:661-7 pubmed publisher
    ..These data suggest that atorvastatin can restore endothelial function in this model, but its effects are gender specific and dependent on the vascular bed. ..
  28. Ding L, Hanawa H, Ota Y, Hasegawa G, Hao K, Asami F, et al. Lipocalin-2/neutrophil gelatinase-B associated lipocalin is strongly induced in hearts of rats with autoimmune myocarditis and in human myocarditis. Circ J. 2010;74:523-30 pubmed
    Lipocalin-2/neutrophil gelatinase-B associated lipocalin (Lcn2/NGAL) is involved in the transport of iron and seems to play an important role in inflammation...
  29. Bousserouel S, Gosse F, Bouhadjar M, Soler L, Marescaux J, Raul F. Long-term administration of aspirin inhibits tumour formation and triggers anti-neoplastic molecular changes in a pre-clinical model of colon carcinogenesis. Oncol Rep. 2010;23:511-7 pubmed
    ..Conversely, we detected an increased expression level of alpha-defensin-5 (Rd-5, 2 fold) and lipocalin-2 (LCN2, 4 fold), two markers of the innate immunity system...
  30. Zhao J, Xi G, Wu G, Keep R, Hua Y. Deferoxamine Attenuated the Upregulation of Lipocalin-2 Induced by Traumatic Brain Injury in Rats. Acta Neurochir Suppl. 2016;121:291-4 pubmed publisher
    ..In summary, TBI resulted in upregulation of LCN-2 and deferoxamine reduced TBI-induced LCN-2 increase, suggesting LCN-2 may have a role in iron-trafficking after TBI. ..
  31. Nanashima N, Yamada T, Shimizu T, Tsuchida S. Deletion of phospholipase A2 group IVc induces apoptosis in rat mammary tumour cells by the nuclear factor-κB/lipocalin 2 pathway. Biochem J. 2015;469:315-24 pubmed publisher
    ..This treatment also induced expression of lipocalin 2 (Lcn2) and other NF-κB (nuclear factor κB)-related genes...
  32. Alwahsh S, Xu M, Seyhan H, Ahmad S, Mihm S, Ramadori G, et al. Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver. World J Gastroenterol. 2014;20:1807-21 pubmed publisher
    ..Fructose diet up-regulates hepatic LCN-2 expression, which correlates with the increased indicators of oxidative stress and mitochondrial dysfunction. The LCN-2 may be involved in liver protection...
  33. Tomczak J, Wasilewska A, Milewski R. Urine NGAL and KIM-1 in children and adolescents with hyperuricemia. Pediatr Nephrol. 2013;28:1863-9 pubmed publisher
    The aim of this study was to test the hypothesis that urine levels of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) are enhanced in pediatric patients with hyperuricemia...
  34. Xu G, Ahn J, Chang S, Eguchi M, Ogier A, Han S, et al. Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation. J Biol Chem. 2012;287:4808-17 pubmed publisher
    Our objective was to determine whether lipocalin-2 (Lcn2) regulates cardiomyocyte apoptosis, the mechanisms involved, and the functional significance...
  35. Yu H, Zhou Q, Huang R, Yuan M, Ao X, Yang J. [Effect of Cordyceps sinensis on the expression of HIF-1? and NGAL in rats with renal ischemia-reperfusion injury]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012;37:57-66 pubmed publisher
    To observe the level of urinary neutrophil gelatinase-associated lipocalin (NGAL), the expression of hypoxia inducible factor-1? (HIF-1?) and NGAL in rat kidney after renal ischemia and reperfusion (I/R), before and after the treatment ..
  36. Bermudez E, Willson G, Parkinson H, Dodd D. Toxicity of methyl tertiary-butyl ether (MTBE) following exposure of Wistar Rats for 13 weeks or one year via drinking water. J Appl Toxicol. 2012;32:687-706 pubmed publisher
  37. Langelueddecke C, Roussa E, Fenton R, Thevenod F. Expression and function of the lipocalin-2 (24p3/NGAL) receptor in rodent and human intestinal epithelia. PLoS ONE. 2013;8:e71586 pubmed publisher
    The lipocalin 2//NGAL/24p3 receptor (NGAL-R/24p3-R) is expressed in rodent distal nephron where it mediates protein endocytosis...
  38. Jung M, Sola A, Hughes J, Kluth D, Vinuesa E, Viñas J, et al. Infusion of IL-10-expressing cells protects against renal ischemia through induction of lipocalin-2. Kidney Int. 2012;81:969-982 pubmed publisher
    ..Thus, adoptive transfer of IL-10 macrophages to ischemic kidneys blunts acute kidney injury. These effects are mediated through the action of intracellular iron to induce lipocalin-2. ..
  39. Aghanasir F, Aghaei H, Imani Fooladi A, Ebrahimi M, Bagherpour G, Nourani M. Expression of neutrophil gelatinase-associated lipocalin (NGAL) in peripheral nerve repair. J Recept Signal Transduct Res. 2016;36:429-34 pubmed publisher
    ..In this study, we assessed the antioxidative role of the NGAL molecule in sciatic nerve repair in rats...
  40. Lieberthal J, Cuthbertson D, Carette S, Hoffman G, Khalidi N, Koening C, et al. urinary biomarkers in relapsing antineutrophil cytoplasmic antibody-associated vasculitis. J Rheumatol. 2013;40:674-83 pubmed publisher
    ..molecule-1 (KIM-1), monocyte chemoattractant protein-1 (MCP-1), and neutrophil gelatinase-associated lipocalin (NGAL)...
  41. Gerhardinger C, Costa M, Coulombe M, Toth I, Hoehn T, Grosu P. Expression of acute-phase response proteins in retinal Müller cells in diabetes. Invest Ophthalmol Vis Sci. 2005;46:349-57 pubmed
    ..The concomitant upregulation of IL-1beta in the retina of diabetic rats points to this cytokine as a possible mediator of the acute-phase response mounted by Müller cells in diabetes. ..
  42. Zhang H, Zhu Y, Jia N, Zhang H, Zheng J, Zhu W, et al. [Expression and significance of neutrophil gelatinase-associated lipocalin in renal interstitial fibrosis in rats]. Zhonghua Yi Xue Za Zhi. 2012;92:2565-9 pubmed
    To explore the expression and significance of neutrophil gelatinase-associated lipocalin(NGAL)in renal interstitial fibrosis (RIF) in rats...
  43. Xing C, Wang X, Cheng C, Montaner J, Mandeville E, Leung W, et al. Neuronal production of lipocalin-2 as a help-me signal for glial activation. Stroke. 2014;45:2085-92 pubmed publisher
    ..These findings provide proof of concept that lipocalin-2 is released by injured neurons as a help me distress signal that activates microglia and astrocytes into potentially prorecovery phenotypes. ..
  44. Abassi Z, Shalabi A, Sohotnik R, Nativ O, Awad H, Bishara B, et al. Urinary NGAL and KIM-1: biomarkers for assessment of acute ischemic kidney injury following nephron sparing surgery. J Urol. 2013;189:1559-66 pubmed publisher
    ..We explored the possibility of using urinary NGAL and KIM-1 excretion as novel biomarkers to assess the extent of acute kidney injury after nephron sparing surgery...
  45. Oh S, Lee E, Kim S, Na K, Chae D, Kim S, et al. Bilirubin attenuates the renal tubular injury by inhibition of oxidative stress and apoptosis. BMC Nephrol. 2013;14:105 pubmed publisher
    ..induced marked increases in urine kidney injury molecule-1 (Kim-1) and neutrophil gelatinase-associated lipocalin (NGAL) concentrations (P?<?0.05). BIL reduced urine Kim-1 in CIN (P?<?0...
  46. Sinha V, Vence L, Salahudeen A. Urinary tubular protein-based biomarkers in the rodent model of cisplatin nephrotoxicity: a comparative analysis of serum creatinine, renal histology, and urinary KIM-1, NGAL, and NAG in the initiation, maintenance, and recovery phases of acute kidne. J Investig Med. 2013;61:564-8 pubmed publisher
    ..To compare urinary kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and N-acetyl glucosaminidase (NAG) against serum creatinine and renal histological score in the initiation, ..
  47. Quiros Y, Sánchez González P, Lopez Hernandez F, Morales A, Lopez Novoa J. Cardiotrophin-1 administration prevents the renal toxicity of iodinated contrast media in rats. Toxicol Sci. 2013;132:493-501 pubmed publisher
    ..Renal hemodynamics, also impaired by the contrast medium, was normal in rats cotreated with CT-1. CT-1 administration significantly prevents the alterations in renal function and structure observed in a rat model of CIN. ..
  48. Bhavsar N, Kottgen A, Coresh J, Astor B. Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis. 2012;60:233-40 pubmed publisher
    ..Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) are known biomarkers of acute kidney injury, but it is unknown whether these ..
  49. Bu D, Hemdahl A, Gabrielsen A, Fuxe J, Zhu C, Eriksson P, et al. Induction of neutrophil gelatinase-associated lipocalin in vascular injury via activation of nuclear factor-kappaB. Am J Pathol. 2006;169:2245-53 pubmed
    Neutrophil gelatinase-associated lipocalin (NGAL) has recently emerged as an important modulator of cell homeostasis. Elevated plasma NGAL levels, possibly because of activation of blood leukocytes, are associated with atherosclerosis...
  50. Bi F, Huang C, Tong J, Qiu G, Huang B, Wu Q, et al. Reactive astrocytes secrete lcn2 to promote neuron death. Proc Natl Acad Sci U S A. 2013;110:4069-74 pubmed publisher
    ..Here, we identify lipocalin 2 (lcn2) as an inducible factor that is secreted by reactive astrocytes and that is selectively toxic to neurons...
  51. Ichino M, Kuroyanagi Y, Kusaka M, Mori T, Ishikawa K, Shiroki R, et al. Increased urinary neutrophil gelatinase associated lipocalin levels in a rat model of upper urinary tract infection. J Urol. 2009;181:2326-31 pubmed publisher
    ..We have further investigated the product of an up-regulated gene product, NGAL, in this animal model to evaluate its potential usefulness as a biomarker of renal scarring...
  52. Yndestad A, Landrø L, Ueland T, Dahl C, Flo T, Vinge L, et al. Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure. Eur Heart J. 2009;30:1229-36 pubmed publisher
    Neutrophil gelatinase-associated lipocalin (NGAL or lipocalin-2) is a glycoprotein with bacteriostatic properties. Growing evidence suggests that NGAL may also be involved in cell survival, inflammation, and matrix degradation...
  53. Luo Q, Chen M, Sun F, Chen Z, Li M, Zeng W, et al. KIM-1 and NGAL as biomarkers of nephrotoxicity induced by gentamicin in rats. Mol Cell Biochem. 2014;397:53-60 pubmed publisher
    ..our study was to determine whether kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) may be useful biomarkers in the assessment of gentamicin-induced nephrotoxicity in rats...
  54. Blázquez Medela A, García Sánchez O, Blanco Gozalo V, Quiros Y, Montero M, Martínez Salgado C, et al. Hypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased NGAL urinary excretion in rats. PLoS ONE. 2014;9:e105988 pubmed publisher
    ..Renal function and NGAL urinary excretion was monitored in rats with spontaneous (SHR) or L-NAME induced hypertension rendered ..
  55. Zhang J, Wu Y, Zhang Y, LeRoith D, Bernlohr D, Chen X. The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Mol Endocrinol. 2008;22:1416-26 pubmed publisher
    ..Herein we show that the levels of LCN2 mRNA are dramatically increased in adipose tissue and liver of ob/ob mice and primary adipose cells isolated from ..