Lats1

Summary

Gene Symbol: Lats1
Description: large tumor suppressor kinase 1
Alias: RGD1564085, serine/threonine-protein kinase LATS1, LATS, large tumor suppressor, homolog 1
Species: rat
Products:     Lats1

Top Publications

  1. St John M, Tao W, Fei X, Fukumoto R, Carcangiu M, Brownstein D, et al. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nat Genet. 1999;21:182-6 pubmed
    ..Mosaic flies carrying somatic cells that are mutant for lats develop large tumours in many organs. The human LATS1 homologue rescues embryonic lethality and inhibits tumour growth in lats mutant flies, demonstrating the ..
  2. Tao W, Zhang S, Turenchalk G, Stewart R, St John M, Chen W, et al. Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat Genet. 1999;21:177-81 pubmed
    ..Here, we have isolated mammalian homologues of Drosophila lats. Human LATS1 suppresses tumour growth and rescues all developmental defects, including embryonic lethality in flies...
  3. Lee J, Kim T, Yang T, Koo B, Oh S, Lee K, et al. A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J. 2008;27:1231-42 pubmed publisher
    ..Moreover, WW45 is required for MST1 activation and translocation to the nucleus for subsequent LATS1/2 activation upon differentiation signal...
  4. Humbert N, Navaratnam N, Augert A, da Costa M, Martien S, Wang J, et al. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. EMBO J. 2010;29:376-86 pubmed publisher
    ..express NUAK1 suffer gross aneuploidies and show diminished expression of the genomic stability regulator LATS1, whereas depletion of NUAK1 with shRNA exerts opposite effects...
  5. Lorthongpanich C, Messerschmidt D, Chan S, Hong W, Knowles B, Solter D. Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation. Genes Dev. 2013;27:1441-6 pubmed publisher
    ..We therefore conclude that precisely timed YAP localization in early morulae is essential to prevent trophectoderm marker expression in, and lineage specification of, the ICM. ..
  6. Britschgi A, Duss S, Kim S, Couto J, Brinkhaus H, Koren S, et al. The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ER?. Nature. 2017;541:541-545 pubmed publisher
    ..Our findings reveal a non-canonical (that is, YAP/TAZ-independent) effect of LATS in the regulation of human breast cell fate. ..
  7. Nishiyama Y, Hirota T, Morisaki T, Hara T, Marumoto T, Iida S, et al. A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. FEBS Lett. 1999;459:159-65 pubmed
    ..These findings suggest that h-warts functions as a component of the mitotic apparatus and is involved in proper progression of mitosis. ..
  8. Nishioka N, Inoue K, Adachi K, Kiyonari H, Ota M, Ralston A, et al. The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cell. 2009;16:398-410 pubmed publisher
    ..Thus, differential signaling between inside and outside cell populations leads to changes in cell fate specification during TE formation. ..
  9. Iida S, Hirota T, Morisaki T, Marumoto T, Hara T, Kuninaka S, et al. Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. Oncogene. 2004;23:5266-74 pubmed
    ..WARTS thus plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G(1) tetraploidy checkpoint. ..

More Information

Publications10

  1. Yang X, Yu K, Hao Y, Li D, Stewart R, Insogna K, et al. LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. Nat Cell Biol. 2004;6:609-17 pubmed
    ..Here we show that human LATS1 binds to LIMK1 in vitro and in vivo and colocalizes with LIMK1 at the actomyosin contractile ring during ..