lamin B receptor

Summary

Gene Symbol: lamin B receptor
Description: lamin B receptor
Alias: Nbp60, lamin-B receptor, integral nuclear envelope inner membrane protein
Species: rat
Products:     lamin B receptor

Top Publications

  1. Verhagen A, de Graaf C, Baldwin T, Goradia A, Collinge J, Kile B, et al. Reduced lymphocyte longevity and homeostatic proliferation in lamin B receptor-deficient mice results in profound and progressive lymphopenia. J Immunol. 2012;188:122-34 pubmed publisher
    The lamin B receptor (LBR) is a highly unusual inner nuclear membrane protein with multiple functions...
  2. Lin F, Noyer C, Ye Q, Courvalin J, Worman H. Autoantibodies from patients with primary biliary cirrhosis recognize a region within the nucleoplasmic domain of inner nuclear membrane protein LBR. Hepatology. 1996;23:57-61 pubmed
    Autoantibodies from rare patients with primary biliary cirrhosis (PBC) recognize LBR, or lamin B receptor, an integral membrane protein of the inner nuclear membrane...
  3. Kawahire S, Tachibana T, Umemoto M, Yoneda Y, Imai N, Saito M, et al. Subcellular distribution and phosphorylation of the nuclear localization signal binding protein, NBP60. Exp Cell Res. 1996;222:385-94 pubmed
    We previously purified a nuclear localization signal binding protein, NBP60, from rat liver (1993, J. Biochem. 113, 308-313). In this study, the subcellular localization of NBP60 was examined using anti-NBP60...
  4. Kawahire S, Takeuchi M, Gohshi T, Sasagawa S, Shimada M, Takahashi M, et al. cDNA cloning of nuclear localization signal binding protein NBP60, a rat homologue of lamin B receptor, and identification of binding sites of human lamin B receptor for nuclear localization signals and chromatin. J Biochem. 1997;121:881-9 pubmed
    ..The sequence revealed that NBP60 is a rat homologue of lamin B receptor (LBR), and is 79 and 63% identical in amino acids to human and chicken LBR, respectively...
  5. Hoffmann K, Dreger C, Olins A, Olins D, Shultz L, Lucke B, et al. Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huët anomaly). Nat Genet. 2002;31:410-4 pubmed
    ..We identified four splice-site, two frameshift and two nonsense mutations in LBR, encoding the lamin B receptor. The lamin B receptor (LBR), a member of the sterol reductase family, is evolutionarily conserved and ..
  6. Wells L, Vosseller K, Cole R, Cronshaw J, Matunis M, Hart G. Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications. Mol Cell Proteomics. 2002;1:791-804 pubmed
    ..then used on a purified nuclear pore complex preparation to map novel sites of O-GlcNAc modification on the Lamin B receptor and the nucleoporin Nup155...
  7. Best S, Salvati F, Kallo J, Garner C, Height S, Thein S, et al. Lamin B-receptor mutations in Pelger-Huët anomaly. Br J Haematol. 2003;123:542-4 pubmed
    ..Our results confirm recently published findings that LBR mutations cause Pelger-Huët. ..
  8. Boonplueang R, Akopian G, Stevenson F, Kuhlenkamp J, Lu S, Walsh J, et al. Increased susceptibility of glutathione peroxidase-1 transgenic mice to kainic acid-related seizure activity and hippocampal neuronal cell death. Exp Neurol. 2005;192:203-14 pubmed
    ..This could be due to alterations in the redox state of the glutathione system resulting in elevated glutathione disulfide (GSSG) levels which, in turn, may directly activate NMDA receptors or enhanced response of the NMDA receptor. ..
  9. Lu R, Wang G. Tudor: a versatile family of histone methylation 'readers'. Trends Biochem Sci. 2013;38:546-55 pubmed publisher
    ..As deregulation of Tudor-containing proteins is associated with certain human disorders, pharmacological targeting of Tudor interactions could provide new avenues for therapeutic intervention. ..
  10. Haino M, Kawahire S, Omata S, Horigome T. Purification of a 60 kDa nuclear localization signal binding protein in rat liver nuclear envelopes and characterization of its properties. J Biochem. 1993;113:308-13 pubmed
    ..A nuclear localization signal binding protein with molecular mass of 60 kDa (NBP60) was detected in the extract...

Detail Information

Publications15

  1. Verhagen A, de Graaf C, Baldwin T, Goradia A, Collinge J, Kile B, et al. Reduced lymphocyte longevity and homeostatic proliferation in lamin B receptor-deficient mice results in profound and progressive lymphopenia. J Immunol. 2012;188:122-34 pubmed publisher
    The lamin B receptor (LBR) is a highly unusual inner nuclear membrane protein with multiple functions...
  2. Lin F, Noyer C, Ye Q, Courvalin J, Worman H. Autoantibodies from patients with primary biliary cirrhosis recognize a region within the nucleoplasmic domain of inner nuclear membrane protein LBR. Hepatology. 1996;23:57-61 pubmed
    Autoantibodies from rare patients with primary biliary cirrhosis (PBC) recognize LBR, or lamin B receptor, an integral membrane protein of the inner nuclear membrane...
  3. Kawahire S, Tachibana T, Umemoto M, Yoneda Y, Imai N, Saito M, et al. Subcellular distribution and phosphorylation of the nuclear localization signal binding protein, NBP60. Exp Cell Res. 1996;222:385-94 pubmed
    We previously purified a nuclear localization signal binding protein, NBP60, from rat liver (1993, J. Biochem. 113, 308-313). In this study, the subcellular localization of NBP60 was examined using anti-NBP60...
  4. Kawahire S, Takeuchi M, Gohshi T, Sasagawa S, Shimada M, Takahashi M, et al. cDNA cloning of nuclear localization signal binding protein NBP60, a rat homologue of lamin B receptor, and identification of binding sites of human lamin B receptor for nuclear localization signals and chromatin. J Biochem. 1997;121:881-9 pubmed
    ..The sequence revealed that NBP60 is a rat homologue of lamin B receptor (LBR), and is 79 and 63% identical in amino acids to human and chicken LBR, respectively...
  5. Hoffmann K, Dreger C, Olins A, Olins D, Shultz L, Lucke B, et al. Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huët anomaly). Nat Genet. 2002;31:410-4 pubmed
    ..We identified four splice-site, two frameshift and two nonsense mutations in LBR, encoding the lamin B receptor. The lamin B receptor (LBR), a member of the sterol reductase family, is evolutionarily conserved and ..
  6. Wells L, Vosseller K, Cole R, Cronshaw J, Matunis M, Hart G. Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications. Mol Cell Proteomics. 2002;1:791-804 pubmed
    ..then used on a purified nuclear pore complex preparation to map novel sites of O-GlcNAc modification on the Lamin B receptor and the nucleoporin Nup155...
  7. Best S, Salvati F, Kallo J, Garner C, Height S, Thein S, et al. Lamin B-receptor mutations in Pelger-Huët anomaly. Br J Haematol. 2003;123:542-4 pubmed
    ..Our results confirm recently published findings that LBR mutations cause Pelger-Huët. ..
  8. Boonplueang R, Akopian G, Stevenson F, Kuhlenkamp J, Lu S, Walsh J, et al. Increased susceptibility of glutathione peroxidase-1 transgenic mice to kainic acid-related seizure activity and hippocampal neuronal cell death. Exp Neurol. 2005;192:203-14 pubmed
    ..This could be due to alterations in the redox state of the glutathione system resulting in elevated glutathione disulfide (GSSG) levels which, in turn, may directly activate NMDA receptors or enhanced response of the NMDA receptor. ..
  9. Lu R, Wang G. Tudor: a versatile family of histone methylation 'readers'. Trends Biochem Sci. 2013;38:546-55 pubmed publisher
    ..As deregulation of Tudor-containing proteins is associated with certain human disorders, pharmacological targeting of Tudor interactions could provide new avenues for therapeutic intervention. ..
  10. Haino M, Kawahire S, Omata S, Horigome T. Purification of a 60 kDa nuclear localization signal binding protein in rat liver nuclear envelopes and characterization of its properties. J Biochem. 1993;113:308-13 pubmed
    ..A nuclear localization signal binding protein with molecular mass of 60 kDa (NBP60) was detected in the extract...
  11. Shultz L, Lyons B, Burzenski L, Gott B, Samuels R, Schweitzer P, et al. Mutations at the mouse ichthyosis locus are within the lamin B receptor gene: a single gene model for human Pelger-Huët anomaly. Hum Mol Genet. 2003;12:61-9 pubmed
    ..We recently found that human PHA is caused by mutations in the gene (LBR) encoding lamin B receptor, an evolutionarily conserved inner nuclear membrane protein involved in nuclear assembly and chromatin ..
  12. Herman G. Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Hum Mol Genet. 2003;12 Spec No 1:R75-88 pubmed
    ..In this review, an overview of the cholesterol biosynthetic pathway will be presented. Clinical features of the human disorders and mouse models of post-squalene cholesterol biosynthesis will then be discussed. ..
  13. Waterham H. Defects of cholesterol biosynthesis. FEBS Lett. 2006;580:5442-9 pubmed
    ..The etiology of the underlying pathophysiology may involve multiple affected processes due to lowered cholesterol and/or the elevated, teratogenic levels of the intermediate sterol precursors. ..
  14. Clayton P, Fischer B, Mann A, Mansour S, Rossier E, Veen M, et al. Mutations causing Greenberg dysplasia but not Pelger anomaly uncouple enzymatic from structural functions of a nuclear membrane protein. Nucleus. 2010;1:354-66 pubmed publisher
    The lamin B receptor (LBR) is an inner nuclear membrane protein with a structural function interacting with chromatin and lamins, and an enzymatic function as a sterol reductase...
  15. Lechner M, Schultz D, Negorev D, Maul G, Rauscher F. The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain. Biochem Biophys Res Commun. 2005;331:929-37 pubmed
    ..Thus, this spectrum of direct binding partners suggests an expanded role for HP1 as factor participating in promoter-enhancer communication, chromatin remodeling/assembly, and sub-nuclear compartmentalization. ..