Gene Symbol: L1cam
Description: L1 cell adhesion molecule
Alias: Hsas, Hyd, N-CAM L1, NCAML1, NgCAM, neural cell adhesion molecule L1, N-CAM-L1, NCAM-L1, NILE, nerve-growth factor-inducible large external glycoprotein, neuron-glia cell adhesion molecule
Species: rat
Products:     L1cam

Top Publications

  1. Miura M, Kobayashi M, Asou H, Uyemura K. Molecular cloning of cDNA encoding the rat neural cell adhesion molecule L1. Two L1 isoforms in the cytoplasmic region are produced by differential splicing. FEBS Lett. 1991;289:91-5 pubmed
    We have isolated and sequenced a full-length cDNA encoding the rat neural cell adhesion molecule L1. The deduced amino acid sequence as a whole shows high homology to mouse L1 sequence...
  2. Dickson T, Mintz C, Benson D, Salton S. Functional binding interaction identified between the axonal CAM L1 and members of the ERM family. J Cell Biol. 2002;157:1105-12 pubmed
    ..Together, our data indicate that L1 binds directly to members of the ERM family and suggest this association may coordinate aspects of axonal morphogenesis. ..
  3. Nakamura Y, Tamura H, Horinouchi K, Shiosaka S. Role of neuropsin in formation and maturation of Schaffer-collateral L1cam-immunoreactive synaptic boutons. J Cell Sci. 2006;119:1341-9 pubmed
  4. Mintz C, Dickson T, Gripp M, Salton S, Benson D. ERMs colocalize transiently with L1 during neocortical axon outgrowth. J Comp Neurol. 2003;464:438-48 pubmed
    ..Furthermore, these data suggest that there is a developmentally regulated switch in MCL function in the developing brain. ..
  5. Boiko T, Vakulenko M, Ewers H, Yap C, Norden C, Winckler B. Ankyrin-dependent and -independent mechanisms orchestrate axonal compartmentalization of L1 family members neurofascin and L1/neuron-glia cell adhesion molecule. J Neurosci. 2007;27:590-603 pubmed
    ..we focused on two L1 family of cell adhesion molecules (L1-CAMs) [L1/neuron-glia cell adhesion molecule (L1/NgCAM) and neurofascin (NF)] and two neuronal ankyrins (ankB and ankG)...
  6. Vits L, Van Camp G, Coucke P, Fransen E, De Boulle K, Reyniers E, et al. MASA syndrome is due to mutations in the neural cell adhesion gene L1CAM. Nat Genet. 1994;7:408-13 pubmed
    ..Since it has been shown that X-linked hydrocephalus can be caused by mutations in L1CAM, a neuronal cell adhesion molecule, we performed an L1CAM mutation analysis in eight unrelated patients with MASA ..
  7. Rünker A, Bartsch U, Nave K, Schachner M. The C264Y missense mutation in the extracellular domain of L1 impairs protein trafficking in vitro and in vivo. J Neurosci. 2003;23:277-86 pubmed
    The neural cell adhesion molecule L1, a member of the immunoglobulin superfamily, performs important functions in the developing and adult nervous system and is implicated in neuronal migration and survival, elongation, fasciculation and ..
  8. Jouet M, Rosenthal A, Armstrong G, Macfarlane J, Stevenson R, Paterson J, et al. X-linked spastic paraplegia (SPG1), MASA syndrome and X-linked hydrocephalus result from mutations in the L1 gene. Nat Genet. 1994;7:402-7 pubmed
    ..We have previously shown that X-linked hydrocephalus is caused by mutations in the gene for neural cell adhesion molecule L1 (L1CAM), an axonal glycoprotein involved in neuronal migration and differentiation...
  9. Tang N, Farah B, He M, Fox S, MALOUF A, Littner Y, et al. Ethanol causes the redistribution of L1 cell adhesion molecule in lipid rafts. J Neurochem. 2011;119:859-67 pubmed publisher
    ..These data indicate that ethanol may inhibit L1-mediated neurite outgrowth by retarding L1 trafficking through a lipid raft compartment. ..

More Information


  1. Montgomery A, Becker J, Siu C, Lemmon V, Cheresh D, Pancook J, et al. Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alpha v beta 3. J Cell Biol. 1996;132:475-85 pubmed
    ..that in addition to the recognition of ECM components, alpha v beta 3 can interact with the neural cell adhesion molecule L1-CAM; a member of the immunoglobulin superfamily (IgSF)...
  2. Bechara A, Nawabi H, Moret F, Yaron A, Weaver E, Bozon M, et al. FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse. EMBO J. 2008;27:1549-62 pubmed publisher
    ..This reveals that specific signalling activities downstream of L1 and Plexin-As cooperate for mediating the axon guidance effects of Sema3A. ..
  3. Schäfer M, Nam Y, Moumen A, Keglowich L, Bouché E, Küffner M, et al. L1 syndrome mutations impair neuronal L1 function at different levels by divergent mechanisms. Neurobiol Dis. 2010;40:222-37 pubmed publisher
    Mutations in the human L1CAM gene cause neurodevelopmental disorders collectively referred to as L1 syndrome. Here, we investigated cellular pathomechanisms underlying two L1 syndrome mutations, R184Q and W1036L...
  4. Schultheis M, Diestel S, Schmitz B. The role of cytoplasmic serine residues of the cell adhesion molecule L1 in neurite outgrowth, endocytosis, and cell migration. Cell Mol Neurobiol. 2007;27:11-31 pubmed
    ..Furthermore, mutation of ser-1181 to leucine results in strongly enhanced antibody-induced endocytosis of L1 and also in enhanced cell migration. ..
  5. Schäfer H, Geismann C, Heneweer C, Egberts J, Korniienko O, Kiefel H, et al. Myofibroblast-induced tumorigenicity of pancreatic ductal epithelial cells is L1CAM dependent. Carcinogenesis. 2012;33:84-93 pubmed publisher
    ..We recently demonstrated that the adhesion molecule L1CAM is involved in epithelial-mesenchymal transition of PMF-cocultured H6c7 human ductal epithelial cells and that ..
  6. Kadmon G, von Bohlen und Halbach F, Horstkorte R, Eckert M, Altevogt P, Schachner M. Evidence for cis interaction and cooperative signalling by the heat-stable antigen nectadrin (murine CD24) and the cell adhesion molecule L1 in neurons. Eur J Neurosci. 1995;7:993-1004 pubmed
    ..Nectadrin therefore appears to join a functional complex of neuronal adhesion molecules and to potentiate the signal transduction pathway of L1, possibly in response to neuron-neuron contact formation. ..
  7. Law C, Kirby R, Aghamohammadzadeh S, Furley A. The neural adhesion molecule TAG-1 modulates responses of sensory axons to diffusible guidance signals. Development. 2008;135:2361-71 pubmed publisher
    ..We suggest that this dependence of chemorepellant sensitivity on the functions of combinations of adhesion molecules is important to ensure that axons project via specific pathways before extending to their final targets. ..
  8. Duan P, Sun S, Li B, Huang C, Xu Y, Han X, et al. miR-29a modulates neuronal differentiation through targeting REST in mesenchymal stem cells. PLoS ONE. 2014;9:e97684 pubmed publisher
    ..REST and its target genes, including synaptosomal-associated protein 25 (SNAP25) and L1 cell adhesion molecular (L1CAM), were detected in MSCs and MSC-NCs...
  9. Fogel M, Gutwein P, Mechtersheimer S, Riedle S, Stoeck A, Smirnov A, et al. L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas. Lancet. 2003;362:869-75 pubmed
    ..L1 expression and cleavage could promote dissemination of tumours by facilitating cell migration. ..
  10. Ruppert M, Aigner S, Hubbe M, Yagita H, Altevogt P. The L1 adhesion molecule is a cellular ligand for VLA-5. J Cell Biol. 1995;131:1881-91 pubmed
    ..Given its rapid downregulation on lymphocytes after induction of cell proliferation, L1 may be important in integrin-mediated and activation-regulated cell-cell interactions. ..
  11. Venero C, Tilling T, Hermans Borgmeyer I, Herrero A, Schachner M, Sandi C. Water maze learning and forebrain mRNA expression of the neural cell adhesion molecule L1. J Neurosci Res. 2004;75:172-81 pubmed
  12. Wallace A, Tan M, Schachner M, Anderson R. L1cam acts as a modifier gene for members of the endothelin signalling pathway during enteric nervous system development. Neurogastroenterol Motil. 2011;23:e510-22 pubmed publisher
    ..We used a two-locus complementation approach to screen for genetic interactions between L1cam and members of the endothelin signalling pathway. Immunohistochemistry was used to label PGP9...
  13. Demyanenko G, Maness P. The L1 cell adhesion molecule is essential for topographic mapping of retinal axons. J Neurosci. 2003;23:530-8 pubmed
    ..Results suggest that retinal axons require the function of L1 in addition to repellent EphA guidance receptors to achieve proper topographic mapping. ..
  14. Lieberoth A, Splittstoesser F, Katagihallimath N, Jakovcevski I, Loers G, Ranscht B, et al. Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth. J Neurosci. 2009;29:6677-90 pubmed publisher
    ..g., Caspr1 and Caspr2, and with their triggered signal transduction pathways elicit cell type-specific promotion or inhibition of neurite outgrowth induced by glial CD24 in a glycan-dependent trans interaction. ..
  15. Díez Revuelta N, Velasco S, Andre S, Kaltner H, Kübler D, Gabius H, et al. Phosphorylation of adhesion- and growth-regulatory human galectin-3 leads to the induction of axonal branching by local membrane L1 and ERM redistribution. J Cell Sci. 2010;123:671-81 pubmed publisher
    ..pGal-3 interacts with neural cell adhesion molecule L1, and enhances L1 association with Thy-1-rich membrane microdomains...
  16. Du Y, Dickerson C, Aylsworth A, Schwartz C. A silent mutation, C924T (G308G), in the L1CAM gene results in X linked hydrocephalus (HSAS). J Med Genet. 1998;35:456-62 pubmed
    The L1 cell adhesion molecule (L1CAM) is a neuronal gene involved in the development of the nervous system...
  17. Sammar M, Aigner S, Altevogt P. Heat-stable antigen (mouse CD24) in the brain: dual but distinct interaction with P-selectin and L1. Biochim Biophys Acta. 1997;1337:287-94 pubmed
    ..Treatment of HSA with OSGE significantly reduced binding of both P-selectin and I.1. Our data suggest that HSA can bind P-selectin and I.1 by distinct mechanism and that the binding epitopes on HSA are in close proximity. ..
  18. Koroll M, Rathjen F, Volkmer H. The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity. J Biol Chem. 2001;276:10646-54 pubmed
    ..Finally, we report that syntenin-1 and -2 both form homodimers and can interact with each other. ..
  19. Bernreuther C, Dihné M, Johann V, Schiefer J, Cui Y, Hargus G, et al. Neural cell adhesion molecule L1-transfected embryonic stem cells promote functional recovery after excitotoxic lesion of the mouse striatum. J Neurosci. 2006;26:11532-9 pubmed
  20. Yap C, Lasiecka Z, Caplan S, Winckler B. Alterations of EHD1/EHD4 protein levels interfere with L1/NgCAM endocytosis in neurons and disrupt axonal targeting. J Neurosci. 2010;30:6646-57 pubmed publisher
    ..The adhesion molecule L1/neuron-glia cell adhesion molecule (NgCAM) travels to axons via an endocytosis-dependent pathway (transcytosis), traversing somatodendritic endosomes...
  21. Alvarez Dolado M, Cuadrado A, Navarro Yubero C, Sonderegger P, Furley A, Bernal J, et al. Regulation of the L1 cell adhesion molecule by thyroid hormone in the developing brain. Mol Cell Neurosci. 2000;16:499-514 pubmed
    ..Thyroid hormone administration reversed the upregulation of L1 expression in vivo and in cultured cells. Thus, alterations of L1 expression may contribute to the profound abnormalities caused by hypothyroidism in the developing brain. ..
  22. Cui Y, Hargus G, Xu J, Schmid J, Shen Y, Glatzel M, et al. Embryonic stem cell-derived L1 overexpressing neural aggregates enhance recovery in Parkinsonian mice. Brain. 2010;133:189-204 pubmed publisher
    ..We have generated substrate-adherent embryonic stem cell-derived neural aggregates overexpressing the neural cell adhesion molecule L1, because it has shown beneficial functions after central nervous system injury...
  23. Venero C, Tilling T, Hermans Borgmeyer I, Schmidt R, Schachner M, Sandi C. Chronic stress induces opposite changes in the mRNA expression of the cell adhesion molecules NCAM and L1. Neuroscience. 2002;115:1211-9 pubmed
    ..Furthermore, they suggest that these effects might be involved in the mechanisms by which stress induces structural and functional alterations in the central nervous system and, particularly, in the hippocampus. ..
  24. Hoffman E, Mintz C, Wang S, McNickle D, Salton S, Benson D. Effects of ethanol on axon outgrowth and branching in developing rat cortical neurons. Neuroscience. 2008;157:556-65 pubmed publisher
    ..cognitive impairment similar to those seen in patients expressing mutant forms of the L1 cell adhesion molecule (L1CAM)...
  25. Strekalova H, Buhmann C, Kleene R, Eggers C, Saffell J, Hemperly J, et al. Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes. Neurobiol Aging. 2006;27:1-9 pubmed
    ..These observations point to an abnormal processing and/or shedding of L1 and NCAM in dementia-related neurodegeneration and age, respectively, reflecting changes in adhesion molecule-related cell interactions. ..
  26. Sauce B, Wass C, Netrakanti M, Saylor J, Schachner M, Matzel L. Heterozygous L1-deficient mice express an autism-like phenotype. Behav Brain Res. 2015;292:432-42 pubmed publisher
    The L1CAM (L1) gene encodes a cell adhesion molecule that contributes to several important processes in the developing and adult nervous system, including neuronal migration, survival, and plasticity...
  27. Lin B, Madan A, Yoon J, Fang X, Yan X, Kim T, et al. Massively parallel signature sequencing and bioinformatics analysis identifies up-regulation of TGFBI and SOX4 in human glioblastoma. PLoS ONE. 2010;5:e10210 pubmed publisher
    ..changes of three up-regulated genes, CHI3L1, CHI3L2, and FOXM1, and two down-regulated genes, neurogranin and L1CAM, were confirmed by quantitative PCR...
  28. Guseva D, Zerwas M, Xiao M, Jakovcevski I, Irintchev A, Schachner M. Adhesion molecule L1 overexpressed under the control of the neuronal Thy-1 promoter improves myelination after peripheral nerve injury in adult mice. Exp Neurol. 2011;229:339-52 pubmed publisher
    ..Our results indicate that L1 is a regulator of myelination in the injured PNS and warrant studies aiming to improve function in demyelinating PNS and CNS disorders using exogenous L1. ..
  29. Runyan S, Roy R, Zhong H, Phelps P. L1 CAM expression in the superficial dorsal horn is derived from the dorsal root ganglion. J Comp Neurol. 2005;485:267-79 pubmed
  30. Takechi T, Tohyama J, Kurashige T, Maruta K, Uyemura K, Ohi T, et al. A deletion of five nucleotides in the L1CAM gene in a Japanese family with X-linked hydrocephalus. Hum Genet. 1996;97:353-6 pubmed
    ..Linkage analysis studies implicated the neural cell adhesion molecule L1 (L1CAM) gene as a candidate gene for these X-linked disorders...
  31. Morales D, Townsend R, Malone J, Ewersmann C, Macy E, Inder T, et al. Alterations in protein regulators of neurodevelopment in the cerebrospinal fluid of infants with posthemorrhagic hydrocephalus of prematurity. Mol Cell Proteomics. 2012;11:M111.011973 pubmed publisher
  32. Kudumala S, Freund J, Hortsch M, Godenschwege T. Differential effects of human L1CAM mutations on complementing guidance and synaptic defects in Drosophila melanogaster. PLoS ONE. 2013;8:e76974 pubmed publisher
    A large number of different pathological L1CAM mutations have been identified that result in a broad spectrum of neurological and non-neurological phenotypes...
  33. Tapanes Castillo A, Weaver E, Smith R, Kamei Y, Caspary T, Hamilton Nelson K, et al. A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice. Neurogenetics. 2010;11:53-71 pubmed publisher
    Humans with L1 cell adhesion molecule (L1CAM) mutations exhibit X-linked hydrocephalus, as well as other severe neurological disorders...
  34. White K, Sabatino J, He M, Davis N, Tang N, Bearer C. Toluene disruption of the functions of L1 cell adhesion molecule at concentrations associated with occupational exposures. Pediatr Res. 2016;80:145-50 pubmed publisher
    ..Results suggest that toluene inhibits L1-lipid raft interactions at occupationally relevant concentrations and may lead to a fetal solvent spectrum disorder similar to fetal alcohol spectrum disorder. ..
  35. Sakurai T, Gil O, Whittard J, Gazdoiu M, Joseph T, Wu J, et al. Interactions between the L1 cell adhesion molecule and ezrin support traction-force generation and can be regulated by tyrosine phosphorylation. J Neurosci Res. 2008;86:2602-14 pubmed publisher
    ..Collectively, these data suggest that L1-ezrin interactions mediated by the L1 juxtamembrane region are involved in traction-force generation and can be regulated by the phosphorylation of L1. ..
  36. Shults C, Alberti L, Kimber T, Stallcup W. Mesostriatal dopaminergic axons transiently express high levels of NILE during development. Exp Neurol. 1992;116:275-85 pubmed
    The distribution of nerve growth factor-inducible large external (NILE) glycoprotein in the developing mesostriatal dopaminergic system was studied by immunolabeling prenatal, postnatal, and adult rat brains for both NILE and tyrosine ..
  37. Prince J, Milona N, Stallcup W. Characterization of a partial cDNA clone for the NILE glycoprotein and identification of the encoded polypeptide domain. J Neurosci. 1989;9:1825-34 pubmed
    A partial cDNA clone [2.4 kilobase (kb)] for the nerve growth factor-inducible large external (NILE) glycoprotein was selected from a lambda gt11 expression library constructed using mRNA from PC 12 cells. A 0...
  38. Wakabayashi Y, Uchida S, Funato H, Matsubara T, Watanuki T, Otsuki K, et al. State-dependent changes in the expression levels of NCAM-140 and L1 in the peripheral blood cells of bipolar disorders, but not in the major depressive disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:1199-205 pubmed publisher
    ..Our results suggest that the reciprocal alteration in the expression of NCAM-140 and L1 mRNAs could be state-dependent and associated with the pathophysiology of bipolar disorder. ..
  39. Prince J, Milona N, Stallcup W. Characterization of a partial cDNA clone for the NILE glycoprotein and identification of the encoded polypeptide domain. J Neurosci. 1989;9:876-83 pubmed
    A partial cDNA clone [2.4 kilobase (kb)] for the nerve growth factor-inducible large external (NILE) glycoprotein was selected from a lambda gt 11 expression library constructed using mRNA from PC 12 cells. A 0...
  40. Barry J, Gu Y, Gu C. Polarized targeting of L1-CAM regulates axonal and dendritic bundling in vitro. Eur J Neurosci. 2010;32:1618-31 pubmed publisher
    ..Here we show that polarized axon-dendrite targeting of an avian L1-CAM protein, NgCAM (neuron-glia cell adhesion molecule), can regulate the switch of bundling of the two major compartments of rat ..
  41. Nishimune H, Bernreuther C, Carroll P, Chen S, Schachner M, Henderson C. Neural adhesion molecules L1 and CHL1 are survival factors for motoneurons. J Neurosci Res. 2005;80:593-9 pubmed
    ..Thus, in this system, too, FGF and L1 may use similar signaling pathways. ..
  42. Yap C, Wisco D, Kujala P, Lasiecka Z, Cannon J, Chang M, et al. The somatodendritic endosomal regulator NEEP21 facilitates axonal targeting of L1/NgCAM. J Cell Biol. 2008;180:827-42 pubmed publisher
    ..We showed previously that axonal accumulation of the cell adhesion molecule L1/neuron-glia cell adhesion molecule (NgCAM) depends on endocytosis (Wisco, D., E.D. Anderson, M.C. Chang, C. Norden, T. Boiko, H. Folsch, and B. Winckler...
  43. Haas M, Vickers J, Dickson T. Binding partners L1 cell adhesion molecule and the ezrin-radixin-moesin (ERM) proteins are involved in development and the regenerative response to injury of hippocampal and cortical neurons. Eur J Neurosci. 2004;20:1436-44 pubmed
    ..We have demonstrated that L1 and the ERM proteins are involved in the neuronal response to injury, and that neurons derived from the hippocampus and cortex may have different post-injury regenerative neurite sprouting abilities. ..
  44. Akopians A, Runyan S, Phelps P. Expression of L1 decreases during postnatal development of rat spinal cord. J Comp Neurol. 2003;467:375-88 pubmed
    ..Furthermore, the L1-positive axons that continue to be detected in adults are likely to be either unmyelinated or sprouting axons. ..
  45. Kurumaji A, Nomoto H, Okano T, Toru M. An association study between polymorphism of L1CAM gene and schizophrenia in a Japanese sample. Am J Med Genet. 2001;105:99-104 pubmed
    b>L1CAM, a neural cell adhesion molecule, plays an important role in the development of the central nervous system. The human L1CAM gene is located in Xq28...
  46. Tagliavacca L, Colombo F, Racchetti G, Meldolesi J. L1CAM and its cell-surface mutants: new mechanisms and effects relevant to the physiology and pathology of neural cells. J Neurochem. 2013;124:397-409 pubmed publisher
    ..that affects 1/30 000 newborn males, is sustained by numerous missense mutations of L1 cell adhesion molecule (L1CAM), an adhesion surface protein active also in transmembrane signaling, essential for the development and function ..
  47. Laifenfeld D, Karry R, Grauer E, Klein E, Ben Shachar D. Antidepressants and prolonged stress in rats modulate CAM-L1, laminin, and pCREB, implicated in neuronal plasticity. Neurobiol Dis. 2005;20:432-41 pubmed
    ..Our findings suggest that noradrenergic-regulated plasticity genes such as CAM-L1, laminin, and CREB play an important role both in stress and in the treatment of depression. ..
  48. Fujita A, Koinuma S, Yasuda S, Nagai H, Kamiguchi H, Wada N, et al. GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70. PLoS ONE. 2013;8:e79689 pubmed publisher
    ..The combination of this study and our previous work on the role of TC10 in EGF-induced exocytosis in HeLa cells suggests that the signaling machinery containing TC10 proposed here may be broadly used for exocytosis. ..
  49. Hai J, Zhu C, Bandarchi B, Wang Y, Navab R, Shepherd F, et al. L1 cell adhesion molecule promotes tumorigenicity and metastatic potential in non-small cell lung cancer. Clin Cancer Res. 2012;18:1914-24 pubmed publisher
    ..Our group previously identified L1 cell adhesion molecule (L1CAM) expression as a member of a prognostic multigene expression signature for NSCLC patients...
  50. Littner Y, Tang N, He M, Bearer C. L1 cell adhesion molecule signaling is inhibited by ethanol in vivo. Alcohol Clin Exp Res. 2013;37:383-9 pubmed publisher
    ..The proportion of L1 present in LRs is significantly increased in pups who received 6 g/kg EtOH compared to intubated controls. L1 is a target for EtOH developmental neurotoxicity in vivo. ..
  51. Hubbe M, Altevogt P. Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function. Eur J Immunol. 1994;24:731-7 pubmed
    ..The possibility of a homotypic HSA/HSA interaction between T lymphocytes and accessory cells is discussed. ..
  52. Thornton M, Shawcross S, Mantovani C, Kingham P, Birchall M, Terenghi G. Neurotrophins 3 and 4 differentially regulate NCAM, L1 and N-cadherin expression during peripheral nerve regeneration. Biotechnol Appl Biochem. 2008;49:165-74 pubmed
    ..Thus we propose that retrograde transport of the NTs to the DRG affects adhesion molecule transcription, reflected by protein expression in peripheral nerve axons. ..
  53. Macias M, Fehr S, Dwornik A, Sulejczak D, Wiater M, Czarkowska Bauch J, et al. Exercise increases mRNA levels for adhesion molecules N-CAM and L1 correlating with BDNF response. Neuroreport. 2002;13:2527-30 pubmed
    ..These results suggest that exercise-induced rearrangements of the spinal network involve N-CAM, L1 and BDNF, crucial in different aspects of synaptic plasticity and synapse formation. ..
  54. Hu Y, Liao H, Dai Hong G, Liu P, Wang Y, Rahman K. Antidepressant-like effects of 3,6'-disinapoyl sucrose on hippocampal neuronal plasticity and neurotrophic signal pathway in chronically mild stressed rats. Neurochem Int. 2010;56:461-5 pubmed publisher
  55. Lim N, Kozlov G, Chang T, Groover O, Siddiqui N, Volpon L, et al. Comparative peptide binding studies of the PABC domains from the ubiquitin-protein isopeptide ligase HYD and poly(A)-binding protein. Implications for HYD function. J Biol Chem. 2006;281:14376-82 pubmed
    ..specifically found in poly(A)-binding protein (PABP) and a HECT ubiquitin-protein isopeptide ligase (E3) known as HYD (hyperplastic discs), EDD (E3 isolated by differential display), or Rat100...
  56. Donier E, Gómez Sánchez J, Grijota Martinez C, Lakomá J, Baars S, Garcia Alonso L, et al. L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling. PLoS ONE. 2012;7:e40674 pubmed publisher
    ..Thus it has been shown that L1CAM-mediated cell adhesion promotes the activation of the EGFR (erbB1) from Drosophila to humans...
  57. Schafer H, Struck B, Feldmann E, Bergmann F, Grage Griebenow E, Geismann C, et al. TGF-?1-dependent L1CAM expression has an essential role in macrophage-induced apoptosis resistance and cell migration of human intestinal epithelial cells. Oncogene. 2013;32:180-9 pubmed publisher
    ..The adhesion molecule L1CAM mediates chemoresistance and migration of tumor cells and is elevated in CRC tissues being associated with ..
  58. Tocco M, Fujita K, Guroff G. Effect of dexamethasone on the nerve growth factor-induced increase in the NILE glycoprotein in PC12 cells. J Neurosci Res. 1992;31:28-32 pubmed
    The long-known and well-documented increase in the NILE glycoprotein produced by nerve growth factor in PC12 cells is prevented by simultaneous treatment with dexamethasone...
  59. Molatore S, Liyanarachchi S, Irmler M, Perren A, Mannelli M, Ercolino T, et al. Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma. Proc Natl Acad Sci U S A. 2010;107:18493-8 pubmed publisher
    ..The expression of GAL, DGKH, BMP7, PHOX2A, L1CAM, TCTE1, EBF3, SOX4, and HASH1 was up-regulated, although with different frequencies...
  60. Itoh K, Shimono K, Lemmon V. Dephosphorylation and internalization of cell adhesion molecule L1 induced by theta burst stimulation in rat hippocampus. Mol Cell Neurosci. 2005;29:245-9 pubmed
    The neural cell adhesion molecule L1 may participate in initiating and maintaining synaptic changes during learning in the hippocampus...
  61. Chatzopoulou E, Miguez A, Savvaki M, Levasseur G, Muzerelle A, Muriel M, et al. Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerve. J Neurosci. 2008;28:7624-36 pubmed publisher
    ..Therefore, TAG-1 is an essential regulator of the structure of RGC axons and their surrounding glial cells in the optic nerve. ..
  62. Kadmon G, von Bohlen und Halbach F, Schachner M, Altevogt P. Differential, LFA-1-sensitive effects of antibodies to nectadrin, the heat-stable antigen, on B lymphoblast aggregation and signal transduction. Biochem Biophys Res Commun. 1994;198:1209-15 pubmed
    ..These results suggest that nectadrin may concomitantly mediate primary and activate secondary adhesion mechanisms whereby each of these processes may be related to a different signal transduction pathway. ..
  63. Senner V, Kismann E, Püttmann S, Hoess N, Baur I, Paulus W. L1 expressed by glioma cells promotes adhesion but not migration. Glia. 2002;38:146-54 pubmed
    ..Our data suggest that L1 expressed on the surface of glioma cells increases cell-matrix and intercellular adhesion, but has no apparent effects on proliferation and invasion. ..
  64. Arlt M, Novak Hofer I, Gast D, Gschwend V, Moldenhauer G, Grünberg J, et al. Efficient inhibition of intra-peritoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatment. Cancer Res. 2006;66:936-43 pubmed
  65. Stallcup W, Beasley L. Involvement of the nerve growth factor-inducible large external glycoprotein (NILE) in neurite fasciculation in primary cultures of rat brain. Proc Natl Acad Sci U S A. 1985;82:1276-80 pubmed
    The nerve growth factor-inducible large external glycoprotein (NILE) has been found only on the surface of neuronal cells and Schwann cells...
  66. Ben Q, Wang J, Liu J, Zhu Y, Yuan F, Yao W, et al. Positive expression of L1-CAM is associated with perineural invasion and poor outcome in pancreatic ductal adenocarcinoma. Ann Surg Oncol. 2010;17:2213-21 pubmed publisher
    ..Enhanced expression of L1-CAM may contribute to the pain syndrome and perineural invasion and may correlate with poor overall survival in human pancreatic cancer. ..
  67. Tsoory M, Guterman A, Richter Levin G. "Juvenile stress" alters maturation-related changes in expression of the neural cell adhesion molecule L1 in the limbic system: relevance for stress-related psychopathologies. J Neurosci Res. 2010;88:369-80 pubmed publisher
    ..Furthermore, the findings support the "network hypothesis," which postulates that information-processing problems within relevant neural networks might underlie stress-induced mood and anxiety disorders. ..
  68. Tang N, He M, O Riordan M, Farkas C, Buck K, Lemmon V, et al. Ethanol inhibits L1 cell adhesion molecule activation of mitogen-activated protein kinases. J Neurochem. 2006;96:1480-90 pubmed
    ..We conclude that ethanol disrupts the signaling pathway between L1 clustering and ERK1/2 activation, and that this occurs independently of the FGFR1 pathway in cerebellar granule cells. ..
  69. Shimada T, Toriyama M, Uemura K, Kamiguchi H, Sugiura T, Watanabe N, et al. Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth. J Cell Biol. 2008;181:817-29 pubmed publisher
    ..These results strengthen the actin flow-CAM linkage model ("clutch" model) for axon outgrowth and suggest that shootin1 is a key molecule involved in this mechanism. ..
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    ..of this predominant astrocytic differentiation of NSCs and expressed the paradigmatic beneficial neural cell adhesion molecule L1 in radial glial cells and reactive and nonreactive astrocytes as novel cellular vehicles to express ..
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    ..Thus, spinal cord transection at an early age induced substantial L1 expression on axons near the lesion site, but was not additionally augmented by exercise. ..
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    The neural cell adhesion molecule L1 plays an important role in axon growth, neuronal survival, and synaptic plasticity...