Genomes and Genes
Gene Symbol: Kmt5c
Description: lysine methyltransferase 5C
Alias: Suv420h2, histone-lysine N-methyltransferase KMT5C, histone-lysine N-methyltransferase SUV420H2, lysine (K)-specific methyltransferase 5C, lysine-specific methyltransferase 5C, su(var)4-20 homolog 2, suppressor of variegation 4-20 homolog 2, suv4-20h2
- Pogribny I, Ross S, Tryndyak V, Pogribna M, Poirier L, Karpinets T. Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats. Carcinogenesis. 2006;27:1180-6 pubmed
- Pogribny I, Tryndyak V, Muskhelishvili L, Rusyn I, Ross S. Methyl deficiency, alterations in global histone modifications, and carcinogenesis. J Nutr. 2007;137:216S-222S pubmed publisher..These results illustrate the complexity and importance of histone modification changes in the etiology of hepatocarcinogenesis induced by MDD. ..
- Souza P, Volkel P, Trinel D, Vandamme J, Rosnoblet C, Heliot L, et al. The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behaviours. BMC Cell Biol. 2009;10:41 pubmed publisher..To gain insights into the mechanisms of SUV420H2 recruitment at heterochromatin, we applied a tandem affinity purification approach coupled to mass spectrometry...
- Zhong Q, Kowluru R. Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy. Diabetes. 2011;60:1304-13 pubmed publisher..H3K9, and NF-?B p65 at the promoter and enhancer of retinal sod2, upregulated protein and gene expression of SUV420h2, and increased the interactions of acetyl H3K9 and NF-?B p65 to H4K20me3...
- Shen J, Jia W, Yu Y, Chen J, Cao X, Du Y, et al. Pwp1 is required for the differentiation potential of mouse embryonic stem cells through regulating Stat3 signaling. Stem Cells. 2015;33:661-73 pubmed publisher..Together, our results suggest that Pwp1 plays important roles in the differentiation potential of mESCs. ..