Klrk1

Summary

Gene Symbol: Klrk1
Description: killer cell lectin like receptor K1
Alias: NKG2D, Nkrp2, NKG2-D type II integral membrane protein, NK cell receptor D, NK lectin-like receptor, NKG2-D-activating NK receptor, NKLLR, NKR-P2, ortholog of human NKG2D, killer cell lectin-like receptor subfamily K, member 1
Species: rat
Products:     Klrk1

Top Publications

  1. Berg S, Dissen E, Westgaard I, Fossum S. Molecular characterization of rat NKR-P2, a lectin-like receptor expressed by NK cells and resting T cells. Int Immunol. 1998;10:379-85 pubmed
    The gene for a rat NK lectin-like receptor (NKLLR), named NKR-P2, has been cloned and characterized...
  2. Diefenbach A, Tomasello E, Lucas M, Jamieson A, Hsia J, Vivier E, et al. Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat Immunol. 2002;3:1142-9 pubmed
    ..Here, we report that alternative splicing leads to two distinct NKG2D polypeptides that associate differentially with the DAP10 and KARAP (also known as DAP12) signaling subunits...
  3. Wu J, Song Y, Bakker A, Bauer S, Spies T, Lanier L, et al. An activating immunoreceptor complex formed by NKG2D and DAP10. Science. 1999;285:730-2 pubmed
    ..NK) and T cells, DAP10 was identified as a cell surface adaptor protein in an activating receptor complex with NKG2D, a receptor for the stress-inducible and tumor-associated major histocompatibility complex molecule MICA...
  4. Koike J, Wakao H, Ishizuka Y, Sato T, Hamaoki M, Seino K, et al. Bone marrow allograft rejection mediated by a novel murine NK receptor, NKG2I. J Exp Med. 2004;199:137-44 pubmed
    ..NKG2I, which was composed of 226 amino acids, showed approximately 40% homology to the murine NKG2D and CD94 in the C-type lectin domain...
  5. Hamerman J, Ogasawara K, Lanier L. Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. J Immunol. 2004;172:2001-5 pubmed
    ..that murine macrophages stimulated with pathogen products known to signal through TLRs express ligands for the NKG2D receptor, found on NK cells, activated CD8(+) T cells and activated macrophages...
  6. Lai C, Zhang Y, Rogers S, Mager D. Creation of the two isoforms of rodent NKG2D was driven by a B1 retrotransposon insertion. Nucleic Acids Res. 2009;37:3032-43 pubmed publisher
    The mouse gene for the natural killer (NK) cell-activating receptor Nkg2d produces two protein isoforms, NKG2D-S and NKG2D-L, which differ by 13 amino acids at the N-terminus and have different signalling capabilities...
  7. Baba T, Iwasaki S, Maruoka T, Suzuki A, Tomaru U, Ikeda H, et al. Rat CD4+CD8+ macrophages kill tumor cells through an NKG2D- and granzyme/perforin-dependent mechanism. J Immunol. 2008;180:2999-3006 pubmed
    ..profile, expressed high levels of Fas ligand, perforin, granzyme B, and NKR-P2 (rat ortholog of human NKG2D), and killed certain tumor cells...
  8. Rosen D, Araki M, Hamerman J, Chen T, Yamamura T, Lanier L. A Structural basis for the association of DAP12 with mouse, but not human, NKG2D. J Immunol. 2004;173:2470-8 pubmed
    Prior studies have revealed that alternative mRNA splicing of the mouse NKG2D gene generates receptors that associate with either the DAP10 or DAP12 transmembrane adapter signaling proteins...
  9. Hoffmann S, Schellack C, Textor S, Konold S, Schmitz D, Cerwenka A, et al. Identification of CLEC12B, an inhibitory receptor on myeloid cells. J Biol Chem. 2007;282:22370-5 pubmed
    ..The extracellular domain of CLEC12B shows considerable homology to the activating natural killer cell receptor NKG2D, but unlike NKG2D, CLEC12B contains an immunoreceptor tyrosine-based inhibition motif in its intracellular domain...

More Information

Publications24

  1. Srivastava R, Varalakshmi C, Khar A. Cross-linking a mAb to NKR-P2/NKG2D on dendritic cells induces their activation and maturation leading to enhanced anti-tumor immune response. Int Immunol. 2007;19:591-607 pubmed
    NKR-P2/NKG2D is the chief tumor recognition receptor of NK cells and some T cells, which recognizes stress inducible ligands on tumors and mediates cell activation...
  2. Shen B, Li J, Yang B. NKG2D blockade significantly attenuates ischemia-reperfusion injury in a cardiac transplantation model. Transplant Proc. 2013;45:2513-6 pubmed publisher
    b>NKG2D (natural killer group 2 member D), are activating or coactivating receptor on NK cells, ?? T, and CD8(+) T cells, stimulates cytokine secretion by the former two and plays a costimulatory role for the last CD8(+) T cells...
  3. Serrano Pertierra E, Cernuda Morollón E, Lopez Larrea C. Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation. Eur J Immunol. 2012;42:2142-51 pubmed publisher
    b>NKG2D is a transmembrane receptor mainly expressed on CD8(+) T cells and NK cells. Engagement of NKG2D with its ligands can trigger a cytotoxic response...
  4. Zhuo M, Fujiki M, Wang M, Piard Ruster K, Wai L, Wei L, et al. Identification of the rat NKG2D ligands, RAE1L and RRLT, and their role in allograft rejection. Eur J Immunol. 2010;40:1748-57 pubmed publisher
    b>NKG2D is a receptor expressed by NK cells and subsets of T lymphocytes. On NK cells, NKG2D functions as a stimulatory receptor that induces effector functions...
  5. Srivastava R, Varalakshmi C, Khar A. The ischemia-responsive protein 94 (Irp94) activates dendritic cells through NK cell receptor protein-2/NK group 2 member D (NKR-P2/NKG2D) leading to their maturation. J Immunol. 2008;180:1117-30 pubmed
    ..of direct tumoricidal activity, we have recently shown NK cell receptor protein-2 (NKR-P2)/NK group 2 member D (NKG2D) as a potent activation receptor on rat DCs...
  6. Karimi M, Cao T, Baker J, Verneris M, Soares L, Negrin R. Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells. J Immunol. 2005;175:7819-28 pubmed
    ..activated cells, which share phenotypic and functional characteristics with NK cells, is mediated principally by NKG2D. NKG2D is a surface receptor that is expressed by all NK cells and transmits an activating signal via the DAP10 ..
  7. Savithri B, Khar A. A transmembrane-anchored rat RAE-1-like transcript as a ligand for NKR-P2, the rat ortholog of human and mouse NKG2D. Eur J Immunol. 2006;36:107-17 pubmed
    b>NKG2D is a potent activating immunoreceptor that has been extensively characterized in NK cells and shown to lend costimulatory functions in CD8(+) T cells under certain conditions...
  8. Lanier L. NKG2D. J Biol Regul Homeost Agents. 2003;17:338-40 pubmed
  9. Alli R, Savithri B, Das S, Varalakshmi C, Rangaraj N, Khar A. Involvement of NKR-P2/NKG2D in DC-mediated killing of tumor targets: indicative of a common, innate, target-recognition paradigm?. Eur J Immunol. 2004;34:1119-26 pubmed
    ..Taken together, these observations suggest that NKR-P2 (the rat orthologue of human NKG2D) acts as a target-recognition molecule on DC.
  10. Hayakawa Y, Kelly J, Westwood J, Darcy P, Diefenbach A, Raulet D, et al. Cutting edge: tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin. J Immunol. 2002;169:5377-81 pubmed
    ..the primary immunity generated in vivo by MHC class I-deficient and -competent tumor cell lines that expressed the NKG2D ligand retinoic acid early inducible-1 (Rae-1) beta...
  11. Takada A, Yoshida S, Kajikawa M, Miyatake Y, Tomaru U, Sakai M, et al. Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D. J Immunol. 2008;180:1678-85 pubmed
    ..as a dominant minor histocompatibility Ag, is an MHC class I-like molecule that serves as a ligand for the NKG2D receptor...
  12. Diefenbach A, Hsia J, Hsiung M, Raulet D. A novel ligand for the NKG2D receptor activates NK cells and macrophages and induces tumor immunity. Eur J Immunol. 2003;33:381-91 pubmed
    ..mode of immune recognition employed by NK cells is "induced self recognition" exemplified by the NKG2D receptor-ligand system...
  13. Wai L, Garcia J, Martinez O, Krams S. Distinct roles for the NK cell-activating receptors in mediating interactions with dendritic cells and tumor cells. J Immunol. 2011;186:222-9 pubmed publisher
    ..NK cells killed immature and mature DCs independently of NKp46, NKp30, and NKG2D; however, cytotoxicity against McA cells was dependent on NKp30 and NKG2D...
  14. Liu J, Liu S, Xia M, Xu S, Wang C, Bao Y, et al. Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation. Proc Natl Acad Sci U S A. 2013;110:7814-9 pubmed publisher
    ..Our study outlines a mechanism for the negative regulation of NK cell activation and also provides clues for the function of the rhomboid proteins in immunity. ..
  15. Girardi M, Oppenheim D, Steele C, Lewis J, Glusac E, Filler R, et al. Regulation of cutaneous malignancy by gammadelta T cells. Science. 2001;294:605-9 pubmed
    ..Each of these is a ligand for NKG2d, a receptor expressed by cytolytic T cells and natural killer (NK) cells...