Gene Symbol: Klc1
Description: kinesin light chain 1
Alias: Kns2, kinesin light chain 1, KLC 1, kinesin 2
Species: rat
Products:     Klc1

Top Publications

  1. Cai D, Hoppe A, Swanson J, Verhey K. Kinesin-1 structural organization and conformational changes revealed by FRET stoichiometry in live cells. J Cell Biol. 2007;176:51-63 pubmed
    ..For Kinesin-1, activation requires a global conformational change that separates the KHC motor and tail domains and a local conformational change that moves the KHC motor domains closer together. ..
  2. Blasius T, Cai D, Jih G, Toret C, Verhey K. Two binding partners cooperate to activate the molecular motor Kinesin-1. J Cell Biol. 2007;176:11-7 pubmed
    ..We show that binding of JIP1 and FEZ1 to Kinesin-1 is sufficient to activate the motor for MT binding and motility. These results provide the first demonstration of the activation of a MT-based motor by cellular binding partners. ..
  3. Ward B, Moss B. Vaccinia virus A36R membrane protein provides a direct link between intracellular enveloped virions and the microtubule motor kinesin. J Virol. 2004;78:2486-93 pubmed
    ..Collectively, these results demonstrated that the viral A36R protein interacts directly with the microtubule motor protein kinesin and that the viral protein A33R may regulate this interaction. ..
  4. Loschi M, Leishman C, Berardone N, Boccaccio G. Dynein and kinesin regulate stress-granule and P-body dynamics. J Cell Sci. 2009;122:3973-82 pubmed publisher
    ..Conversely, impairment of anterograde transport by knockdown of kinesin-1 heavy chain (KIF5B) or kinesin light chain 1 (KLC1) delayed SG dissolution. Strikingly, SG dissolution is not required to restore translation...
  5. Konishi Y, Setou M. Tubulin tyrosination navigates the kinesin-1 motor domain to axons. Nat Neurosci. 2009;12:559-67 pubmed publisher
    ..Our study identifies a molecular mechanism that discriminates the axonal microtubules from somatodendritic microtubules, as well as a previously unknown linkage between tubulin modification and polarized trafficking in neurons. ..
  6. Kimura T, Watanabe H, Iwamatsu A, Kaibuchi K. Tubulin and CRMP-2 complex is transported via Kinesin-1. J Neurochem. 2005;93:1371-82 pubmed
    ..The C-terminal region of CRMP-2 directly binds to the tetratricopeptide repeat domain of kinesin light chain 1 (KLC1). Soluble tubulin binds to the middle of CRMP-2 and forms a trimeric complex with CRMP-2/KLC1...
  7. Utton M, Noble W, Hill J, Anderton B, Hanger D. Molecular motors implicated in the axonal transport of tau and alpha-synuclein. J Cell Sci. 2005;118:4645-54 pubmed
  8. Rahman A, Friedman D, Goldstein L. Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins. J Biol Chem. 1998;273:15395-403 pubmed
    ..These results indicate that the mammalian nervous system contains multiple kinesin light chain gene products with potentially distinct functions. ..
  9. Taya S, Shinoda T, Tsuboi D, Asaki J, Nagai K, Hikita T, et al. DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. J Neurosci. 2007;27:15-26 pubmed
    ..Furthermore, the knockdown of NUDEL or LIS1 inhibited axon elongation. Together, these results indicate that DISC1 regulates the localization of NUDEL/LIS1/14-3-3epsilon complex into the axons as a cargo receptor for axon elongation. ..

More Information


  1. Dhaenens C, Van Brussel E, Schraen Maschke S, Pasquier F, Delacourte A, Sablonniere B. Association study of three polymorphisms of kinesin light-chain 1 gene with Alzheimer's disease. Neurosci Lett. 2004;368:290-2 pubmed
    The transport of amyloid precursor protein is mediated through its interaction with kinesin light-chain 1 (KNS2). We hypothesized that kinesin light-chain dysfunction might be involved in the pathogenesis of Alzheimer's disease (AD)...
  2. Konecna A, Frischknecht R, Kinter J, Ludwig A, Steuble M, Meskenaite V, et al. Calsyntenin-1 docks vesicular cargo to kinesin-1. Mol Biol Cell. 2006;17:3651-63 pubmed
    ..a direct interaction between the neuronal transmembrane protein calsyntenin-1 and the light chain of Kinesin-1 (KLC1)...
  3. von Otter M, Landgren S, Nilsson S, Lundvall C, Minthon L, Bogdanovic N, et al. Kinesin light chain 1 gene haplotypes in three conformational diseases. Neuromolecular Med. 2010;12:229-36 pubmed publisher
    ..Genetic variation in the kinesin light chain 1-encoding gene (KLC1) was tagged by six tag single nucleotide polymorphisms (SNPs)...
  4. Aoyama T, Hata S, Nakao T, Tanigawa Y, Oka C, Kawaichi M. Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains. J Cell Sci. 2009;122:4177-85 pubmed publisher
    ..The tetratricopeptide-repeat region of KLC1 recognizes the ELEWED sequence (amino acids 115-120) of caytaxin...
  5. Bracale A, Cesca F, Neubrand V, Newsome T, Way M, Schiavo G. Kidins220/ARMS is transported by a kinesin-1-based mechanism likely to be involved in neuronal differentiation. Mol Biol Cell. 2007;18:142-52 pubmed
    ..We identified kinesin light chain 1 (KLC1) as a binding partner for Kidins220/ARMS by a yeast two-hybrid screen...
  6. Kamm C, Boston H, Hewett J, Wilbur J, Corey D, Hanson P, et al. The early onset dystonia protein torsinA interacts with kinesin light chain 1. J Biol Chem. 2004;279:19882-92 pubmed
    ..We identified the light chain subunit (KLC1) of kinesin-I as an interacting partner for torsinA, with binding occurring between the tetratricopeptide repeat ..
  7. Kamal A, Almenar Queralt A, Leblanc J, Roberts E, Goldstein L. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature. 2001;414:643-8 pubmed
  8. Ligon L, Tokito M, Finklestein J, Grossman F, Holzbaur E. A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity. J Biol Chem. 2004;279:19201-8 pubmed
    ..There is also a vesicle population with both dynein and kinesin I bound that may be capable of bi-directional motility along cellular microtubules. ..
  9. Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. A cytoskeleton motor protein genetic variant may exert a protective effect on the occurrence of multiple sclerosis: the janus face of the kinesin light-chain 1 56836CC genetic variant. Neuromolecular Med. 2007;9:335-9 pubmed
    ..In this study, we examined how the kinesin light-chain 1 (KLC1) G56836C (rs8702) single nucleotide polymorphism (SNP) in intron 13 affects the occurrence of MS...
  10. Traina G, Federighi G, Brunelli M. Up-regulation of kinesin light-chain 1 gene expression by acetyl-L-carnitine: therapeutic possibility in Alzheimer's disease. Neurochem Int. 2008;53:244-7 pubmed publisher
    ..In this scenario, our results are of relevant importance for possible therapeutic intervention, suggesting a pathway for the treatment of Alzheimer's disease. ..
  11. Roux K, Crisp M, Liu Q, Kim D, Kozlov S, Stewart C, et al. Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization. Proc Natl Acad Sci U S A. 2009;106:2194-9 pubmed publisher
    ..These effects can be accounted for entirely by Nesp4's kinesin-binding function. The implication is that Nesp4 may contribute to microtubule-dependent nuclear positioning. ..
  12. Pigino G, Morfini G, Pelsman A, Mattson M, Brady S, Busciglio J. Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J Neurosci. 2003;23:4499-508 pubmed
    ..These findings suggest that mutations in PS1 may compromise neuronal function by affecting GSK-3 activity and kinesin-I-based motility. ..
  13. Cyr J, Pfister K, Bloom G, Slaughter C, Brady S. Molecular genetics of kinesin light chains: generation of isoforms by alternative splicing. Proc Natl Acad Sci U S A. 1991;88:10114-8 pubmed
    ..Synthesis of multiple light chains, differing from one another in primary structure, could provide a means of generating multiple, functionally specialized forms of the kinesin holoenzyme. ..
  14. Yang J, Li T. The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos. Exp Cell Res. 2005;309:379-89 pubmed
    ..These findings indicate that ciliary rootlets may provide a scaffold for kinesin-1 vesicular cargos and, thus, play a role in the intracellular transport in ciliated cells. ..
  15. Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. A genetic variant in cytoskeleton motors amplifies susceptibility to leukoaraiosis in hypertensive smokers: gene-environmental interactions behind vascular white matter demyelinization. J Mol Neurosci. 2007;33:173-9 pubmed
    ..Setting out from this assumption, we examined how the kinesin light-chain 1 (KNS2) G56836C single nucleotide polymorphism in intron 13 affects the susceptibility to LA...
  16. Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. Evaluation of the roles of the A185C and C406T kinesin light-chain 1 variants in the development of leukoaraiosis. Neurosci Lett. 2007;429:101-4 pubmed
    ..Setting out from this assumption, we earlier found that the kinesin light-chain 1 (KNS2) cytoskeleton motor protein 56836CC single nucleotide polymorphism conferred a risk of LA in hypertensive smokers...