Kl

Summary

Gene Symbol: Kl
Description: Klotho
Alias: klotho
Species: rat
Products:     Kl

Top Publications

  1. Hu M, Shi M, Zhang J, QUINONES H, Griffith C, Kuro O M, et al. Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol. 2011;22:124-36 pubmed publisher
    Soft-tissue calcification is a prominent feature in both chronic kidney disease (CKD) and experimental Klotho deficiency, but whether Klotho deficiency is responsible for the calcification in CKD is unknown...
  2. Maekawa Y, Ishikawa K, Yasuda O, Oguro R, Hanasaki H, Kida I, et al. Klotho suppresses TNF-alpha-induced expression of adhesion molecules in the endothelium and attenuates NF-kappaB activation. Endocrine. 2009;35:341-6 pubmed publisher
    b>Klotho is a senescence suppressor protein that, when overexpressed, extends the lifespan of mice...
  3. Cha S, Hu M, Kurosu H, Kuro O M, Moe O, Huang C. Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho. Mol Pharmacol. 2009;76:38-46 pubmed publisher
    b>Klotho is an aging-suppression protein predominantly expressed in kidney, parathyroid glands, and choroids plexus of the brain...
  4. Thurston R, Larmonier C, Majewski P, Ramalingam R, Midura Kiela M, Laubitz D, et al. Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis. Gastroenterology. 2010;138:1384-94, 1394.e1-2 pubmed publisher
    b>Klotho (KL) is an anti-inflammatory protein that protects the endothelium from nitric oxide (NO)-induced dysfunction, reduces the expression of endothelial adhesion molecules, and potentially regulates T-cell functions...
  5. Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature. 2006;444:770-4 pubmed
    ..Here we show that a previously undescribed receptor conversion by Klotho, a senescence-related molecule, generates the FGF23 receptor...
  6. Doi S, Zou Y, Togao O, Pastor J, John G, Wang L, et al. Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem. 2011;286:8655-65 pubmed publisher
    ..ureteral obstruction and metastasis of human cancer xenografts are suppressed by administration of secreted Klotho protein to mice. Klotho is a single-pass transmembrane protein expressed in renal tubular epithelial cells...
  7. Kuro O M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 1997;390:45-51 pubmed
    A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes...
  8. Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, Rosenblatt K, et al. Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem. 2006;281:6120-3 pubmed
    The aging suppressor gene Klotho encodes a single-pass transmembrane protein...
  9. Chen C, Podvin S, Gillespie E, Leeman S, Abraham C. Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci U S A. 2007;104:19796-801 pubmed
    ..Evidence suggests that the antiaging transmembrane protein Klotho (KL) is shed from the cell surface by proteolytic cleavage...

More Information

Publications66

  1. Ben Dov I, Galitzer H, Lavi Moshayoff V, Goetz R, Kuro O M, Mohammadi M, et al. The parathyroid is a target organ for FGF23 in rats. J Clin Invest. 2007;117:4003-8 pubmed
    ..FGF23 signals with highest efficacy through several FGF receptors (FGFRs) bound by the transmembrane protein Klotho as a coreceptor. Since most tissues express FGFR, expression of Klotho determines FGF23 target organs...
  2. Ogata N, Matsumura Y, Shiraki M, Kawano K, Koshizuka Y, Hosoi T, et al. Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women. Bone. 2002;31:37-42 pubmed
    Based on the fact that the klotho-deficient mouse exhibits multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints, we explored the possibility of whether human klotho gene polymorphism is associated with two ..
  3. Koh N, Fujimori T, Nishiguchi S, Tamori A, Shiomi S, Nakatani T, et al. Severely reduced production of klotho in human chronic renal failure kidney. Biochem Biophys Res Commun. 2001;280:1015-20 pubmed
    We recently identified a novel gene, termed klotho (kl) that is involved in the development of a syndrome in mice resembling human aging...
  4. Sugiura H, Yoshida T, Tsuchiya K, Mitobe M, Nishimura S, Shirota S, et al. Klotho reduces apoptosis in experimental ischaemic acute renal failure. Nephrol Dial Transplant. 2005;20:2636-45 pubmed
    b>Klotho is associated with the suppression of several ageing phenotypes...
  5. Mitani H, Ishizaka N, Aizawa T, Ohno M, Usui S, Suzuki T, et al. In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension. 2002;39:838-43 pubmed
    The klotho gene, originally identified by insertional mutagenesis in mice, suppresses the expression of multiple aging-associated phenotypes. This gene is predominantly expressed in the kidney...
  6. Wang Y, Sun Z. Antiaging gene Klotho regulates endothelin-1 levels and endothelin receptor subtype B expression in kidneys of spontaneously hypertensive rats. J Hypertens. 2014;32:1629-36; discussion 1636 pubmed publisher
    b>Klotho is an antiaging gene and is predominately expressed in kidneys. The endothelin system is critical in the regulation of kidney function...
  7. Takei Y, Yamamoto H, Sato T, Otani A, Kozai M, Masuda M, et al. Stanniocalcin 2 is associated with ectopic calcification in ?-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells. Bone. 2012;50:998-1005 pubmed publisher
    ..The mRNA of STCs is upregulated in the kidney of ?-klotho mutant (kl/kl) mice, which have hypercalcemia, hyperphosphatemia and hypervitaminosis D and exhibit a short life ..
  8. Hofman Bang J, Martuseviciene G, Santini M, Olgaard K, Lewin E. Increased parathyroid expression of klotho in uremic rats. Kidney Int. 2010;78:1119-27 pubmed publisher
    b>Klotho is a protein of significant importance for mineral homeostasis...
  9. Rhee E, Oh K, Lee W, Kim S, Jung C, Kim B, et al. The differential effects of age on the association of KLOTHO gene polymorphisms with coronary artery disease. Metabolism. 2006;55:1344-51 pubmed
    The Klotho knockout mouse is thought to be a good animal model for human aging. Recent studies have reported on the association of KLOTHO gene mutation with cardiovascular disease in humans...
  10. Huang K, Cherng Y, Chen L, Hsu C, Cheng J. Rosiglitazone is effective to improve renal damage in type-1-like diabetic rats. Horm Metab Res. 2014;46:240-4 pubmed publisher
    A marked decrease of klotho expression was observed in the kidney of streptozotocin-induced diabetic rats (STZ rats) showing diabetic nephropathy. It has been documented that klotho is the target gene of PPAR?...
  11. Song S, Si L. Klotho ameliorated isoproterenol-induced pathological changes in cardiomyocytes via the regulation of oxidative stress. Life Sci. 2015;135:118-23 pubmed publisher
    Oxidative stress is a common pathological process in stress-stimulated heart failure. Klotho, known as an anti-aging protein, has been shown to play important pleiotropic roles...
  12. Huang J, Chuang C, Liu M, Lin S, Guh J, Chuang L. Klotho attenuates high glucose-induced fibronectin and cell hypertrophy via the ERK1/2-p38 kinase signaling pathway in renal interstitial fibroblasts. Mol Cell Endocrinol. 2014;390:45-53 pubmed publisher
    Although exogenous klotho attenuates renal fibrosis, it is not known if exogenous klotho attenuates diabetic nephropathy (DN)...
  13. Wang X, Sun Z. RNAi silencing of brain klotho potentiates cold-induced elevation of blood pressure via the endothelin pathway. Physiol Genomics. 2010;41:120-6 pubmed publisher
    b>Klotho is a recently identified antiaging gene. Brain endothelin-1 (ET1) is important in the regulation of blood pressure (BP)...
  14. Farinelli P, Arango Gonzalez B, Völkl J, Alesutan I, Lang F, Zrenner E, et al. Retinitis Pigmentosa: over-expression of anti-ageing protein Klotho in degenerating photoreceptors. J Neurochem. 2013;127:868-79 pubmed publisher
    ..The secretable protein ?-Klotho has a function related to ageing processes, and ?-Klotho-deficient mice have reduced lifespan and declining ..
  15. Cheng X, Zhou Q, Lin S, Wu R. Fosinopril and valsartan intervention in gene expression of Klotho, MMP-9, TIMP-1, and PAI-1 in the kidney of spontaneously hypertensive rats. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010;35:1048-56 pubmed publisher
    To determine the role of fosinopril and valsartan intervention in Klotho, matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1) and plasminogen activator inhibitor (PAI-1) gene expression in hypertensive ..
  16. Adijiang A, Niwa T. An oral sorbent, AST-120, increases Klotho expression and inhibits cell senescence in the kidney of uremic rats. Am J Nephrol. 2010;31:160-4 pubmed publisher
    b>Klotho, an anti-aging gene, is primarily expressed in the kidney, and its renal expression is decreased in chronic renal failure (CRF)...
  17. Muñoz Castañeda J, Herencia C, Pendón Ruiz de Mier M, Rodriguez Ortiz M, Díaz Tocados J, Vergara N, et al. Differential regulation of renal Klotho and FGFR1 in normal and uremic rats. FASEB J. 2017;31:3858-3867 pubmed publisher
    ..Abnormal regulation of the FGFR1-Klotho receptor complex may cause a resistance to the phosphaturic action of FGF23...
  18. Carpinelli M, Wise A, Burt R. Vitamin D-deficient diet rescues hearing loss in Klotho mice. Hear Res. 2011;275:105-9 pubmed publisher
    b>Klotho-deficient mice exhibit a premature aging syndrome, a feature of which is mild hearing loss...
  19. Tsezou A, Furuichi T, Satra M, Makrythanasis P, Ikegawa S, Malizos K. Association of KLOTHO gene polymorphisms with knee osteoarthritis in Greek population. J Orthop Res. 2008;26:1466-70 pubmed publisher
    Based on the fact that klotho-deficient mice exhibit multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints and on the recent observation that KLOTHO gene plays an important role in calcium/phosphate ..
  20. Kim Y, Kim J, Nam Y, Kong M, Kim Y, Yu K, et al. Klotho is a genetic risk factor for ischemic stroke caused by cardioembolism in Korean females. Neurosci Lett. 2006;407:189-94 pubmed
    An aging-suppressor gene, klotho, is a candidate factor for vascular disease because its deficiency leads to impaired endothelium-dependent vasodilation and impaired angiogenesis...
  21. Kato Y, Arakawa E, Kinoshita S, Shirai A, Furuya A, Yamano K, et al. Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys. Biochem Biophys Res Commun. 2000;267:597-602 pubmed
    A novel gene, klotho (kl), which is involved in the development of a syndrome resembling human aging in mice, was recently identified...
  22. Arking D, Atzmon G, Arking A, Barzilai N, Dietz H. Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Circ Res. 2005;96:412-8 pubmed
    We previously identified a functional variant of KLOTHO, termed KL-VS, that is associated with human aging and early-onset occult coronary artery disease...
  23. Ohyama Y, Kurabayashi M, Masuda H, Nakamura T, Aihara Y, Kaname T, et al. Molecular cloning of rat klotho cDNA: markedly decreased expression of klotho by acute inflammatory stress. Biochem Biophys Res Commun. 1998;251:920-5 pubmed
    We have recently identified a novel gene, termed klotho, that is involved in the suppression of several aging phenotypes...
  24. Imamura A, Okumura K, Ogawa Y, Murakami R, Torigoe M, Numaguchi Y, et al. Klotho gene polymorphism may be a genetic risk factor for atherosclerotic coronary artery disease but not for vasospastic angina in Japanese. Clin Chim Acta. 2006;371:66-70 pubmed
    The klotho gene, originally identified by insertional mutagenesis in mice, suppresses multiple aging phenotypes, including atherosclerosis...
  25. Li B, Ma H, Wang Y, Wu P. [Klotho gene attenuates the progression of hypertension and heart damage in spontaneous hypertensive rats]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012;29:662-8 pubmed publisher
    To assess the effect of Klotho gene transduction on the progression of hypertension and heart damage in spontaneous hypertensive rats (SHRs). An adeno-associated virus (AAV) carrying full-length mouse Klotho cDNA (rAAV...
  26. Hiyama A, Arai F, Sakai D, Yokoyama K, Mochida J. The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells. Arthritis Res Ther. 2012;14:R105 pubmed publisher
    ..We investigated the expression of Klotho, a newly identified antiaging gene, and whether its regulation is attributable to the suppression of Wnt signaling...
  27. Kosakai A, Ito D, Nihei Y, Yamashita S, Okada Y, Takahashi K, et al. Degeneration of mesencephalic dopaminergic neurons in klotho mouse related to vitamin D exposure. Brain Res. 2011;1382:109-17 pubmed publisher
    ..However, no consensus exists regarding how advancing age may predispose the dopaminergic system to PD. The Klotho-insufficient (klotho) mouse exhibits a syndrome that resembles human aging...
  28. Saito K, Ishizaka N, Mitani H, Ohno M, Nagai R. Iron chelation and a free radical scavenger suppress angiotensin II-induced downregulation of klotho, an anti-aging gene, in rat. FEBS Lett. 2003;551:58-62 pubmed
    Administration of angiotensin II to rats decreases renal expression of klotho, an aging-related gene, and also causes abnormal iron deposition in renal cells...
  29. Wu X, Lemon B, Li X, Gupte J, Weiszmann J, Stevens J, et al. C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors. J Biol Chem. 2008;283:33304-9 pubmed publisher
    ..To determine the mechanism regulating the binding and specificity among FGF19 subfamily members to Klotho family proteins, chimeric proteins between FGF19 subfamily members or chimeric proteins between Klotho family ..
  30. Aizawa H, Saito Y, Nakamura T, Inoue M, Imanari T, Ohyama Y, et al. Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats. Biochem Biophys Res Commun. 1998;249:865-71 pubmed
    We recently reported the isolation of the klotho gene, which in predominantly expressed in the kidney and involved in human aging phenotypes...
  31. Nagai R, Saito Y, Ohyama Y, Aizawa H, Suga T, Nakamura T, et al. Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases. Cell Mol Life Sci. 2000;57:738-46 pubmed
    ..We recently identified the klotho gene as a possible regulator of human aging...
  32. Lorenzi O, Veyrat Durebex C, Wollheim C, Villemin P, Rohner Jeanrenaud F, Zanchi A, et al. Evidence against a direct role of klotho in insulin resistance. Pflugers Arch. 2010;459:465-73 pubmed publisher
    The klotho gene may be involved in the aging process. Klotho is a coactivator of FGF23, a regulator of phosphate and vitamin D metabolism...
  33. Imura A, Iwano A, Tohyama O, Tsuji Y, Nozaki K, Hashimoto N, et al. Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett. 2004;565:143-7 pubmed
    b>Klotho mutant mice exhibit a set of phenotypes resembling human ageing. Although the function of Klotho remains unclear, mediation of its pleiotropic functions by putative humoral factor(s) has been presumed...
  34. Clinton S, Glover M, Maltare A, Laszczyk A, Mehi S, Simmons R, et al. Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood. Brain Res. 2013;1527:1-14 pubmed publisher
    Without the age-regulating protein klotho, mouse lifespan is shortened and the rapid onset of age-related disorders occurs. Conversely, overexpression of klotho extends mouse lifespan...
  35. Yu L, Meng W, Ding J, Cheng M. Klotho inhibits angiotensin II-induced cardiomyocyte hypertrophy through suppression of the AT1R/beta catenin pathway. Biochem Biophys Res Commun. 2016;473:455-61 pubmed publisher
    Myocardial hypertrophy is an independent risk factor for cardiac morbidity and mortality. The antiaging protein klotho reportedly possesses a protective role in cardiac diseases...
  36. Chang J, Guo J, Wang Y, Hou Y, Lu W, Zhang J, et al. Intermedin1-53 attenuates vascular calcification in rats with chronic kidney disease by upregulation of α-Klotho. Kidney Int. 2016;89:586-600 pubmed publisher
    Deficiency in α-Klotho is involved in the pathogenesis of vascular calcification...
  37. Chen C, Sloane J, Li H, Aytan N, Giannaris E, Zeldich E, et al. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci. 2013;33:1927-39 pubmed publisher
    ..myelin abnormalities characterize the normal aging process of the brain and that an age-associated reduction in Klotho is conserved across species...
  38. Tang R, Zhou Q, Ao X, Peng W, Veeraragoo P, Tang T. Fosinopril and losartan regulate klotho gene and nicotinamide adenine dinucleotide phosphate oxidase expression in kidneys of spontaneously hypertensive rats. Kidney Blood Press Res. 2011;34:350-7 pubmed publisher
    b>Klotho, a newly identified antiaging gene, predominantly detected in the kidney, has pleiotropic protective effects on kidney diseases. Several studies have confirmed the association between Klotho and oxidative stress...
  39. Inoue S, Sato T, Suzuki Utsunomiya K, Komori Y, Hozumi K, Chiba T, et al. Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice. Shock. 2013;39:311-6 pubmed publisher
    ..b>Klotho knockout mice (Klotho mice) are a mouse model of accelerated aging and shortened life span...
  40. Cheng M, Chen L, Cheng J. Decrease of Klotho in the kidney of streptozotocin-induced diabetic rats. J Biomed Biotechnol. 2010;2010:513853 pubmed publisher
    The klotho gene is expressed in a limited number of tissues, most notably in distal convoluted tubules in the kidney and choroid plexus in the brain. A previous study suggested that Klotho increases resistance to oxidative stress...
  41. Tang R, Zhou Q, Liu Z, Xiao Z, Pouranan V. Effects of fosinopril and losartan on renal Klotho expression and oxidative stress in spontaneously hypertensive rats. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011;36:27-33 pubmed publisher
    To explore effects of fosinopril and losartan on renal Klotho expression and oxidative stress in spontaneously hypertensive rats (SHR) and the mechanisms underlying the protection against renal damage...
  42. Shimizu M, Volpini R, de Bragança A, Campos R, Canale D, Sanches T, et al. N-acetylcysteine attenuates renal alterations induced by senescence in the rat. Exp Gerontol. 2013;48:298-303 pubmed publisher
    ..together with Western blotting of kidney tissue for NKCC2, aquaporin 2 (AQP2), urea transporter A1 (UT-A1) and Klotho protein...
  43. Shimizu H, Bolati D, Adijiang A, Adelibieke Y, Muteliefu G, Enomoto A, et al. Indoxyl sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor-?B. Am J Nephrol. 2011;33:319-24 pubmed publisher
    b>Klotho, an anti-aging gene, is expressed in the kidneys, and its renal expression is decreased in chronic kidney disease (CKD)...
  44. Li X, Zhou Q. [Effect of valsartan on ultrastructure in the brain tissue and expression of Klotho gene in spontaneously hypertensive rats]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010;35:254-61 pubmed publisher
    To observe the effect of valsartan on brian ultrastructure, Klotho gene and micro-inflammatory factor [intercellular adhesion molecule-1(ICAM-1) and vascular cell adhesion molecule-l(VCAM-1)] expression in spontaneously hypertensive rat ..
  45. Takeshita K, Fujimori T, Kurotaki Y, Honjo H, Tsujikawa H, Yasui K, et al. Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. Circulation. 2004;109:1776-82 pubmed
    Homozygous mutant mice with a defect of klotho gene expression (kl/kl) show multiple age-related disorders and premature death from unknown causes...
  46. Chen T, Kuro O M, Chen C, Sue Y, Chen Y, Wu H, et al. The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice. Eur J Pharmacol. 2013;698:67-73 pubmed publisher
    b>Klotho was identified as the responsible gene in a mutant mouse line whose disruption results in a variety of premature aging-related phenotypes. Nonetheless, the related mechanisms were still unknown...
  47. Deng M, Luo Y, Li Y, Yang Q, Deng X, Wu P, et al. Klotho gene delivery ameliorates renal hypertrophy and fibrosis in streptozotocin-induced diabetic rats by suppressing the Rho-associated coiled-coil kinase signaling pathway. Mol Med Rep. 2015;12:45-54 pubmed publisher
    The present study aimed to investigate whether klotho gene delivery attenuated renal hypertrophy and fibrosis in streptozotocin-induced diabetic rats...
  48. Panesso M, Shi M, Cho H, Paek J, Ye J, Moe O, et al. Klotho has dual protective effects on cisplatin-induced acute kidney injury. Kidney Int. 2014;85:855-70 pubmed publisher
    b>Klotho protects the kidney from ischemia-reperfusion injury, but its effect on nephrotoxins is unknown. Here we determined whether Klotho protects the kidney from cisplatin toxicity...
  49. Kuang X, Chen Y, Wang L, Li Y, Liu K, Zhang M, et al. Klotho upregulation contributes to the neuroprotection of ligustilide in an Alzheimer's disease mouse model. Neurobiol Aging. 2014;35:169-78 pubmed publisher
    b>Klotho, an aging-suppressor gene, encodes a protein that potentially acts as a neuroprotective factor by modulating insulin-like growth factor 1 signaling and oxidative stress...
  50. Zanchi C, Locatelli M, Benigni A, Corna D, Tomasoni S, Rottoli D, et al. Renal expression of FGF23 in progressive renal disease of diabetes and the effect of ACE inhibitor. PLoS ONE. 2013;8:e70775 pubmed publisher
    ..23 (FGF23) is a phosphaturic hormone mainly produced by bone that acts in the kidney through FGF receptors and Klotho. Here we investigated whether the kidney was an additional source of FGF23 during renal disease using a model of ..
  51. Mori K, Yahata K, Mukoyama M, Suganami T, Makino H, Nagae T, et al. Disruption of klotho gene causes an abnormal energy homeostasis in mice. Biochem Biophys Res Commun. 2000;278:665-70 pubmed
    b>klotho mice, which genetically lack klotho gene expression, are characterized with various systemic phenotypes resembling human aging, and also with growth retardation...
  52. Lin S, Zhou Q, Zhan F, Chen D, Li W. [Fosinopril up-regulates and ameliorates the Ang II induced down-expression of klotho gene in NRK-52E]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2010;26:348-51 pubmed
    To investigate the effect of fosinopril (Fos) on regulating klotho gene expression and elucidate the mechanism of Fos regulating the Angiotensin II (AngII) -induced down-expression of klotho gene...
  53. Saito Y, Nakamura T, Ohyama Y, Suzuki T, Iida A, Shiraki Iida T, et al. In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Biochem Biophys Res Commun. 2000;276:767-72 pubmed
    The klotho gene, originally identified by insertional mutagenesis in mice, suppresses multiple aging phenotypes (e.g., arteriosclerosis, pulmonary emphysema, osteoporosis, infertility, and short life span)...
  54. Zuo Z, Lei H, Wang X, Wang Y, Sonntag W, Sun Z. Aging-related kidney damage is associated with a decrease in klotho expression and an increase in superoxide production. Age (Dordr). 2011;33:261-74 pubmed publisher
    The purpose of this study was to determine changes in klotho, endothelin (ET) receptors, and superoxide production in kidneys of aged rats and whether these changes are exacerbated in aged rats with cognitive impairment...
  55. Chen L, Cheng M, Ku P, Cheng J. Cerebral klotho protein as a humoral factor for maintenance of baroreflex. Horm Metab Res. 2015;47:125-32 pubmed publisher
    The klotho protein produced by the choroid plexus is known as a humoral factor in central nervous system. Many hormones affecting the baroreflex sensitivity have been introduced in the brain...
  56. Arking D, Krebsova A, Macek M, Arking A, Mian I, Fried L, et al. Association of human aging with a functional variant of klotho. Proc Natl Acad Sci U S A. 2002;99:856-61 pubmed
    Mice deficient in Klotho gene expression exhibit a syndrome resembling premature human aging...
  57. Fletcher J, Meers G, Laughlin M, Ibdah J, Thyfault J, Rector R. Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction. Appl Physiol Nutr Metab. 2012;37:1054-62 pubmed publisher
    ..2 (FGFR2, mRNA expression), hepatic FGF-21 receptor substrate 2 (FRS2, protein content), and co-receptor ?-Klotho (protein content) - were all elevated (60%-100%, ~40%, and +30%-50%, respectively) in the OLETF-EX and OLETF-CR ..