Gene Symbol: Kif5c
Description: kinesin family member 5C
Alias: kinesin heavy chain isoform 5C, kinesin heavy chain, kinesin heavy chain neuron-specific 2
Species: rat
Products:     Kif5c

Top Publications

  1. Kozielski F, Sack S, Marx A, Thormählen M, Schonbrunn E, Biou V, et al. The crystal structure of dimeric kinesin and implications for microtubule-dependent motility. Cell. 1997;91:985-94 pubmed
    ..This arrangement is unexpected since it is not compatible with the microtubule lattice. In this arrangement, the two heads of a kinesin dimer could not have equivalent interactions with microtubules. ..
  2. Verhey K, Meyer D, Deehan R, Blenis J, Schnapp B, Rapoport T, et al. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. J Cell Biol. 2001;152:959-70 pubmed
  3. Zivraj K, Rehbein M, Ölschläger Schütt J, Schob C, Falley K, Buck F, et al. The RNA-binding protein MARTA2 regulates dendritic targeting of MAP2 mRNAs in rat neurons. J Neurochem. 2013;124:670-84 pubmed publisher
    ..Thus, in neurons MARTA2 appears to represent a key trans-acting factor involved in KIF5-mediated dendritic targeting of MAP2 mRNAs. ..
  4. Brickley K, Smith M, Beck M, Stephenson F. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. J Biol Chem. 2005;280:14723-32 pubmed
    ..GRIF-1 and OIP106 were shown by co-immunoprecipitation to be specifically associated with an endogenous kinesin heavy chain species of 115 kDa and exogenous KIF5C...
  5. Wang X, Schwarz T. The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility. Cell. 2009;136:163-74 pubmed publisher
    ..Disrupting Ca(2+)-dependent regulation diminishes neuronal resistance to excitotoxicity. ..
  6. Kindler S, Dieterich D, Schütt J, Sahin J, Karpova A, Mikhaylova M, et al. Dendritic mRNA targeting of Jacob and N-methyl-d-aspartate-induced nuclear translocation after calpain-mediated proteolysis. J Biol Chem. 2009;284:25431-40 pubmed publisher
    ..Our data suggest that local synthesis in dendrites may be necessary to replenish dendritic Jacob pools after truncation of the N-terminal membrane anchor and concomitant translocation of Jacob to the nucleus. ..
  7. Sanger A, Yip Y, Randall T, Pernigo S, Steiner R, Dodding M. SKIP controls lysosome positioning using a composite kinesin-1 heavy and light chain-binding domain. J Cell Sci. 2017;130:1637-1651 pubmed publisher
    ..Thus, cargo recognition and concurrent activation of kinesin-1 proceed in hierarchical stepwise fashion driven by a dynamic network of inter- and intra-molecular interactions. ..
  8. Lin M, Sheng Z. Regulation of mitochondrial transport in neurons. Exp Cell Res. 2015;334:35-44 pubmed publisher
    ..The review focuses on microtubule (MT)-based mitochondrial trafficking and anchoring. Additional insight from different perspectives can be found in other in-depth reviews. ..
  9. Kaul N, Soppina V, Verhey K. Effects of ?-tubulin K40 acetylation and detyrosination on kinesin-1 motility in a purified system. Biophys J. 2014;106:2636-43 pubmed publisher
    ..Thus, additional mechanisms for regulating kinesin-1 transport in cells must be explored in future work...

More Information


  1. Ma B, Savas J, Yu M, Culver B, Chao M, Tanese N. Huntingtin mediates dendritic transport of ?-actin mRNA in rat neurons. Sci Rep. 2011;1:140 pubmed publisher
    ..These findings support a role for Htt in participating in the mRNA transport machinery that also contains HAP1, KIF5A, and dynein. ..
  2. Hammond J, Huang C, Kaech S, Jacobson C, Banker G, Verhey K. Posttranslational modifications of tubulin and the polarized transport of kinesin-1 in neurons. Mol Biol Cell. 2010;21:572-83 pubmed publisher
  3. Yang J, Li T. The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos. Exp Cell Res. 2005;309:379-89 pubmed
    ..These findings indicate that ciliary rootlets may provide a scaffold for kinesin-1 vesicular cargos and, thus, play a role in the intracellular transport in ciliated cells. ..
  4. Kanai Y, Okada Y, Tanaka Y, Harada A, Terada S, Hirokawa N. KIF5C, a novel neuronal kinesin enriched in motor neurons. J Neurosci. 2000;20:6374-84 pubmed
    ..In the present work, we cloned a novel member of KIF5, KIF5C, and generated specific antibodies against three KIF5s to investigate their distribution and functions...
  5. Bergen S, O Dushlaine C, Lee P, Fanous A, Ruderfer D, Ripke S, et al. Genetic modifiers and subtypes in schizophrenia: investigations of age at onset, severity, sex and family history. Schizophr Res. 2014;154:48-53 pubmed publisher
    ..002). Family history positive analyses showed the greatest association with KIF5C (p=1.96×10(-8)), however, genetic risk burden overall does not differ by family history...
  6. Iworima D, Pasqualotto B, Rintoul G. Kif5 regulates mitochondrial movement, morphology, function and neuronal survival. Mol Cell Neurosci. 2016;72:22-33 pubmed publisher
    ..We evaluated the consequences of disrupted kif5c-mediated mitochondrial trafficking on mitochondrial form and function in primary rat cortical neurons...
  7. Sack S, Muller J, Marx A, Thormählen M, Mandelkow E, Brady S, et al. X-ray structure of motor and neck domains from rat brain kinesin. Biochemistry. 1997;36:16155-65 pubmed
    ..B., et al. (1997) Cell 90, 959-966], take the form of beta-strands attached to the central beta-sheet of the structure. ..
  8. Bae S, Kim Y, Lee J, Namkoong S, Kim C, Ahn W. Expression profiling of the cellular processes in uterine leiomyomas: omic approaches and IGF-2 association with leiomyosarcomas. Cancer Res Treat. 2004;36:31-42 pubmed publisher
    ..The CDKN2A, ADH1A, DCX, IGF2, CRABP2 and KIF5C were found to increase the reliability of this study, and correlate with the leiomyosarcomas...
  9. Kuzma Kozakiewicz M, Chudy A, Gajewska B, Dziewulska D, Usarek E, Baranczyk Kuzma A. Kinesin expression in the central nervous system of humans and transgenic hSOD1G93A mice with amyotrophic lateral sclerosis. Neurodegener Dis. 2013;12:71-80 pubmed publisher
    ..Disturbances in kinesin expression in the CNS may dysregulate both anterograde and retrograde axonal transports leading to motor neuron degeneration. ..
  10. Sepulveda Falla D, Barrera Ocampo A, Hagel C, Korwitz A, Vinueza Veloz M, Zhou K, et al. Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis. J Clin Invest. 2014;124:1552-67 pubmed publisher
    ..Ca2+ channels IP3Rs and CACNA1A were downregulated, and Ca2+-dependent mitochondrial transport proteins MIRO1 and KIF5C were reduced...
  11. Falley K, Schütt J, Iglauer P, Menke K, Maas C, Kneussel M, et al. Shank1 mRNA: dendritic transport by kinesin and translational control by the 5'untranslated region. Traffic. 2009;10:844-57 pubmed publisher
    ..particles (mRNPs) containing shank1 mRNAs associates with the cargo-binding domain of the motor protein KIF5C. Through expression of dominant negative proteins, we show that dendritic targeting of shank1 mRNA granules ..
  12. Lockhart A, Crevel I, Cross R. Kinesin and ncd bind through a single head to microtubules and compete for a shared MT binding site. J Mol Biol. 1995;249:763-71 pubmed
    ..We have used recombinant single-headed and double-headed constructs of both rat kinesin heavy chain and non claret disjunctional to investigate the interactions of these motor proteins with microtubules...
  13. Junco A, Bhullar B, Tarnasky H, van der Hoorn F. Kinesin light-chain KLC3 expression in testis is restricted to spermatids. Biol Reprod. 2001;64:1320-30 pubmed
    ..of the three known KHCs and KLC3 differ significantly: Kif5a and Kif5b are not expressed after meiosis, and Kif5c is expressed at an extremely low level in spermatids but is not detectable in sperm tails...
  14. Cho K, Cai Y, Yi H, Yeh A, Aslanukov A, Ferreira P. Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function. Traffic. 2007;8:1722-35 pubmed the central nervous system (CNS), and directly, with the ubiquitous and CNS-specific kinesins, KIF5B and KIF5C, respectively, but not with the highly homologous KIF5A...