Gene Symbol: Kif5a
Description: kinesin family member 5A
Alias: kinesin heavy chain isoform 5A, NKHC, kinesin heavy chain neuron-specific 1, neuronal kinesin heavy chain
Species: rat
Products:     Kif5a

Top Publications

  1. Macioce P, Gambara G, Bernassola M, Gaddini L, Torreri P, Macchia G, et al. Beta-dystrobrevin interacts directly with kinesin heavy chain in brain. J Cell Sci. 2003;116:4847-56 pubmed
    ..Four overlapping clones were identified that encoded Kif5A, a neuronal member of the Kif5 family of proteins that consists of the heavy chains of conventional kinesin...
  2. Setou M, Seog D, Tanaka Y, Kanai Y, Takei Y, Kawagishi M, et al. Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites. Nature. 2002;417:83-7 pubmed
    ..These results indicate that directly binding proteins can determine the traffic direction of a motor protein. ..
  3. Reid E, Kloos M, Ashley Koch A, Hughes L, Bevan S, Svenson I, et al. A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). Am J Hum Genet. 2002;71:1189-94 pubmed
    We have identified a missense mutation in the motor domain of the neuronal kinesin heavy chain gene KIF5A, in a family with hereditary spastic paraplegia...
  4. Liu M, Nadar V, Kozielski F, Kozlowska M, Yu W, Baas P. Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching. J Neurosci. 2010;30:14896-906 pubmed publisher
  5. Twelvetrees A, Yuen E, Arancibia Carcamo I, Macaskill A, Rostaing P, Lumb M, et al. Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin. Neuron. 2010;65:53-65 pubmed publisher
    ..Its disruption by mutant huntingtin may explain some of the defects in brain information processing occurring in Huntington's disease and provides a molecular target for therapeutic approaches. ..
  6. Karle K, Möckel D, Reid E, Schöls L. Axonal transport deficit in a KIF5A( -/- ) mouse model. Neurogenetics. 2012;13:169-79 pubmed publisher
    ..loci have been identified, among them SPG10, an autosomal dominant HSP caused by point mutations in the neuronal kinesin heavy chain protein KIF5A. Constitutive KIF5A knockout (KIF5A( -/- )) mice die early after birth...
  7. Tooker B, Newman L, Bowler R, Karjalainen A, Oksa P, Vainio H, et al. Proteomic detection of cancer in asbestosis patients using SELDI-TOF discovered serum protein biomarkers. Biomarkers. 2011;16:181-91 pubmed publisher
    ..The first two peaks were identified as KIF18A and KIF5A, respectively, and are part of the Kinesin Superfamily of proteins...
  8. Shinoda T, Taya S, Tsuboi D, Hikita T, Matsuzawa R, Kuroda S, et al. DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2. J Neurosci. 2007;27:4-14 pubmed
    ..DISC1 formed a ternary complex with Grb2 and kinesin heavy chain KIF5A of Kinesin-1...
  9. Taya S, Shinoda T, Tsuboi D, Asaki J, Nagai K, Hikita T, et al. DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. J Neurosci. 2007;27:15-26 pubmed
    ..Furthermore, the knockdown of NUDEL or LIS1 inhibited axon elongation. Together, these results indicate that DISC1 regulates the localization of NUDEL/LIS1/14-3-3epsilon complex into the axons as a cargo receptor for axon elongation. ..

More Information


  1. Ma B, Savas J, Yu M, Culver B, Chao M, Tanese N. Huntingtin mediates dendritic transport of ?-actin mRNA in rat neurons. Sci Rep. 2011;1:140 pubmed publisher
    ..that Htt and the huntingtin-associated protein 1 (HAP1) are co-localized with the microtubule motor proteins, the KIF5A kinesin and dynein, during dendritic transport of ?-actin mRNA...
  2. Danoy P, Wei M, Johanna H, Jiang L, He D, Sun L, et al. Association of variants in MMEL1 and CTLA4 with rheumatoid arthritis in the Han Chinese population. Ann Rheum Dis. 2011;70:1793-7 pubmed publisher
    ..and CTLA4, and modest association was identified for another six loci: PADI4, STAT4, PRDM1, CDK6, TRAF1-C5 and KIF5A-PIP4K2C. All three markers genotyped in MMEL1 demonstrated association, with peak signal for rs3890745 (p=2...
  3. Schule R, Kremer B, Kassubek J, Auer Grumbach M, Kostic V, Klopstock T, et al. SPG10 is a rare cause of spastic paraplegia in European families. J Neurol Neurosurg Psychiatry. 2008;79:584-7 pubmed publisher
    ..form of hereditary spastic paraplegia (HSP), which is caused by mutations in the neural kinesin heavy chain KIF5A gene, the neuronal motor of fast anterograde axonal transport. Only four mutations have been identified to date...
  4. Baptista F, Pinto M, Elvas F, Almeida R, Ambrósio A. Diabetes alters KIF1A and KIF5B motor proteins in the hippocampus. PLoS ONE. 2013;8:e65515 pubmed publisher
  5. Romero A, Renau Piqueras J, Marín M, Esteban Pretel G. Chronic alcohol exposure affects the cell components involved in membrane traffic in neuronal dendrites. Neurotox Res. 2015;27:43-54 pubmed publisher
  6. Vignali G, Niclas J, Sprocati M, Vale R, Sirtori C, Navone F. Differential expression of ubiquitous and neuronal kinesin heavy chains during differentiation of human neuroblastoma and PC12 cells. Eur J Neurosci. 1996;8:536-44 pubmed
    ..Our results suggest that these cells represent an adequate model to study the function of conventional kinesin and its isoforms. ..
  7. Melo T, D unhao A, Martins S, Farizatto K, Chaves R, Ferrari M. Rotenone-dependent changes of anterograde motor protein expression and mitochondrial mobility in brain areas related to neurodegenerative diseases. Cell Mol Neurobiol. 2013;33:327-35 pubmed publisher
    ..These findings suggest that change in intracellular trafficking might be critical and one of the primary events for impairment of cell physiology during neurodegeneration associated with protein inclusions. ..
  8. Lynch D, Koutsis G, Tucci A, Panas M, Baklou M, Breza M, et al. Hereditary spastic paraplegia in Greece: characterisation of a previously unexplored population using next-generation sequencing. Eur J Hum Genet. 2016;24:857-63 pubmed publisher
    ..We made a genetic diagnosis in >50% of cases and identified 11 novel variants. Variants in SPAST and KIF5A were the most common causes of autosomal dominant HSP, whereas SPG11 and CYP7B1 were the most common cause of ..
  9. Nakajima K, Yin X, Takei Y, Seog D, Homma N, Hirokawa N. Molecular motor KIF5A is essential for GABA(A) receptor transport, and KIF5A deletion causes epilepsy. Neuron. 2012;76:945-61 pubmed publisher
    KIF5 (also known as kinesin-1) family members, consisting of KIF5A, KIF5B, and KIF5C, are microtubule-dependent molecular motors that are important for neuronal function...
  10. Oh J, Kwon A, Jo A, Kim H, Goo Y, Lee J, et al. Activity-dependent synaptic localization of processing bodies and their role in dendritic structural plasticity. J Cell Sci. 2013;126:2114-23 pubmed publisher
    ..which are involved in mRNA degradation or storage, are transported to dendrites by conventional kinesin (KIF5A) as a motor protein...
  11. Kuzma Kozakiewicz M, Chudy A, Gajewska B, Dziewulska D, Usarek E, Baranczyk Kuzma A. Kinesin expression in the central nervous system of humans and transgenic hSOD1G93A mice with amyotrophic lateral sclerosis. Neurodegener Dis. 2013;12:71-80 pubmed publisher
    ..The purpose of the study was to investigate and compare the expression of kinesins involved in anterograde (KIF5A, 5C) and retrograde (KIFC3/C2) axonal transport in SALS in humans and FALS in mice with the hSOD1G93A mutation...
  12. Carosi L, Lo Giudice T, Di Lullo M, Lombardi F, Babalini C, Gaudiello F, et al. Hereditary spastic paraplegia: a novel mutation and expansion of the phenotype variability in SPG10. J Neurol Neurosurg Psychiatry. 2015;86:702-4 pubmed publisher
  13. Matsuzaki F, Shirane M, Matsumoto M, Nakayama K. Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. Mol Biol Cell. 2011;22:4602-20 pubmed publisher
    ..Given that mutation of protrudin or KIF5 is a cause of human hereditary spastic paraplegia, the protrudin-KIF5 axis appears to be integral to neuronal function. ..
  14. Yang J, Li T. The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos. Exp Cell Res. 2005;309:379-89 pubmed
    ..These findings indicate that ciliary rootlets may provide a scaffold for kinesin-1 vesicular cargos and, thus, play a role in the intracellular transport in ciliated cells. ..
  15. Brickley K, Smith M, Beck M, Stephenson F. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. J Biol Chem. 2005;280:14723-32 pubmed
    ..Further studies revealed that GRIF-1 was predominantly associated with KIF5A in the brain and with KIF5B in both the heart and in HEK 293 cells...
  16. Vignali G, Lizier C, Sprocati M, Sirtori C, Battaglia G, Navone F. Expression of neuronal kinesin heavy chain is developmentally regulated in the central nervous system of the rat. J Neurochem. 1997;69:1840-9 pubmed
  17. Falnikar A, Tole S, Baas P. Kinesin-5, a mitotic microtubule-associated motor protein, modulates neuronal migration. Mol Biol Cell. 2011;22:1561-74 pubmed publisher
    ..In so doing, kinesin-5 regulates the rate and directionality of neuronal migration and possibly the cessation of migration when the neuron reaches its destination. ..
  18. Nadar V, Lin S, Baas P. Microtubule redistribution in growth cones elicited by focal inactivation of kinesin-5. J Neurosci. 2012;32:5783-94 pubmed publisher
  19. Dictenberg J, Swanger S, Antar L, Singer R, Bassell G. A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome. Dev Cell. 2008;14:926-39 pubmed publisher
    ..These findings highlight a mechanism for stimulus-induced dendritic mRNA transport and link its impairment in a mouse model of FXS to altered developmental morphologic plasticity. ..
  20. Ikegami K, Heier R, Taruishi M, Takagi H, Mukai M, Shimma S, et al. Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function. Proc Natl Acad Sci U S A. 2007;104:3213-8 pubmed
    ..These data provide evidence for a role of polyglutamylation of alpha-tubulin in vivo, as a molecular traffic sign for targeting of KIF1 kinesin required for continuous synaptic transmission. ..
  21. Lindberg J, Mills I, Klevebring D, Liu W, Neiman M, Xu J, et al. The mitochondrial and autosomal mutation landscapes of prostate cancer. Eur Urol. 2013;63:702-8 pubmed publisher
    ..or mixed-lineage leukemia 3 (MLL3), lysine (K)-specific demethylase 6A (KDM6A), and kinesin family member 5A (KIF5A) were identified. The mutation rate in the mitochondrial genome was 55 times higher than that of the autosomes...
  22. Fichera M, Lo Giudice M, Falco M, Sturnio M, Amata S, Calabrese O, et al. Evidence of kinesin heavy chain (KIF5A) involvement in pure hereditary spastic paraplegia. Neurology. 2004;63:1108-10 pubmed
    ..Subsequent to a denaturing high performance liquid chromatography (dHPLC) mutation screening we found a new missense mutation 838C>T (R280C) at an invariant arginine residue in a region involved in the microtubule binding activity...
  23. Lin M, Sheng Z. Regulation of mitochondrial transport in neurons. Exp Cell Res. 2015;334:35-44 pubmed publisher
    ..The review focuses on microtubule (MT)-based mitochondrial trafficking and anchoring. Additional insight from different perspectives can be found in other in-depth reviews. ..
  24. Niclas J, Navone F, Hom Booher N, Vale R. Cloning and localization of a conventional kinesin motor expressed exclusively in neurons. Neuron. 1994;12:1059-72 pubmed
    ..thought to serve all cell types, we document here that neurons express a second conventional kinesin heavy chain (nKHC) that is 65% identical in amino acid sequence to the ubiquitously expressed kinesin heavy chain (uKHC)...
  25. Alcina A, Vandenbroeck K, Otaegui D, Saiz A, Gonzalez J, Fernandez O, et al. The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis. Genes Immun. 2010;11:439-45 pubmed publisher
    ..Three SNPs were found to be associated with MS: rs1678542 in KIF5A (P=0.001, odds ratio (OR)=1.13, 95% confidence interval (CI)=1.05-1.23); rs3184504 in SH2B3 (P=0.00001, OR=1...
  26. Jalil S, Bhatti A, Demirci F, Wang X, Ahmed I, Ahmed M, et al. Replication of European rheumatoid arthritis loci in a Pakistani population. J Rheumatol. 2013;40:401-7 pubmed publisher
    ..05E-06 to 3.72E-02, the most significant being the KIF5A-PIP4K2C/rs1678542 SNP...
  27. Muglia M, Citrigno L, D Errico E, Magariello A, Distaso E, Gasparro A, et al. A novel KIF5A mutation in an Italian family marked by spastic paraparesis and congenital deafness. J Neurol Sci. 2014;343:218-20 pubmed publisher
    ..The SPG10 form is due to alteration in the kinesin1A gene (KIF5A) that encodes the neuronal kinesin heavy chain, a protein required for the anterograde axonal transport...