Kif3b

Summary

Gene Symbol: Kif3b
Description: kinesin family member 3B
Alias: kinesin-like protein KIF3B
Species: rat
Products:     Kif3b

Top Publications

  1. Fan J, Beck K. A role for the spectrin superfamily member Syne-1 and kinesin II in cytokinesis. J Cell Sci. 2004;117:619-29 pubmed
    ..An association of this fragment with the C-terminal tail domain of the kinesin II subunit KIF3B was identified by yeast two-hybrid and co-precipitation assays, suggesting that the role of Syne-1 in cytokinesis ..
  2. Haraguchi K, Hayashi T, Jimbo T, Yamamoto T, Akiyama T. Role of the kinesin-2 family protein, KIF3, during mitosis. J Biol Chem. 2006;281:4094-9 pubmed
    ..Furthermore, we found that expression of a mutant KIF3B, which is able to associate with KIF3A but not KAP3 in NIH3T3 cells, caused chromosomal aneuploidy and abnormal ..
  3. Baker S, Freeman K, Luby Phelps K, Pazour G, Besharse J. IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia. J Biol Chem. 2003;278:34211-8 pubmed
    ..IFT20 exhibited a strong interaction with IFT57/Hippi and the kinesin II subunit, KIF3B. Our data indicate that all four mammalian IFT proteins are part of a highly conserved complex in multiple ..
  4. Aguado Fraile E, Ramos E, Sáenz Morales D, Conde E, Blanco Sánchez I, Stamatakis K, et al. miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target. PLoS ONE. 2012;7:e44305 pubmed publisher
    ..In fact, we have identified the Kinesin Family Member 3B (KIF3B), involved in cell trafficking, as a target of miR-127 in rat proximal tubule cells...
  5. Muresan V, Abramson T, Lyass A, Winter D, Porro E, Hong F, et al. KIF3C and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles. Mol Biol Cell. 1998;9:637-52 pubmed
    ..Native KIF3C binds to microtubules in a kinesin-like, nucleotide-dependent manner. KIF3C is most similar to mouse KIF3B and KIF3A, two closely related kinesins that are normally present as a heteromer...
  6. Waters A, Asfahani R, Carroll P, Bicknell L, Lescai F, Bright A, et al. The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes. J Med Genet. 2015;52:147-56 pubmed publisher
    ..Our data identify CENPF as a new centriolar disease gene implicated in severe human ciliopathy and microcephaly related phenotypes. CENP-F has a novel putative function in ciliogenesis and cortical neurogenesis. ..
  7. Insinna C, Humby M, Sedmak T, Wolfrum U, Besharse J. Different roles for KIF17 and kinesin II in photoreceptor development and maintenance. Dev Dyn. 2009;238:2211-22 pubmed publisher
    ..In contrast, dominant-negative KIF17 has no obvious effect on inner segment or synaptic organization but has an immediate impact on outer segment assembly. ..
  8. Aoki T, Ueda S, Kataoka T, Satoh T. Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10. BMC Cell Biol. 2009;10:56 pubmed publisher
    ..We further isolated the kinesin-like motor protein KIF3B as a binding partner of ARHGEF10. Knockdown of KIF3B again caused multipolar spindle phenotypes...
  9. Yu X, Wen H, Cao J, Sun B, Ding T, Li M, et al. Temporal and spatial expression of KIF3B after acute spinal cord injury in adult rats. J Mol Neurosci. 2013;49:387-94 pubmed publisher
    The KIF3 subunit KIF3B was proved to be associated with mitosis. It has been known to be engaged in intracellular transport of neurons...

More Information

Publications10

  1. Broekhuis J, Verhey K, Jansen G. Regulation of cilium length and intraflagellar transport by the RCK-kinases ICK and MOK in renal epithelial cells. PLoS ONE. 2014;9:e108470 pubmed publisher
    ..the effects of ICK and MOK on the IFT machinery, we set up live imaging of five fluorescently tagged IFT proteins: KIF3B, a subunit of kinesin-II, the main anterograde IFT motor, complex A protein IFT43, complex B protein IFT20, BBSome ..