Kif1b

Summary

Gene Symbol: Kif1b
Description: kinesin family member 1B
Alias: kinesin-like protein KIF1B, kinesin-family protein KIF1Bbeta3
Species: rat
Products:     Kif1b

Top Publications

  1. Chen J, Wang Y, Lv W, Gan Y, Chang W, Tian N, et al. Effects of interactions between environmental factors and KIF1B genetic variants on the risk of hepatocellular carcinoma in a Chinese cohort. World J Gastroenterol. 2016;22:4183-90 pubmed publisher
    To examine the effect of the potential interaction between KIF1B variants (rs17401966 and rs3748578) and environmental factors on the risk of hepatocellular carcinoma (HCC) in a high-risk region in China...
  2. Nangaku M, Sato Yoshitake R, Okada Y, Noda Y, Takemura R, Yamazaki H, et al. KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria. Cell. 1994;79:1209-20 pubmed
    ..further elucidate the mechanism of organelle transport, we cloned a novel member of the mouse kinesin superfamily, KIF1B. This N-terminal-type motor protein is expressed ubiquitously in various kinds of tissues...
  3. Nakamura N, Miyake Y, Matsushita M, Tanaka S, Inoue H, Kanazawa H. KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles. J Biochem. 2002;132:483-91 pubmed
    ..KIF1Bbeta2 is a member of the KIF1 subfamily of kinesin-related proteins, and consists of an amino terminal KIF1B-type motor domain followed by a tail region highly similar to that of KIF1A...
  4. Kim E, Niethammer M, Rothschild A, Jan Y, Sheng M. Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Nature. 1995;378:85-8 pubmed
    ..3) and syntrophin), suggest that PDZ-domain-containing polypeptides may be widely involved in the organization of proteins at sites of membrane specialization. ..
  5. Yang S, Wang J, Yu W, Liu Q, Wu Y, Chen S. Downregulation of KIF1B mRNA in hepatocellular carcinoma tissues correlates with poor prognosis. World J Gastroenterol. 2015;21:8418-24 pubmed publisher
    To compare kinesin family member 1B (KIF1B) expression with clinicopathologic parameters and prognosis in hepatocellular carcinoma (HCC) patients...
  6. Shi T, Jiang Z, Jiang R, Yin S, Wang M, Yu K, et al. Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women. Tumour Biol. 2015;36:6919-27 pubmed publisher
    The kinesin-like factor 1 B (KIF1B) gene plays an important role in the process of apoptosis and the transformation and progression of malignant cells. Genetic variations in KIF1B may contribute to risk of epithelial ovarian cancer (EOC)...
  7. Tan Z, Sun X, Hou F, Oh H, Hilgenberg L, Hol E, et al. Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration. Cell Death Differ. 2007;14:1721-32 pubmed
  8. Aulchenko Y, Hoppenbrouwers I, Ramagopalan S, Broer L, Jafari N, Hillert J, et al. Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis. Nat Genet. 2008;40:1402-3 pubmed publisher
    ..An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10))...
  9. Chen Z, Wallis K, Fell S, Sobrado V, Hemmer M, Ramsk├Âld D, et al. RNA helicase A is a downstream mediator of KIF1B? tumor-suppressor function in neuroblastoma. Cancer Discov. 2014;4:434-51 pubmed publisher
    Inherited KIF1B loss-of-function mutations in neuroblastomas and pheochromocytomas implicate the kinesin KIF1B as a 1p36.2 tumor suppressor. However, the mechanism of tumor suppression is unknown...

More Information

Publications20

  1. Booth D, Heard R, Stewart G, Cox M, Scott R, Lechner Scott J, et al. Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis. Nat Genet. 2010;42:469-70; author reply 470-1 pubmed publisher
  2. Mok H, Shin H, Kim S, Lee J, Yoon J, Kim E. Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins. J Neurosci. 2002;22:5253-8 pubmed
    Mutation in KIF1B, a kinesin superfamily motor protein, causes a peripheral neuropathy known as Charcot-Marie-Tooth disease type 2A (CMT2A). Little is known, however, about how a defective KIF1B gene leads to CMT2A...
  3. Lin M, Sheng Z. Regulation of mitochondrial transport in neurons. Exp Cell Res. 2015;334:35-44 pubmed publisher
    ..The review focuses on microtubule (MT)-based mitochondrial trafficking and anchoring. Additional insight from different perspectives can be found in other in-depth reviews. ..
  4. Maximino J, de Oliveira G, Alves C, Chadi G. Deregulated expression of cytoskeleton related genes in the spinal cord and sciatic nerve of presymptomatic SOD1(G93A) Amyotrophic Lateral Sclerosis mouse model. Front Cell Neurosci. 2014;8:148 pubmed publisher
    ..b>Kif1b was the unique deregulated gene in more than one studied region or presymptomatic age...
  5. Melo T, D unhao A, Martins S, Farizatto K, Chaves R, Ferrari M. Rotenone-dependent changes of anterograde motor protein expression and mitochondrial mobility in brain areas related to neurodegenerative diseases. Cell Mol Neurobiol. 2013;33:327-35 pubmed publisher
    ..the present study, we aimed to evaluate mitochondria mobility as well as protein and messenger RNA expression of KIF1B and KIF5 that are molecular motors for neuronal anterograde traffic, in hippocampus, substantia nigra, and locus ..
  6. Matsushita M, Tanaka S, Nakamura N, Inoue H, Kanazawa H. A novel kinesin-like protein, KIF1Bbeta3 is involved in the movement of lysosomes to the cell periphery in non-neuronal cells. Traffic. 2004;5:140-51 pubmed
    The kinesin superfamily protein, KIF1Bbeta, a splice variant of KIF1B, is involved in the transport of synaptic vesicles in neuronal cells, and is also expressed in various non-neuronal tissues...
  7. Faire K, Gruber D, Bulinski J. Identification of kinesin-like molecules in myogenic cells. Eur J Cell Biol. 1998;77:27-34 pubmed
    ..The second molecule identified is a rat homolog of murine KIF1B, a putative mitochondrial transporter...
  8. Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, et al. Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell. 2001;105:587-97 pubmed
    The kinesin superfamily motor protein KIF1B has been shown to transport mitochondria. Here, we describe an isoform of KIF1B, KIF1Bbeta, that is distinct from KIF1B in its cargo binding domain...
  9. Matsushita M, Yamamoto R, Mitsui K, Kanazawa H. Altered motor activity of alternative splice variants of the mammalian kinesin-3 protein KIF1B. Traffic. 2009;10:1647-54 pubmed publisher
    ..However, the roles of many motor protein splice variants remain unclear. The kinesin-3 motor protein KIF1B has alternatively spliced isoforms distinguished by the presence or absence of insertion sequences in the ..
  10. Chung C, Koprich J, Siddiqi H, Isacson O. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. J Neurosci. 2009;29:3365-73 pubmed publisher
    ..Levels of anterograde transport motor proteins (KIF1A, KIF1B, KIF2A, and KIF3A) were decreased in the striatum, whereas retrograde motor proteins (dynein, dynamitin, and ..
  11. Pantelidou M, Zographos S, Lederer C, Kyriakides T, Pfaffl M, Santama N. Differential expression of molecular motors in the motor cortex of sporadic ALS. Neurobiol Dis. 2007;26:577-89 pubmed
    ..No mutations causing splicing defects or altering protein-coding sequences were identified in the genes of the three proteins. The present study implicates two motor proteins as possible candidates in SALS pathology. ..