Kdm7a

Summary

Gene Symbol: Kdm7a
Description: lysine demethylase 7A
Alias: Jhdm1d, lysine-specific demethylase 7A, jumonji C domain containing histone demethylase 1, lysine (K)-specific demethylase 7A
Species: rat
Products:     Kdm7a

Top Publications

  1. Horton J, Upadhyay A, Qi H, Zhang X, Shi Y, Cheng X. Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases. Nat Struct Mol Biol. 2010;17:38-43 pubmed publisher
    ..repressive marks, is differentially 'read' by two related human demethylases, PHF8 and KIAA1718 (also known as JHDM1D)...
  2. Tsukada Y, Ishitani T, Nakayama K. KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development. Genes Dev. 2010;24:432-7 pubmed publisher
    ..Our findings identify KDM7 as a dual demethylase for H3K9 and H3K27 that functions as an eraser of silencing marks on chromatin during brain development...
  3. Qi H, Sarkissian M, Hu G, Wang Z, Bhattacharjee A, Gordon D, et al. Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature. 2010;466:503-7 pubmed publisher
    ..Our findings indicate that an imbalance of histone methylation dynamics has a critical role in XLMR. ..
  4. Osawa T, Muramatsu M, Wang F, Tsuchida R, Kodama T, Minami T, et al. Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via down-regulating angiogenesis. Proc Natl Acad Sci U S A. 2011;108:20725-9 pubmed publisher
    Histone demethylase JHDM1D (also known as KDM7A) modifies the level of methylation in histone and participates in epigenetic gene regulation; however, the role of JHDM1D in tumor progression is unknown...