Kcnq2

Summary

Gene Symbol: Kcnq2
Description: potassium voltage-gated channel subfamily Q member 2
Alias: potassium voltage-gated channel subfamily KQT member 2, KQT-like 2, potassium channel subunit alpha KvLQT2, potassium channel, voltage-gated KQT-like subfamily Q, member 2, potassium voltage-gated channel, KQT-like subfamily, member 2, voltage-gated potassium channel subunit Kv7.2
Species: rat
Products:     Kcnq2

Top Publications

  1. Wladyka C, Feng B, Glazebrook P, Schild J, Kunze D. The KCNQ/M-current modulates arterial baroreceptor function at the sensory terminal in rats. J Physiol. 2008;586:795-802 pubmed
    ..immunohistochemistry and an isolated aortic arch preparation were used to demonstrate the presence and function of KCNQ2, KCNQ3 and KCNQ5 channels in aortic baroreceptors...
  2. Schwarz J, Glassmeier G, Cooper E, Kao T, Nodera H, Tabuena D, et al. KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of Ranvier. J Physiol. 2006;573:17-34 pubmed
    Mutations that reduce the function of KCNQ2 channels cause neuronal hyperexcitability, manifested as epileptic seizures and myokymia...
  3. Wang H, Pan Z, Shi W, Brown B, Wymore R, Cohen I, et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science. 1998;282:1890-3 pubmed
    ..The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined...
  4. Hoshi N, Zhang J, Omaki M, Takeuchi T, Yokoyama S, Wanaverbecq N, et al. AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Nat Neurosci. 2003;6:564-71 pubmed
    M-type (KCNQ2/3) potassium channels are suppressed by activation of G(q/11)-coupled receptors, thereby increasing neuronal excitability. We show here that rat KCNQ2 can bind directly to the multivalent A-kinase-anchoring protein AKAP150...
  5. Rasmussen H, Frøkjaer Jensen C, Jensen C, Jensen H, Jørgensen N, Misonou H, et al. Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment. J Cell Sci. 2007;120:953-63 pubmed
    The potassium channel subunits KCNQ2 and KCNQ3 are believed to underlie the M current of hippocampal neurons...
  6. Kosenko A, Kang S, Smith I, Greene D, Langeberg L, Scott J, et al. Coordinated signal integration at the M-type potassium channel upon muscarinic stimulation. EMBO J. 2012;31:3147-56 pubmed publisher
    ..PKC phosphorylation of the KCNQ2 channel subunit induces dissociation of calmodulin from the M-channel complex...
  7. Watanabe H, Nagata E, Kosakai A, Nakamura M, Yokoyama M, Tanaka K, et al. Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability. J Neurochem. 2000;75:28-33 pubmed
    ..Recently, two novel voltage-dependent potassium channel genes, KCNQ2 and KCNQ3, were identified by positional cloning as being responsible for BFNC...
  8. Yus Najera E, Santana Castro I, Villarroel A. The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels. J Biol Chem. 2002;277:28545-53 pubmed
    ..CaM co-immunoprecipitates with KCNQ2, KCNQ3, or KCNQ5 subunits better in the absence than in the presence of Ca2+...
  9. Pan Z, Selyanko A, Hadley J, Brown D, Dixon J, McKinnon D. Alternative splicing of KCNQ2 potassium channel transcripts contributes to the functional diversity of M-currents. J Physiol. 2001;531:347-58 pubmed
    The region of alternative splicing in the KCNQ2 potassium channel gene was determined by RNase protection analysis of KCNQ2 mRNA transcripts...

More Information

Publications37

  1. Wen H, Levitan I. Calmodulin is an auxiliary subunit of KCNQ2/3 potassium channels. J Neurosci. 2002;22:7991-8001 pubmed
    Calmodulin (CaM) was identified as a KCNQ2 and KCNQ3 potassium channel-binding protein, using a yeast two-hybrid screen...
  2. Shahidullah M, Santarelli L, Wen H, Levitan I. Expression of a calmodulin-binding KCNQ2 potassium channel fragment modulates neuronal M-current and membrane excitability. Proc Natl Acad Sci U S A. 2005;102:16454-9 pubmed
    b>KCNQ2 and KCNQ3 ion channel pore-forming subunits coassemble to form a heteromeric voltage-gated potassium channel that underlies the neuronal M-current...
  3. Pan Z, Kao T, Horvath Z, Lemos J, Sul J, Cranstoun S, et al. A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. J Neurosci. 2006;26:2599-613 pubmed
    ..Here, antibodies against four different KCNQ2 and KCNQ3 polypeptide epitopes show these subunits concentrated at the axonal initial segment (AIS) and node of ..
  4. Schwake M, Pusch M, Kharkovets T, Jentsch T. Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy. J Biol Chem. 2000;275:13343-8 pubmed
    Mutations in either KCNQ2 or KCNQ3 underlie benign familial neonatal convulsions (BFNC), an inherited epilepsy. The corresponding proteins are co-expressed in broad regions of the brain and associate to heteromeric K(+) channels...
  5. Ekberg J, Schuetz F, Boase N, Conroy S, Manning J, Kumar S, et al. Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2. J Biol Chem. 2007;282:12135-42 pubmed
    ..The M-current is mediated by heteromeric channels consisting of KCNQ3 subunits in association with either KCNQ2 or KCNQ5 subunits...
  6. Chung H, Jan Y, Jan L. Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains. Proc Natl Acad Sci U S A. 2006;103:8870-5 pubmed
    The M channels, important regulators of neuronal excitability, are voltage-gated potassium channels composed of KCNQ2-5 subunits...
  7. Shah M, Mistry M, Marsh S, Brown D, Delmas P. Molecular correlates of the M-current in cultured rat hippocampal neurons. J Physiol. 2002;544:29-37 pubmed
    ..In sympathetic neurons, M-channels are thought to be composed of a heteromeric assembly of KCNQ2 and KCNQ3 K(+) channel subunits...
  8. Martire M, D Amico M, Panza E, Miceli F, Viggiano D, Lavergata F, et al. Involvement of KCNQ2 subunits in [3H]dopamine release triggered by depolarization and pre-synaptic muscarinic receptor activation from rat striatal synaptosomes. J Neurochem. 2007;102:179-93 pubmed
    b>KCNQ2 and KCNQ3 subunits encode for the muscarinic-regulated current (I(KM)), a sub-threshold voltage-dependent K+ current regulating neuronal excitability...
  9. Ohya S, Asakura K, Muraki K, Watanabe M, Imaizumi Y. Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2002;282:G277-87 pubmed
    ..The membrane depolarization by 1 microM E-4031 indicates the contribution of K(+) channels encoded by ERG1/KCNE2 to the resting membrane potential in stomach SMCs...
  10. Anta B, Martín Rodríguez C, Gomis Pèrez C, Calvo L, López Benito S, Calderón García A, et al. Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3). J Biol Chem. 2016;291:19132-45 pubmed publisher
    ..2/3 channel regulation. Our results demonstrate that USP36 binds to and regulates the actions of Nedd4-2 over different substrates affecting their expression and functions. ..
  11. Klinger F, Gould G, Boehm S, Shapiro M. Distribution of M-channel subunits KCNQ2 and KCNQ3 in rat hippocampus. Neuroimage. 2011;58:761-9 pubmed publisher
    ..M-channel is composed of heteromeric or homomeric assemblies of subunits belonging to the Kv7/KCNQ family, with KCNQ2/3 heteromers being the most abundant form...
  12. Jin Z, Liang G, Cooper E, Jarlebark L. Expression and localization of K channels KCNQ2 and KCNQ3 in the mammalian cochlea. Audiol Neurootol. 2009;14:98-105 pubmed publisher
    ..Here, we describe Kcnq2/3 gene expression and distribution of M channel subunits KCNQ2 and 3 in the cochlea...
  13. Zheng Y, Xu H, Zhan L, Zhou X, Chen X, Gao Z. Activation of peripheral KCNQ channels relieves gout pain. Pain. 2015;156:1025-35 pubmed publisher
    ..Our data indicate that activation of peripheral KCNQ channels mediates the pain relief effects of BBR, potentially providing a new strategy for the development of more effective therapies for gout. ..
  14. Kang S, Xu M, Cooper E, Hoshi N. Channel-anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin. J Biol Chem. 2014;289:11536-44 pubmed publisher
    M-type potassium channels, encoded by the KCNQ family genes (KCNQ2-5), require calmodulin as an essential co-factor. Calmodulin bound to the KCNQ2 subunit regulates channel trafficking and stabilizes channel activity...
  15. Penschuck S, Bastlund J, Jensen H, Stensbol T, Egebjerg J, Watson W. Changes in KCNQ2 immunoreactivity in the amygdala in two rat models of temporal lobe epilepsy. Brain Res Mol Brain Res. 2005;141:66-73 pubmed
    Potassium channels containing the KCNQ2 subunit play an important role in the regulation of neuronal excitability and therefore have been implicated in epilepsy...
  16. Jow F, Wang K. Cloning and functional expression of rKCNQ2 K(+) channel from rat brain. Brain Res Mol Brain Res. 2000;80:269-78 pubmed
    ..rKCNQ2 shares 96% amino acid identity with human KCNQ2 in which mutations cause a form of epilepsy known as benign familial neonatal convulsions (BFNC)...
  17. Zhou X, Wei J, Song M, Francis K, Yu S. Novel role of KCNQ2/3 channels in regulating neuronal cell viability. Cell Death Differ. 2011;18:493-505 pubmed publisher
    ..The present investigation examined a possible role of the KCNQ2/3 channel or M-channel (also named Kv7.2/7.3 channels) in the pro-apoptotic process...
  18. Kosenko A, Hoshi N. A change in configuration of the calmodulin-KCNQ channel complex underlies Ca2+-dependent modulation of KCNQ channel activity. PLoS ONE. 2013;8:e82290 pubmed publisher
    ..In this study, we investigated the molecular mechanism of KCNQ2 current suppression mediated by calcium-bound calmodulin...
  19. Strulovich R, Tobelaim W, Attali B, Hirsch J. Structural Insights into the M-Channel Proximal C-Terminus/Calmodulin Complex. Biochemistry. 2016;55:5353-65 pubmed publisher
    ..Functional testing of the chimeric channel found it to have a voltage-dependence similar to the M channel, thereby demonstrating helix A's importance in imparting gating properties. ..
  20. Sander S, Lambrecht C, Richter A. The K(V)7.2/3 preferring channel opener ICA 27243 attenuates L-DOPA-induced dyskinesia in hemiparkinsonian rats. Neurosci Lett. 2013;545:59-63 pubmed publisher
    ..2/3 channels might be interesting candidates for the treatment of LID as antidyskinetic effects occurred at well-tolerated doses and did not interfere with the antiparkinsonian effect of L-DOPA. ..
  21. Li C, Lu Q, Huang P, Fu T, Li C, Guo L, et al. Activity-dependent downregulation of M-Type (Kv7) K⁺ channels surface expression requires the activation of iGluRs/Ca²⁺/PKC signaling pathway in hippocampal neuron. Neuropharmacology. 2015;95:154-67 pubmed publisher
    M-type (Kv7) K(+) channels, encoded by KCNQ2-KCNQ5 genes, play a pivotal role in controlling neuronal excitability. However, precisely how neuronal activity regulates Kv7 channel translocation has not yet been fully defined...
  22. Crozier R, Ajit S, Kaftan E, Pausch M. MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability. J Neurosci. 2007;27:4492-6 pubmed
    ..cell line, we first assessed the functional significance of MrgD activation by coexpressing MrgD with the KCNQ2/3 potassium channel, a channel implicated in pain...
  23. Wang W, Gao X, Xiao L, Xiang Z, He C. K(V)7/KCNQ channels are functionally expressed in oligodendrocyte progenitor cells. PLoS ONE. 2011;6:e21792 pubmed publisher
    ..b>KCNQ2-5 mRNAs existed in all three developmental stages of rat primary cultured OLCs...
  24. Rose K, Ooi L, Dalle C, Robertson B, Wood I, Gamper N. Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury. Pain. 2011;152:742-54 pubmed publisher
    ..We investigated transcriptional regulation of the Kcnq2 gene, which encodes the Kv7...
  25. Zheng Q, Fang D, Liu M, Cai J, Wan Y, Han J, et al. Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model. Pain. 2013;154:434-48 pubmed publisher
    ..pain based on intratibial injection of MRMT-1 tumour cells, we documented a prominent decrease in expression of KCNQ2 and KCNQ3 proteins and a reduction of M-current density in small-sized dorsal root ganglia (DRG) neurons, which ..
  26. Cavaretta J, Sherer K, Lee K, Kim E, Issema R, Chung H. Polarized axonal surface expression of neuronal KCNQ potassium channels is regulated by calmodulin interaction with KCNQ2 subunit. PLoS ONE. 2014;9:e103655 pubmed publisher
    KCNQ potassium channels composed of KCNQ2 and KCNQ3 subunits give rise to the M-current, a slow-activating and non-inactivating voltage-dependent potassium current that limits repetitive firing of action potentials...
  27. Wickenden A, Krajewski J, London B, Wagoner P, Wilson W, Clark S, et al. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol. 2008;73:977-86 pubmed
    b>KCNQ2 (Kv7.2) and KCNQ3 (Kv7.3) are voltage-gated K(+) channel subunits that underlie the neuronal M current. In humans, mutations in these genes lead to a rare form of neonatal epilepsy (Biervert et al., 1998; Singh et al...
  28. Zhou N, Huang S, Li L, Huang D, Yan Y, Du X, et al. Suppression of KV7/KCNQ potassium channel enhances neuronal differentiation of PC12 cells. Neuroscience. 2016;333:356-67 pubmed publisher
    ..M-type Kv7 channels are likely involved in regulating neurite growth because overexpression of KCNQ2/Q3 inhibited neurite growth whereas suppression of KCNQ2/Q3 with shRNA promoted neurite growth...