Gene Symbol: Kcnn2
Description: potassium calcium-activated channel subfamily N member 2
Alias: KCa2.2, SK2, SKCa 2, SKCa2, small conductance calcium-activated potassium channel protein 2, potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Species: rat
Products:     Kcnn2

Top Publications

  1. Kohler M, Hirschberg B, Bond C, Kinzie J, Marrion N, Maylie J, et al. Small-conductance, calcium-activated potassium channels from mammalian brain. Science. 1996;273:1709-14 pubmed
  2. Adelman J, Maylie J, Sah P. Small-conductance Ca2+-activated K+ channels: form and function. Annu Rev Physiol. 2012;74:245-69 pubmed publisher
    ..In this review we discuss the molecular and functional properties of SK channels and their physiological roles in central neurons. ..
  3. Monaghan A, Benton D, Bahia P, Hosseini R, Shah Y, Haylett D, et al. The SK3 subunit of small conductance Ca2+-activated K+ channels interacts with both SK1 and SK2 subunits in a heterologous expression system. J Biol Chem. 2004;279:1003-9 pubmed
    ..heteromeric channels can be formed by co-assembly of rat SK3 (rSK3) potassium channel subunits with either SK1 or SK2 subunits...
  4. Gymnopoulos M, Cingolani L, Pedarzani P, Stocker M. Developmental mapping of small-conductance calcium-activated potassium channel expression in the rat nervous system. J Comp Neurol. 2014;522:1072-101 pubmed publisher
    ..in situ hybridization mapping study, providing comprehensive distribution profiles of all three SK subunits (SK1, SK2, and SK3) in the rat CNS during embryonic and postnatal development...
  5. Kakizawa S, Kishimoto Y, Hashimoto K, Miyazaki T, Furutani K, Shimizu H, et al. Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. EMBO J. 2007;26:1924-33 pubmed
    ..Therefore, JPs support the Ca(2+)-mediated communication between voltage-gated Ca(2+) channels, RyRs and SK channels, which modulates the excitability of PCs and is fundamental to cerebellar LTD and motor functions. ..
  6. Lu L, Timofeyev V, Li N, Rafizadeh S, Singapuri A, Harris T, et al. Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel). Proc Natl Acad Sci U S A. 2009;106:18402-7 pubmed publisher
    ..we directly demonstrate that proper membrane localization of a small-conductance Ca(2+)-activated K(+) channel (SK2 or K(Ca)2.2) is dependent on its interacting protein, alpha-actinin2, a major F-actin crosslinking protein...
  7. N GOUEMO P, Yasuda R, Faingold C. Protein expression of small conductance calcium-activated potassium channels is altered in inferior colliculus neurons of the genetically epilepsy-prone rat. Brain Res. 2009;1270:107-11 pubmed publisher
    ..of SK1 and SK3 subtypes of the small conductance Ca2+-activated K+ channels were significantly decreased, while SK2 channel proteins were increased in IC neurons of seizure-naive GEPR-3s (SN-GEPR-3), as compared to control Sprague-..
  8. Mongan L, Hill M, Chen M, Tate S, Collins S, Buckby L, et al. The distribution of small and intermediate conductance calcium-activated potassium channels in the rat sensory nervous system. Neuroscience. 2005;131:161-75 pubmed
    ..We show that SK1, SK2, SK3 and IK1 are all expressed in DRG and spinal cord...
  9. Yu C, Ko J, Ai T, Tsai W, Chen Z, Rubart M, et al. Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current. Heart Rhythm. 2016;13:1716-23 pubmed publisher
    ..transiently transfected into human embryonic kidney 293 cells that stably express subtype 2 of SK protein channels (SK2 cells). Whole-cell voltage-clamp recording was used to determine apamin-sensitive current densities...

More Information


  1. Lu L, Zhang Q, Timofeyev V, Zhang Z, Young J, Shin H, et al. Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2. Circ Res. 2007;100:112-20 pubmed
    ..Here, we demonstrate that a small conductance Ca(2+)-activated K(+) channels (SK2 channel), present in a variety of cells, where they integrate changes in intracellular Ca(2+) concentration [Ca(2+)(..
  2. Murthy S, Teodorescu G, Nijholt I, Dolga A, Grissmer S, Spiess J, et al. Identification and characterization of a novel, shorter isoform of the small conductance Ca2+ -activated K+ channel SK2. J Neurochem. 2008;106:2312-21 pubmed publisher
    ..We have identified a novel, shorter isoform of standard SK2 (SK2-std) in mouse brain which we named SK2-sh...
  3. Terentyev D, Rochira J, Terentyeva R, Roder K, Koren G, Li W. Sarcoplasmic reticulum Ca²? release is both necessary and sufficient for SK channel activation in ventricular myocytes. Am J Physiol Heart Circ Physiol. 2014;306:H738-46 pubmed publisher
    ..b>SK2 channels were overexpressed in adult rat ventricular myocytes using adenovirus gene transfer...
  4. Zhang M, ABRAMS C, Wang L, Gizzi A, He L, Lin R, et al. Structural basis for calmodulin as a dynamic calcium sensor. Structure. 2012;20:911-23 pubmed publisher
    ..Here, we take advantage of two splice variants of SK2 channels, which are activated by Ca(2+)-bound calmodulin but show different sensitivity to Ca(2+) for their ..
  5. Katz E, Elgoyhen A, Gómez Casati M, Knipper M, Vetter D, Fuchs P, et al. Developmental regulation of nicotinic synapses on cochlear inner hair cells. J Neurosci. 2004;24:7814-20 pubmed
    ..Calcium influx through that receptor activates calcium-dependent (SK2-containing) potassium channels...
  6. Honrath B, Matschke L, Meyer T, Magerhans L, Perocchi F, Ganjam G, et al. SK2 channels regulate mitochondrial respiration and mitochondrial Ca2+ uptake. Cell Death Differ. 2017;24:761-773 pubmed publisher
    ..respiration and complex I activity upon pharmacological activation and overexpression of mitochondrial SK2 channels resulting in reduced mitochondrial ROS formation...
  7. Seki T, Goto K, Kiyohara K, Kansui Y, Murakami N, Haga Y, et al. Downregulation of Endothelial Transient Receptor Potential Vanilloid Type 4 Channel and Small-Conductance of Ca2+-Activated K+ Channels Underpins Impaired Endothelium-Dependent Hyperpolarization in Hypertension. Hypertension. 2017;69:143-153 pubmed
    ..These findings suggest that EDH-mediated responses are impaired in superior mesenteric arteries of SHRSP because of a reduction in both TRPV4 and SKCa input to EDH. ..
  8. Hosy E, Piochon C, Teuling E, Rinaldo L, Hansel C. SK2 channel expression and function in cerebellar Purkinje cells. J Physiol. 2011;589:3433-40 pubmed publisher
    ..Here we review evidence that SK2 channels are expressed in rat cerebellar Purkinje cells during development and throughout adulthood, and play a key ..
  9. Noble K, Floyd R, Shmygol A, Shmygol A, Mobasheri A, Wray S. Distribution, expression and functional effects of small conductance Ca-activated potassium (SK) channels in rat myometrium. Cell Calcium. 2010;47:47-54 pubmed publisher
    ..They contribute more to quiescence that BK channels...
  10. Lamy C, Goodchild S, Weatherall K, Jane D, Liégeois J, Seutin V, et al. Allosteric block of KCa2 channels by apamin. J Biol Chem. 2010;285:27067-77 pubmed publisher
    ..This multidisciplinary approach suggested that apamin does not behave as a classical pore blocker but blocks using an allosteric mechanism that is consistent with observed differences between binding affinity and potency of block. ..
  11. Li W, Aldrich R. Activation of the SK potassium channel-calmodulin complex by nanomolar concentrations of terbium. Proc Natl Acad Sci U S A. 2009;106:1075-80 pubmed publisher
  12. Deardorff A, Romer S, Deng Z, Bullinger K, Nardelli P, Cope T, et al. Expression of postsynaptic Ca2+-activated K+ (SK) channels at C-bouton synapses in mammalian lumbar -motoneurons. J Physiol. 2013;591:875-97 pubmed publisher
    ..labelling of rat, mouse and cat spinal cord, we reveal a differential and overlapping expression of SK2 and SK3 isoforms across specific types of ?-MNs...
  13. Li N, Timofeyev V, Tuteja D, Xu D, Lu L, Zhang Q, et al. Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation. J Physiol. 2009;587:1087-100 pubmed publisher
    ..We have recently reported the functional existence of SK2 channels in human and mouse cardiac myocytes...
  14. Maingret F, Coste B, Hao J, Giamarchi A, Allen D, Crest M, et al. Neurotransmitter modulation of small-conductance Ca2+-activated K+ channels by regulation of Ca2+ gating. Neuron. 2008;59:439-49 pubmed publisher
    ..By recording coupled activities of Ca2+ and SK2 channels, we showed that SK2 channels can be inhibited by neurotransmitters independently of changes in the ..
  15. Schumacher M, Crum M, Miller M. Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex. Structure. 2004;12:849-60 pubmed
    ..Here we present crystal structures of apoCaM and apoCaM/SK2 CaMBD complex...
  16. Rafizadeh S, Zhang Z, Woltz R, Kim H, Myers R, Lu L, et al. Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel. Proc Natl Acad Sci U S A. 2014;111:9989-94 pubmed publisher
    ..Here, we demonstrate that filamin A, a cytoskeletal protein, augments the trafficking of SK2 channels in cardiac myocytes. The trafficking of SK2 channel is Ca(2+)-dependent...
  17. Yang D, Wang T, Ni Y, Song B, Ning F, Hu P, et al. Apamin-Sensitive K+ Current Upregulation in Volume-Overload Heart Failure is Associated with the Decreased Interaction of CK2 with SK2. J Membr Biol. 2015;248:1181-9 pubmed publisher
    ..In HF rat left ventricle, SK3 was increased by 100 % (P < 0.05), and SK2 was not significantly changed. PP2A protein was increased by 94.7 % in HF rats (P < 0...
  18. Schumacher M, Rivard A, Bachinger H, Adelman J. Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin. Nature. 2001;410:1120-4 pubmed
    ..Together with biochemical data, the structure suggests a possible gating mechanism for the SK channel. ..
  19. Xia X, Fakler B, Rivard A, Wayman G, Johnson Pais T, Keen J, et al. Mechanism of calcium gating in small-conductance calcium-activated potassium channels. Nature. 1998;395:503-7 pubmed
    ..Our data support a model in which calcium gating of SK channels is mediated by binding of calcium to calmodulin and subsequent conformational alterations in the channel protein. ..