Gene Symbol: Kcnn1
Description: potassium calcium-activated channel subfamily N member 1
Alias: KCa2.1, small conductance calcium-activated potassium channel protein 1, SK1, SKCa 1, SKCa1, potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1-like
Species: rat
Products:     Kcnn1

Top Publications

  1. Kohler M, Hirschberg B, Bond C, Kinzie J, Marrion N, Maylie J, et al. Small-conductance, calcium-activated potassium channels from mammalian brain. Science. 1996;273:1709-14 pubmed
  2. D hoedt D, Hirzel K, Pedarzani P, Stocker M. Domain analysis of the calcium-activated potassium channel SK1 from rat brain. Functional expression and toxin sensitivity. J Biol Chem. 2004;279:12088-92 pubmed
    ..However, the functional role and pharmacological profile of SK1 channels from rat brain (rSK1) is still largely unknown, as so far rSK1 homomeric channels could not be ..
  3. Shmukler B, Bond C, Wilhelm S, Bruening Wright A, Maylie J, Adelman J, et al. Structure and complex transcription pattern of the mouse SK1 K(Ca) channel gene, KCNN1. Biochim Biophys Acta. 2001;1518:36-46 pubmed
    Small conductance calcium-gated K(+) channels (SK channels) are encoded by the three SK genes, SK1, SK2, and SK3. These channels likely contribute to slow synaptic afterhyperpolarizations of apamin-sensitive and apamin-insensitive types...
  4. Monaghan A, Benton D, Bahia P, Hosseini R, Shah Y, Haylett D, et al. The SK3 subunit of small conductance Ca2+-activated K+ channels interacts with both SK1 and SK2 subunits in a heterologous expression system. J Biol Chem. 2004;279:1003-9 pubmed
    ..heteromeric channels can be formed by co-assembly of rat SK3 (rSK3) potassium channel subunits with either SK1 or SK2 subunits...
  5. Adelman J, Maylie J, Sah P. Small-conductance Ca2+-activated K+ channels: form and function. Annu Rev Physiol. 2012;74:245-69 pubmed publisher
    ..In this review we discuss the molecular and functional properties of SK channels and their physiological roles in central neurons. ..
  6. Joiner W, Wang L, Tang M, Kaczmarek L. hSK4, a member of a novel subfamily of calcium-activated potassium channels. Proc Natl Acad Sci U S A. 1997;94:11013-8 pubmed
    ..Together with the relatively low homology of hSK4 to other SK channel polypeptides (approximately 40% identical), these data suggest that hSK4 belongs to a novel subfamily of SK channels. ..
  7. Gui L, LaGrange L, Larson R, Gu M, Zhu J, Chen Q. Role of small conductance calcium-activated potassium channels expressed in PVN in regulating sympathetic nerve activity and arterial blood pressure in rats. Am J Physiol Regul Integr Comp Physiol. 2012;303:R301-10 pubmed publisher
    ..Western blot and RT-PCR analysis of punched PVN tissue showed abundant expression of SK1-3 channels...
  8. Mongan L, Hill M, Chen M, Tate S, Collins S, Buckby L, et al. The distribution of small and intermediate conductance calcium-activated potassium channels in the rat sensory nervous system. Neuroscience. 2005;131:161-75 pubmed
    ..We show that SK1, SK2, SK3 and IK1 are all expressed in DRG and spinal cord...
  9. Andres M, Baptista N, Efird J, Ogata K, Bellinger F, Zeyda T. Depletion of SK1 channel subunits leads to constitutive insulin secretion. FEBS Lett. 2009;583:369-76 pubmed publisher
    ..Here, we show that three SK subtypes are expressed in the rat insulinoma cells. Our findings demonstrate that rat SK1 (rSK1) channels ensure appropriate insulin secretion by establishing the cell's negative resting membrane potential ..

More Information


  1. Gymnopoulos M, Cingolani L, Pedarzani P, Stocker M. Developmental mapping of small-conductance calcium-activated potassium channel expression in the rat nervous system. J Comp Neurol. 2014;522:1072-101 pubmed publisher
    ..in situ hybridization mapping study, providing comprehensive distribution profiles of all three SK subunits (SK1, SK2, and SK3) in the rat CNS during embryonic and postnatal development...
  2. Wang Y, Qu L, Wang X, Gao L, Li Z, Gao G, et al. Firing pattern modulation through SK channel current increase underlies neuronal survival in an organotypic slice model of Parkinson's disease. Mol Neurobiol. 2015;51:424-36 pubmed publisher
    ..Thus, SK channel current is a substantial element in sustaining the SNc DA neuronal rhythmic pacemaking and homeostasis and perturbing SK channel activity underlies 6-OHDA-induced neurotoxicity. ..
  3. Tuteja D, Xu D, Timofeyev V, Lu L, Sharma D, Zhang Z, et al. Differential expression of small-conductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes. Am J Physiol Heart Circ Physiol. 2005;289:H2714-23 pubmed
    ..2) channels in human and mouse cardiac myocytes. Here, we report cloning of SK1 (KCa2.1) and SK3 (KCa2.3) channels from mouse atria and ventricles using RT-PCR...
  4. N GOUEMO P, Yasuda R, Faingold C. Protein expression of small conductance calcium-activated potassium channels is altered in inferior colliculus neurons of the genetically epilepsy-prone rat. Brain Res. 2009;1270:107-11 pubmed publisher
    ..The present report shows that the levels of protein expression of SK1 and SK3 subtypes of the small conductance Ca2+-activated K+ channels were significantly decreased, while SK2 ..
  5. Noble K, Floyd R, Shmygol A, Shmygol A, Mobasheri A, Wray S. Distribution, expression and functional effects of small conductance Ca-activated potassium (SK) channels in rat myometrium. Cell Calcium. 2010;47:47-54 pubmed publisher
    ..This study therefore characterises the expression of the three SK channel isoforms (SK1-3) in rat myometrium throughout pregnancy and investigates their effect on cytosolic [Ca] and force and compares ..