Gene Symbol: Kcnmb1
Description: potassium calcium-activated channel subfamily M regulatory beta subunit 1
Alias: BKbeta, BKbeta1, k(VCA)beta-1, slo-beta, slo-beta-1, calcium-activated potassium channel subunit beta-1, BK channel subunit beta-1, calcium-activated potassium channel beta subunit, calcium-activated potassium channel subunit beta, calcium-activated potassium channel, subfamily M subunit beta-1, charybdotoxin receptor subunit beta-1, maxi K channel subunit beta-1, potassium channel subfamily M regulatory beta subunit 1, potassium large conductance calcium-activated channel, subfamily M, beta member 1, slowpoke-beta
Species: rat
Products:     Kcnmb1

Top Publications

  1. Leo M, Zhai X, Muralidharan P, Kuruvilla K, Bulley S, Boop F, et al. Membrane depolarization activates BK channels through ROCK-mediated β1 subunit surface trafficking to limit vasoconstriction. Sci Signal. 2017;10: pubmed publisher
    ..Thus, membrane depolarization activates BK channels through stimulation of ROCK- and Rab11A-dependent trafficking of β1 subunits to the surface of arterial myocytes. ..
  2. Seidel K, Derst C, Salzmann M, Höltje M, Priller J, Markgraf R, et al. Expression of the voltage- and Ca2+-dependent BK potassium channel subunits BK?1 and BK?4 in rodent astrocytes. Glia. 2011;59:893-902 pubmed publisher
    ..Thus, BK?4 expression in astrocytes likely participates in regulating astrocytic voltage gradients and maintaining K(+) homeostasis, hence enabling astrocytes to fulfill their complex regulatory influence on proper brain function. ..
  3. Chang T, Wu L, Wang R. Altered expression of BK channel beta1 subunit in vascular tissues from spontaneously hypertensive rats. Am J Hypertens. 2006;19:678-85 pubmed
    ..Expression of BK beta1 in mesenteric arteries is closely correlated with BP in SHR. Increased BK beta1 expression in mesenteric arteries may represent a compensatory reaction to limit the development of hypertension. ..
  4. Bukiya A, McMillan J, Fedinec A, Patil S, Miller D, Leffler C, et al. Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel ?1-subunit by a novel nonsteroidal agent. Mol Pharmacol. 2013;83:1030-44 pubmed publisher
    ..HENA failed to dilate the arteries from the KCNMB1 knockout mouse, underscoring BK ?1's role in HENA action...
  5. Via M, Valveny N, López Alomar A, Athanasiadis G, Pintó X, Domingo E, et al. E65 K polymorphism in KCNMB1 gene is not associated with ischaemic heart disease in Spanish patients. J Hum Genet. 2005;50:604-6 pubmed
    ..A recent study reported a new polymorphism (E65 K) in the beta(1) subunit (KCNMB1) gene of the Ca(2+)-dependent potassium channel with a protective effect against the severity of diastolic ..
  6. Wang Y, Zhang H, Su X, Deng X, Yuan B, Zhang W, et al. Experimental diabetes mellitus down-regulates large-conductance Ca2+-activated K+ channels in cerebral artery smooth muscle and alters functional conductance. Curr Neurovasc Res. 2010;7:75-84 pubmed
  7. Shi L, Liu B, Li N, Xue Z, Liu X. Aerobic exercise increases BK(Ca) channel contribution to regulation of mesenteric arterial tone by upregulating ?1-subunit. Exp Physiol. 2013;98:326-36 pubmed publisher
  8. Ohya S, Kuwata Y, Sakamoto K, Muraki K, Imaizumi Y. Cardioprotective effects of estradiol include the activation of large-conductance Ca(2+)-activated K(+) channels in cardiac mitochondria. Am J Physiol Heart Circ Physiol. 2005;289:H1635-42 pubmed
    ..BK-beta1 may be an important molecular component that functionally couples with both Cco1 and mitoK(Ca) pore-forming alpha-subunit. ..
  9. Sun F, Hayama E, Katsube Y, Matsuoka R, Nakanishi T. The role of the large-conductance voltage-dependent and calcium-activated potassium (BK(Ca)) channels in the regulation of rat ductus arteriosus tone. Heart Vessels. 2010;25:556-64 pubmed publisher
    ..Activation of BK(Ca) channels led to vasodilatation in the preconstricted DA induced by O?, possibly suggesting a way to maintain the patency of DA after birth. ..

More Information


  1. Morimoto T, Sakamoto K, Sade H, Ohya S, Muraki K, Imaizumi Y. Voltage-sensitive oxonol dyes are novel large-conductance Ca2+-activated K+ channel activators selective for beta1 and beta4 but not for beta2 subunits. Mol Pharmacol. 2007;71:1075-88 pubmed
    ..These findings provide a molecular and structural basis for understanding the regulatory mechanism of BK channel activity by an auxiliary beta subunit and will be fundamental to the development of beta-selective BK channel openers. ..
  2. Jiang Z, Wallner M, Meera P, Toro L. Human and rodent MaxiK channel beta-subunit genes: cloning and characterization. Genomics. 1999;55:57-67 pubmed
    ..We cloned and analyzed human and rodent genes for the modulatory beta subunit, KCNMB1. The human and mouse beta-subunit genes are approximately 11 and approximately 9 kb in length, respectively, and ..
  3. Wang Y, Zhao L, Su X, Yu W, Deng X. [Ca(2+)-activated K(+) channel switching in smooth muscle participates in atherosclerosis development in diabetic rats]. Nan Fang Yi Ke Da Xue Xue Bao. 2014;34:188-92 pubmed
    ..1 channels was obviously enhanced in the middle layer of the aorta in the diabetic rats. KCa channel switching in smooth muscles may play a role in the development of atherosclerosis in diabetic rats. ..
  4. Albarwani S, Al Siyabi S, Baomar H, Hassan M. Exercise training attenuates ageing-induced BKCa channel downregulation in rat coronary arteries. Exp Physiol. 2010;95:746-55 pubmed publisher
    ..We conclude that low-intensity ET may be beneficial in restoring age-related decline in coronary vasodilatory properties mediated by BK(Ca) channels. ..
  5. Li J, Al Khalili O, Ramosevac S, Eaton D, Denson D. Protein-protein interaction between cPLA2 and splice variants of alpha-subunit of BK channels. Am J Physiol Cell Physiol. 2010;298:C251-62 pubmed publisher
  6. Nehrke K, Quinn C, Begenisich T. Molecular identification of Ca2+-activated K+ channels in parotid acinar cells. Am J Physiol Cell Physiol. 2003;284:C535-46 pubmed
    ..RT-PCR analysis revealed the presence of two mSlo beta-subunits (Kcnmb1 and Kcnmb4) in parotid tissue...
  7. Barman S, Zhu S, White R. PKC activates BKCa channels in rat pulmonary arterial smooth muscle via cGMP-dependent protein kinase. Am J Physiol Lung Cell Mol Physiol. 2004;286:L1275-81 pubmed
  8. Wynne P, Puig S, Martin G, Treistman S. Compartmentalized beta subunit distribution determines characteristics and ethanol sensitivity of somatic, dendritic, and terminal large-conductance calcium-activated potassium channels in the rat central nervous system. J Pharmacol Exp Ther. 2009;329:978-86 pubmed publisher
    ..This hypothesis is supported immunohistochemically by the appearance of distinct punctate beta1 or beta4 channel clusters in the membrane of somatic and dendritic or nerve terminal compartments, respectively. ..
  9. Amberg G, Santana L. Downregulation of the BK channel beta1 subunit in genetic hypertension. Circ Res. 2003;93:965-71 pubmed
    ..These results support the view that changes in the molecular composition of BK channels may be a fundamental event contributing to the development of vascular dysfunction during hypertension. ..
  10. Shi L, Liu X, Li N, Liu B, Liu Y. Aging decreases the contribution of MaxiK channel in regulating vascular tone in mesenteric artery by unparallel downregulation of ?- and ?1-subunit expression. Mech Ageing Dev. 2013;134:416-25 pubmed publisher
    ..These data suggest that aging decreases capability of MaxiK channel in regulating vascular tone in the MA, which may be partially mediated by unparallel downregulation of ?- and ?1-subunit expression. ..
  11. Li S, Deng Z, Wei L, Liang L, Ai W, Shou X, et al. Reduction of large-conductance Ca²(+) -activated K(+) channel with compensatory increase of nitric oxide in insulin resistant rats. Diabetes Metab Res Rev. 2011;27:461-9 pubmed publisher
    ..These impairments may be related to the down-regulation of ?1 subunit expression and compensatory increase in plasma nitric oxide levels. ..
  12. Tang X, Qian L, Wang R, Yao Y, Dang S, Wu Y, et al. Regulation of Coronary Arterial Large Conductance Ca2+-Activated K+ Channel Protein Expression and Function by n-3 Polyunsaturated Fatty Acids in Diabetic Rats. J Vasc Res. 2017;54:329-343 pubmed publisher
  13. Bukiya A, McMillan J, Liu J, Shivakumar B, Parrill A, Dopico A. Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4. J Biol Chem. 2014;289:35314-25 pubmed publisher
    ..Moreover, the identification of LTB4 as a highly potent ligand for BK channels is critical for the future development of β1-specific BK channel activators. ..
  14. Bukiya A, Singh A, Parrill A, Dopico A. The steroid interaction site in transmembrane domain 2 of the large conductance, voltage- and calcium-gated potassium (BK) channel accessory ?1 subunit. Proc Natl Acad Sci U S A. 2011;108:20207-12 pubmed publisher
    ..Because this amino acid triplet is unique to BK ?1, our study provides a structural basis for advancing ?1 subunit-specific pharmacology of BK channels. ..
  15. Lu T, Ye D, He T, Wang X, Wang H, Lee H. Impaired Ca2+-dependent activation of large-conductance Ca2+-activated K+ channels in the coronary artery smooth muscle cells of Zucker Diabetic Fatty rats. Biophys J. 2008;95:5165-77 pubmed publisher
    ..These abnormalities in BK channel gating lead to an increase in the energy barrier for channel activation, and may contribute to the development of vascular dysfunction and complications in type 2 diabetes mellitus. ..
  16. Senti M, Fernández Fernández J, Tomas M, Vazquez E, Elosua R, Marrugat J, et al. Protective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk. Circ Res. 2005;97:1360-5 pubmed
  17. Falk T, Kilani R, Strazdas L, Borders R, Steidl J, Yool A, et al. Developmental regulation of the A-type potassium-channel current in hippocampal neurons: role of the Kvbeta 1.1 subunit. Neuroscience. 2003;120:387-404 pubmed
    ..1 is capable of decreasing the electrical excitability of post-mitotic hippocampal neurons, suggesting this approach has applicability to gene therapy of neurological diseases associated with hyperexcitability. ..
  18. McGahon M, Dash D, Arora A, Wall N, Dawicki J, Simpson D, et al. Diabetes downregulates large-conductance Ca2+-activated potassium beta 1 channel subunit in retinal arteriolar smooth muscle. Circ Res. 2007;100:703-11 pubmed
    ..The BKbeta1 subunit confers Ca(2+)-sensitivity to BK channel complexes and both transcript and protein levels for BKbeta1 ..
  19. Bukiya A, Liu J, Dopico A. The BK channel accessory beta1 subunit determines alcohol-induced cerebrovascular constriction. FEBS Lett. 2009;583:2779-84 pubmed publisher
    ..Knocking-down KCNMB1 suppresses EtOH-reduction of arterial myocyte BK current and vessel diameter...
  20. Chang C, Dworetzky S, Wang J, Goldstein M. Differential expression of the alpha and beta subunits of the large-conductance calcium-activated potassium channel: implication for channel diversity. Brain Res Mol Brain Res. 1997;45:33-40 pubmed
    ..These observations provide a structural basis for the BK channel diversity observed in a variety of tissues. ..
  21. Bautista L, Castro M, Lopez Barneo J, Castellano A. Hypoxia inducible factor-2alpha stabilization and maxi-K+ channel beta1-subunit gene repression by hypoxia in cardiac myocytes: role in preconditioning. Circ Res. 2009;104:1364-72 pubmed publisher
    ..We report here that beta(1) protein may interact with mitochondrial proteins and that the beta(1)-subunit gene (KCNMB1) is repressed by sustained hypoxia in dispersed cardiomyocytes as well as in heart intact tissue...
  22. Chang H, Ma Y, Wang Y, Song Z, Li Q, Yang N, et al. High glucose alters apoptosis and proliferation in HEK293 cells by inhibition of cloned BK Ca channel. J Cell Physiol. 2011;226:1660-75 pubmed publisher
    ..In conclusion, cloned BK(Ca) channel directly regulated apoptosis and proliferation of HEK293 cell under hyperglycemia condition. ..
  23. Salzmann M, Seidel K, Bernard R, Prüss H, Veh R, Derst C. BKbeta1 subunits contribute to BK channel diversity in rat hypothalamic neurons. Cell Mol Neurobiol. 2010;30:967-76 pubmed publisher
    ..gene, channel diversity is mainly generated by alternative splicing and interaction with auxiliary beta-subunits (BKbeta1-4)...