Gene Symbol: Kcnma1
Description: potassium calcium-activated channel subfamily M alpha 1
Alias: BKCa, KCNMA1b, KCNMA1c, Kcnma, Slo, cbv1, calcium-activated potassium channel subunit alpha-1, BK channel, BKCA alpha, KCa1.1, calcium-activated potassium channel alpha subunit, calcium-activated potassium channel, subfamily M subunit alpha-1, k(VCA)alpha, maxi K channel, maxiK, potassium channel, calcium activated large conductance subfamily M alpha, member 1, potassium large conductance calcium-activated channel, subfamily M, alpha member 1, slo homolog, slo-alpha, slo1, slowpoke homolog
Species: rat
Products:     Kcnma1

Top Publications

  1. Marijic J, Li Q, Song M, Nishimaru K, Stefani E, Toro L. Decreased expression of voltage- and Ca(2+)-activated K(+) channels in coronary smooth muscle during aging. Circ Res. 2001;88:210-6 pubmed
    ..Because large-conductance voltage- and Ca(2+)-activated K(+) channels (MaxiK) are key regulators of vascular tone, we explored the possibility that this class of channels is diminished with ..
  2. Ermolinsky B, Skinner F, Garcia I, Arshadmansab M, Otalora L, Zarei M, et al. Upregulation of STREX splice variant of the large conductance Ca2+-activated potassium (BK) channel in a rat model of mesial temporal lobe epilepsy. Neurosci Res. 2011;69:73-80 pubmed publisher
    ..large conductance Ca(2+) activated potassium (BK) channels are determined by complex alternative splicing of the Kcnma1 gene encoding the alpha pore-forming subunit...
  3. Fretwell L, Dickenson J. Role of large-conductance Ca²+-activated K+ channels in adenosine A? receptor-mediated pharmacological postconditioning in H9c2 cells. Can J Physiol Pharmacol. 2011;89:24-30 pubmed publisher
    ..These results have shown for the first time that BK(Ca) channels are involved in adenosine A? receptor-induced pharmacological postconditioning in a cell model system. ..
  4. Zarei M, Zhu N, Alioua A, Eghbali M, Stefani E, Toro L. A novel MaxiK splice variant exhibits dominant-negative properties for surface expression. J Biol Chem. 2001;276:16232-9 pubmed
    We identified a novel MaxiK alpha subunit splice variant (SV1) from rat myometrium that is also present in brain...
  5. Meredith A, Thorneloe K, Werner M, Nelson M, Aldrich R. Overactive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel. J Biol Chem. 2004;279:36746-52 pubmed
    ..To address the role of the BK channel in urinary bladder function, the gene mSlo1 for the pore-forming subunit of the BK channel was deleted...
  6. Tseng Crank J, Foster C, Krause J, Mertz R, Godinot N, DiChiara T, et al. Cloning, expression, and distribution of functionally distinct Ca(2+)-activated K+ channel isoforms from human brain. Neuron. 1994;13:1315-30 pubmed
    ..Splice variants differ significantly in their Ca2+ sensitivity, suggesting a broad functional role for these channels in the regulation of neuronal excitability. ..
  7. Butler A, Tsunoda S, McCobb D, Wei A, Salkoff L. mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels. Science. 1993;261:221-4 pubmed
    ..A large number of variant mSlo cDNAs were isolated, indicating that several diverse mammalian BK channel types are produced by a single gene.
  8. Bukiya A, Liu J, Toro L, Dopico A. Beta1 (KCNMB1) subunits mediate lithocholate activation of large-conductance Ca2+-activated K+ channels and dilation in small, resistance-size arteries. Mol Pharmacol. 2007;72:359-69 pubmed
    ..This study pinpoints the BK beta1 subunit as the molecule that senses LC, which results in myocyte BK channel activation and, thus, endothelial-independent relaxation of small, resistance-size arteries.
  9. Shipston M, Duncan R, Clark A, Antoni F, Tian L. Molecular components of large conductance calcium-activated potassium (BK) channels in mouse pituitary corticotropes. Mol Endocrinol. 1999;13:1728-37 pubmed
    ..This report represents the first corticotrope ion channel to be characterized at the molecular level and demonstrates that mouse corticotrope BK channels are composed of alpha-subunits expressing the mouse STREX-1 exon. ..

More Information


  1. Pyott S, Meredith A, Fodor A, Vazquez A, Yamoah E, Aldrich R. Cochlear function in mice lacking the BK channel alpha, beta1, or beta4 subunits. J Biol Chem. 2007;282:3312-24 pubmed
    ..To understand the role of the BK channel alpha and beta subunits in mammalian inner hair cells, we analyzed the morphology, physiology, and function of ..
  2. Chen L, Tian L, MacDonald S, McClafferty H, Hammond M, Huibant J, et al. Functionally diverse complement of large conductance calcium- and voltage-activated potassium channel (BK) alpha-subunits generated from a single site of splicing. J Biol Chem. 2005;280:33599-609 pubmed
    ..Here we demonstrated that alternative splicing at site of splicing C2 in the mouse BK channel C terminus generates five distinct splice variants: ZERO, e20, e21(STREX), e22, and a novel variant deltae23...
  3. Sausbier M, Arntz C, Bucurenciu I, Zhao H, Zhou X, Sausbier U, et al. Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice. Circulation. 2005;112:60-8 pubmed
    ..However, the BK channel may also affect blood pressure by regulating salt and fluid homeostasis, particularly by adjusting the renin-..
  4. Ruttiger L, Sausbier M, Zimmermann U, Winter H, Braig C, Engel J, et al. Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss. Proc Natl Acad Sci U S A. 2004;101:12922-7 pubmed
    ..Analyzing the hearing function and cochlear phenotype of BK channel alpha-(BKalpha-/-) and beta1-subunit (BKbeta1-/-) knockout mice, we demonstrate normal hearing function and ..
  5. Sausbier M, Hu H, Arntz C, Feil S, Kamm S, Adelsberger H, et al. Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency. Proc Natl Acad Sci U S A. 2004;101:9474-8 pubmed
    ..However, the functional roles of the large-conductance voltage- and Ca(2+)-activated K(+) channel (BK channel), a unique calcium, and voltage-activated potassium channel type have remained elusive...
  6. Xie J, McCobb D. Control of alternative splicing of potassium channels by stress hormones. Science. 1998;280:443-6 pubmed
    ..Expression of alternative splice variants of Slo, a gene encoding calcium- and voltage-activated potassium channels, was measured in rat adrenal chromaffin tissue ..
  7. Langer P, Grunder S, Rusch A. Expression of Ca2+-activated BK channel mRNA and its splice variants in the rat cochlea. J Comp Neurol. 2003;455:198-209 pubmed
    ..Extensive splicing of BK channel transcripts, however, does not seem to be used in mammalian hair cells as is done in lower vertebrates.
  8. McCobb D, Fowler N, Featherstone T, Lingle C, Saito M, Krause J, et al. A human calcium-activated potassium channel gene expressed in vascular smooth muscle. Am J Physiol. 1995;269:H767-77 pubmed
    ..The molecular basis of mammalian BK channel heterogeneity is unknown, since only a single gene (mSlo) has been identified...
  9. Alioua A, Lu R, Kumar Y, Eghbali M, Kundu P, Toro L, et al. Slo1 caveolin-binding motif, a mechanism of caveolin-1-Slo1 interaction regulating Slo1 surface expression. J Biol Chem. 2008;283:4808-17 pubmed
    The large conductance, voltage- and Ca2+-activated potassium (MaxiK, BK) channel and caveolin-1 play important roles in regulating vascular contractility...
  10. Engel J, Braig C, Ruttiger L, Kuhn S, Zimmermann U, Blin N, et al. Two classes of outer hair cells along the tonotopic axis of the cochlea. Neuroscience. 2006;143:837-49 pubmed
    ..Our findings propose new mechanisms and candidate genes for explaining high and low frequency hearing loss. ..
  11. Ha T, Jeong S, Cho S, Jeon H, Roh G, Choi W, et al. Functional characteristics of two BKCa channel variants differentially expressed in rat brain tissues. Eur J Biochem. 2000;267:910-8 pubmed
    ..Ca2+-activated and voltage-activated K+ currents characteristic of neuronal large-conductance Ca2+-activated K+ (BKCa) channels...
  12. Jaggar J, Li A, Parfenova H, Liu J, Umstot E, Dopico A, et al. Heme is a carbon monoxide receptor for large-conductance Ca2+-activated K+ channels. Circ Res. 2005;97:805-12 pubmed
  13. Oliver D, Taberner A, Thurm H, Sausbier M, Arntz C, Ruth P, et al. The role of BKCa channels in electrical signal encoding in the mammalian auditory periphery. J Neurosci. 2006;26:6181-9 pubmed
    Large-conductance voltage- and Ca(2+)-activated K+ channels (BKCa) are involved in shaping spiking patterns in many neurons...
  14. Budelli G, Sun Q, Ferreira J, Butler A, Santi C, Salkoff L. SLO2 Channels Are Inhibited by All Divalent Cations That Activate SLO1 K+ Channels. J Biol Chem. 2016;291:7347-56 pubmed publisher
    Two members of the family of high conductance K(+)channels SLO1 and SLO2 are both activated by intracellular cations. However, SLO1 is activated by Ca(2+)and other divalent cations, while SLO2 (Slack or SLO2...
  15. Kim S, Lee B, Lee A, Won S, Park C. Effects of palmitoylation on the diffusional movement of BKCa channels in live cells. FEBS Lett. 2014;588:713-9 pubmed publisher
    b>BKCa channels are palmitoylated at a cluster of cysteine residues within the cytosolic linker connecting the 1st and 2nd transmembrane domains, and this lipid modification affects their surface expression...
  16. Iozzi D, Schubert R, Kalenchuk V, Neri A, Sgaragli G, Fusi F, et al. Quercetin relaxes rat tail main artery partly via a PKG-mediated stimulation of KCa 1.1 channels. Acta Physiol (Oxf). 2013;208:329-39 pubmed publisher
    ..1 transient currents in a ryanodine-like manner. The natural flavonoid quercetin relaxes the rat tail main artery partly via a PKG-mediated stimulation of smooth muscle KC a 1.1 channels. ..
  17. Jing F, Liu M, Yang N, Liu Y, Li X, Li J. Relaxant effect of chloroquine in rat ileum: possible involvement of nitric oxide and BKCa. J Pharm Pharmacol. 2013;65:847-54 pubmed publisher
    ..This study investigated the effects of bitter compounds on the spontaneous contraction of longitudinal smooth muscle strips of rat ileum...
  18. Yan J, Olsen J, Park K, Li W, Bildl W, Schulte U, et al. Profiling the phospho-status of the BKCa channel alpha subunit in rat brain reveals unexpected patterns and complexity. Mol Cell Proteomics. 2008;7:2188-98 pubmed publisher
  19. Avdonin V, Tang X, Hoshi T. Stimulatory action of internal protons on Slo1 BK channels. Biophys J. 2003;84:2969-80 pubmed
    ..These results indicate that the acid-sensitivity of the Slo BK channel may involve the channel domain implicated in the divalent-dependent activation.
  20. Dworetzky S, Trojnacki J, Gribkoff V. Cloning and expression of a human large-conductance calcium-activated potassium channel. Brain Res Mol Brain Res. 1994;27:189-93 pubmed
    A putative BK channel gene was cloned from a human brain (substantia nigra) cDNA library by hybridization screening...
  21. Bell T, Miyashiro K, Sul J, McCullough R, Buckley P, Jochems J, et al. Cytoplasmic BK(Ca) channel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neurons. Proc Natl Acad Sci U S A. 2008;105:1901-6 pubmed publisher
    ..These data suggest a new regulatory mechanism for modulating the membrane properties and ion channel gradients of hippocampal neurons. ..
  22. Li J, Al Khalili O, Ramosevac S, Eaton D, Denson D. Protein-protein interaction between cPLA2 and splice variants of alpha-subunit of BK channels. Am J Physiol Cell Physiol. 2010;298:C251-62 pubmed publisher
  23. Misonou H, Menegola M, Buchwalder L, Park E, Meredith A, Rhodes K, et al. Immunolocalization of the Ca2+-activated K+ channel Slo1 in axons and nerve terminals of mammalian brain and cultured neurons. J Comp Neurol. 2006;496:289-302 pubmed
    Ca(2+)-activated voltage-dependent K(+) channels (Slo1, KCa1.1, Maxi-K, or BK channel) play a crucial role in controlling neuronal signaling by coupling channel activity to both membrane depolarization and intracellular Ca(2+) signaling...
  24. McCartney C, McClafferty H, Huibant J, Rowan E, Shipston M, Rowe I. A cysteine-rich motif confers hypoxia sensitivity to mammalian large conductance voltage- and Ca-activated K (BK) channel alpha-subunits. Proc Natl Acad Sci U S A. 2005;102:17870-6 pubmed
    ..Here, we demonstrate that the hypoxia sensitivity of BK channel alpha-subunits is splice-variant-specific...
  25. Coppi E, Pedata F, Gibb A. P2Y1 receptor modulation of Ca2+-activated K+ currents in medium-sized neurons from neonatal rat striatal slices. J Neurophysiol. 2012;107:1009-21 pubmed publisher
    ..Therefore, P2Y(1) signaling leading to activation of I(K(Ca)) may be important in regulating the activity of medium-sized neurons in the striatum. ..
  26. Wang R, Shi H, Chai Q, Wu Y, Sun W, Ji Y, et al. Molecular mechanisms of diabetic coronary dysfunction due to large conductance Ca2?-activated K? channel impairment. Chin Med J (Engl). 2012;125:2548-55 pubmed
    ..The purpose of this study is to determine the role of vascular large conductance Ca(2+)-activated K(+) (BK) channel activities in coronary dysfunction in streptozotocin-induced diabetic rats...
  27. Nehrke K, Quinn C, Begenisich T. Molecular identification of Ca2+-activated K+ channels in parotid acinar cells. Am J Physiol Cell Physiol. 2003;284:C535-46 pubmed
    ..with the intermediate and maxi-K classes of Ca(2+)-activated K(+) channels, typified by the mIK1 (Kcnn4) and mSlo (Kcnma1) genes, respectively. The presence of mIK1 mRNA was established in acinar cells by in situ hybridization...
  28. Fhaner M, Galligan J, Swain G. Increased catecholamine secretion from single adrenal chromaffin cells in DOCA-salt hypertension is associated with potassium channel dysfunction. ACS Chem Neurosci. 2013;4:1404-13 pubmed publisher
    ..This work reveals that there is altered vesicular release of catecholamines from these cells (and possibly from perivascular sympathetic nerves) and this may contribute to increased vasomotor tone in DOCA-salt hypertension. ..
  29. Zhu N, Eghbali M, Helguera G, Song M, Stefani E, Toro L. Alternative splicing of Slo channel gene programmed by estrogen, progesterone and pregnancy. FEBS Lett. 2005;579:4856-60 pubmed
    STREX alternative-exon adds to Slo channel a phosphorylation sequence that can invert protein kinase A (PKA) regulation from excitatory to inhibitory...
  30. Mizutani H, Yamamura H, Muramatsu M, Hagihara Y, Suzuki Y, Imaizumi Y. Modulation of Ca2+ oscillation and melatonin secretion by BKCa channel activity in rat pinealocytes. Am J Physiol Cell Physiol. 2016;310:C740-7 pubmed publisher
    ..Here we examined the involvement of large-conductance Ca(2+)-activated K(+) (BKCa) channel conductance on the regulation of Ca(2+) oscillation and melatonin production in rat pinealocytes...
  31. Wu S, Lin M, Wang Y. Stimulatory actions of di-8-butyl-amino-naphthyl-ethylene-pyridinium-propyl-sulfonate (di-8-ANEPPS), voltage-sensitive dye, on the BKCa channel in pituitary tumor (GH3) cells. Pflugers Arch. 2008;455:687-99 pubmed
    ..Taken together, this study suggests that during the exposure to di-8-ANEPPS, the stimulatory effects on BK(Ca) channels could be one of potential mechanisms through which it may affect cell excitability. ..
  32. Wu Y, Yang Y, Ye S, Jiang Y. Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel. Nature. 2010;466:393-7 pubmed publisher
    ..Here we present the crystal structure of the entire cytoplasmic region of the human BK channel in a Ca(2+)-free state...
  33. Liu G, Razanau A, Hai Y, Yu J, Sohail M, Lobo V, et al. A conserved serine of heterogeneous nuclear ribonucleoprotein L (hnRNP L) mediates depolarization-regulated alternative splicing of potassium channels. J Biol Chem. 2012;287:22709-16 pubmed publisher
    ..Here we show that the regulation of the stress axis-regulated exon of the Slo1 potassium channel transcripts by membrane depolarization requires a highly conserved CaMKIV target serine (Ser-513) ..
  34. Shanley L, Irving A, Rae M, Ashford M, Harvey J. Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels. Nat Neurosci. 2002;5:299-300 pubmed
  35. Ma D, Nakata T, Zhang G, Hoshi T, Li M, Shikano S. Differential trafficking of carboxyl isoforms of Ca2+-gated (Slo1) potassium channels. FEBS Lett. 2007;581:1000-8 pubmed
    The pore-forming subunit of the large-conductance Ca(2+)-dependent K(+) (Slo1) channel is encoded by one gene...
  36. Silva J, Lewis D. Nitric oxide enhances Ca(2+)-dependent K(+) channel activity in rat carotid body cells. Pflugers Arch. 2002;443:671-5 pubmed
  37. Pan N, Bai Y, Yang Y, Hokfelt T, Xu Z. Activation of galanin receptor 2 stimulates large conductance Ca(2+)-dependent K(+) (BK) channels through the IP3 pathway in human embryonic kidney (HEK293) cells. Biochem Biophys Res Commun. 2014;446:316-21 pubmed publisher
    ..Taken together, activation of GalR2 leads to elevation of intracellular Ca(2+) is due to Ca(2+) efflux from ER through IP3R sequentially opening BK channels. ..
  38. Riddle M, Walker B. Regulation of endothelial BK channels by heme oxygenase-derived carbon monoxide and caveolin-1. Am J Physiol Cell Physiol. 2012;303:C92-C101 pubmed publisher
    ..We conclude that EC BK channel activity is HO dependent in the absence of the inhibitory effect of the Cav-1 scaffolding domain.
  39. Vivas O, Moreno C, Santana L, Hille B. Proximal clustering between BK and CaV1.3 channels promotes functional coupling and BK channel activation at low voltage. elife. 2017;6: pubmed publisher
    ..We propose that this spatial arrangement allows tight tracking between local BK channel activation and the gating of CaV1...
  40. Allard B, Couble M, Magloire H, Bleicher F. Characterization and gene expression of high conductance calcium-activated potassium channels displaying mechanosensitivity in human odontoblasts. J Biol Chem. 2000;275:25556-61 pubmed
    ..These channels could be involved in mineralization processes. Their mechanosensitivity suggests that the fluid displacement within dentinal tubules could be transduced into electrical cell signals. ..
  41. Wersinger E, McLean W, Fuchs P, Pyott S. BK channels mediate cholinergic inhibition of high frequency cochlear hair cells. PLoS ONE. 2010;5:e13836 pubmed publisher
    ..The objectives of this study were to investigate the tonotopic contribution of BK channels to voltage- and ligand-gated currents in mature outer hair cells from the rat cochlea...
  42. Li M, Tanaka Y, Alioua A, Wu Y, Lu R, Kundu P, et al. Thromboxane A2 receptor and MaxiK-channel intimate interaction supports channel trans-inhibition independent of G-protein activation. Proc Natl Acad Sci U S A. 2010;107:19096-101 pubmed publisher
    Large conductance voltage- and calcium-activated potassium channels (MaxiK, BK(Ca)) are well known for sustaining cerebral and coronary arterial tone and for their linkage to vasodilator ?-adrenergic receptors...
  43. Bukiya A, McMillan J, Liu J, Shivakumar B, Parrill A, Dopico A. Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4. J Biol Chem. 2014;289:35314-25 pubmed publisher
    ..b>BK channel regulation by direct interaction between lipid and channel protein sites has received increasing attention...
  44. Singh S, O HARA B, Talukder J, Rajendran V. Aldosterone induces active K? secretion by enhancing mucosal expression of Kcnn4c and Kcnma1 channels in rat distal colon. Am J Physiol Cell Physiol. 2012;302:C1353-60 pubmed publisher
    Although both Kcnn4c and Kcnma1 channels are present on colonic mucosal membranes, only Kcnma1 has been suggested to mediate K(+) secretion in the colon...
  45. Williams S, Brazier S, Baban N, Telezhkin V, Müller C, Riccardi D, et al. A structural motif in the C-terminal tail of slo1 confers carbon monoxide sensitivity to human BK Ca channels. Pflugers Arch. 2008;456:561-72 pubmed publisher
    ..Using the human BK Ca channel alpha1-subunit (hSlo1; KCNMA1) stably and transiently expressed in human embryonic kidney 293 cells, the mechanism and structural basis of ..
  46. Chen M, Sun H, Hu P, Wang C, Li B, Li S, et al. Activation of BKca channels mediates hippocampal neuronal death after reoxygenation and reperfusion. Mol Neurobiol. 2013;48:794-807 pubmed publisher
    ..It is hypothesized that the activation of large-conductance Ca(2+)-activated K(+) channels (BKCa) mediates hypoxia/reoxygenation (H/R)- and ischemia/reperfusion (I/R)-induced neuronal apoptosis...
  47. Wu S, Chern J, Shen S, Chen H, Hsu Y, Lee C, et al. Stimulatory actions of a novel thiourea derivative on large-conductance, calcium-activated potassium channels. J Cell Physiol. 2017;232:3409-3421 pubmed publisher
    ..The BKCa channels could be an important target for compound #326 if similar in vivo results occur, and the multi-functionality of BKCa channels in modulating microglial immunity merit further investigation. ..
  48. Gong L, Gao T, Huang H, Tong Z. Properties of large conductance calcium-activated potassium channels in pyramidal neurons from the hippocampal CA1 region of adult rats. Jpn J Physiol. 2001;51:725-31 pubmed
  49. Li Z, Lu N, Shi L. Exercise training reverses alterations in Kv and BKCa channel molecular expression in thoracic aorta smooth muscle cells from spontaneously hypertensive rats. J Vasc Res. 2014;51:447-57 pubmed publisher
    ..alterations in voltage-gated potassium channels (Kv) and large-conductance, calcium-activated potassium channels (BKCa) in thoracic aorta smooth muscle cells from spontaneously hypertensive rats (SHRs)...
  50. Hu H, Shao L, Chavoshy S, Gu N, Trieb M, Behrens R, et al. Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release. J Neurosci. 2001;21:9585-97 pubmed
    ..Double-labeling immunogold analysis with BK channel and glutamate receptor antibodies indicated that BK channels are targeted to the presynaptic membrane facing the ..
  51. Sun F, Hayama E, Katsube Y, Matsuoka R, Nakanishi T. The role of the large-conductance voltage-dependent and calcium-activated potassium (BK(Ca)) channels in the regulation of rat ductus arteriosus tone. Heart Vessels. 2010;25:556-64 pubmed publisher
    ..Activation of BK(Ca) channels led to vasodilatation in the preconstricted DA induced by O?, possibly suggesting a way to maintain the patency of DA after birth. ..
  52. Kwan H, Shen B, Ma X, Kwok Y, Huang Y, Man Y, et al. TRPC1 associates with BK(Ca) channel to form a signal complex in vascular smooth muscle cells. Circ Res. 2009;104:670-8 pubmed publisher
    ..The hyperpolarizing effect of TRPC1-BK(Ca) coupling could serve to reduce agonist-induced membrane depolarization, thereby preventing excessive contraction of VSMCs to contractile agonists. ..
  53. Nagai T, Ito M, Nakamichi N, Mizoguchi H, Kamei H, Fukakusa A, et al. The rewards of nicotine: regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1. J Neurosci. 2006;26:12374-83 pubmed
    ..Targeting the tPA-plasmin-PAR1 system would provide new therapeutic approaches to the treatment of nicotine dependence. ..
  54. Davies K, Zhao W, Tar M, Figueroa J, Desai P, Verselis V, et al. Diabetes-induced changes in the alternative splicing of the slo gene in corporal tissue. Eur Urol. 2007;52:1229-37 pubmed
    Erectile dysfunction is a common diabetic complication. Preclinical studies have documented that the Slo gene (encoding the BK or Maxi-K channel alpha-subunit) plays a critical role in erectile function...
  55. Liu Y, Pleyte K, Knaus H, Rusch N. Increased expression of Ca2+-sensitive K+ channels in aorta of hypertensive rats. Hypertension. 1997;30:1403-9 pubmed
  56. Tang X, Xu R, Reynolds M, Garcia M, Heinemann S, Hoshi T. Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels. Nature. 2003;425:531-5 pubmed
    ..This direct regulation of the BK channel identifies a previously unknown role of haem as an acute signalling molecule.
  57. Beisel K, Rocha Sanchez S, Ziegenbein S, Morris K, Kai C, Kawai J, et al. Diversity of Ca2+-activated K+ channel transcripts in inner ear hair cells. Gene. 2007;386:11-23 pubmed
    ..These channels are thought to play a role in the tonotopic gradient observed in the mammalian cochlea. Mouse Kcnma1 transcripts, 5' and 3' ESTs, and genomic sequences were examined for the utilization of alternative splicing in ..
  58. Denson D, Li J, Eaton D. Co-localization of the alpha-subunit of BK-channels and c-PLA2 in GH3 cells. Biochem Biophys Res Commun. 2006;350:39-49 pubmed
    ..of the BK-channel was strongly co-immunoprecipitated by c-PLA2 antibodies, suggesting that most of the BK channel alpha-subunits are associated with c-PLA2...
  59. Brainard A, Miller A, Martens J, England S. Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current. Am J Physiol Cell Physiol. 2005;289:C49-57 pubmed
    ..These data indicate that the actin cytoskeleton is involved as part of a caveolar complex in the regulation of myometrial maxi-K channel function. ..
  60. Hei H, Gao J, Dong J, Tao J, Tian L, Pan W, et al. BK Knockout by TALEN-Mediated Gene Targeting in Osteoblasts: KCNMA1 Determines the Proliferation and Differentiation of Osteoblasts. Mol Cells. 2016;39:530-5 pubmed publisher
  61. Christ G, Day N, Day M, Santizo C, Zhao W, Sclafani T, et al. Bladder injection of "naked" hSlo/pcDNA3 ameliorates detrusor hyperactivity in obstructed rats in vivo. Am J Physiol Regul Integr Comp Physiol. 2001;281:R1699-709 pubmed
    ..These initial observations indicate a potential utility of gene therapy for urinary incontinence...
  62. Yang Y, Kan J, Kong X. [Changes of BKCa during aging and its correlation with blood pressure]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2009;25:511-5 pubmed
    To investigate the changes of large-conductance calcium-activated potassium channels (BKCa, MaxiK) during aging and relations between the changes and blood pressure...
  63. Shi L, Liu X, Li N, Liu B, Liu Y. Aging decreases the contribution of MaxiK channel in regulating vascular tone in mesenteric artery by unparallel downregulation of ?- and ?1-subunit expression. Mech Ageing Dev. 2013;134:416-25 pubmed publisher
    ..Large-conductance Ca(2+)-activated K(+)(MaxiK) channel, with pore-forming ?-subunit and modulatory ?1-subunit, is a key regulator of vascular tone...
  64. Barman S, Zhu S, Han G, White R. cAMP activates BKCa channels in pulmonary arterial smooth muscle via cGMP-dependent protein kinase. Am J Physiol Lung Cell Mol Physiol. 2003;284:L1004-11 pubmed
  65. Mahmoud S, McCobb D. Regulation of Slo potassium channel alternative splicing in the pituitary by gonadal testosterone. J Neuroendocrinol. 2004;16:237-43 pubmed
    b>Slo gene-encoded BK potassium channels are prominent in both adrenomedullary and pituitary tissues. At one alternative splicing site, both tissues express variants with and without the optional 'STREX' exon...
  66. Ding J, Lingle C. Steady-state and closed-state inactivation properties of inactivating BK channels. Biophys J. 2002;82:2448-65 pubmed
    ..voltage-dependent K+ channels in chromaffin cells exhibit an inactivation that probably arises from coassembly of Slo1 alpha subunits with auxiliary beta subunits...
  67. He Y, He W, Qin G, Luo J, Xiao M. Transplantation KCNMA1 modified bone marrow-mesenchymal stem cell therapy for diabetes mellitus-induced erectile dysfunction. Andrologia. 2014;46:479-86 pubmed publisher
    This study assessed the effect of KCNMA1 transfected bone marrow-mesenchymal stem cells (BM-MSCs) on the improvement of erectile function in diabetic rats...
  68. Poulsen A, Jansen Olesen I, Olesen J, Klaerke D. Neuronal fast activating and meningeal silent modulatory BK channel splice variants cloned from rat. Pflugers Arch. 2011;461:65-75 pubmed publisher
    ..may be important for a subpopulation of BK channels in the brain, while the "silent" truncated variants X2(92) and X2(188) may play a role as modulators of other BK channel variants in a way similar to well known beta subunits.
  69. Chen M, Li J, Jiang F, Fu J, Xia X, Du J, et al. Orai1 forms a signal complex with BKCa channel in mesenteric artery smooth muscle cells. Physiol Rep. 2016;4: pubmed publisher
  70. Fernández Fernández J, Nobles M, Currid A, Vazquez E, Valverde M. Maxi K+ channel mediates regulatory volume decrease response in a human bronchial epithelial cell line. Am J Physiol Cell Physiol. 2002;283:C1705-14 pubmed
    ..This channel, TRPV4, which senses changes in volume, might provide the pathway for Ca2+ influx under hypotonic solutions and, consequently, for the activation of maxi K+ channels. ..
  71. Lee J, Kim H, Kim H, Lee B, Chun J, Park C. Modulation of the conductance-voltage relationship of the BK(Ca) channel by shortening the cytosolic loop connecting two RCK domains. Biophys J. 2009;97:730-7 pubmed publisher
    ..Thus, the functional activity of the BK(Ca) channel can be modulated by altering the tension of this loop region. ..
  72. Singh H, Lu R, Bopassa J, Meredith A, Stefani E, Toro L. MitoBK(Ca) is encoded by the Kcnma1 gene, and a splicing sequence defines its mitochondrial location. Proc Natl Acad Sci U S A. 2013;110:10836-41 pubmed publisher
    The large-conductance Ca(2+)- and voltage-activated K(+) channel (BK(Ca), MaxiK), which is encoded by the Kcnma1 gene, is generally expressed at the plasma membrane of excitable and nonexcitable cells...
  73. Lai G, McCobb D. Regulation of alternative splicing of Slo K+ channels in adrenal and pituitary during the stress-hyporesponsive period of rat development. Endocrinology. 2006;147:3961-7 pubmed
    ..Previous evidence indicates that pituitary and steroid hormones regulate alternative splicing of the Slo gene at the stress axis-regulated exon (STREX), with functional implications for the calcium-activated K+ channels ..
  74. Riddle M, Hughes J, Walker B. Role of caveolin-1 in endothelial BKCa channel regulation of vasoreactivity. Am J Physiol Cell Physiol. 2011;301:C1404-14 pubmed publisher
    ..We conclude that CH unmasks EC BK(Ca) channel activity by removing an inhibitory action of the Cav-1 scaffolding domain that may depend on cellular cholesterol levels. ..
  75. Ren J, Xing Y, Fan K, Yu B, Jin W, Jiang Y, et al. Pharmacological blockade of the MaxiK channel attenuates experimental acute pancreatitis and associated lung injury in rats. Int Immunopharmacol. 2014;21:220-4 pubmed publisher
    ..Our previous work has provided a valuable clue that a large-conductance K(+) channel (MaxiK) was involved in the HS-stimulated activation of murine macrophages...
  76. Romanenko V, Nakamoto T, Srivastava A, Melvin J, Begenisich T. Molecular identification and physiological roles of parotid acinar cell maxi-K channels. J Biol Chem. 2006;281:27964-72 pubmed
  77. Dimitropoulou C, West L, Field M, White R, Reddy L, Falck J, et al. Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation. Prostaglandins Other Lipid Mediat. 2007;83:50-61 pubmed
    ..These findings provide initial evidence that PP2A activity contributes to 11,12-EET and 11,12-EET analog activation of mesenteric resistant artery BK(Ca) channels and vasorelaxation. ..