Genomes and Genes
Gene Symbol: Kcnk1
Description: potassium two pore domain channel subfamily K member 1
Alias: Twik, potassium channel subfamily K member 1, inward rectifying potassium channel protein TWIK-1, potassium channel K2P1, potassium channel, subfamily K, member 1, potassium channel, two pore domain subfamily K, member 1, rTWIK
- Zhou M, Xu G, Xie M, Zhang X, Schools G, Ma L, et al. TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slices. J Neurosci. 2009;29:8551-64 pubmed publisher..the following evidence supporting significant contribution of the two-pore domain K(+) channel (K(2P)) isoforms, TWIK-1 and TREK-1, to this conductance...
- Miller A, Long S. Crystal structure of the human two-pore domain potassium channel K2P1. Science. 2012;335:432-6 pubmed publisher..Here, we present the 3.4 angstrom resolution crystal structure of a human K2P channel, K2P1 (TWIK-1). Unlike other K(+) channel structures, K2P1 is dimeric...
- Plant L, Dementieva I, Kollewe A, Olikara S, Marks J, Goldstein S. One SUMO is sufficient to silence the dimeric potassium channel K2P1. Proc Natl Acad Sci U S A. 2010;107:10743-8 pubmed publisher..Although channels engineered with one Lys274 site carry just one SUMO1 they are activated and silenced by SENP1 and SUMO1 like wild-type channels. ..
- Ma L, Zhang X, Chen H. TWIK-1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemia. Sci Signal. 2011;4:ra37 pubmed publisher..Here, we show that human cardiac TWIK-1 (also known as K2P1) two-pore domain K+ channels change ion selectivity, becoming permeable to external Na+, and ..