Gene Symbol: Kcnk1
Description: potassium two pore domain channel subfamily K member 1
Alias: Twik, potassium channel subfamily K member 1, inward rectifying potassium channel protein TWIK-1, potassium channel K2P1, potassium channel, subfamily K, member 1, potassium channel, two pore domain subfamily K, member 1, rTWIK
Species: rat
Products:     Kcnk1

Top Publications

  1. Nicolas M, Barhanin J, Reyes R, Dememes D. Cellular localization of TWIK-1, a two-pore-domain potassium channel in the rodent inner ear. Hear Res. 2003;181:20-6 pubmed
    ..We studied the expression and cellular localization of TWIK-1 and TWIK-2, two-pore-domain K(+) channels responsible for background K(+) currents...
  2. Cooper B, Johnson R, Rau K. Characterization and function of TWIK-related acid sensing K+ channels in a rat nociceptive cell. Neuroscience. 2004;129:209-24 pubmed
    ..The current had features consistent with K(+) leak currents of the KCNK family (TASK-1, TASK-3; TWIK-related acid sensing K(+))...
  3. Popper P, Winkler J, Erbe C, Lerch Gaggl A, Siebeneich W, Wackym P. Distribution of two-pore-domain potassium channels in the adult rat vestibular periphery. Hear Res. 2008;246:1-8 pubmed publisher
    ..1 and 6.1 like immunoreactivity (corresponding to Kcnk genes 1, 2, 3 and 6) in the vestibular periphery. K(2P)1.1 (TWIK 1) immunoreactivity was detected along nerve terminals, supporting cells and blood vessels of the crista ampullaris ..
  4. Lesage F, Lauritzen I, Duprat F, Reyes R, Fink M, Heurteaux C, et al. The structure, function and distribution of the mouse TWIK-1 K+ channel. FEBS Lett. 1997;402:28-32 pubmed
    ..b>TWIK-1 mRNA is expressed abundantly in brain and at lower levels in lung, kidney, and skeletal muscle...
  5. Cluzeaud F, Reyes R, Escoubet B, Fay M, Lazdunski M, Bonvalet J, et al. Expression of TWIK-1, a novel weakly inward rectifying potassium channel in rat kidney. Am J Physiol. 1998;275:C1602-9 pubmed
    ..By immunolocalization, we show that a new inward rectifying K+ channel, TWIK-1, is specifically expressed in distinct tubular segments and cell types of the rat kidney...
  6. Konu O -, Kane J, Barrett T, Vawter M, Chang R, Ma J, et al. Region-specific transcriptional response to chronic nicotine in rat brain. Brain Res. 2001;909:194-203 pubmed
    ..e. the weak inward rectifier K(+) channel (TWIK-1), and phosphate and tensin homolog (PTEN) by using real-time quantitative RT-PCR technique...
  7. Washburn C, Bayliss D, Guyenet P. Cardiorespiratory neurons of the rat ventrolateral medulla contain TASK-1 and TASK-3 channel mRNA. Respir Physiol Neurobiol. 2003;138:19-35 pubmed
    ..TASK channels presumably mediate excitatory effects of numerous transmitters on these neurons and may contribute to their pH-sensitivity. ..
  8. Decressac S, Franco M, Bendahhou S, Warth R, Knauer S, Barhanin J, et al. ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6. EMBO Rep. 2004;5:1171-5 pubmed
    ..EFA6 interacts with TWIK1 only when it is bound to ARF6. Because ARF6 modulates endocytosis at the apical surface of epithelial cells, the ARF6/EFA6/TWIK1 association is probably important for channel internalization and recycling. ..
  9. Cui Y, Holt A, Lomax C, Altschuler R. Deafness associated changes in two-pore domain potassium channels in the rat inferior colliculus. Neuroscience. 2007;149:421-33 pubmed
    ..TASK-5, relatively specific to auditory neurons, had the greatest decrease. TWIK-1 was significantly decreased at 3 weeks and 3 months following deafness and TREK-2 was only significantly ..

More Information


  1. Zhou M, Xu G, Xie M, Zhang X, Schools G, Ma L, et al. TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slices. J Neurosci. 2009;29:8551-64 pubmed publisher
    ..the following evidence supporting significant contribution of the two-pore domain K(+) channel (K(2P)) isoforms, TWIK-1 and TREK-1, to this conductance...
  2. Miller A, Long S. Crystal structure of the human two-pore domain potassium channel K2P1. Science. 2012;335:432-6 pubmed publisher
    ..Here, we present the 3.4 angstrom resolution crystal structure of a human K2P channel, K2P1 (TWIK-1). Unlike other K(+) channel structures, K2P1 is dimeric...
  3. Plant L, Dementieva I, Kollewe A, Olikara S, Marks J, Goldstein S. One SUMO is sufficient to silence the dimeric potassium channel K2P1. Proc Natl Acad Sci U S A. 2010;107:10743-8 pubmed publisher
    ..Although channels engineered with one Lys274 site carry just one SUMO1 they are activated and silenced by SENP1 and SUMO1 like wild-type channels. ..
  4. Ma L, Zhang X, Chen H. TWIK-1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemia. Sci Signal. 2011;4:ra37 pubmed publisher
    ..Here, we show that human cardiac TWIK-1 (also known as K2P1) two-pore domain K+ channels change ion selectivity, becoming permeable to external Na+, and ..