Gene Symbol: Kcnip4
Description: potassium voltage-gated channel interacting protein 4
Alias: Kchip4, Kv channel-interacting protein 4, A-type potassium channel modulatory protein 4, Kv channel interacting protein 4, potassium channel-interacting protein 4
Species: rat
Products:     Kcnip4

Top Publications

  1. Liang P, Wang H, Chen H, Cui Y, Gu L, Chai J, et al. Structural Insights into KChIP4a Modulation of Kv4.3 Inactivation. J Biol Chem. 2009;284:4960-7 pubmed publisher
    ..3, can confer slow inactivation. We propose that N-terminal binding of Kv4.3 to the core of KChIP4a mobilizes the KChIP4a N terminus, which serves as the slow inactivation gate. ..
  2. Rainnie D, Hazra R, Dabrowska J, Guo J, Li C, Dewitt S, et al. Distribution and functional expression of Kv4 family ? subunits and associated KChIP ? subunits in the bed nucleus of the stria terminalis. J Comp Neurol. 2014;522:609-25 pubmed publisher
    ..These results are discussed in relation to potential modulation of IA channels by chronic stress. ..
  3. Rosati B, Pan Z, Lypen S, Wang H, Cohen I, Dixon J, et al. Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. J Physiol. 2001;533:119-25 pubmed
    ..3 [alpha] subunit gene, is the primary determinant regulating the transmural gradient of Ito expression in the ventricular free wall of canine and human heart. ..
  4. Holmqvist M, Cao J, Hernandez Pineda R, Jacobson M, Carroll K, Sung M, et al. Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain. Proc Natl Acad Sci U S A. 2002;99:1035-40 pubmed
    ..Together, these results demonstrate that specific auxiliary subunits with distinct functions actively modulate gating of potassium channels that govern membrane excitability. ..
  5. Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, et al. Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. J Biol Chem. 2002;277:14965-75 pubmed
    ..During our attempts to identify binding partners of PS2, we cloned CALP (calsenilin-like protein)/KChIP4, a novel member of calsenilin/KChIP protein family that interacts with the C-terminal region of PS...
  6. Shibata R, Misonou H, Campomanes C, Anderson A, Schrader L, Doliveira L, et al. A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. J Biol Chem. 2003;278:36445-54 pubmed
    ..2 hydrophobic domain. These studies point to an essential role for KChIPs in determining both the biophysical and molecular characteristics of Kv4 channels and provide a molecular basis for the dramatic phenotype of KChIP knockout mice. ..
  7. Marionneau C, LeDuc R, Rohrs H, Link A, Townsend R, Nerbonne J. Proteomic analyses of native brain K(V)4.2 channel complexes. Channels (Austin). 2009;3:284-94 pubmed
    ..2 channel complexes. Additional biochemical and functional approaches will be required to elucidate the physiological roles of these newly identified K(V)4 interacting proteins. ..
  8. McCue H, Haynes L, Burgoyne R. The diversity of calcium sensor proteins in the regulation of neuronal function. Cold Spring Harb Perspect Biol. 2010;2:a004085 pubmed publisher
    ..In this article, we summarize synaptotagmins in neurotransmitter release, the neuronal roles of calmodulin, and the functional significance of the NCS and the CaBP/calneuron protein families of neuronal Ca(2+) sensors. ..
  9. Norris A, Foeger N, Nerbonne J. Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons. J Neurosci. 2010;30:13644-55 pubmed publisher
    ..These combined experiments revealed that KChIP2, KChIP3, and KChIP4 are robustly expressed in adult mouse posterior (visual) cortex and that all three proteins coimmunoprecipitate ..

More Information


  1. Kitazawa M, Kubo Y, Nakajo K. The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression level. J Biol Chem. 2014;289:17597-609 pubmed publisher
    ..In this study, we expressed Kv4.2 and KChIP4 with various ratios in Xenopus oocytes and observed that the biophysical properties of Kv4...
  2. Rhodes K, Carroll K, Sung M, Doliveira L, Monaghan M, Burke S, et al. KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain. J Neurosci. 2004;24:7903-15 pubmed
    ..Immunoreactivity for KChIP2, KChIP4, and Kv4.2 is concentrated in the apical and basal dendrites of hippocampal and neocortical pyramidal cells...