Kcnip3

Summary

Gene Symbol: Kcnip3
Description: Kv channel interacting protein 3, calsenilin
Alias: Csen, Dream, rKChIP3, A-type potassium channel modulating protein 3, A-type potassium channel modulatory protein 3, DRE-antagonist modulator, KChIP3, calsenilin, calsenilin presenilin-binding protein EF hand transcription factor, calsenilin, presenilin binding protein, EF hand transcription factor, calsenilin, presenilin-binding protein, EF hand transcription fa, calsenilin, presenilin-binding protein, EF hand transcription factor, downstream regulatory element-antagonist modulator, kv channel-interacting protein 3
Species: rat

Top Publications

  1. ncbi Transcriptional repressor DREAM interacts with thyroid transcription factor-1 and regulates thyroglobulin gene expression
    Marcos Rivas
    Dpto Biología Molecular y Celular, Centro Nacional de Biotecnologia, CSIC 28049 Madrid, Spain
    J Biol Chem 279:33114-22. 2004
  2. doi Nitric oxide modulated the expression of DREAM/calsenilin/KChIP3 in inflammatory pain of rats
    Hong Bo Jin
    Department of Physiology, Harbin Medical University, 194 Xuefu Rd, Nangang District, Harbin 150081, People s Republic of China
    Inflammation 35:1867-71. 2012
  3. ncbi Regional and cellular distribution of DREAM in adult rat brain consistent with multiple sensory processing roles
    Pamela I Hammond
    Department of Molecular Pharmacology and Experimental Therapeutics, Guggenheim 7, Mayo Clinic 200 First Street Southwest, Rochester, MN 55905, USA
    Brain Res Mol Brain Res 111:104-10. 2003
  4. doi Subcellular localization and transcription regulatory potency of KCNIP/Calsenilin/DREAM/KChIP proteins in cultured primary cortical neurons do not provide support for their role in CRE-dependent gene expression
    Priit Pruunsild
    Department of Gene Technology, Tallinn University of Technology, Estonia
    J Neurochem 123:29-43. 2012
  5. doi Hyperglycemia induces early upregulation of the calcium sensor KChIP3/DREAM/calsenilin in the rat retina
    Erika Chavira-Suárez
    Departamento de Farmacobiologia, Centro de Investigación y de Estudios Avanzados del IPN CINVESTAV IPN, Mexico Distrito Federal, Mexico
    Biochem Biophys Res Commun 418:420-5. 2012
  6. pmc The diversity of calcium sensor proteins in the regulation of neuronal function
    Hannah V McCue
    The Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, United Kingdom
    Cold Spring Harb Perspect Biol 2:a004085. 2010
  7. pmc Ca2+-calmodulin-dependent protein kinase II represses cardiac transcription of the L-type calcium channel alpha(1C)-subunit gene (Cacna1c) by DREAM translocation
    Jarkko J Ronkainen
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, PO Box 1627, Neulaniementie 2, FI 70211 Kuopio, Finland
    J Physiol 589:2669-86. 2011
  8. doi Increases in mRNA and DREAM protein expression in the rat spinal cord after formalin induced pain
    Idris Long
    School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia
    Neurochem Res 36:533-9. 2011
  9. doi Expression and high glucose-mediated regulation of K+ channel interacting protein 3 (KChIP3) and KV4 channels in retinal Müller glial cells
    Erika Chavira-Suárez
    Department of Pharmacobiology, Centro de Investigación y de Estudios Avanzados Cinvestav, Mexico City, Mexico
    Biochem Biophys Res Commun 404:678-83. 2011
  10. doi Sumoylation regulates nuclear localization of repressor DREAM
    Malgorzata Palczewska
    Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
    Biochim Biophys Acta 1813:1050-8. 2011

Research Grants

Scientific Experts

  • Pamela I Hammond
  • Priit Pruunsild
  • Henry H Jerng
  • Koichi Takimoto
  • Ylva Edling
  • Erika Chavira-Suárez
  • Bruce Pitt
  • Monica Lamas
  • Yi Li
  • Ying Zhang
  • Hong Bo Jin
  • Alejandro Sandoval
  • Ricardo Felix
  • Idris Long
  • Jarkko J Ronkainen
  • Malgorzata Palczewska
  • Kenneth J Rhodes
  • Hannah V McCue
  • Jose R Naranjo
  • Yun Wang
  • Britt Mellstrom
  • Ji Sheng Han
  • Barbara D'Andrea
  • Marcos Rivas
  • Lisa C Doliveira
  • James S Trimmer
  • Karen I Carroll
  • Riichi Shibata
  • Gilles M Leclerc
  • Heberto Quintero
  • Yu rong Li
  • Yong Liang Yang
  • Prisca Bustamante
  • Yong Bin Yang
  • Ying Li Song
  • S Ohya
  • Ana M Rojas
  • Sini Rautio
  • Pasi Tavi
  • Sandra L Hänninen
  • Reka Skoumal
  • Miguel Lafarga
  • Veli Pekka Ronkainen
  • Alfonso Valencia
  • Jussi T Koivumäki
  • Zalina Ismail
  • Rapeah Suppian
  • Iñigo Casafont
  • Kedar Ghimire
  • Topi Korhonen
  • Lee P Haynes
  • Robert D Burgoyne
  • W F An
  • Monica Ramirez
  • Hai Hao Zhu
  • Yan Rui Yang
  • Tina Di Palma
  • Lucio Nitsch
  • Anna Mascia
  • Maria Letizia Motti
  • Giuseppe Viglietto
  • Mariastella Zannini
  • Milena Menegola
  • Jie Cao
  • Brian W Strassle
  • Pilar Santisteban
  • M Amy Sung
  • W Frank An
  • Sharon L Burke
  • Michael M Monaghan
  • Lynn Buchwalder
  • Hiroaki Misonou
  • Laura A Schrader
  • J David Sweatt
  • Anne E Anderson
  • Claire R Campomanes
  • Fredric R Boockfor
  • L Stephen Frawley
  • Guy J Leclerc
  • Spencer L Shorte
  • Y Imaizumi
  • T Tomita
  • T Iwatsubo
  • Y Morohashi
  • M Watanabe
  • K Muraki
  • K I Mattsson
  • H P Ling
  • J W Hinson
  • M Betty

Detail Information

Publications22

  1. ncbi Transcriptional repressor DREAM interacts with thyroid transcription factor-1 and regulates thyroglobulin gene expression
    Marcos Rivas
    Dpto Biología Molecular y Celular, Centro Nacional de Biotecnologia, CSIC 28049 Madrid, Spain
    J Biol Chem 279:33114-22. 2004
    ..b>DREAM is a Ca2+-dependent transcriptional repressor widely expressed in the brain where it participates in nociception ..
  2. doi Nitric oxide modulated the expression of DREAM/calsenilin/KChIP3 in inflammatory pain of rats
    Hong Bo Jin
    Department of Physiology, Harbin Medical University, 194 Xuefu Rd, Nangang District, Harbin 150081, People s Republic of China
    Inflammation 35:1867-71. 2012
    Downstream regulatory element antagonistic modulator (DREAM) is a critical transcriptional repressor for pain modulation. The role of nitric oxide (NO) plays in modulating DREAM pain pathway in the periphery is unclear...
  3. ncbi Regional and cellular distribution of DREAM in adult rat brain consistent with multiple sensory processing roles
    Pamela I Hammond
    Department of Molecular Pharmacology and Experimental Therapeutics, Guggenheim 7, Mayo Clinic 200 First Street Southwest, Rochester, MN 55905, USA
    Brain Res Mol Brain Res 111:104-10. 2003
    We used immunohistochemistry to map the recently discovered EF-hand protein, DREAM (downstream regulatory element antagonist modulator), and compare its expression in rat brain with that of other key neural proteins...
  4. doi Subcellular localization and transcription regulatory potency of KCNIP/Calsenilin/DREAM/KChIP proteins in cultured primary cortical neurons do not provide support for their role in CRE-dependent gene expression
    Priit Pruunsild
    Department of Gene Technology, Tallinn University of Technology, Estonia
    J Neurochem 123:29-43. 2012
    KCNIP3/KChIP3 (voltage-dependent K+ channel interacting protein 3), alias Calsenilin and downstream regulatory element antagonist modulator (DREAM), is a multifunctional protein that modulates A-type potassium channels, affects processing ..
  5. doi Hyperglycemia induces early upregulation of the calcium sensor KChIP3/DREAM/calsenilin in the rat retina
    Erika Chavira-Suárez
    Departamento de Farmacobiologia, Centro de Investigación y de Estudios Avanzados del IPN CINVESTAV IPN, Mexico Distrito Federal, Mexico
    Biochem Biophys Res Commun 418:420-5. 2012
    ..The potassium channel interacting protein 3 (KChIP3) also known as DREAM (Downstream Regulatory Element Antagonist Modulator) or calsenilin (KChIP3/DREAM/calsenilin), a member of the neuronal calcium sensor protein ..
  6. pmc The diversity of calcium sensor proteins in the regulation of neuronal function
    Hannah V McCue
    The Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, United Kingdom
    Cold Spring Harb Perspect Biol 2:a004085. 2010
    ..In this article, we summarize synaptotagmins in neurotransmitter release, the neuronal roles of calmodulin, and the functional significance of the NCS and the CaBP/calneuron protein families of neuronal Ca(2+) sensors...
  7. pmc Ca2+-calmodulin-dependent protein kinase II represses cardiac transcription of the L-type calcium channel alpha(1C)-subunit gene (Cacna1c) by DREAM translocation
    Jarkko J Ronkainen
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, PO Box 1627, Neulaniementie 2, FI 70211 Kuopio, Finland
    J Physiol 589:2669-86. 2011
    ..abolished by deletion of the downstream regulatory element (DRE), which binds transcriptional repressor DREAM/calsenilin/KChIP3...
  8. doi Increases in mRNA and DREAM protein expression in the rat spinal cord after formalin induced pain
    Idris Long
    School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia
    Neurochem Res 36:533-9. 2011
    b>Downstream Regulatory Element Antagonist Modulator (DREAM) protein modulates pain by regulating prodynorphin gene transcription...
  9. doi Expression and high glucose-mediated regulation of K+ channel interacting protein 3 (KChIP3) and KV4 channels in retinal Müller glial cells
    Erika Chavira-Suárez
    Department of Pharmacobiology, Centro de Investigación y de Estudios Avanzados Cinvestav, Mexico City, Mexico
    Biochem Biophys Res Commun 404:678-83. 2011
    ..Recently, we showed that Müller cells express the pleiotropic protein potassium channel interacting protein 3 (KChIP3), an integral component of the voltage-gated K(+) channels K(V)4...
  10. doi Sumoylation regulates nuclear localization of repressor DREAM
    Malgorzata Palczewska
    Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
    Biochim Biophys Acta 1813:1050-8. 2011
    b>DREAM is a Ca(2+)-binding protein with specific functions in different cell compartments. In the nucleus, DREAM acts as a transcriptional repressor, although the mechanism that controls its nuclear localization is unknown...
  11. doi Distinct responses of DREAM to electroacupuncture stimulation with different frequencies during physiological and inflammatory conditions in rats
    Yi Li
    Neuroscience Research Institute and Department of Neurobiology, The Key Laboratory for Neuroscience of the Ministry of Education and of Health, Peking University, 38 Xueyuan Road, Beijing 100083, People s Republic of China
    Neurochem Res 33:2070-7. 2008
    ..Here we report that the transcriptional repressor downstream regulatory element antagonist modulator (DREAM) of dynorphin precursor-preprodynorphin (PPD) may participate in this process...
  12. doi D-Serine/N-methyl-D-aspartate receptor signaling decreases DNA-binding activity of the transcriptional repressor DREAM in Müller glia from the retina
    Erika Chavira-Suárez
    Departamento de Farmacobiologia, CINVESTAV Sede Sur, Mexico DF, Mexico
    Neurosci Lett 432:121-6. 2008
    ..We have found that the transcription factor DREAM (downstream regulatory element antagonist modulator), which acts as a transcriptional repressor by binding as a tetramer to regulatory elements ..
  13. ncbi Distribution of downstream regulatory element antagonist modulator (DREAM) in rat spinal cord and upregulation of its expression during inflammatory pain
    Ying Zhang
    Neuroscience Research Institute, Department of Neurobiology, The Key Laboratory for Neuroscience, The Ministry of Education, Peking University Health Science Center, Beijing, 100083, P R China
    Neurochem Res 32:1592-9. 2007
    A previous knockout study revealed the critical role of downstream regulatory element antagonist modulator (DREAM) in pain processing in the spinal cord by transcriptional regulation of prodynorphin (PPD) gene...
  14. ncbi Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2
    S Ohya
    Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabedori, Mizuhoku, Nagoya, 467 8603, Japan
    Biochem Biophys Res Commun 282:96-102. 2001
    ..3 and KChIP2S/L were analyzed in native and Kv4.3-expressed HEK293 cells. Specific localization of GFP-fused KChIP2S/L proteins on or near cell membrane was observed only in Kv4.3-expressed HEK293 cells...
  15. ncbi Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels
    Koichi Takimoto
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
    J Biol Chem 277:26904-11. 2002
    The Ca(2+)-binding proteins KChIP1-4 (KChIP3 is also known as DREAM and calsenilin) act as auxiliary subunits for voltage-gated K(+) channels in the Kv4 family...
  16. ncbi Cloning and mRNA expression of the Ca2+-binding DREAM protein in the pituitary
    Gilles M Leclerc
    Laboratory of Molecular Dynamics, Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston 29425, USA
    Gen Comp Endocrinol 129:45-55. 2002
    ..Recently, a novel gene has been identified in neuroendocrine cells that encodes DREAM, a calcium-binding protein that acts as a transcriptional repressor by binding specific downstream regulatory ..
  17. ncbi A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels
    Riichi Shibata
    Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, New York 11794, USA
    J Biol Chem 278:36445-54. 2003
    ..2 hydrophobic domain. These studies point to an essential role for KChIPs in determining both the biophysical and molecular characteristics of Kv4 channels and provide a molecular basis for the dramatic phenotype of KChIP knockout mice...
  18. ncbi KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain
    Kenneth J Rhodes
    Neuroscience, Wyeth Discovery Research, Princeton, New Jersey 08543, USA
    J Neurosci 24:7903-15. 2004
    ....
  19. ncbi The transcriptional repressor DREAM is involved in thyroid gene expression
    Barbara D'Andrea
    Istituto di Endocrinologia ed Oncologia Sperimentale CNR and Dpt di Biologia e Patologia Cellulare e Molecolare, Via Pansini 5, 80131 Napoli, Italy
    Exp Cell Res 305:166-78. 2005
    Downstream regulatory element antagonistic modulator (DREAM) was originally identified in neuroendocrine cells as a calcium-binding protein that specifically binds to downstream regulatory elements (DRE) on DNA, and represses ..
  20. pmc Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties
    Henry H Jerng
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, S630, Houston, TX 77030, USA
    J Physiol 568:767-88. 2005
    ..Since KChIP and DPL distributions overlap in the brain, we investigated the potential coassembly of Kv4.2, KChIP3 and DPL proteins, and the contribution of DPLs to ternary complex properties...
  21. ncbi Glutamate activates c-fos in glial cells via a novel mechanism involving the glutamate receptor subtype mGlu5 and the transcriptional repressor DREAM
    Ylva Edling
    Department of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Glia 55:328-40. 2007
    ..reporter assays, DRE, which actively represses c-fos by binding the calcium-binding transcriptional repressor DREAM, was activated by glutamate, whereas SRE and CRE were not...
  22. ncbi Modulation of A-type potassium channels by a family of calcium sensors
    W F An
    Millennium Pharmaceuticals, Cambridge, Massachusetts 02139, USA
    Nature 403:553-6. 2000
    ..As the activity and density of neuronal A-type currents tightly control responses to excitatory synaptic inputs, these KChIPs may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium...

Research Grants8

  1. REGULATION OF CARDIAC POTASSIUM CHANNEL GENE EXPRESSION
    Koichi Takimoto; Fiscal Year: 2002
    ..x gene expression independently of hypertrophy. Hence, this proposal is to test these possibilities using hypertension animal models and neonatal myocyte cultures. ..
  2. Regulation of Kv Channels by Anorexigens
    Bruce Pitt; Fiscal Year: 2007
    ..1 proteins, inhibition of Kv1.5 gene transcription and blockade of Kv currents at plasma membrane. ..