Gene Symbol: Katnb1
Description: katanin regulatory subunit B1
Alias: katanin p80 WD40 repeat-containing subunit B1, katanin p80 (WD repeat containing) subunit B 1, katanin p80 (WD40-containing) subunit B 1
Hartman J, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, et al
. Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. Cell. 1998;93:277-87 pubmed
..These results indicate katanin's activities are segregated into a subunit (p60) that possesses enzymatic activity and a subunit (p80) that targets the enzyme to the centrosome...
McNally K, Bazirgan O, McNally F. Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. J Cell Sci. 2000;113 ( Pt 9):1623-33 pubmed
..We propose that both domains of p80 are essential in precisely regulating katanin's activity in vivo. ..
Toyo oka K, Sasaki S, Yano Y, Mori D, Kobayashi T, Toyoshima Y, et al
. Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. Hum Mol Genet. 2005;14:3113-28 pubmed
..Our results suggest that NDEL1 is essential for mitotic cell division and neuronal migration not only via regulation of cytoplasmic dynein function but also by modulation of katanin p60 localization and function. ..
Yang S, Oh K, Park E, Chang H, Park J, Seong M, et al
. USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate katanin-p60-mediated axonal growth. J Neurosci. 2013;33:12728-38 pubmed publisher
..These results indicate that USP47 plays a crucial role in the control of axonal growth during neuronal development by antagonizing CHIP-mediated katanin-p60 degradation. ..
Yu W, Solowska J, Qiang L, Karabay A, Baird D, Baas P. Regulation of microtubule severing by katanin subunits during neuronal development. J Neurosci. 2005;25:5573-83 pubmed
Cheung K, Senese S, Kuang J, Bui N, Ongpipattanakul C, Gholkar A, et al
. Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing. Mol Cell Proteomics. 2016;15:1658-69 pubmed publisher
..Katanin is composed of a catalytic p60 subunit (A subunit, KATNA1) and a regulatory p80 subunit (B subunit, KATNB1)...
Sudo H, Maru Y. LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 katanin. FASEB J. 2007;21:2086-100 pubmed
..These results suggest that LAPSER1 participates in cytokinesis by interacting with p80 katanin, the disruption of which may potentially cause genetic instability and cancer. ..