Junb

Summary

Gene Symbol: Junb
Description: jun B proto-oncogene
Alias: Jun-B oncogene, transcription factor jun-B
Species: rat

Top Publications

  1. ncbi The differential molecular mechanisms underlying proenkephalin mRNA expression induced by forskolin and phorbol-12-myristic-13-acetate in primary cultured astrocytes
    J S Won
    Department of Pharmacology, College of Medicine, Hallym University, 1 Okchun dong, Chunchon, Kangwon Do, 200 702, South Korea
    Brain Res Mol Brain Res 84:41-51. 2000
  2. ncbi Chronic antipsychotic drug treatment induces long-lasting expression of fos and jun family genes and activator protein 1 complex in the rat prefrontal cortex
    Outi Kontkanen
    A I Virtanen Institute, University of Kuopio, Kuopio, Finland
    Neuropsychopharmacology 27:152-62. 2002
  3. pmc A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers
    Marina R Bergman
    Cardiology Section, Department of Medicine, San Francisco Veterans Affairs Medical Center, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    Biochem J 369:485-96. 2003
  4. ncbi Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site
    S Varghese
    Department of Research and Medicine, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105, USA
    Endocrinology 141:2185-91. 2000
  5. doi Activation of the cAMP pathway synergistically increases IL-1-induced IL-6 gene expression in FRTL-5 thyroid cells: involvement of AP-1 transcription factors
    Nicolas Szabo-Fresnais
    INSERM U 486, Faculte de Pharmacie, F 92296 Chatenay Malabry, France
    Mol Cell Endocrinol 284:28-37. 2008
  6. ncbi Expressions of junB and c-fos are enhanced in 4-nitroquinoline 1-oxide-induced rat tongue cancers
    Masanobu Ohyama
    Department of Oral Pathology, Kagoshima University Dental School, Kagoshima, Japan
    Pathol Int 54:35-40. 2004
  7. ncbi Mechanical stretch and progesterone differentially regulate activator protein-1 transcription factors in primary rat myometrial smooth muscle cells
    Jennifer A Mitchell
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Am J Physiol Endocrinol Metab 287:E439-45. 2004
  8. ncbi Fos- and Jun-related transcription factors are involved in the signal transduction pathway of mechanical loading in condylar chondrocytes
    Dionisios Papachristou
    Department of Pathology, School of Medicine, University of Ioannina, Greece
    Eur J Orthod 28:20-6. 2006
  9. ncbi Heterodimerization with Jun family members regulates c-Fos nucleocytoplasmic traffic
    Cecile E Malnou
    Institut de Genetique Moleculaire de Montpellier, CNRS, UMR5535, 1919 Route de Mende, Montpellier F 34293, France
    J Biol Chem 282:31046-59. 2007
  10. pmc Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge
    Anita C Hansson
    Department of Neuroscience, Karolinska Institutet, 10401 Stockholm, Sweden
    Brain Res 1215:1-10. 2008

Scientific Experts

  • Joanna M Williams
  • S Varghese
  • A C Hansson
  • Gilles Mercier
  • A M Francois-Bellan
  • Marcin Rylski
  • Jennifer A Mitchell
  • Nicolas Szabo-Fresnais
  • Cecile E Malnou
  • Dionisios Papachristou
  • Masanobu Ohyama
  • Stephen J Lye
  • Marina R Bergman
  • Sebastian Bisler
  • Outi Kontkanen
  • J S Won
  • S C Sharma
  • Martine Pomerance
  • Jean Paul Blondeau
  • Frederique Brockly
  • Isabelle Jariel-Encontre
  • Tamara Salem
  • Marc Piechaczyk
  • Harald Wodrich
  • Tuomo Kantomaa
  • Pertti Pirttiniemi
  • Efthimia K Basdra
  • Niki Agnantis
  • Motoo Kitano
  • Hayase Shisa
  • Hiroshi Hiai
  • Ichiro Semba
  • Oksana Shynlova
  • Yoshikazu Hirayama
  • S Urakami
  • Jun Ichi Tanuma
  • Masato Hirano
  • B Lowell Langille
  • Kazumasa Sugihara
  • Lucia Piacentini
  • David H Lovett
  • Joel S Karliner
  • Sunfa Cheng
  • Norman Honbo
  • Garry Wong
  • Jorg H Stehle
  • Axel Schleicher
  • Merja Lakso
  • Eero Castren
  • Karl Zilles
  • Jochen F Staiger
  • Peter Gass
  • J S Richards
  • H W Suh
  • I Kitabayashi
  • T Kobayashi
  • K Orimoto
  • Z Kawakami
  • H Tsuchiya
  • M Igawa
  • O Hino
  • G Gachelin
  • K Yokoyama
  • T Matsuoka
  • R Chiu

Detail Information

Publications20

  1. ncbi The differential molecular mechanisms underlying proenkephalin mRNA expression induced by forskolin and phorbol-12-myristic-13-acetate in primary cultured astrocytes
    J S Won
    Department of Pharmacology, College of Medicine, Hallym University, 1 Okchun dong, Chunchon, Kangwon Do, 200 702, South Korea
    Brain Res Mol Brain Res 84:41-51. 2000
    ..Differential regulation of AP-1 proteins by PMA and FSK was also observed. While c-Fos, Fra-2 and JunB were increased in response to either stimuli, only Fra-1, c-Jun and JunD were increased by PMA...
  2. ncbi Chronic antipsychotic drug treatment induces long-lasting expression of fos and jun family genes and activator protein 1 complex in the rat prefrontal cortex
    Outi Kontkanen
    A I Virtanen Institute, University of Kuopio, Kuopio, Finland
    Neuropsychopharmacology 27:152-62. 2002
    ..of chronic clozapine and haloperidol treatments on the expression of fos (c-fos, fosB, fra-2) and jun (c-jun, junB, junD) family genes in the rat forebrain...
  3. pmc A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers
    Marina R Bergman
    Cardiology Section, Department of Medicine, San Francisco Veterans Affairs Medical Center, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    Biochem J 369:485-96. 2003
    ..Antibody-supershift EMSAs of nuclear extracts from normoxic rat cardiac fibroblasts demonstrated Fra1 and JunB binding to the -1410 to -1362 bp oligonucleotide...
  4. ncbi Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site
    S Varghese
    Department of Research and Medicine, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105, USA
    Endocrinology 141:2185-91. 2000
    ..Supershift analysis of nuclear extracts revealed that bFGF stimulates the occupancy of AP-1 site by c-Jun, JunB, JunD, c-Fos, FosB, and Fra2...
  5. doi Activation of the cAMP pathway synergistically increases IL-1-induced IL-6 gene expression in FRTL-5 thyroid cells: involvement of AP-1 transcription factors
    Nicolas Szabo-Fresnais
    INSERM U 486, Faculte de Pharmacie, F 92296 Chatenay Malabry, France
    Mol Cell Endocrinol 284:28-37. 2008
    ..These findings contribute to elucidating the synergistic mechanisms that regulate IL-6 secretion by thyroid cells, and suggest that such mechanisms may be involved in the development of thyroid autoimmune disorders...
  6. ncbi Expressions of junB and c-fos are enhanced in 4-nitroquinoline 1-oxide-induced rat tongue cancers
    Masanobu Ohyama
    Department of Oral Pathology, Kagoshima University Dental School, Kagoshima, Japan
    Pathol Int 54:35-40. 2004
    ..study investigated the expression levels of genes that encode the components of AP-1, the jun gene family (c-jun, junB and junD) and the fos gene family (c-fos, fra-1, fra-2 and fosB)...
  7. ncbi Mechanical stretch and progesterone differentially regulate activator protein-1 transcription factors in primary rat myometrial smooth muscle cells
    Jennifer A Mitchell
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Am J Physiol Endocrinol Metab 287:E439-45. 2004
    ..Static stretch induced an increase in the expression of c-fos, fosB, fra-1, c-jun, and junB. The expression of both c-fos and junB was maximally induced at 30 min by static stretch...
  8. ncbi Fos- and Jun-related transcription factors are involved in the signal transduction pathway of mechanical loading in condylar chondrocytes
    Dionisios Papachristou
    Department of Pathology, School of Medicine, University of Ioannina, Greece
    Eur J Orthod 28:20-6. 2006
    ..downstream effector in the early response of stress-sensitive cells to mechanical loading, and the Fra-1, Fra-2, JunB and JunD members of the AP-1 transcription factor family, as mediators in bone remodelling and apoptotic phenomena...
  9. ncbi Heterodimerization with Jun family members regulates c-Fos nucleocytoplasmic traffic
    Cecile E Malnou
    Institut de Genetique Moleculaire de Montpellier, CNRS, UMR5535, 1919 Route de Mende, Montpellier F 34293, France
    J Biol Chem 282:31046-59. 2007
    c-Fos proto-oncoprotein forms AP-1 transcription complexes with heterodimerization partners such as c-Jun, JunB, and JunD. Thereby, it controls essential cell functions and exerts tumorigenic actions...
  10. pmc Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge
    Anita C Hansson
    Department of Neuroscience, Karolinska Institutet, 10401 Stockholm, Sweden
    Brain Res 1215:1-10. 2008
    ..We examined the region- and time-dependent transcriptional profiles of six IEGs (c-fos, fosB, fra-1, junB, c-jun and egr-1) by in situ hybridization after acute corticosterone challenge in the hippocampus and the primary ..
  11. pmc Conserved structural motifs among mammalian junB genes
    Z Kawakami
    Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Nucleic Acids Res 20:914. 1992
  12. ncbi Differential expression of activator protein-1 transcription factors in pregnant rat myometrium
    Jennifer A Mitchell
    Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
    Biol Reprod 67:240-6. 2002
    ..Expression of c-fos, fosB, fra-1, fra-2, and junB was low during early gestation, with a 5- to 10-fold increase on Day 23 during labor, and returned to low levels 1 ..
  13. ncbi Expression of c-Fos, ICER, Krox-24 and JunB in the whisker-to-barrel pathway of rats: time course of induction upon whisker stimulation by tactile exploration of an enriched environment
    Sebastian Bisler
    C and O Vogt Institut für Hirnforschung, Heinrich Heine Universitat, Universitatsstr 1, D 40225 Dusseldorf, Germany
    J Chem Neuroanat 23:187-98. 2002
    ..b>JunB was induced after 1 h of exploration, declined at 6 h and returned to basal levels after this time point...
  14. ncbi Rapid effects of triiodothyronine on immediate-early gene expression in Schwann cells
    G Mercier
    U488 INSERM, Kremlin Bicetre, France
    Glia 35:81-9. 2001
    ..Expression of egr-1 (krox-24), egr-2 (krox-20), egr-3, c-jun, junB, c-fos, fosB, fra-1, fra-2, and CREB genes was analyzed by reverse transcription-polymerase chain reaction (RT-PCR) ..
  15. ncbi Is light-regulated AP-1 binding in the rat suprachiasmatic nucleus gated by the circadian clock?
    A M Francois-Bellan
    INSERM U 501, Institut Federatif Jean Roche, Faculte de Medecine Nord, Universite de la Mediterranee, Bd Pierre Dramard, 13916 Marseille Cedex 20, France
    Brain Res Mol Brain Res 85:161-70. 2000
    ..It was then shown that the mechanisms by which the circadian clock gates the photic induction of AP-1 components differed according to the nature of the protein...
  16. ncbi Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation
    S C Sharma
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 275:33718-28. 2000
    ..b>JunB, c-Jun, c-Fos, and Fra2 were rapidly but transiently induced by FSH in immature granulosa cells...
  17. ncbi Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation
    J M Williams
    Department of Biochemistry and Centre for Gene Research, University of Otago, Dunedin, New Zealand
    Brain Res Mol Brain Res 77:258-66. 2000
    ..These data indicate that binding of Egr-1 and AP-1 to their response elements is increased in two phases. This may result in activation of distinct banks of target genes which contribute to the establishment of persistent LTP...
  18. ncbi Overexpression of members of the AP-1 transcriptional factor family from an early stage of renal carcinogenesis and inhibition of cell growth by AP-1 gene antisense oligonucleotides in the Tsc2 gene mutant (Eker) rat model
    S Urakami
    Department of Experimental Pathology, Cancer Institute, 1 37 1 Kami Ikebukuro, Tokyo, Toshima ku, 170, Japan
    Biochem Biophys Res Commun 241:24-30. 1997
    ..In the present study, overexpression of fra-1, fra-2, c-jun, junB, and junD mRNAs was demonstrated in RCs by Northern blot analysis...
  19. ncbi Two cis-regulatory elements that mediate different signaling pathways for serum-dependent activation of the junB gene
    I Kitabayashi
    Tsukuba Life Science Center, RIKEN The Institute of Physical and Chemical Research, Ibaraki, Japan
    J Biol Chem 268:14482-9. 1993
    Transcription of the junB gene is rapidly and transiently induced by a variety of extracellular signals...
  20. doi JunB is a repressor of MMP-9 transcription in depolarized rat brain neurons
    Marcin Rylski
    Department of Molecular and Cellular Neurobiology, Nencki Institute, Pasteura 3, 02 093 Warsaw, Poland
    Mol Cell Neurosci 40:98-110. 2009
    ..Furthermore, we demonstrate that in the rat hippocampus neuronal activation strongly induces JunB expression, simultaneously leading to an accumulation of JunB/FosB complexes onto the -88/-80 bp site of the rat ..