Gene Symbol: Jun
Description: Jun proto-oncogene, AP-1 transcription factor subunit
Alias: transcription factor AP-1, AP1, Avian sarcoma virus 17 (v-jun) oncogene homolog, Jun oncogene, V-jun avian sarcoma virus 17 oncogene homolog, activator protein 1, proto-oncogene c-jun, v-jun sarcoma virus 17 oncogene homolog
Species: rat
Products:     Jun

Top Publications

  1. Kinoshita I, Leaner V, Katabami M, Manzano R, Dent P, Sabichi A, et al. Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: increased expression of stathmin is necessary for cJun-mediated anchorage-independent growth. Oncogene. 2003;22:2710-22 pubmed
    ..These results suggest that stathmin plays an essential role in anchorage-independent growth by cJun and may be a potential target for specific inhibitors for AP-1-dependent processes involved in carcinogenesis. ..
  2. Oya M, Mikami S, Mizuno R, Marumo K, Mukai M, Murai M. C-jun activation in acquired cystic kidney disease and renal cell carcinoma. J Urol. 2005;174:726 pubmed
    ..Activator protein-1 is composed of 2 proto-oncogene families, namely Jun and Fos. Of them c-Jun has been suggested to have a role in cell cycle progression and neoplastic transformation...
  3. Lindwall C, Kanje M. Retrograde axonal transport of JNK signaling molecules influence injury induced nuclear changes in p-c-Jun and ATF3 in adult rat sensory neurons. Mol Cell Neurosci. 2005;29:269-82 pubmed
    In the present study, we investigated if the previously observed JNK-mediated activation of c-Jun and induction of ATF3 could be ascribed to axonal transport of JNK signaling components, or if axonal transport of the transcription ..
  4. Vleugel M, Greijer A, Bos R, van der Wall E, van Diest P. c-Jun activation is associated with proliferation and angiogenesis in invasive breast cancer. Hum Pathol. 2006;37:668-74 pubmed
    c-Jun is a component of the transcription factor activator protein 1 (AP-1), which binds and activates transcription at TRE/AP-1 elements...
  5. Amir M, Liu K, Zhao E, Czaja M. Distinct functions of JNK and c-Jun in oxidant-induced hepatocyte death. J Cell Biochem. 2012;113:3254-65 pubmed publisher
    Overactivation of c-Jun N-terminal kinase (JNK)/c-Jun signaling is a central mechanism of hepatocyte injury and death including that from oxidative stress...
  6. Miao B, Yin X, Pei D, Zhang Q, Zhang G. Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation. J Biol Chem. 2005;280:21693-9 pubmed
    ..results, ischemic preconditioning could not only inhibit activations of mixed lineage kinase 3, JNK1/2, and c-Jun but also enhanced activation of Akt1...
  7. Kitabayashi I, Kawakami Z, Chiu R, Ozawa K, Matsuoka T, Toyoshima S, et al. Transcriptional regulation of the c-jun gene by retinoic acid and E1A during differentiation of F9 cells. EMBO J. 1992;11:167-75 pubmed
    ..The transcription of the c-jun gene is stimulated by either RA or E1A...
  8. Serra R, Fang M, Park S, Hutchinson L, Green M. A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. elife. 2014;3:e02313 pubmed publisher
    ..Finally, we show that ZNF304 also directs transcriptional silencing of INK4-ARF in human embryonic stem cells. DOI: http://dx.doi.org/10.7554/eLife.02313.001...
  9. Levy A, Izumiya Y, Brunovskis P, Xia L, Parcells M, Reddy S, et al. Characterization of the chromosomal binding sites and dimerization partners of the viral oncoprotein Meq in Marek's disease virus-transformed T cells. J Virol. 2003;77:12841-51 pubmed
    ..Meq has a bZIP (basic leucine zipper) structure resembling the family of Jun/Fos. The mechanism whereby Meq transforms T cells remains poorly understood...

More Information


  1. Fischer T, Ludwig S, Flory E, Gambaryan S, Singh K, Finn P, et al. Activation of cardiac c-Jun NH(2)-terminal kinases and p38-mitogen-activated protein kinases with abrupt changes in hemodynamic load. Hypertension. 2001;37:1222-8 pubmed
    ..we examined whether activation of MAPK pathways, namely, the extracellular signal-regulated protein kinase (ERK), c-Jun NH(2)-terminal kinase (JNK), and the p38-MAPK pathways, occurs during rapid changes in hemodynamic load in vivo...
  2. Zhang H, Liu H, Iles K, Liu R, Postlethwait E, Laperche Y, et al. 4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling. Am J Respir Cell Mol Biol. 2006;34:174-81 pubmed
    ..Immunodepletion gel shift assays demonstrated that GP5 EpRE bound JunB, c-Jun, FosB, and Fra2 from unstimulated cells, and that after exposure to HNE, EpRE binding complexes contained nuclear ..
  3. Alvarez E, Northwood I, Gonzalez F, Latour D, Seth A, Abate C, et al. Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase. J Biol Chem. 1991;266:15277-85 pubmed
    ..In this report we describe two novel substrates: (a) the human c-myc protein at Ser62 and (b) the rat c-jun protein at Ser246...
  4. Mermod N, Williams T, Tjian R. Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Nature. 1988;332:557-61 pubmed
    ..Thus by manipulating the levels of different trans-acting factors in vitro, we can recreate the pattern of SV40 late initiation observed during the viral lytic cycle in vivo. ..
  5. Zhao H, Wang J, Wang X, Dong J, Zhou H, Yang Y. [Effects of polychlorinated biphenyl on the expression of c-fos and c-jun in mesenchymal cells of rats]. Wei Sheng Yan Jiu. 2012;41:180-4, 190 pubmed
    To study the effects of polychlorinated biphenyl (PCB126) on the expression of c-fos and c-jun in mesenchymal cells (MSCs) of rats. MSCs were separated by percoll cell separating medium (density 1.073 g/cm3)...
  6. Khachigian L, Fahmy R, Zhang G, Bobryshev Y, Kaniaros A. c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury. Inhibition by a novel DNA enzyme targeting c-Jun. J Biol Chem. 2002;277:22985-91 pubmed
    ..Determination of whether the bZIP transcription factor c-Jun plays a direct regulatory role in arterial lesion formation, or indeed in other disease, has been hampered by the ..
  7. Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Sakurai K, et al. miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism. J Mol Biol. 2008;378:492-504 pubmed publisher
    ..Since exogenous miR-21 expression moderately induced endogenous miR-21, an evolutionarily conserved double-negative feedback regulation would be operating as a mechanism to sustain miR-21 expression. ..
  8. Singal T, Dhalla N, Tappia P. Reciprocal regulation of transcription factors and PLC isozyme gene expression in adult cardiomyocytes. J Cell Mol Med. 2010;14:1824-35 pubmed publisher
    ..C (PLC) activity is involved in the regulation of gene expression of transcription factors such as c-Fos and c-Jun in cardiomyocytes in response to norepinephrine (NE)...
  9. Vinit S, Darlot F, Aoulaïche H, Boulenguez P, Kastner A. Distinct expression of c-Jun and HSP27 in axotomized and spared bulbospinal neurons after cervical spinal cord injury. J Mol Neurosci. 2011;45:119-33 pubmed publisher
    ..nervous system neurons, axon damage can lead to an up-regulation of some transcription factors among which is c-Jun, known to be a key regulator of neuron cell body response to injury and of its intrinsic potential for axon ..
  10. Sukhareva E, Dygalo N, Kalinina T. [Influence of dexamethasone on the expression of immediate early genes c-fos and c-jun in different regions of the neonatal brain]. Mol Biol (Mosk). 2016;50:266-71 pubmed publisher
    The ratio of the expression levels of the immediate early genes c-jun and c-fos that encode components of the AP-1 transcription complex determines the direction of changes in the expression of genes controlled by the complex, including ..
  11. Chung W, Bennett B, Racz W, Brien J, Massey T. Induction of c-jun and TGF-beta 1 in Fischer 344 rats during amiodarone-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2001;281:L1180-8 pubmed
    ..In the present study, the potential roles of c-Jun and transforming growth factor (TGF)-beta 1 in AM-induced inflammation and fibrogenesis were examined after ..
  12. Wlodarczyk B, Craig J, Bennett G, Calvin J, Finnell R. Valproic acid-induced changes in gene expression during neurulation in a mouse model. Teratology. 1996;54:284-97 pubmed
    ..to examine differential changes in gene expression for selected transcription factor (Pax-3, Emx-1, Emx-2, c-fos, c-jun, creb) and cell cycle checkpoint genes (bcl-2, p53, wee-1) during neural tube closure...
  13. Wertz I, O Rourke K, Zhang Z, Dornan D, Arnott D, Deshaies R, et al. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science. 2004;303:1371-4 pubmed
    ..that human DET1 (hDET1) promotes ubiquitination and degradation of the proto-oncogenic transcription factor c-Jun by assembling a multisubunit ubiquitin ligase containing DNA Damage Binding Protein-1 (DDB1), cullin 4A (CUL4A), ..
  14. Ye W, Zhou J, Markova D, Tian Y, Li J, Anderson D, et al. Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3. Am J Pathol. 2015;185:485-95 pubmed publisher
    ..Analysis of human NP tissues showed that XT-1 expression is unaffected by degeneration severity; XT-1 and Jun, Fos, and Sp1 mRNA were positively correlated. Cytokines failed to inhibit XT-1 promoter activity and expression...
  15. Hortala M, Estival A, Pradayrol L, Susini C, Clemente F. Identification of c-Jun as a critical mediator for the intracrine 24 kDa FGF-2 isoform-induced cell proliferation. Int J Cancer. 2005;114:863-9 pubmed
    ..Among the 18 upregulated genes was c-jun, which is often involved in cell proliferation...
  16. Zhang Y, Jin H, Xu Z, Nan W. [Role of c-jun in the effect of genistein on neonatal rat calvaria osteoblasts proliferation and differentiation]. Wei Sheng Yan Jiu. 2008;37:308-10 pubmed
    To study the role of the c-jun in the effects of genistein on osteoblasts in neonatal rat calvaria cultures in vitro...
  17. Singal T, Dhalla N, Tappia P. Regulation of c-Fos and c-Jun gene expression by phospholipase C activity in adult cardiomyocytes. Mol Cell Biochem. 2009;327:229-39 pubmed publisher
    This study was undertaken to determine whether gene expression for transcriptional factors such as c-Fos and c-Jun is regulated by phospholipase C (PLC) activity...
  18. Herdegen T, Claret F, Kallunki T, Martin Villalba A, Winter C, Hunter T, et al. Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury. J Neurosci. 1998;18:5124-35 pubmed
    Transcription factor c-Jun is proposed to control neuronal cell death and survival, but its activation by N-terminal phosphorylation and the underlying activity of the c-Jun N-terminal kinases (JNKs) remain to be elucidated in the adult ..
  19. Ding A, Wang F, Wu L. [Effects of anoxia/reoxygenation on Fos and Jun expression and apoptosis in cultured rat hippocampal neurons]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2002;18:213-7 pubmed
    To investigate the effects of anoxia/reoxygenation on Fos and Jun expression and apoptosis in cultured rat hippocampal neurons...
  20. Haas C, Deller T, Frotscher M. Basal expression, subcellular distribution, and up-regulation of the proto-oncogene c-JUN in the rat dentate gyrus after unilateral entorhinal cortex lesion. Neuroscience. 1997;81:33-45 pubmed
    The expression of the transcription factor c-JUN was investigated in the rat fascia dentata under normal conditions and after entorhinal cortex lesion...
  21. Yu Y, Platoshyn O, Zhang J, Krick S, Zhao Y, Rubin L, et al. c-Jun decreases voltage-gated K(+) channel activity in pulmonary artery smooth muscle cells. Circulation. 2001;104:1557-63 pubmed
    ..Whether c-Jun, a transcription factor that stimulates cell proliferation, affects K(v) channel activity in PASMCs was ..
  22. Yamagishi S, Yamada M, Koshimizu H, Takai S, Hatanaka H, Takeda K, et al. Apoptosis-signal regulating kinase-1 is involved in the low potassium-induced activation of p38 mitogen-activated protein kinase and c-Jun in cultured cerebellar granule neurons. J Biochem. 2003;133:719-24 pubmed
    ..Apoptosis signal-regulating kinase-1 (ASK1), a MAPK kinase kinase (MAPKKK) protein, is known to activate both c-Jun N-terminal kinase (JNK) and p38 via MAPK kinase (MKK) 4/7 and MKK3/6, respectively...
  23. Won J, Suh H. The differential molecular mechanisms underlying proenkephalin mRNA expression induced by forskolin and phorbol-12-myristic-13-acetate in primary cultured astrocytes. Brain Res Mol Brain Res. 2000;84:41-51 pubmed
    ..While c-Fos, Fra-2 and JunB were increased in response to either stimuli, only Fra-1, c-Jun and JunD were increased by PMA...
  24. Mohamed J, Lopez M, Cox G, Boriek A. Anisotropic regulation of Ankrd2 gene expression in skeletal muscle by mechanical stretch. FASEB J. 2010;24:3330-40 pubmed publisher
    ..Taken together, our data show the anisotropic regulation of Ankrd2 gene expression in the diaphragm muscles of WT and mdm mice via two distinct mechanosensitive signaling pathways. ..
  25. Senechal K, Heaney C, Druker B, Sawyers C. Structural requirements for function of the Crkl adapter protein in fibroblasts and hematopoietic cells. Mol Cell Biol. 1998;18:5082-90 pubmed
    ..this site enhanced Crkl function as measured by complex formation with SH2 binding proteins, signal transduction to Jun Kinase, and fibroblast transformation...
  26. Lian S, Xia Y, Khoi P, Ung T, Yoon H, Kim N, et al. Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells. Toxicology. 2015;338:104-16 pubmed publisher
    ..These results demonstrated that Cd induces MMP-9 expression via ROS-dependent EGFR->Erk1/2, JNK1/2->AP-1 and EGFR->Akt->NF-κB signaling pathways and, in turn, stimulates invasiveness in human endothelial cells. ..
  27. Li H, Xie P, Li G, Hao L, Xiong Q. In vivo study on the effects of microcystin extracts on the expression profiles of proto-oncogenes (c-fos, c-jun and c-myc) in liver, kidney and testis of male Wistar rats injected i.v. with toxins. Toxicon. 2009;53:169-75 pubmed publisher
    ..7 mug MC-LR eq/kg bw (MC-LR eq, MC-LR equivalents). mRNA levels of three proto-oncogenes c-fos, c-jun and c-myc in liver, kidney and testis were analyzed using quantitative real-time PCR at several time points post-..
  28. Whitfield J, Neame S, Paquet L, Bernard O, Ham J. Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. Neuron. 2001;29:629-43 pubmed
    ..Key steps in the death pathway include c-Jun activation, mitochondrial cytochrome c release, and caspase activation...
  29. Zhang Y, Ai X, Zhang J, Yao X. Differential role of YiGanKang decoction in IL-1? induction of IL-1RI and AP-1 in rat hepatic stellate cell. J Ethnopharmacol. 2012;141:599-602 pubmed publisher
    ..role of YiGanKang Decoction in interleukin-1? (IL-1?) induction of the type I receptor (IL-1RI) and the activator protein 1 (AP-1) in rat hepatic stellate cell (HSC). Flow cytometry was used to detect the IL-1RI expression...
  30. Eferl R, Sibilia M, Hilberg F, Fuchsbichler A, Kufferath I, Guertl B, et al. Functions of c-Jun in liver and heart development. J Cell Biol. 1999;145:1049-61 pubmed
    Mice lacking the AP-1 transcription factor c-Jun die around embryonic day E13.0 but little is known about the cell types affected as well as the cause of embryonic lethality. Here we show that a fraction of mutant E13...
  31. Zhang H, Zhang T, Shen B, Liu M, Liu J. Toxicological insight from AP-1 silencing study on proliferation, migration, and dedifferentiation of rat vascular smooth muscle cell. Cardiovasc Toxicol. 2012;12:25-38 pubmed publisher
    ..Thus, AP-1 siRNA provides a novel method to prevent intimal hyperplasia in blood vessel angioplasty. ..
  32. Tindberg N, Bengtsson I, Hu Y. A novel lipopolysaccharide-modulated Jun binding repressor in intron 2 of CYP2E1. J Neurochem. 2004;89:1336-46 pubmed
    ..b>Jun proteins were found to interact with the site...
  33. Mathas S, Hinz M, Anagnostopoulos I, Krappmann D, Lietz A, Jundt F, et al. Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. EMBO J. 2002;21:4104-13 pubmed
    ..Here, we show that constitutively activated AP-1 with robust c-Jun and JunB overexpression is found in all tumor cells of patients with classical Hodgkin's disease...
  34. Bircan S, Ensari A, Ozturk S, Erdogan N, Dundar I, Ortac F. Immunohistochemical analysis of c-myc, c-jun and estrogen receptor in normal, hyperplastic and neoplastic endometrium. Pathol Oncol Res. 2005;11:32-9 pubmed
    To evaluate the role of c-jun and c-myc proto-oncogenes in normal, hyperplastic and neoplastic endometrium in relation to estrogen receptor (ER) status and to investigate whether these genes can be related to other histopathological ..
  35. Yuan Z, Gong S, Luo J, Zheng Z, Song B, Ma S, et al. Opposing roles for ATF2 and c-Fos in c-Jun-mediated neuronal apoptosis. Mol Cell Biol. 2009;29:2431-42 pubmed publisher
    The activator protein 1 (AP-1) transcription factor c-Jun is crucial for neuronal apoptosis. However, c-Jun dimerization partners and the regulation of these proteins in neuronal apoptosis remain unknown...
  36. Zhou D, Liang Q, He X, Zhan C. Changes of c-fos and c-jun mRNA expression in angiotensin II-induced cardiomyocyte hypertrophy and effects of sodium tanshinone IIA sulfonate. J Huazhong Univ Sci Technolog Med Sci. 2008;28:531-4 pubmed publisher
    The changes of proto-oncogene c-fos and c-jun mRNA expression in angiotensin II (Ang II)-induced hypertrophy and effects of sodium tanshinone IIA sulfonate (STS) in the primary culture of neonatal rat cardiomyocytes were investigated...
  37. Auer K, Contessa J, Brenz Verca S, Pirola L, Rusconi S, Cooper G, et al. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Mol Biol Cell. 1998;9:561-73 pubmed
    The ability of signaling via the JNK (c-Jun NH2-terminal kinase)/stress-activated protein kinase cascade to stimulate or inhibit DNA synthesis in primary cultures of adult rat hepatocytes was examined...
  38. Hull R, Srivastava P, D Souza Z, Atanur S, Mechta Grigoriou F, Game L, et al. Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1? synthesis in macrophages. BMC Genomics. 2013;14:92 pubmed publisher
    ..JunD is over-expressed in WKY BMDMs and its silencing reduces Fc receptor-mediated oxidative burst in these cells...
  39. Wang Z, Chang X, Fu X, Sun T, Yang Y, Chen W, et al. [Expression of protooncogene c-jun, p38 and proliferating cell nuclear antigen in intestinal epithelial cells in rats different development stages]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2003;15:77-80 pubmed
    To investigate the expression characteristics of protooncogene c-jun and its related gene p38 in different developmental intestinal epithelial cells in rats, and to explore their biological roles in the intestinal wound healing after ..
  40. Mitchell J, Shynlova O, Langille B, Lye S. Mechanical stretch and progesterone differentially regulate activator protein-1 transcription factors in primary rat myometrial smooth muscle cells. Am J Physiol Endocrinol Metab. 2004;287:E439-45 pubmed
    ..Static stretch induced an increase in the expression of c-fos, fosB, fra-1, c-jun, and junB. The expression of both c-fos and junB was maximally induced at 30 min by static stretch...
  41. Ikematsu K, Takahashi H, Kondo T, Tsuda R, Nakasono I. Temporal expression of immediate early gene mRNA during the supravital reaction in mouse brain and lung after mechanical asphyxiation. Forensic Sci Int. 2008;179:152-6 pubmed publisher
    ..aim of this study was to examine the gene expression of immediate early genes (IEGs) including c-fos, fos-B and c-jun in mechanically asphyxiated mouse brain and lung after somatic death and to identify the IEGs expressed at the ..
  42. Zheng W, Li Z, Huang X, Wang Z, Xu W, Song Z. [Expression of C-fos, C-jun in hippocampus under the model of transmitting epileptic discharge from brain tissue to muscular tissue on its own skull]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2011;28:1014-8 pubmed
    The objective of this study was to investigate the changes of the behaviors, EEG and expression of c-fos, c-jun on induced seizure in rats by injecting penicillin after transmitting epileptic discharge from brain tissue to muscular ..
  43. Hsieh Y, Chen P, Yu C, Liao J, Kuo D. The neuropeptide Y Y1 receptor knockdown modulates activator protein 1-involved feeding behavior in amphetamine-treated rats. Mol Brain. 2013;6:46 pubmed publisher
    Hypothalamic neuropeptide Y (NPY) and two immediate early genes, c-fos and c-jun, have been found to be involved in regulating the appetite-suppressing effect of amphetamine (AMPH)...
  44. Wrynn A, Sebens J, Koch T, Leonard B, Korf J. Prolonged c-Jun expression in the basolateral amygdala following bulbectomy: possible implications for antidepressant activity and time of onset. Brain Res Mol Brain Res. 2000;76:7-17 pubmed
    ..Following bulbectomy, long term (up to 64 days post-lesion) Jun expression, not coincident with silver staining, was observed in the basolateral nucleus...
  45. Ishige K, Ito Y, Fukuda H. Characterization of absence seizure-dependent cyclic AMP responsive element-and activator protein 1 DNA-binding activities in lethargic (lh/lh) mice. Neurosci Lett. 1999;262:53-6 pubmed
    The characterized nuclear cyclic AMP responsive element (CRE)- and activator protein 1 (AP-1) DNA-binding activities in various brain regions of lethargic (lh/lh) mice, a genetic model of absence seizures...
  46. Marini M, Asunis I, Chan K, Chan J, Kan Y, Porcu L, et al. Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation. Blood Cells Mol Dis. 2002;29:145-58 pubmed
    ..These observations suggest that a complex network of small Maf and CNC-AP1 protein interactions might be involved in regulating transcription in diverse tissues or developmental stages.
  47. Carter D. Modulation of cellular AP-1 DNA binding activity by heat shock proteins. FEBS Lett. 1997;416:81-5 pubmed
    ..Further studies on the effect of Hsps on recombinant Fos/Jun protein binding activity indicated that the mechanism of action involves a selective attenuation of high affinity c-..
  48. Nephew K, Choi C, Polek T, McBride R, Bigsby R, Khan S, et al. Expression of fos and jun proto-oncogenes in benign versus malignant human uterine tissue. Gynecol Oncol. 2000;76:388-96 pubmed
    The objective of this study was to evaluate expression of fos and jun proto-oncogenes in benign human uterine tissue compared with malignant uterine tissue. Forty-two endometrial tissue specimens were obtained at the time of hysterectomy...
  49. Shi L, Ruan C. Expression and significance of MMP-7, c-Jun and c-Fos in rats skin photoaging. Asian Pac J Trop Med. 2013;6:768-70 pubmed publisher
    To investigate the expression and significance of the MMP-7, c-Jun and c-Fos in rat photoaging skin...
  50. Zhang Y, Yao X. Role of c-Jun N-terminal kinase and p38/activation protein-1 in interleukin-1?-mediated type I collagen synthesis in rat hepatic stellate cells. APMIS. 2012;120:101-7 pubmed publisher
    ..The aims of this study were to investigate the role of c-Jun N-terminal kinase (JNK) and p38/activation protein (AP-1) in IL-1?-mediated type I collagen synthesis in rat HSCs...
  51. Levkovitz Y, Baraban J. A dominant negative Egr inhibitor blocks nerve growth factor-induced neurite outgrowth by suppressing c-Jun activation: role of an Egr/c-Jun complex. J Neurosci. 2002;22:3845-54 pubmed
    ..mechanism of action of ZnEgr indicates that it blocks NGF-induced neurite outgrowth by suppressing activation of c-Jun, a critical step in the signaling pathway mediating this response...
  52. Ding A, Wang F, Yu S, Wu L, Zhao T, Fan M. [Effects of hypoxic-preconditioning on anoxic-tolerance and Jun expression in cultured rat hippocampal neurons]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2002;18:26-9 pubmed
    To study the effects of hypoxic preconditioning on anoxic tolerance and Jun expression in cultured rat hippocampal neurons after anoxia/reoxygenation...
  53. Li C, Cheung W, Lin Z, Li T, Lim J, Wang D. Oral steroids enhance epithelial repair in nasal polyposis via upregulation of the AP-1 gene network. Thorax. 2009;64:306-12 pubmed publisher
    ..The highest scoring network was assembled around activation protein 1 (AP-1), a heterodimer of c-Fos and c-Jun oncoprotein, and five AP-1-related genes (COX-2, IL-6, AREG, HBEGF and EGR1) with tissue repair function...