Jak2

Summary

Gene Symbol: Jak2
Description: Janus kinase 2
Alias: tyrosine-protein kinase JAK2, JAK-2, Janus kinase 2 (a protein tyrosine kinase)
Species: rat
Products:     Jak2

Top Publications

  1. Shi S, Martin R, Duncan R, Choi D, Lu S, Schroer S, et al. Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance. J Biol Chem. 2012;287:10277-88 pubmed publisher
    ..Mice with hepatocyte-specific deletion of Janus kinase 2 (L-JAK2 KO mice) develop spontaneous steatosis as early as 2 weeks of age...
  2. Argetsinger L, Kouadio J, Steen H, Stensballe A, Jensen O, Carter Su C. Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity. Mol Cell Biol. 2004;24:4955-67 pubmed
    The tyrosine kinase JAK2 is a key signaling protein for at least 20 receptors in the cytokine/hematopoietin receptor superfamily and is a component of signaling by insulin receptor and several G-protein-coupled receptors...
  3. Watanabe S, Mu W, Kahn A, Jing N, Li J, Lan H, et al. Role of JAK/STAT pathway in IL-6-induced activation of vascular smooth muscle cells. Am J Nephrol. 2004;24:387-92 pubmed
    ..Rat VSMC were stimulated with IL-6 in the presence or absence of a JAK 2 inhibitor, and the activation of STAT 3 (by Western), MCP-1 (by ELISA) and DNA synthesis (by (3)H-thymidine ..
  4. Murray P. The JAK-STAT signaling pathway: input and output integration. J Immunol. 2007;178:2623-9 pubmed
    ..New data suggests that SOCS proteins introduce additional diversity into the JAK-STAT pathway by adjusting the output of activated STATs that alters downstream gene activation. ..
  5. Ryu H, Lee J, Kim K, Jeong S, Kim P, Chung H. Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin. J Immunol. 2000;165:2116-23 pubmed
    ..Pituitary GH triggered the tyrosine phosphorylation of Janus kinase 2 (Jak2) and STAT3 in neutrophils...
  6. Dey B, Spence S, Nissley P, Furlanetto R. Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. J Biol Chem. 1998;273:24095-101 pubmed
    ..These results raise the possibility that SOCS proteins may also play a regulatory role in IGF-I receptor signaling. ..
  7. Pan J, Fukuda K, Kodama H, Makino S, Takahashi T, Sano M, et al. Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in the rat heart. Circ Res. 1997;81:611-7 pubmed
    ..Immunoprecipitation-Western blot analysis revealed that pressure overload activated JAK1, JAK2, and Tyk2 as early as 5 minutes and that STAT1, STAT2, and STAT3 were tyrosine-phosphorylated rapidly after ..
  8. Chiba T, Yamada M, Sasabe J, Terashita K, Shimoda M, Matsuoka M, et al. Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons. Mol Psychiatry. 2009;14:206-22 pubmed publisher
    ..Recently, we found that HN derivatives activate the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling axis...
  9. Zapparoli A, Calegari V, Velloso L, Guadagnini D, Boer P, Gontijo J. Hypothalamic SOCS-3 expression and the effect of intracerebroventricular angiotensin II injection on water intake and renal sodium handling in SHR. J Physiol Sci. 2010;60:425-33 pubmed publisher

More Information

Publications62

  1. Rane S, Reddy E. JAKs, STATs and Src kinases in hematopoiesis. Oncogene. 2002;21:3334-58 pubmed
  2. Thirone A, Jebailey L, Bilan P, Klip A. Opposite effect of JAK2 on insulin-dependent activation of mitogen-activated protein kinases and Akt in muscle cells: possible target to ameliorate insulin resistance. Diabetes. 2006;55:942-51 pubmed
    ..Intriguingly, insulin acting through its own receptor kinase also activates JAK2. However, the impact of such activation on insulin action remains unknown...
  3. James C, Ugo V, Le Couedic J, Staerk J, Delhommeau F, Lacout C, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005;434:1144-8 pubmed
    ..Here, we describe a clonal and recurrent mutation in the JH2 pseudo-kinase domain of the Janus kinase 2 (JAK2) gene in most (> 80%) polycythaemia vera patients...
  4. Neeli I, Liu Z, Dronadula N, Ma Z, Rao G. An essential role of the Jak-2/STAT-3/cytosolic phospholipase A(2) axis in platelet-derived growth factor BB-induced vascular smooth muscle cell motility. J Biol Chem. 2004;279:46122-8 pubmed
    ..Together, these results for the first time show that PDGF-BB-induced VSMC motility requires activation of the Jak-2/STAT-3/cPLA(2) signaling axis. ..
  5. Bacon C, McVicar D, Ortaldo J, Rees R, O Shea J, Johnston J. Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J Exp Med. 1995;181:399-404 pubmed
    ..IL-12, but not IL-2, stimulates the tyrosine phosphorylation of TYK2 and JAK2, whereas JAK1 and JAK3, which are phosphorylated in response to IL-2, are not phosphorylated after IL-12 treatment...
  6. Kralovics R, Passamonti F, Buser A, Teo S, Tiedt R, Passweg J, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005;352:1779-90 pubmed
    ..Microsatellite mapping identified a 9pLOH region that included the Janus kinase 2 (JAK2) gene...
  7. Baxter E, Scott L, Campbell P, East C, Fourouclas N, Swanton S, et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005;365:1054-61 pubmed
    ..We investigated the role of the cytoplasmic tyrosine kinase JAK2 in patients with a myeloproliferative disorder...
  8. Ungureanu D, Wu J, Pekkala T, Niranjan Y, Young C, Jensen O, et al. The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling. Nat Struct Mol Biol. 2011;18:971-6 pubmed publisher
    Human JAK2 tyrosine kinase mediates signaling through numerous cytokine receptors...
  9. Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U, Pfeffer K. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell. 1998;93:397-409 pubmed
    ..A targeted inactivation of Jak2 was performed. Jak2-/- embryos are anemic and die around day 12.5 postcoitum...
  10. Krempler A, Qi Y, Triplett A, Zhu J, Rui H, Wagner K. Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice. Genesis. 2004;40:52-7 pubmed
    To study biologically relevant functions of the Janus kinase 2 (Jak2) in multiple cytokine and hormone receptor signal transduction pathways, we generated a conditional knockout (floxed) allele of this gene by placing loxP sites around ..
  11. Parganas E, Wang D, Stravopodis D, Topham D, Marine J, Teglund S, et al. Jak2 is essential for signaling through a variety of cytokine receptors. Cell. 1998;93:385-95 pubmed
    ..To assess the role of Jak2, we have derived Jak2-deficient mice...
  12. Howard J, Flier J. Attenuation of leptin and insulin signaling by SOCS proteins. Trends Endocrinol Metab. 2006;17:365-71 pubmed
  13. Zhang Y, Zhou B, Deng B, Zhang F, Wu J, Wang Y, et al. Amyloid-? induces hepatic insulin resistance in vivo via JAK2. Diabetes. 2013;62:1159-66 pubmed publisher
    ..A? can induce insulin resistance in cultured hepatocytes by activating the JAK2/STAT3/SOCS-1 signaling pathway...
  14. Shaw S, Schmidt A, Banes A, Wang X, Stern D, Marrero M. S100B-RAGE-mediated augmentation of angiotensin II-induced activation of JAK2 in vascular smooth muscle cells is dependent on PLD2. Diabetes. 2003;52:2381-8 pubmed
    ..We recently found that activation of janus kinase 2 (JAK2) is essential for the Ang II-induced proliferation of vascular smooth muscle cells (VSMCs) and that high glucose ..
  15. Hwang Y, Shaw S, Kaneko M, Redd H, Marrero M, Ramasamy R. Aldose reductase pathway mediates JAK-STAT signaling: a novel axis in myocardial ischemic injury. FASEB J. 2005;19:795-7 pubmed
    ..Induction of global ischemia in rats resulted in JAK2 activation followed by STAT5 activation...
  16. Lee S, DUHE R. Kinase activity and subcellular distribution of a chimeric green fluorescent protein-tagged Janus kinase 2. J Biomed Sci. 2006;13:773-86 pubmed
    Janus kinase 2 (JAK2) is an essential intracellular signal transducer for numerous cytokines and hormones...
  17. Lin C, Lee I, Chi P, Hsieh H, Cheng S, Hsiao L, et al. C-Src/Jak2/PDGFR/PKC?-dependent MMP-9 induction is required for thrombin-stimulated rat brain astrocytes migration. Mol Neurobiol. 2014;49:658-72 pubmed publisher
    ..which were attenuated by pretreatment with the inhibitor of receptor tyrosine kinase (Genistein), c-Src (PP1), Jak2 (AG490), PDGFR (AG1296), PI3K (LY294002), Akt (SH-5), PKCs (Ro318220), PKC? (Rottlerin), or NF-?B (Bay11-7082) and ..
  18. Kou Z, Li C, Tang J, Hu J, Qu J, Liao Y, et al. Down-regulation of insulin signaling is involved in painful diabetic neuropathy in type 2 diabetes. Pain Physician. 2013;16:E71-83 pubmed
    ..Then we investigated the alternations of IR and pIRS-1 and the activity of the JAK2/STAT3 pathway by immunohistochemistry, Western Blotting, and cell culture...
  19. Wang G, Zhou D, Wang C, Gao Y, Zhou Q, Qian G, et al. Hypoxic preconditioning suppresses group III secreted phospholipase A2-induced apoptosis via JAK2-STAT3 activation in cortical neurons. J Neurochem. 2010;114:1039-48 pubmed publisher
  20. Wiezel D, Assadi M, Landau D, Troib A, Kachko L, Rabkin R, et al. Impaired renal growth hormone JAK/STAT5 signaling in chronic kidney disease. Nephrol Dial Transplant. 2014;29:791-9 pubmed publisher
    ..Kidney GHR mRNA and protein levels were reduced and basal phosphorylation of JAK2 and STAT5 was significantly impaired...
  21. Carvalho C, Carvalheira J, Lima M, Zimmerman S, Caperuto L, Amanso A, et al. Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: activation of Janus kinase/signal transducer and activator of transcription and phosphoinositol 3-kinase/Akt pathways. Endocrinology. 2003;144:638-47 pubmed
    ..In the present study we showed that LH induced rapid tyrosine phosphorylation and activation of the Janus kinase 2 (JAK2) in rat ovary...
  22. Xie J, LeBaron M, Nevalainen M, Rui H. Role of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cells. J Biol Chem. 2002;277:14020-30 pubmed
    ..In addition to Jak2, several other tyrosine kinases reportedly also are associated with prolactin receptors and may phosphorylate Stat5...
  23. Singh N, Wang D, Kundumani Sridharan V, Van Quyen D, Niu J, Rao G. 15-Lipoxygenase-1-enhanced Src-Janus kinase 2-signal transducer and activator of transcription 3 stimulation and monocyte chemoattractant protein-1 expression require redox-sensitive activation of epidermal growth factor receptor in vascular wall rem. J Biol Chem. 2011;286:22478-88 pubmed publisher
    ..15(S)-HETE also induced tyrosine phosphorylation of Janus kinase 2 (Jak2) in VSMCs, and its inhibition substantially reduced STAT3 phosphorylation, MCP-1 expression, and VSMC migration...
  24. Lefrançois Martinez A, Blondet Trichard A, Binart N, Val P, Chambon C, Sahut Barnola I, et al. Transcriptional control of adrenal steroidogenesis: novel connection between Janus kinase (JAK) 2 protein and protein kinase A (PKA) through stabilization of cAMP response element-binding protein (CREB) transcription factor. J Biol Chem. 2011;286:32976-85 pubmed publisher
    ..PRL triggers JAK2/STAT5-dependent transcription in adrenal cells, but this does not influence corticosterone release...
  25. Argetsinger L, Hsu G, Myers M, Billestrup N, White M, Carter Su C. Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J Biol Chem. 1995;270:14685-92 pubmed
    The identification of JAK2 as a growth hormone (GH) receptor-associated, GH-activated tyrosine kinase has established tyrosyl phosphorylation as a signaling mechanism for GH...
  26. Liang Y, Jin Y, Li Y. Expression of JAKs/STATs pathway molecules in rat model of rapid focal segmental glomerulosclerosis. Pediatr Nephrol. 2009;24:1661-71 pubmed publisher
    ..The expressions of JAK1, JAK2, STAT1, STAT3, suppressors of cytokine signaling (SOCS)1, SOCS3, protein inhibitors of activated STAT (PIAS)1, and ..
  27. Mascareno E, Beckles D, Siddiqui M. Janus kinase-2 signaling mediates apoptosis in rat cardiomyocytes. Vascul Pharmacol. 2005;43:327-35 pubmed
    We tested the hypothesis that activation Jak2, which is prominently involved in the up-regulation of the renin-angiotensin system (RAS), constitutes a focal point in relaying signals triggered by a Angiotensin II (Ang II) and hypoxia/..
  28. Digicaylioglu M, Lipton S. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature. 2001;412:641-7 pubmed
    ..by NMDA (N-methyl-d-aspartate) or NO by triggering cross-talk between the signalling pathways of Janus kinase-2 (Jak2) and nuclear factor-kappaB (NF-kappaB)...
  29. Duhe R, Rui H, Greenwood J, Garvey K, Farrar W. Cloning of the gene encoding rat JAK2, a protein tyrosine kinase. Gene. 1995;158:281-5 pubmed
    A complete cDNA clone encoding the rat JAK2 protein tyrosine kinase was isolated from an Nb2-SP (rat pre-T lymphoma cell line) cDNA library...
  30. Banes A, Shaw S, Jenkins J, Redd H, Amiri F, Pollock D, et al. Angiotensin II blockade prevents hyperglycemia-induced activation of JAK and STAT proteins in diabetic rat kidney glomeruli. Am J Physiol Renal Physiol. 2004;286:F653-9 pubmed
    ..Furthermore, we demonstrated that the tyrosine kinase enzyme JAK2 plays a key role in both ANG II- and hyperglycemia-induced growth in these cells...
  31. Jin H, Lanning N, Carter Su C. JAK2, but not Src family kinases, is required for STAT, ERK, and Akt signaling in response to growth hormone in preadipocytes and hepatoma cells. Mol Endocrinol. 2008;22:1825-41 pubmed publisher
    Janus kinase 2 (JAK2), a tyrosine kinase that associates with the GH receptor and is activated by GH, has been implicated as a key mediator of GH signaling...
  32. Gerland K, Bataille Simoneau N, Basle M, Fourcin M, Gascan H, Mercier L. Activation of the Jak/Stat signal transduction pathway in GH-treated rat osteoblast-like cells in culture. Mol Cell Endocrinol. 2000;168:1-9 pubmed
    ..01 that expresses high affinity GH receptors. The results show a GH-induced and sustained phosphorylation of Jak2 and Stat5 on tyrosine residues...
  33. Shaw S, Bencherif M, Marrero M. Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid. J Biol Chem. 2002;277:44920-4 pubmed
    ..stimulation of alpha7 nAChR transduces signals to phosphatidylinositol 3-kinase and Akt via Janus kinase 2 (JAK2) in a cascade, which results in neuroprotection...
  34. Wang K, Wu Y, Su J, Zhang J, Zhang P, Qi X. Total glucosides of paeony regulates JAK2/STAT3 activation and macrophage proliferation in diabetic rat kidneys. Am J Chin Med. 2012;40:521-36 pubmed
    ..Herein, we investigated the ability of TGP to modulate JAK2/STAT3 activation and macrophage proliferation in rats with streptozotocin (STZ)-induced diabetes...
  35. Ghosh A, Pechota A, Coleman D, Upchurch G, Eliason J. Cigarette smoke-induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak/Stat pathway. Hum Pathol. 2015;46:284-94 pubmed publisher
    ..Western blot with protein extracts from CSE-treated RASMC showed up-regulation of pStat3, pJak2, and T-Jak2 and unchanged levels of T-Stat3...
  36. Lakner A, Moore C, Gulledge A, Schrum L. Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation. World J Gastroenterol. 2010;16:5047-56 pubmed
    ..The significance of JAK/STAT signaling to HSC transdifferentiation was determined by treating cells with a JAK2 inhibitor...
  37. Sugiyama T, Yoshimoto T, Tsuchiya K, Gochou N, Hirono Y, Tateno T, et al. Aldosterone induces angiotensin converting enzyme gene expression via a JAK2-dependent pathway in rat endothelial cells. Endocrinology. 2005;146:3900-6 pubmed
    ..of aldosterone on ACE mRNA expression was completely blocked by a protein tyrosine kinase inhibitor (genistein) and JAK2 inhibitor (AG490), partially by Src kinase inhibitor (PP2) and epidermal growth factor receptor kinase inhibitor (..
  38. Shaw S, Wang X, Redd H, Alexander G, Isales C, Marrero M. High glucose augments the angiotensin II-induced activation of JAK2 in vascular smooth muscle cells via the polyol pathway. J Biol Chem. 2003;278:30634-41 pubmed
    ..protein kinase C (PKC), reactive oxygen species (ROS) generated by NADPH oxidase, the activation of Janus kinase 2 (JAK2), and the polyol pathway play important parts in the hyperproliferation of vascular smooth muscle cells (VSMC), a ..
  39. Shillingford J, Miyoshi K, Flagella M, Shull G, Hennighausen L. Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis. Mol Endocrinol. 2002;16:1309-21 pubmed
  40. Zhu H, Zou L, Tian J, Du G, Gao Y. SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway. Eur J Pharmacol. 2013;714:23-31 pubmed publisher
    ..In this study, we used AG490, a specific inhibitor of the signaling pathway involving the Janus Kinase 2 (JAK2)/Signal Transducers and Activators of Transcription 3 (STAT3) signaling molecules and suramin, a potent inhibitor ..
  41. Chen C, Zhang X, Wang Y. Analysis of JAK2 and STAT3 polymorphisms in patients with ankylosing spondylitis in Chinese Han population. Clin Immunol. 2010;136:442-6 pubmed publisher
    b>JAK2 and STAT3 polymorphisms have been implicated to be associated with inflammatory bowel disease, which might share common immunogenesis and genetic factors with AS...
  42. Colaizzo D, Amitrano L, Tiscia G, Scenna G, Grandone E, Guardascione M, et al. The JAK2 V617F mutation frequently occurs in patients with portal and mesenteric venous thrombosis. J Thromb Haemost. 2007;5:55-61 pubmed
    ..We aimed to assess whether the Janus kinase 2 (JAK2) V617F mutation, an acquired mutation that occurs in MPD patients, is a risk factor for portal and mesenteric ..
  43. Cai W, Yang X, Han S, Guo H, Zheng Z, Wang H, et al. Notch1 Pathway Protects against Burn-Induced Myocardial Injury by Repressing Reactive Oxygen Species Production through JAK2/STAT3 Signaling. Oxid Med Cell Longev. 2016;2016:5638943 pubmed publisher
    ..Notably, Notch signaling blockade downregulated p-JAK2 and p-STAT3 expression...
  44. Yu J, Kim K, Kim H. Suppression of IL-1beta expression by the Jak 2 inhibitor AG490 in cerulein-stimulated pancreatic acinar cells. Biochem Pharmacol. 2006;72:1555-62 pubmed
    ..cells stimulated with cerulein in vitro as well as the rats with cerulein pancreatitis in vivo using AG490, the Jak2 inhibitor...
  45. Banes Berceli A, Ketsawatsomkron P, Ogbi S, Patel B, Pollock D, Marrero M. Angiotensin II and endothelin-1 augment the vascular complications of diabetes via JAK2 activation. Am J Physiol Heart Circ Physiol. 2007;293:H1291-9 pubmed
    ..course study [days 7, 14, and 28 after streptozotocin (STZ) injection] to determine changes in phosphorylation of JAK2, STAT1, and STAT3 in thoracic aorta using standard Western blot techniques...
  46. Marty C, Saint Martin C, Pecquet C, Grosjean S, Saliba J, Mouton C, et al. Germ-line JAK2 mutations in the kinase domain are responsible for hereditary thrombocytosis and are resistant to JAK2 and HSP90 inhibitors. Blood. 2014;123:1372-83 pubmed publisher
    ..We have identified 2 families with hereditary thrombocytosis presenting novel heterozygous germ-line mutations of JAK2. One family carries the JAK2 R867Q mutation located in the kinase domain, whereas the other presents 2 JAK2 ..
  47. Murata T, Noguchi P, Puri R. IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling. J Immunol. 1996;156:2972-8 pubmed
    ..We show that JAK2 kinase is rapidly phosphorylated and activated in response to IL-13...
  48. Bhattacharyya S, Zhao Y, Kay T, Muglia L. Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation. Proc Natl Acad Sci U S A. 2011;108:9554-9 pubmed publisher
    ..Our data show that SOCS1 and type I interferons are critical GC targets for regulating STAT1 activity and may account for overall GC effectiveness in inflammation suppression in the clinically relevant time frame. ..
  49. Gorina R, Sanfeliu C, Galitó A, Messeguer A, Planas A. Exposure of glia to pro-oxidant agents revealed selective Stat1 activation by H2O2 and Jak2-independent antioxidant features of the Jak2 inhibitor AG490. Glia. 2007;55:1313-24 pubmed
    ..Stat1 (pStat1), and we evaluated the effect of antioxidants (trolox, propyl gallate, and N-acetylcysteine) and of Jak2 (Janus tyrosine kinases) inhibitors (AG490 and Jak2-Inhibitor-II)...
  50. Zhang Y, Zheng J, Zhou Z, Zhou H, Wang Y, Gong Z, et al. Fractalkine promotes chemotaxis of bone marrow-derived mesenchymal stem cells towards ischemic brain lesions through Jak2 signaling and cytoskeletal reorganization. FEBS J. 2015;282:891-903 pubmed publisher
    ..Moreover, significant inhibition of signaling and migration was detected after treatment of cells with Jak2-interfering RNA or the antagonist AG490...
  51. Zhu F, Guan Y, Zhang R. High-Dose Linoleic Acid Activated JAK2-STAT3 Signaling Pathway Involved in Cytokine Production and Lipogenesis in Pancreatic Exocrine Cells. Curr Mol Med. 2016;16:668-676 pubmed
    ..Current study aimed to explore the impact of high-dose linoleic acid on the activation of Janus kinase 2 (JAK2)-signal transducers and activators of transcription 3 (STAT3) pathway, cytokine production, and lipogenesis in ..
  52. Radi Z, Nagappan M, Huang X, Heintz C, Gardner J. Development and characterization of a JAK-2-specific antibody suitable for immunohistochemical investigative studies. Appl Immunohistochem Mol Morphol. 2011;19:41-7 pubmed publisher
    ..In conclusion, we show the development and characterization of a JAK-2-specific antibody that can be used in investigative and mechanistic studies such as preclinical efficacy models. ..
  53. Irie Sasaki J, Sasaki T, Matsumoto W, Opavsky A, Cheng M, Welstead G, et al. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature. 2001;409:349-54 pubmed
    ..Our data identify an unexpected and novel function for CD45 as a haematopoietic JAK phosphatase that negatively regulates cytokine receptor signalling. ..