Gene Symbol: Itgax
Description: integrin subunit alpha X
Alias: RGD1561123, integrin alpha-X, integrin, alpha X
Species: rat
Products:     Itgax

Top Publications

  1. Guerriero A, Langmuir P, Spain L, Scott E. PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells. Blood. 2000;95:879-85 pubmed
    ..PU. 1(-/-)lymphoid DC were functionally equivalent to WT DC for stimulating T-cell proliferation in mixed lymphocyte reactions. These results demonstrate that PU.1 is required for the development of myeloid DC but not lymphoid DC. ..
  2. Wu H, Rodgers J, Perrard X, Perrard J, Prince J, Abe Y, et al. Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol. 2004;173:297-306 pubmed
  3. Malinin N, Zhang L, Choi J, Ciocea A, Razorenova O, Ma Y, et al. A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nat Med. 2009;15:313-8 pubmed publisher
    ..Furthermore, allogeneic bone marrow transplantation was shown to alleviate the symptoms of the disease. ..
  4. Roberts L, Robinson C. Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines. Immunology. 2014;141:39-51 pubmed publisher
    ..tuberculosis. These findings suggest that M. tuberculosis modulates DC adhesion and migration to increase the time required to initiate an adaptive immune response. ..
  5. Liu Y, Jones B, Brady W, Janeway C, Linsley P, Linley P. Co-stimulation of murine CD4 T cell growth: cooperation between B7 and heat-stable antigen. Eur J Immunol. 1992;22:2855-9 pubmed
    ..These results demonstrate that functionally defined co-stimulation involves at least B7 and HSA and suggest that signals delivered by B7 and HSA synergize in promoting T cell growth. ..
  6. Yokota A, Oikawa A, Matsuda C, Shinohara N, Eshima K. Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody. Microbiol Immunol. 2003;47:285-93 pubmed
    ..Both immature (class II MHClow) and mature (class II MHChigh) DCs were sensitive to the Fas-based induction of apoptosis. ..
  7. Matsuzaki J, Tsuji T, Chamoto K, Takeshima T, Sendo F, Nishimura T. Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo. Cell Immunol. 2003;224:98-105 pubmed
    ..Thus, we initially demonstrated that anti-Gr-1 mAb might become a good tool to investigate a precise role for memory-type CD8(+) T cells in vivo. ..
  8. Yada A, Ebihara S, Matsumura K, Endo S, Maeda T, Nakamura A, et al. Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake. Cell Immunol. 2003;225:21-32 pubmed
    ..These results support the therapeutic benefits of antigen-targeting to FcgammaR on APC in the various inflammatory disorders. ..
  9. Carlyle J, Jamieson A, Gasser S, Clingan C, Arase H, Raulet D. Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc Natl Acad Sci U S A. 2004;101:3527-32 pubmed
    ..Remarkably, Ocil/Clr-b is frequently down-regulated on mouse tumor cell lines, indicating a role for this receptor-ligand system in a new form of "missing self-recognition" of tumor cells. ..

More Information


  1. Dai Y, Marrero I, Gros P, Zaghouani H, Wicker L, Sercarz E. Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens. Diabetes. 2009;58:156-64 pubmed publisher
    ..Thus, non-MHC genes could affect the MHC-restricted T-cell response through altered antigen processing and presentation. ..