Gene Symbol: Itgad
Description: integrin subunit alpha D
Alias: Itgax, integrin alpha-D, integrin alpha X (Cd11c)
Shelley C, Teodoridis J, Park H, Farokhzad O, Bottinger E, Arnaout M. During differentiation of the monocytic cell line U937, Pur alpha mediates induction of the CD11c beta 2 integrin gene promoter. J Immunol. 2002;168:3887-93 pubmed
..Together, these increases in the functional activity of both Puralpha and Sp1 combine to induce CD11c expression. ..
Hynes R. Integrins: bidirectional, allosteric signaling machines. Cell. 2002;110:673-87 pubmed
..Long-range conformational changes couple these functions via allosteric equilibria. ..
Thomas A, Dunn T, Oort P, Grino M, Adams S. Inflammatory phenotyping identifies CD11d as a gene markedly induced in white adipose tissue in obese rodents and women. J Nutr. 2011;141:1172-80 pubmed publisher
Wu H, Rodgers J, Perrard X, Perrard J, Prince J, Abe Y, et al
. Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol. 2004;173:297-306 pubmed
Hurtado A, Marcillo A, Frydel B, Bunge M, Bramlett H, Dietrich W. Anti-CD11d monoclonal antibody treatment for rat spinal cord compression injury. Exp Neurol. 2012;233:606-11 pubmed publisher
Tamatani T, Kotani M, Miyasaka M. Characterization of the rat leukocyte integrin, CD11/CD18, by the use of LFA-1 subunit-specific monoclonal antibodies. Eur J Immunol. 1991;21:627-33 pubmed
..Both WT.1 (anti-CD11a) and WT.3 (anti-CD18) apparently recognize a "low-affinity" as well as a "high-affinity" form of LFA-1 and do not discriminate between the two. ..
Zhou C, Robertson J, Wu J, Bartkowiak T, Parker K, McMahon J, et al
. Natural recovery from antiglomerular basement membrane glomerulonephritis is associated with glomeruli-infiltrating CD8?+CD11c+MHC class II+ cells. Am J Nephrol. 2011;34:519-28 pubmed publisher
..We investigated if GIL CD8?(+) cells were also associated with the recovery in LEW rats...