Gene Symbol: Itga8
Description: integrin subunit alpha 8
Alias: RGD1564327, integrin alpha-8, integrin, alpha 8
Species: rat
Products:     Itga8

Top Publications

  1. Hartner A, Schocklmann H, Prols F, Muller U, Sterzel R. Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis. Kidney Int. 1999;56:1468-80 pubmed
    ..However, in view of its abundance in the mesangium, alpha8beta1 integrin could be an important MC receptor of matrix ligands and may play a role in the embryology, physiology, and pathophysiology of the glomerular capillary tuft. ..
  2. Littlewood Evans A, Muller U. Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1. Nat Genet. 2000;24:424-8 pubmed
    ..In mice homozygous for a targeted mutation of Itga8 (encoding the alphabeta8 subunit), this co-localization is perturbed and hair cells in the utricle, a vestibular ..
  3. Zargham R, Wamhoff B, Thibault G. RNA interference targeting alpha8 integrin attenuates smooth muscle cell growth. FEBS Lett. 2007;581:939-43 pubmed
    ..Our data suggest that alpha8 integrin expression is critical for VSMC growth, which has potential implications in postangioplasty neointimal hyperplasia. ..
  4. Einheber S, Schnapp L, Salzer J, Cappiello Z, Milner T. Regional and ultrastructural distribution of the alpha 8 integrin subunit in developing and adult rat brain suggests a role in synaptic function. J Comp Neurol. 1996;370:105-34 pubmed
    ..They mediate both cell-extracellular matrix and cell-cell interactions. The integrin alpha 8 beta 1 is a receptor for fibronectin, tenascin, and vitronectin that has been localized to axonal tracts and ..
  5. Zargham R, Touyz R, Thibault G. alpha 8 Integrin overexpression in de-differentiated vascular smooth muscle cells attenuates migratory activity and restores the characteristics of the differentiated phenotype. Atherosclerosis. 2007;195:303-12 pubmed
    ..Our findings suggest a dynamic role for alpha 8 beta 1 integrin to induce contractile phenotype as well as suppression of VSMC migration, a key player during arterial stenosis. ..
  6. Zeltner R, Hilgers K, Schmieder R, Porst M, Schulze B, Hartner A. A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease. Nephron Clin Pract. 2008;108:c169-75 pubmed publisher
    ..We investigated whether the -414 T/C polymorphism in the promoter region of the alpha 8 integrin chain gene (ITGA8) is associated with the progression of renal disease in ADPKD...
  7. Humbert C, Silbermann F, Morar B, Parisot M, Zarhrate M, Masson C, et al. Integrin alpha 8 recessive mutations are responsible for bilateral renal agenesis in humans. Am J Hum Genet. 2014;94:288-94 pubmed publisher
    ..several fetuses with bilateral renal agenesis, we identified recessive mutations in the integrin ?8-encoding gene ITGA8 in two families. Itga8 homozygous knockout in mice is known to result in absence of kidney development...
  8. Marek I, Volkert G, Hilgers K, Bieritz B, Rascher W, Reinhardt D, et al. Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells. Cell Adh Migr. 2014;8:389-95 pubmed publisher
  9. Cai L, Abe M, Izumi S, Imura M, Yasugi T, Ushijima T. Identification of PRTFDC1 silencing and aberrant promoter methylation of GPR150, ITGA8 and HOXD11 in ovarian cancers. Life Sci. 2007;80:1458-65 pubmed
    ..cancer cell lines were analyzed by methylation-specific PCR, and seven (GPR150, LOC222171, PRTFDC1, LOC339210, ITGA8, C9orf64 and HOXD11) of the 33 CGIs were methylated in one or more of the cell lines...

More Information


  1. Linton J, Martin G, Reichardt L. The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression. Development. 2007;134:2501-9 pubmed
    ..Our results thus place nephronectin and alpha8beta1 integrin in a pathway that regulates Gdnf expression and is essential for kidney development. ..
  2. Chan C, Weeber E, Kurup S, Sweatt J, Davis R. Integrin requirement for hippocampal synaptic plasticity and spatial memory. J Neurosci. 2003;23:7107-16 pubmed
    ..These results demonstrate that several different integrins are involved in physiological plasticity and provide the first evidence of their requirement for behavioral plasticity in vertebrates. ..