Gene Symbol: Ist1
Description: IST1, ESCRT-III associated factor
Alias: RGD1307799, IST1 homolog, MAPK activating protein PM28, increased sodium tolerance 1 homolog
Bajorek M, Morita E, Skalicky J, Morham S, Babst M, Sundquist W. Biochemical analyses of human IST1 and its function in cytokinesis. Mol Biol Cell. 2009;20:1360-73 pubmed publisher
..Here, we report that human IST1 also functions in the ESCRT pathway and is required for efficient abscission during HeLa cell cytokinesis...
Agromayor M, Carlton J, Phelan J, Matthews D, Carlin L, Ameer Beg S, et al
. Essential role of hIST1 in cytokinesis. Mol Biol Cell. 2009;20:1374-87 pubmed publisher
..Here, we describe the previously uncharacterized KIAA0174 as the human homologue of IST1 (hIST1), and we report its conserved interaction with VPS4, CHMP1A/B, and LIP5...
Renvoisé B, Parker R, Yang D, Bakowska J, Hurley J, Blackstone C. SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis. Mol Biol Cell. 2010;21:3293-303 pubmed publisher
..Spartin colocalizes with Ist1 at the midbody, and depletion of Ist1 in cells by small interfering RNA significantly decreases the number of cells ..
Bajorek M, Schubert H, McCullough J, Langelier C, Eckert D, Stubblefield W, et al
. Structural basis for ESCRT-III protein autoinhibition. Nat Struct Mol Biol. 2009;16:754-62 pubmed publisher
..Here we show that the N-terminal core domains of increased sodium tolerance-1 (IST1) and charged multivesicular body protein-3 (CHMP3) form equivalent four-helix bundles, revealing that IST1 is a ..
Osako Y, Maemoto Y, Tanaka R, Suzuki H, Shibata H, Maki M. Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction. FEBS J. 2010;277:4412-26 pubmed publisher
..the interaction between calpain 7 and a newly reported ESCRT-III family member, increased sodium tolerance-1 (IST1), which possesses two different types of MIT-interacting motifs (MIM1 and MIM2)...
Renvoisé B, Stadler J, Singh R, Bakowska J, Blackstone C. Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling. Hum Mol Genet. 2012;21:3604-18 pubmed publisher
..and which required its interaction with the endosomal sorting complex required for transport (ESCRT)-III protein IST1. Analysis of the bone morphogenetic protein (BMP) signaling pathway in Spg20-/- embryonic fibroblasts indicated ..
Gu M, LaJoie D, Chen O, von Appen A, Ladinsky M, Redd M, et al
. LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. Proc Natl Acad Sci U S A. 2017;114:E2166-E2175 pubmed publisher
..We further found that, during nuclear envelope formation, recruitment of the ESCRT factors CHMP7, CHMP2A, and IST1/CHMP8 all depend on LEM2 in human cells...
Li Y, Zhang Y, Qiu F, Qiu Z. Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC. Electrophoresis. 2011;32:1976-83 pubmed publisher
..The LRG1 was found to be expressed at higher levels in urinary exosomes and lung tissue of NSCLC patients. These results suggested that LRG1 may be a candidate biomarker for non-invasive diagnosis of NSCLC in urine. ..
Lee S, Chang J, Renvoisé B, Tipirneni A, Yang S, Blackstone C. MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis. Mol Biol Cell. 2012;23:4347-61 pubmed publisher
..strong interactions with charged multivesicular body protein 1B (CHMP1B), CHMP2A, and increased sodium tolerance-1 (IST1)...