Gene Symbol: Irak4
Description: interleukin-1 receptor-associated kinase 4
Alias: interleukin-1 receptor-associated kinase 4
Species: rat
Products:     Irak4

Top Publications

  1. Yang Y, Chen Z, Hu S, Hu J, Li B, Li J, et al. Interleukin-1 receptor associated kinases-1/4 inhibition protects against acute hypoxia/ischemia-induced neuronal injury in vivo and in vitro. Neuroscience. 2011;196:25-34 pubmed publisher
    ..These data suggest that IRAK-1/4 inhibition plays a neuroprotective role in H/I-induced brain injury. ..
  2. Bai S, Li D, Zhou Z, Cao J, Xu T, Zhang X, et al. Interleukin-1 Receptor-Associated Kinase 1/4 as a Novel Target for Inhibiting Neointimal Formation After Carotid Balloon Injury. J Atheroscler Thromb. 2015;22:1317-37 pubmed publisher
    Interleukin-1 receptor-associated kinase 1 (IRAK1) and IRAK4 play essential roles in the induction of inflammatory gene products...
  3. Sun K, Chen Y, Liang S, Liu Z, Liao W, Ou Z, et al. Effect of taurine on IRAK4 and NF-kappa B in Kupffer cells from rat liver grafts after ischemia-reperfusion injury. Am J Surg. 2012;204:389-95 pubmed publisher
  4. Kumar H, Kawai T, Akira S. Pathogen recognition by the innate immune system. Int Rev Immunol. 2011;30:16-34 pubmed publisher
    ..In this review, we comprehensively review the recent progress in the field of PAMP recognition by PRRs and the signaling pathways activated by PRRs. ..
  5. Chen H, Zhu W, Feng J, Li S. Protective effect of diallyl trisulfide on liver in rats with sepsis and the mechanism. J Huazhong Univ Sci Technolog Med Sci. 2012;32:657-662 pubmed publisher
    ..The protective effect might be related to its ability to inhibit the signal pathway of IRAK-4 and NF-?B, thereby decreasing the production of oxygen free radicals and down-regulating the expression of c-fos and c-jun. ..
  6. Li J, Lai X, Chen Y, Niu B, Gong J. Endotoxin tolerance attenuates liver ischemia/reperfusion injury by down-regulation of interleukin-1 receptor-associated kinase 4 in kupffer cells. Transplant Proc. 2011;43:2531-5 pubmed publisher
    ..05). Endotoxin preconditioning attenuated the liver I/R injury caused by transplantation. The expression of IRAK-4 in KCs may play an important role in the formation of ET. ..
  7. Weber A, Wasiliew P, Kracht M. Interleukin-1 (IL-1) pathway. Sci Signal. 2010;3:cm1 pubmed publisher
    ..Of note, most intracellular components that participate in the cellular response to IL-1 also mediate responses to other cytokines (IL-18 and IL-33), Toll-like-receptors (TLRs), and many forms of cytotoxic stresses. ..
  8. Li S, Strelow A, Fontana E, Wesche H. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci U S A. 2002;99:5567-72 pubmed
  9. Chandrasekar B, Mummidi S, Valente A, Patel D, Bailey S, Freeman G, et al. The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt. J Biol Chem. 2005;280:26263-77 pubmed
    ..inhibitor SP600125, antisense JNK and dominant negative MyD88, interleukin-1 receptor-associated kinase (IRAK)-1, IRAK4, and phosphatidylinositol 3-kinase expression all attenuated IL-18-mediated AP-1 binding and reporter activity, ..

More Information


  1. Felderhoff Mueser U, Sifringer M, Polley O, Dzietko M, Leineweber B, Mahler L, et al. Caspase-1-processed interleukins in hyperoxia-induced cell death in the developing brain. Ann Neurol. 2005;57:50-9 pubmed
    ..These cytokines might serve as useful targets for therapeutic approaches aimed at preserving neuronal function in the immature brain, which is exquisitely sensitive to a variety of iatrogenic measures including oxygen. ..
  2. Picard C, Puel A, Bonnet M, Ku C, Bustamante J, Yang K, et al. Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science. 2003;299:2076-9 pubmed
    ..These findings suggest that, in humans, the TIR-IRAK signaling pathway is crucial for protective immunity against specific bacteria but is redundant against most other microorganisms. ..
  3. Heinz L, Rebsamen M, Rossi D, Staehli F, Schroder K, Quadroni M, et al. The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade. Cell Death Differ. 2012;19:722-31 pubmed publisher
    ..Unc5CL required IRAK1, IRAK4 and TNF receptor-associated factor 6 but not MyD88 for its ability to activate these pathways...
  4. Lye E, Mirtsos C, Suzuki N, Suzuki S, Yeh W. The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J Biol Chem. 2004;279:40653-8 pubmed
    ..These results suggest that IRAK-4 is an integral part of the IL-1R signaling cascade and is capable of transmitting signals both dependent on and independent of its kinase activity. ..
  5. Dzietko M, Hahnemann M, Polley O, Sifringer M, Felderhoff Mueser U, Bührer C. Effects of PMA (PHORBOL-12-MYRISTATE-13-ACETATE) on the Developing Rodent Brain. Biomed Res Int. 2015;2015:318306 pubmed publisher
    ..Mice deficient in IL-18 or IRAK-4 were protected against PMA induced brain injury. PMA treatment during a vulnerable period can alter brain development. IL-18 and IRAK-4 appear to be important for the development of PMA induced injury. ..
  6. Mendoza Barberá E, Corral Rodríguez M, Soares Schanoski A, Velarde M, Macieira S, Messerschmidt A, et al. Contribution of globular death domains and unstructured linkers to MyD88.IRAK-4 heterodimer formation: an explanation for the antagonistic activity of MyD88s. Biochem Biophys Res Commun. 2009;380:183-7 pubmed publisher
  7. Bouma G, Doffinger R, Patel S, Peskett E, Sinclair J, Barcenas Morales G, et al. Impaired neutrophil migration and phagocytosis in IRAK-4 deficiency. Br J Haematol. 2009;147:153-6 pubmed publisher
  8. Wang D, Miao C, Gong J. [Effect of the liver X receptor agonist on LPS-induced inflammatory response associated factor IRAK-4 and NF-kappaB]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009;25:293-5, 298 pubmed
    ..The levels of IRAK4 and NF-kappaB mRNA and protein in the combined-treatment group were evidently lower than those in LPS group...
  9. Verstrepen L, Bekaert T, Chau T, Tavernier J, Chariot A, Beyaert R. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Cell Mol Life Sci. 2008;65:2964-78 pubmed publisher
    ..In this review, we will discuss our current knowledge of NF-kappaB signaling in response to TLR-4, TNF-R and IL-1R stimulation, with a special focus on the similarities and dissimilarities among these pathways. ..